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SIRT2 encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Zusätzlich bieten wir Ihnen Sirtuin 2 Kits (29) und Sirtuin 2 Proteine (19) und viele weitere Produktgruppen zu diesem Protein an.
Showing 10 out of 129 products:
Human Polyclonal SIRT2 Primary Antibody für ELISA, ICC - ABIN4353911
Zhao, Mo, Li, Zou, Cheng, Sun, Xiong, Guan, Lei: NOTCH-induced aldehyde dehydrogenase 1A1 deacetylation promotes breast cancer stem cells. in The Journal of clinical investigation 2014
Human Monoclonal SIRT2 Primary Antibody für WB - ABIN2668611
Pandithage, Lilischkis, Harting, Wolf, Jedamzik, Lüscher-Firzlaff, Vervoorts, Lasonder, Kremmer, Knöll, Lüscher: The regulation of SIRT2 function by cyclin-dependent kinases affects cell motility. in The Journal of cell biology 2008
Human Polyclonal SIRT2 Primary Antibody für ICC, IF - ABIN2668615
Dryden, Nahhas, Nowak, Goustin, Tainsky: Role for human SIRT2 NAD-dependent deacetylase activity in control of mitotic exit in the cell cycle. in Molecular and cellular biology 2003
Mouse (Murine) Polyclonal SIRT2 Primary Antibody für ICC, IF - ABIN2668616
Southwood, Peppi, Dryden, Tainsky, Gow: Microtubule deacetylases, SirT2 and HDAC6, in the nervous system. in Neurochemical research 2007
Cow (Bovine) Polyclonal SIRT2 Primary Antibody für WB - ABIN2779604
Borra, Langer, Slama, Denu: Substrate specificity and kinetic mechanism of the Sir2 family of NAD+-dependent histone/protein deacetylases. in Biochemistry 2004
Show all 2 Pubmed References
Human Polyclonal SIRT2 Primary Antibody für IHC, IHC (p) - ABIN4353913
Bajpe, Prahallad, Horlings, Nagtegaal, Beijersbergen, Bernards: A chromatin modifier genetic screen identifies SIRT2 as a modulator of response to targeted therapies through the regulation of MEK kinase activity. in Oncogene 2015
Sirt2 has an role in the regulation of mitochondrial energy metabolism.
SRT2 is important in fine-tuning mitochondrial energy metabolism.
AtSRT2 is a deacetylase that negatively regulates the plant basal defense and PR1 (zeige TMEM37 Antikörper) expression.
SIRT2 inhibition may improve microtubule assembly thus representing a valid approach as disease-modifying therapy for Alzheimer's disease.
Data show that single nucleotide polymorphism rs2015C in sirtuin 2 protein (SIRT2) gene 3'-UTR (zeige UTS2R Antikörper) was significantly associated with increased risk of colorectal cancer (CRC (zeige CALR Antikörper)).
Authors show that SIRT2 is downregulated in insulin-resistant hepatocytes and livers, and this was accompanied by increased generation of reactive oxygen species, activation of stress-sensitive ERK1/2 kinase, and mitochondrial dysfunction.
Those findings highlight the potential role of SIRT2 in HBV and HBV-mediated HCC (zeige FAM126A Antikörper) by interaction with HBx.
The SIRT2 functions as a mitochondrial sirtuin (zeige SIRT1 Antikörper), as well as a regulator of autophagy/mitophagy to maintain mitochondrial biology, thus facilitating cell survival.
increased expression of SRF that was observed in the aged heart may affect SIRT2 gene expression and contribute to altered metabolic status in senescence
SIRT2 and RIPK1 (zeige RIPK1 Antikörper) were localized to the syncytiotrophoblast, villous leukocytes and vasculature in all preterm placentas. A significant reduction in SIRT2 protein expression in both preeclampsia and fetal growth restricted placentas was identified. Immunofluorescence identified both SIRT2 and RIPK1 (zeige RIPK1 Antikörper) in the cytotrophoblast cytoplasm.
mutations in sirtuin2 increase the stability of the conserved catalytic sirtuin (zeige SIRT1 Antikörper) domain, thereby increasing the catalytic efficiency of the mutant enzymes.
targeting SIRT2 may be a rational strategy for diminishing Slug abundance and its associated malignant traits in basal-like breast cancer.
BEX4 (zeige BEX4 Antikörper) overexpression causes an imbalance between TUB (zeige TUB Antikörper) acetylation and deacetylation by SIRT2 inhibition and induces oncogenic aneuploidy transformation.
The results indicate that the variations in the class I sirtuin (zeige SIRT1 Antikörper) genes and their corresponding genotypes may be considered as molecular markers for economic traits in cattle breeding.
An association analysis showed that the two loci of SIRT2 were significantly correlated with some body size traits and the H2H2 (-CT-CT (zeige CALCA Antikörper)-) diplotypes performed better than other combinations.
Data suggest that the silent information regulator 2 (SIRT2) gene may be a candidate gene for marker-assisted selection in the development of breeding programs for Qinchuan cattle.
Given the significance of KRAS activity as a driver in tumorigenesis, identification of K147 acetylation as a novel post-translational modification directed by SIRT2 in vivo may provide a better understanding of the mechanistic link regarding the crosstalk between non-genetic and genetic factors in KRAS driven tumors.
SIRT2 modulates microvascular inflammation in sepsis and affects survival
This study showed that Sirt2-dependent GKRP (zeige GCKR Antikörper) deacetylation improves impaired HGU and suggest that it may be a therapeutic target for type 2 diabetes.
AMPK (zeige PRKAA1 Antikörper) and Sirt2 control compensatory glucose uptake in metabolically arrested mitochondria.
SIRT2 promotes AMPK (zeige PRKAA1 Antikörper) activation by deacetylating the kinase LKB1 (zeige STK11 Antikörper). Loss of SIRT2 reduces AMPK (zeige PRKAA1 Antikörper) activation, promotes aging-related and Ang II (zeige AGT Antikörper)-induced cardiac hypertrophy, and blunts metformin-mediated cardioprotective effects.
found a decreased ratio of dopaminergic neurons in primary midbrain cultures treated with the SIRT2 inhibitor AK-7 (zeige AK7 Antikörper)
mitochondrial dysfunction triggers LKB1 (zeige STK11 Antikörper)-mediated AMPK (zeige PRKAA1 Antikörper) activation, which stimulates Sirt2 phosphorylation, leading to activation of mTOR (zeige FRAP1 Antikörper)-RAPTOR (zeige RPTOR Antikörper) and Glut1 (zeige SLC2A1 Antikörper)-mediated glucose uptake.
SIRT-2 regulates microvascular inflammation in obese mice with sepsis.
This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined\; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class I of the sirtuin family. Several transcript variants are resulted from alternative splicing of this gene.
, sirtuin (silent mating type information regulation 2 homolog) 2 (S. cerevisiae)
, sirtuin 2
, NAD-dependent deacetylase SIRT2
, NAD-dependent deacetylase sirtuin-2
, histone NADC
, silent information regulator 2
, nicotinamide adenine dinucleotide-dependent histone deacetylase
, NAD-dependent deacetylase sirtuin 2 homolog
, NAD-dependent protein deacetylase sirtuin-2
, SIR2-like protein 2
, regulatory protein SIR2 homolog 2
, sir2-related protein type 2
, sirtuin type 2
, sirtuin-like protein 2
, silent mating type information regulation 2, (S.cerevisiae, homolog)-like; sirtuin 2
, 5E5 antigen