anti-Sirtuin 2 (SIRT2) Antikörper

SIRT2 encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Zusätzlich bieten wir Ihnen Sirtuin 2 Kits (33) und Sirtuin 2 Proteine (20) und viele weitere Produktgruppen zu diesem Protein an.

Alle Antikörper anzeigen Gen GeneID UniProt
SIRT2 22933 Q8IXJ6
SIRT2 64383 Q8VDQ8
SIRT2 361532 Q5RJQ4
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Top anti-Sirtuin 2 Antikörper auf antikoerper-online.de

Showing 10 out of 149 products:

Katalog Nr. Reaktivität Wirt Konjugat Applikation Bilder Menge Anbieter Lieferzeit Preis Details
Rind (Kuh) Kaninchen Unkonjugiert WB WB Suggested Anti-SIRT2 Antibody Titration:  0.2-1 ug/ml  ELISA Titer:  1:312500  Positive Control:  Human brain 100 μL Anmelden zum Anzeigen 2 bis 3 Tage
$289.00
Details
Rind (Kuh) Kaninchen Unkonjugiert WB WB Suggested Anti-SIRT2 Antibody Titration:  0.2-1 ug/ml  Positive Control:  Human brain Lanes:   1. 30 ug mouse pancreas extract 2. 30 ug mouse pancreas extract 3. 30 ug mouse pancreas extract  Primary Antibody Dilution:   1:1000  Secondary Antibody:   Anti-rabbit HRP  Secondary Antibody Dilution:   1:2000  Gene Name:   SIRT2  Submitted by:   Dr. Jin Hee Lee, Ph.D., Winthrop-University Hospital 100 μL Anmelden zum Anzeigen 2 bis 3 Tage
$289.00
Details
Human Kaninchen Unkonjugiert IHC (p), WB Anti-SIRT2 Picoband antibody,  IHC(P): Rat Brain Tissue Anti-SIRT2 Picoband antibody,  IHC(P): Mouse Brain Tissue 100 μg Anmelden zum Anzeigen 4 bis 6 Tage
$280.00
Details
Human Kaninchen Unkonjugiert IHC, IHC (p), WB Western Blot: SIRT2 Antibody [NBP1-87039] - Lane 1: Marker [kDa] 250, 130, 95, 72, 55, 36, 28, 17, 10.Lane 2: Negative control (vector only transfected HEK293T lysate).Lane 3: Over-expression lysate (Co-expressed with a C-terminal myc-DDK tag (~3.1 kDa) in mammalian HEK293T cells, LY402172) Immunohistochemistry-Paraffin: SIRT2 Antibody [NBP1-87039] - Staining of human colon shows strong cytoplasmic and membranous positivity in glandular cells. 0.1 mL Anmelden zum Anzeigen 10 bis 13 Tage
$491.63
Details
Human Kaninchen Unkonjugiert EIA, IHC (p), WB Human Brain, Cerebellum (formalin-fixed, paraffin-embedded) stained with SIRT2at 5 µg/ml followed by biotinylated goat anti-rabbit IgG secondary antibody, alkaline phosphatase-streptavidin and chromogen. Human Heart (formalin-fixed, paraffin-embedded) stained with SIRT2at 5 µg/ml followed by biotinylated goat anti-rabbit IgG secondary antibody, alkaline phosphatase-streptavidin and chromogen. 50 μg Anmelden zum Anzeigen 6 bis 8 Tage
$390.50
Details
Human Kaninchen Unkonjugiert WB   200 μL Anmelden zum Anzeigen 13 bis 14 Tage
$487.50
Details
Human Kaninchen Unkonjugiert IHC, WB 100 μg Anmelden zum Anzeigen 2 bis 3 Tage
$335.00
Details
Human Maus Unkonjugiert ELISA, IF, WB Antibody Reactive Against Recombinant Protein.Western Blot detection against Immunogen (36.63 KDa) . Dilution: 1:500~1000 100 μg Anmelden zum Anzeigen 8 bis 11 Tage
$461.00
Details
Human Kaninchen Unkonjugiert WB 100 μg Anmelden zum Anzeigen 2 bis 3 Tage
$245.00
Details
Ratte Kaninchen Unkonjugiert ICC, IHC, WB Figure. Western Blot; Sample: Lane1: Rat Brain Tissue; Lane2: Mouse Brain Tissue. 100 μg Anmelden zum Anzeigen 15 bis 18 Tage
$342.00
Details

Am meisten referenzierte anti-Sirtuin 2 Antikörper

  1. Cow (Bovine) Polyclonal SIRT2 Primary Antibody für WB - ABIN2779604 : Borra, Langer, Slama, Denu: Substrate specificity and kinetic mechanism of the Sir2 family of NAD+-dependent histone/protein deacetylases. in Biochemistry 2004 (PubMed)
    Show all 2 Pubmed References

  2. Human Monoclonal SIRT2 Primary Antibody für WB - ABIN2668611 : Pandithage, Lilischkis, Harting, Wolf, Jedamzik, Lüscher-Firzlaff, Vervoorts, Lasonder, Kremmer, Knöll, Lüscher: The regulation of SIRT2 function by cyclin-dependent kinases affects cell motility. in The Journal of cell biology 2008 (PubMed)

  3. Human Polyclonal SIRT2 Primary Antibody für ICC, IF - ABIN2668615 : Dryden, Nahhas, Nowak, Goustin, Tainsky: Role for human SIRT2 NAD-dependent deacetylase activity in control of mitotic exit in the cell cycle. in Molecular and cellular biology 2003 (PubMed)

  4. Mouse (Murine) Polyclonal SIRT2 Primary Antibody für ICC, IF - ABIN2668616 : Southwood, Peppi, Dryden, Tainsky, Gow: Microtubule deacetylases, SirT2 and HDAC6, in the nervous system. in Neurochemical research 2007 (PubMed)

  5. Human Polyclonal SIRT2 Primary Antibody für ELISA, ICC - ABIN4353911 : Zhao, Mo, Li, Zou, Cheng, Sun, Xiong, Guan, Lei: NOTCH-induced aldehyde dehydrogenase 1A1 deacetylation promotes breast cancer stem cells. in The Journal of clinical investigation 2014 (PubMed)

  6. Human Polyclonal SIRT2 Primary Antibody für IHC, IHC (p) - ABIN4353913 : Bajpe, Prahallad, Horlings, Nagtegaal, Beijersbergen, Bernards: A chromatin modifier genetic screen identifies SIRT2 as a modulator of response to targeted therapies through the regulation of MEK kinase activity. in Oncogene 2015 (PubMed)

Weitere Antikörper gegen Sirtuin 2 Interaktionspartner

Fruit Fly (Drosophila melanogaster) Sirtuin 2 (SIRT2) Interaktionspartner

  1. Sirt2 has an role in the regulation of mitochondrial energy metabolism.

Arabidopsis thaliana Sirtuin 2 (SIRT2) Interaktionspartner

  1. SRT2 is important in fine-tuning mitochondrial energy metabolism.

  2. AtSRT2 is a deacetylase that negatively regulates the plant basal defense and PR1 (zeige TMEM37 Antikörper) expression.

Human Sirtuin 2 (SIRT2) Interaktionspartner

  1. Studied association of SIRT2 and p53 (zeige TP53 Antikörper)/NF-kB p65 signal pathways in preventing high glucose-induced vascular endothelial cell injury. Results demonstrated that SIRT2 overexpression is associated with deacetylation of p53 (zeige TP53 Antikörper) and NF-kB p65, which inhibits the high glucose induced apoptosis and vascular endothelial cell inflammation response.

  2. The authors report that one of the K-Ras (zeige HRAS Antikörper) splice variants, K-Ras4a, is subject to lysine fatty acylation, a previously under-studied protein post-translational modification. Sirtuin 2 (SIRT2), one of the mammalian nicotinamide adenine dinucleotide (NAD)-dependent lysine deacylases, catalyzes the removal of fatty acylation from K-Ras4a.

  3. Low SIRT2 expression is associated with recurrence in prostate cancer.

  4. SIRT2 participates in the activation of fibroblasts and tubulointerstitial fibrosis, which is mediated via regulation of the MDM2 (zeige MDM2 Antikörper) pathway, and the downregulation of SIRT2.

  5. Findings suggested that the DNA sequence variants may increase SIRT2 gene promoter activity and SIRT2 levels, contributing to T2D development as a risk factor.

  6. Chemical inhibitors against SIRT2 suppress G6PD (zeige G6PD Antikörper) activity, leading to reduced cell proliferation of leukaemia cells, but not normal hematopoietic stem and progenitor cells. Importantly, SIRT2 is overexpressed in clinical acute myeloid leukaemia samples, while K403 acetylation is downregulated and G6PD (zeige G6PD Antikörper) catalytic activity is increased comparing to that of normal control.

  7. SIRT2 may have a role in unfavorable prognosis of acute myeloid leukemia (zeige BCL11A Antikörper)

  8. Data suggest that inhibition of sirtuin 1 and sirtuin 2 in hepatocellular carcinoma cells (a) impairs cell survival and cell migration and (b) down-regulates expression of P-glycoprotein and MRP3 (ATP binding cassette subfamily C member 3).

  9. SIRT2 inhibition may improve microtubule assembly thus representing a valid approach as disease-modifying therapy for Alzheimer's disease.

  10. Data show that single nucleotide polymorphism rs2015C in sirtuin 2 protein (SIRT2) gene 3'-UTR (zeige UTS2R Antikörper) was significantly associated with increased risk of colorectal cancer (CRC (zeige CALR Antikörper)).

Cow (Bovine) Sirtuin 2 (SIRT2) Interaktionspartner

  1. The results indicate that the variations in the class I sirtuin (zeige SIRT1 Antikörper) genes and their corresponding genotypes may be considered as molecular markers for economic traits in cattle breeding.

  2. An association analysis showed that the two loci of SIRT2 were significantly correlated with some body size traits and the H2H2 (-CT-CT (zeige CALCA Antikörper)-) diplotypes performed better than other combinations.

  3. Data suggest that the silent information regulator 2 (SIRT2) gene may be a candidate gene for marker-assisted selection in the development of breeding programs for Qinchuan cattle.

Mouse (Murine) Sirtuin 2 (SIRT2) Interaktionspartner

  1. both NAD and NADH significantly increased the intracellular ATP levels of BV2 (zeige DNAH9 Antikörper) microglia, which were attenuated by SIRT2 siRNA, the SIRT2 inhibitor AGK2 (zeige GUK1 Antikörper), and the phosphatidylinositol 3-kinase/Akt (zeige AKT1 Antikörper) inhibitor LY294002. Results suggested that SIRT2 mediates the NAD-induced and NADH-induced increase in Akt (zeige AKT1 Antikörper) phosphorylation in BV2 (zeige DNAH9 Antikörper) microglia.

  2. These findings suggest that SIRT2 inhibited atherosclerotic plaque progression and enhanced plaque stability in LDL receptor (zeige LDLR Antikörper) knockout mice by inhibiting macrophage polarization towards the M1 phenotype.

  3. Results provide a novel link between SIRT2 and physiological aging impacting the axonal compartment of the central nervous system, while supporting a major role for SIRT2 in orchestrating its metabolic regulation.

  4. CDK5 (zeige CDK5 Antikörper)-mediated phosphorylation of Sirt2 has a role in to depressive-like behavior induced by social defeat stress

  5. These results confirm that SIRT2 inhibition is able to reverse anhedonia in different animal models and highlight the need to further investigate the role of SIRT2 inhibitors as new antidepressant agents.

  6. SIRT2 knockout mice show marked up-regulation in AMPAR acetylation and protein accumulation, aberrant synaptic plasticity and impaired memory.

  7. SIRT2 inhibition may improve microtubule assembly thus representing a valid approach as disease-modifying therapy for Alzheimer's disease.

  8. Authors show that SIRT2 is downregulated in insulin-resistant hepatocytes and livers, and this was accompanied by increased generation of reactive oxygen species, activation of stress-sensitive ERK1/2 kinase, and mitochondrial dysfunction.

  9. Given the significance of KRAS activity as a driver in tumorigenesis, identification of K147 acetylation as a novel post-translational modification directed by SIRT2 in vivo may provide a better understanding of the mechanistic link regarding the crosstalk between non-genetic and genetic factors in KRAS driven tumors.

  10. SIRT2 modulates microvascular inflammation in sepsis and affects survival

Sirtuin 2 (SIRT2) Antigen-Profil

Protein Überblick

This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined\; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class I of the sirtuin family. Several transcript variants are resulted from alternative splicing of this gene.

Genbezeichner und Symbole assoziert mit anti-Sirtuin 2 (SIRT2) Antikörper

  • Sirtuin 2 (Sirt2) Antikörper
  • sirtuin 2 (SIRT2) Antikörper
  • sirtuin 2 S homeolog (sirt2.S) Antikörper
  • NAD-dependent deacetylase sirtuin 2 homolog (Sirt2) Antikörper
  • sirtuin 2 (SRT2) Antikörper
  • sirtuin 2 (sirt2) Antikörper
  • sirtuin 2 (Sirt2) Antikörper
  • sirtuin 2 (silent mating type information regulation 2, homolog) 2 (S. cerevisiae) (sirt2) Antikörper
  • 5730427M03Rik Antikörper
  • AtSRT2 Antikörper
  • BmSirt2 Antikörper
  • CG5085 Antikörper
  • D.mel2 Antikörper
  • Dmel\\CG5085 Antikörper
  • dSIRT2 Antikörper
  • SIR2 Antikörper
  • Sir2l Antikörper
  • SIR2L2 Antikörper
  • Sirt2 Antikörper
  • sirtuin 2 Antikörper
  • T2K12.8 Antikörper
  • wu:fb57d05 Antikörper
  • zgc:55966 Antikörper
  • zgc:77003 Antikörper

Bezeichner auf Proteinebene für anti-Sirtuin 2 (SIRT2) Antikörper

CG5085-PA , Sirt2-PA , sirtuin (silent mating type information regulation 2 homolog) 2 (S. cerevisiae) , sirtuin 2 , NAD-dependent deacetylase SIRT2 , NAD-dependent deacetylase sirtuin-2 , histone NADC , silent information regulator 2 , nicotinamide adenine dinucleotide-dependent histone deacetylase , NAD-dependent deacetylase sirtuin 2 homolog , NAD-dependent protein deacetylase sirtuin-2 , SIR2-like protein 2 , regulatory protein SIR2 homolog 2 , sir2-related protein type 2 , sirtuin type 2 , sirtuin-like protein 2 , mSIR2L2 , silent mating type information regulation 2, (S.cerevisiae, homolog)-like; sirtuin 2 , 5E5 antigen

GENE ID SPEZIES
42414 Drosophila melanogaster
456013 Pan troglodytes
495688 Xenopus laevis
548628 Gallus gallus
612558 Canis lupus familiaris
692483 Bombyx mori
830782 Arabidopsis thaliana
100380582 Salmo salar
22933 Homo sapiens
100125964 Sus scrofa
504463 Bos taurus
64383 Mus musculus
361532 Rattus norvegicus
100172430 Pongo abelii
322309 Danio rerio
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