anti-Sirtuin 2 (SIRT2) Antikörper

SIRT2 encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Zusätzlich bieten wir Ihnen Sirtuin 2 Kits (33) und Sirtuin 2 Proteine (20) und viele weitere Produktgruppen zu diesem Protein an.

Alle Antikörper anzeigen Gen GeneID UniProt
SIRT2 22933 Q8IXJ6
SIRT2 64383 Q8VDQ8
SIRT2 361532 Q5RJQ4
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Top anti-Sirtuin 2 Antikörper auf antikoerper-online.de

Showing 10 out of 153 products:

Katalog Nr. Reaktivität Wirt Konjugat Applikation Bilder Menge Anbieter Lieferzeit Preis Details
Rind (Kuh) Kaninchen Unkonjugiert WB WB Suggested Anti-SIRT2 Antibody Titration:  0.2-1 ug/ml  ELISA Titer:  1:312500  Positive Control:  Human brain 100 μL Anmelden zum Anzeigen 2 bis 3 Tage
$289.00
Details
Rind (Kuh) Kaninchen Unkonjugiert WB WB Suggested Anti-SIRT2 Antibody Titration:  0.2-1 ug/ml  Positive Control:  Human brain Lanes:   1. 30 ug mouse pancreas extract 2. 30 ug mouse pancreas extract 3. 30 ug mouse pancreas extract  Primary Antibody Dilution:   1:1000  Secondary Antibody:   Anti-rabbit HRP  Secondary Antibody Dilution:   1:2000  Gene Name:   SIRT2  Submitted by:   Dr. Jin Hee Lee, Ph.D., Winthrop-University Hospital 100 μL Anmelden zum Anzeigen 2 bis 3 Tage
$289.00
Details
Human Kaninchen Unkonjugiert IHC (p), WB Anti-SIRT2 Picoband antibody,  IHC(P): Rat Brain Tissue Anti-SIRT2 Picoband antibody,  IHC(P): Mouse Brain Tissue 100 μg Anmelden zum Anzeigen 4 bis 6 Tage
$280.00
Details
Human Kaninchen Unkonjugiert EIA, IHC (p), WB Human Brain, Cerebellum (formalin-fixed, paraffin-embedded) stained with SIRT2at 5 µg/ml followed by biotinylated goat anti-rabbit IgG secondary antibody, alkaline phosphatase-streptavidin and chromogen. Human Heart (formalin-fixed, paraffin-embedded) stained with SIRT2at 5 µg/ml followed by biotinylated goat anti-rabbit IgG secondary antibody, alkaline phosphatase-streptavidin and chromogen. 50 μg Anmelden zum Anzeigen 6 bis 8 Tage
$390.50
Details
Human Kaninchen Unkonjugiert IHC, IHC (p), WB Western Blot: SIRT2 Antibody [NBP1-87039] - Lane 1: Marker [kDa] 250, 130, 95, 72, 55, 36, 28, 17, 10.Lane 2: Negative control (vector only transfected HEK293T lysate).Lane 3: Over-expression lysate (Co-expressed with a C-terminal myc-DDK tag (~3.1 kDa) in mammalian HEK293T cells, LY402172) Immunohistochemistry-Paraffin: SIRT2 Antibody [NBP1-87039] - Staining of human colon shows strong cytoplasmic and membranous positivity in glandular cells. 0.1 mL Anmelden zum Anzeigen 10 bis 13 Tage
$494.38
Details
Human Kaninchen Unkonjugiert WB   200 μL Anmelden zum Anzeigen 13 bis 14 Tage
$487.50
Details
Human Kaninchen Unkonjugiert IHC, WB 100 μg Anmelden zum Anzeigen 2 bis 3 Tage
$335.00
Details
Human Kaninchen Unkonjugiert ELISA, IHC, IHC (p), WB Human Brain, Cerebellum (formalin-fixed, paraffin-embedded) stained with SIRT2 antibody ABIN461915 at 5 ug/ml followed by biotinylated goat anti-rabbit IgG secondary antibody ABIN481713, alkaline phosphatase-streptavidin and chromogen. Human Heart (formalin-fixed, paraffin-embedded) stained with SIRT2 antibody ABIN461915 at 5 ug/ml followed by biotinylated goat anti-rabbit IgG secondary antibody ABIN481713, alkaline phosphatase-streptavidin and chromogen. 50 μg Anmelden zum Anzeigen 11 bis 14 Tage
$484.00
Details
Human Maus Unkonjugiert ELISA, IF, WB Antibody Reactive Against Recombinant Protein.Western Blot detection against Immunogen (36.63 KDa) . Dilution: 1:500~1000 100 μg Anmelden zum Anzeigen 8 bis 11 Tage
$527.50
Details
Human Kaninchen Unkonjugiert WB 100 μg Anmelden zum Anzeigen 2 bis 3 Tage
$245.00
Details

Am meisten referenzierte anti-Sirtuin 2 Antikörper

  1. Human Polyclonal SIRT2 Primary Antibody für WB - ABIN549524 : Werner, Kuhlmann, Shen, Uecker, Schardt, Dimova, Orfaniotou, Dhaunchak, Brinkmann, Möbius, Guarente, Casaccia-Bonnefil, Jahn, Nave: Proteolipid protein is required for transport of sirtuin 2 into CNS myelin. in The Journal of neuroscience : the official journal of the Society for Neuroscience 2007 (PubMed)
    Show all 3 Pubmed References

  2. Human Polyclonal SIRT2 Primary Antibody für IHC (p), WB - ABIN541686 : Frye: Characterization of five human cDNAs with homology to the yeast SIR2 gene: Sir2-like proteins (sirtuins) metabolize NAD and may have protein ADP-ribosyltransferase activity. in Biochemical and biophysical research communications 1999 (PubMed)
    Show all 3 Pubmed References

  3. Human Polyclonal SIRT2 Primary Antibody für IHC (p), WB - ABIN541684 : North, Marshall, Borra, Denu, Verdin: The human Sir2 ortholog, SIRT2, is an NAD+-dependent tubulin deacetylase. in Molecular cell 2003 (PubMed)
    Show all 3 Pubmed References

  4. Human Monoclonal SIRT2 Primary Antibody für WB - ABIN2668611 : Pandithage, Lilischkis, Harting, Wolf, Jedamzik, Lüscher-Firzlaff, Vervoorts, Lasonder, Kremmer, Knöll, Lüscher: The regulation of SIRT2 function by cyclin-dependent kinases affects cell motility. in The Journal of cell biology 2008 (PubMed)

  5. Human Polyclonal SIRT2 Primary Antibody für ICC, IF - ABIN2668615 : Dryden, Nahhas, Nowak, Goustin, Tainsky: Role for human SIRT2 NAD-dependent deacetylase activity in control of mitotic exit in the cell cycle. in Molecular and cellular biology 2003 (PubMed)

  6. Mouse (Murine) Polyclonal SIRT2 Primary Antibody für ICC, IF - ABIN2668616 : Southwood, Peppi, Dryden, Tainsky, Gow: Microtubule deacetylases, SirT2 and HDAC6, in the nervous system. in Neurochemical research 2007 (PubMed)

  7. Cow (Bovine) Polyclonal SIRT2 Primary Antibody für WB - ABIN2779604 : Borra, Langer, Slama, Denu: Substrate specificity and kinetic mechanism of the Sir2 family of NAD+-dependent histone/protein deacetylases. in Biochemistry 2004 (PubMed)
    Show all 2 Pubmed References

  8. Human Polyclonal SIRT2 Primary Antibody für IHC, IHC (p) - ABIN4353913 : Bajpe, Prahallad, Horlings, Nagtegaal, Beijersbergen, Bernards: A chromatin modifier genetic screen identifies SIRT2 as a modulator of response to targeted therapies through the regulation of MEK kinase activity. in Oncogene 2015 (PubMed)

  9. Human Polyclonal SIRT2 Primary Antibody für ELISA, ICC - ABIN4353911 : Zhao, Mo, Li, Zou, Cheng, Sun, Xiong, Guan, Lei: NOTCH-induced aldehyde dehydrogenase 1A1 deacetylation promotes breast cancer stem cells. in The Journal of clinical investigation 2014 (PubMed)

Weitere Antikörper gegen Sirtuin 2 Interaktionspartner

Fruit Fly (Drosophila melanogaster) Sirtuin 2 (SIRT2) Interaktionspartner

  1. Sirt2 has an role in the regulation of mitochondrial energy metabolism.

Arabidopsis thaliana Sirtuin 2 (SIRT2) Interaktionspartner

  1. SRT2 is important in fine-tuning mitochondrial energy metabolism.

  2. AtSRT2 is a deacetylase that negatively regulates the plant basal defense and PR1 expression.

Human Sirtuin 2 (SIRT2) Interaktionspartner

  1. Our data provide strong evidence that sirtuin-2 controls the functional ability of the autophagic system through acetylation and highlight the association between mitochondrial metabolism and neurodegeneration in sporadic Parkinson's disease.

  2. Data found that SIRT2 is a novel deacetylase of HSP90, enhances its ubiquitination-mediated proteasomal degradation, and consequently down-regulates HSP90/LIMK1/cofilin-linked actin polymerization regulation pathway. The deacetylase activity of SIRT2 is required to reduce cell motility by regulating the stability of HSP90. These results demonstrate that SIRT2 functions as a tumor suppressor.

  3. we provide insight into the regulation of SIRT2 on gastric cancer metabolism and metastasis. SIRT2 increased PEPCK1 protein levels and mitochondrial activity, as well as induced cell migration and invasion by activating the RAS/ERK/JNK/MMP-9 pathway

  4. MiR150 plays an important role in the development of lung cancer by serving as an oncogene via the SIRT2/JMJD2A signaling pathway.

  5. Studied association of SIRT2 and p53/NF-kB p65 signal pathways in preventing high glucose-induced vascular endothelial cell injury. Results demonstrated that SIRT2 overexpression is associated with deacetylation of p53 and NF-kB p65, which inhibits the high glucose induced apoptosis and vascular endothelial cell inflammation response.

  6. The authors report that one of the K-Ras splice variants, K-Ras4a, is subject to lysine fatty acylation, a previously under-studied protein post-translational modification. Sirtuin 2 (SIRT2), one of the mammalian nicotinamide adenine dinucleotide (NAD)-dependent lysine deacylases, catalyzes the removal of fatty acylation from K-Ras4a.

  7. Low SIRT2 expression is associated with recurrence in prostate cancer.

  8. SIRT2 participates in the activation of fibroblasts and tubulointerstitial fibrosis, which is mediated via regulation of the MDM2 pathway, and the downregulation of SIRT2.

  9. Findings suggested that the DNA sequence variants may increase SIRT2 gene promoter activity and SIRT2 levels, contributing to T2D development as a risk factor.

  10. Chemical inhibitors against SIRT2 suppress G6PD activity, leading to reduced cell proliferation of leukaemia cells, but not normal hematopoietic stem and progenitor cells. Importantly, SIRT2 is overexpressed in clinical acute myeloid leukaemia samples, while K403 acetylation is downregulated and G6PD catalytic activity is increased comparing to that of normal control.

  11. SIRT2 may have a role in unfavorable prognosis of acute myeloid leukemia

  12. Data suggest that inhibition of sirtuin 1 and sirtuin 2 in hepatocellular carcinoma cells (a) impairs cell survival and cell migration and (b) down-regulates expression of P-glycoprotein and MRP3 (ATP binding cassette subfamily C member 3).

  13. SIRT2 inhibition may improve microtubule assembly thus representing a valid approach as disease-modifying therapy for Alzheimer's disease.

  14. Data show that single nucleotide polymorphism rs2015C in sirtuin 2 protein (SIRT2) gene 3'-UTR was significantly associated with increased risk of colorectal cancer (CRC).

  15. Authors show that SIRT2 is downregulated in insulin-resistant hepatocytes and livers, and this was accompanied by increased generation of reactive oxygen species, activation of stress-sensitive ERK1/2 kinase, and mitochondrial dysfunction.

  16. Those findings highlight the potential role of SIRT2 in HBV and HBV-mediated HCC by interaction with HBx.

  17. The SIRT2 functions as a mitochondrial sirtuin, as well as a regulator of autophagy/mitophagy to maintain mitochondrial biology, thus facilitating cell survival.

  18. increased expression of SRF that was observed in the aged heart may affect SIRT2 gene expression and contribute to altered metabolic status in senescence

  19. SIRT2 and RIPK1 were localized to the syncytiotrophoblast, villous leukocytes and vasculature in all preterm placentas. A significant reduction in SIRT2 protein expression in both preeclampsia and fetal growth restricted placentas was identified. Immunofluorescence identified both SIRT2 and RIPK1 in the cytotrophoblast cytoplasm.

  20. mutations in sirtuin2 increase the stability of the conserved catalytic sirtuin domain, thereby increasing the catalytic efficiency of the mutant enzymes.

Cow (Bovine) Sirtuin 2 (SIRT2) Interaktionspartner

  1. the novel 12-bp indel of SIRT1 gene, the 7-bp indel of SIRT2 gene and the 26-bp indel of SIRT3 gene were firstly reported, respectively. The association analysis indicated that the indels within SIRT1 and SIRT2 genes were significantly associated with body measurement traits such as body weight, chest circumference, height at hip cross, hip width, body height, etc.

  2. The results indicate that the variations in the class I sirtuin genes and their corresponding genotypes may be considered as molecular markers for economic traits in cattle breeding.

  3. An association analysis showed that the two loci of SIRT2 were significantly correlated with some body size traits and the H2H2 (-CT-CT-) diplotypes performed better than other combinations.

  4. Data suggest that the silent information regulator 2 (SIRT2) gene may be a candidate gene for marker-assisted selection in the development of breeding programs for Qinchuan cattle.

Mouse (Murine) Sirtuin 2 (SIRT2) Interaktionspartner

  1. These findings indicate that the NAD(+)/SIRT2 pathway is an important mediator through which silybin prevents NLRP3 inflammasome activation during NAFLD

  2. both NAD and NADH significantly increased the intracellular ATP levels of BV2 microglia, which were attenuated by SIRT2 siRNA, the SIRT2 inhibitor AGK2, and the phosphatidylinositol 3-kinase/Akt inhibitor LY294002. Results suggested that SIRT2 mediates the NAD-induced and NADH-induced increase in Akt phosphorylation in BV2 microglia.

  3. These findings suggest that SIRT2 inhibited atherosclerotic plaque progression and enhanced plaque stability in LDL receptor knockout mice by inhibiting macrophage polarization towards the M1 phenotype.

  4. Results provide a novel link between SIRT2 and physiological aging impacting the axonal compartment of the central nervous system, while supporting a major role for SIRT2 in orchestrating its metabolic regulation.

  5. CDK5-mediated phosphorylation of Sirt2 has a role in to depressive-like behavior induced by social defeat stress

  6. These results confirm that SIRT2 inhibition is able to reverse anhedonia in different animal models and highlight the need to further investigate the role of SIRT2 inhibitors as new antidepressant agents.

  7. SIRT2 knockout mice show marked up-regulation in AMPAR acetylation and protein accumulation, aberrant synaptic plasticity and impaired memory.

  8. SIRT2 inhibition may improve microtubule assembly thus representing a valid approach as disease-modifying therapy for Alzheimer's disease.

  9. Authors show that SIRT2 is downregulated in insulin-resistant hepatocytes and livers, and this was accompanied by increased generation of reactive oxygen species, activation of stress-sensitive ERK1/2 kinase, and mitochondrial dysfunction.

  10. Given the significance of KRAS activity as a driver in tumorigenesis, identification of K147 acetylation as a novel post-translational modification directed by SIRT2 in vivo may provide a better understanding of the mechanistic link regarding the crosstalk between non-genetic and genetic factors in KRAS driven tumors.

  11. SIRT2 modulates microvascular inflammation in sepsis and affects survival

  12. This study showed that Sirt2-dependent GKRP deacetylation improves impaired HGU and suggest that it may be a therapeutic target for type 2 diabetes.

  13. AMPK and Sirt2 control compensatory glucose uptake in metabolically arrested mitochondria.

  14. SIRT2 promotes AMPK activation by deacetylating the kinase LKB1. Loss of SIRT2 reduces AMPK activation, promotes aging-related and Ang II-induced cardiac hypertrophy, and blunts metformin-mediated cardioprotective effects.

  15. found a decreased ratio of dopaminergic neurons in primary midbrain cultures treated with the SIRT2 inhibitor AK-7

  16. mitochondrial dysfunction triggers LKB1-mediated AMPK activation, which stimulates Sirt2 phosphorylation, leading to activation of mTOR-RAPTOR and Glut1-mediated glucose uptake.

  17. SIRT-2 regulates microvascular inflammation in obese mice with sepsis.

  18. Loss of SIRT2 expression is associated with breast Cancer.

  19. Genetic manipulation of sirtuin 2 levels in vitro and in vivo modulates the levels of alpha-synuclein acetylation, its aggregation, and autophagy.

  20. QKI directly plays a crucial role in the post-transcriptional regulation and expression of Sirt2 to facilitate oligodendrocyte differentiation.

Sirtuin 2 (SIRT2) Antigen-Profil

Protein Überblick

This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined\; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class I of the sirtuin family. Several transcript variants are resulted from alternative splicing of this gene.

Genbezeichner und Symbole assoziert mit anti-Sirtuin 2 (SIRT2) Antikörper

  • Sirtuin 2 (Sirt2) Antikörper
  • sirtuin 2 (SIRT2) Antikörper
  • sirtuin 2 S homeolog (sirt2.S) Antikörper
  • NAD-dependent deacetylase sirtuin 2 homolog (Sirt2) Antikörper
  • sirtuin 2 (SRT2) Antikörper
  • sirtuin 2 (sirt2) Antikörper
  • sirtuin 2 (Sirt2) Antikörper
  • sirtuin 2 (silent mating type information regulation 2, homolog) 2 (S. cerevisiae) (sirt2) Antikörper
  • 5730427M03Rik Antikörper
  • AtSRT2 Antikörper
  • BmSirt2 Antikörper
  • CG5085 Antikörper
  • D.mel2 Antikörper
  • Dmel\\CG5085 Antikörper
  • dSIRT2 Antikörper
  • SIR2 Antikörper
  • Sir2l Antikörper
  • SIR2L2 Antikörper
  • Sirt2 Antikörper
  • sirtuin 2 Antikörper
  • T2K12.8 Antikörper
  • wu:fb57d05 Antikörper
  • zgc:55966 Antikörper
  • zgc:77003 Antikörper

Bezeichner auf Proteinebene für anti-Sirtuin 2 (SIRT2) Antikörper

CG5085-PA , Sirt2-PA , sirtuin (silent mating type information regulation 2 homolog) 2 (S. cerevisiae) , sirtuin 2 , NAD-dependent deacetylase SIRT2 , NAD-dependent deacetylase sirtuin-2 , histone NADC , silent information regulator 2 , nicotinamide adenine dinucleotide-dependent histone deacetylase , NAD-dependent deacetylase sirtuin 2 homolog , NAD-dependent protein deacetylase sirtuin-2 , SIR2-like protein 2 , regulatory protein SIR2 homolog 2 , sir2-related protein type 2 , sirtuin type 2 , sirtuin-like protein 2 , mSIR2L2 , silent mating type information regulation 2, (S.cerevisiae, homolog)-like; sirtuin 2 , 5E5 antigen

GENE ID SPEZIES
42414 Drosophila melanogaster
456013 Pan troglodytes
495688 Xenopus laevis
548628 Gallus gallus
612558 Canis lupus familiaris
692483 Bombyx mori
830782 Arabidopsis thaliana
100380582 Salmo salar
22933 Homo sapiens
100125964 Sus scrofa
504463 Bos taurus
64383 Mus musculus
361532 Rattus norvegicus
100172430 Pongo abelii
322309 Danio rerio
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