SIRT2 Antikörper (C-Term)

Produktnummer ABIN6972719

Dieser Kaninchen Polyklonal Antikörper detektiert spezifisch SIRT2 in WB und IP. Es zeigt Reaktivität gegenüber Proben von Human.

Kurzübersicht für SIRT2 Antikörper (C-Term) (ABIN6972719)

Target: SIRT2 (Sirtuin 2 (SIRT2))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser SIRT2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunoprecipitation (IP)

Produktdetails anti-SIRT2 Antikörper

Bindungsspezifität: C-Term

Produktmerkmale: SIRT2 is a member of the SIR2 / Sirtuin family of NAD-dependant deacetylase enzymes. It has multiple targets for deacetylation, including tubulin, P53, HOXA10, FOXO3A, P300, FOXO1. SIRT2 suppresses adipogenesis by deacetylating FOXO1, promoting the binding of FOXO1 to PPARg and subsequent repression of PPARg mediated transcriptional activation. Similar to SIRT1, SIRT2 also deacetylates H4AcK16 similar to SIRT1, SIRT2 deacetylates histone H4 at lysine 16. SIRT2 is present in the cytoplasm during most of the cell cycle except in the G2/M transition and in mitosis, where it is found in the nucleus and in contact with chromatin and required for exit from mitosis. SIRT2 antibody (pAb) was raised in a Rabbit host. It has been validated for use in Immunoprecipitation and Western blot, it has been shown to react with Human samples.

Aufreinigung: Affinity Purified

Immunogen: This SIRT2 antibody was raised against a synthetic peptide derived from the C-terminal region of human SIRT2.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Buffer: Purified IgG in 70 mM Tris ( pH 8), 105 mM NaCl, 31 mM glycine, 0.07 mM EDTA, 30 % glycerol and 0.035 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Avoid repeated freeze/thaw cycles by aliquoting items into single-use fractions for storage at -20°C for up to 2 years. Keep all reagents on ice when not in storage.

Details zu SIRT2

Target: SIRT2 (Sirtuin 2 (SIRT2))

Andere Bezeichnung: SIRT2

Molekulargewicht: 40 & 45 kDa

NCBI Accession: NP_036369