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The protein encoded by NEU1 is a lysosomal enzyme that cleaves terminal sialic acid residues from substrates such as glycoproteins and glycolipids.
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Transmembrane topology and dimerization ability of NEU1 have been reported.
this work identified NEU1 as a novel biomarker for both diagnosis and prognosis in hepatocellular carcinoma
Our combined data indicate that as HPMECs achieve confluence and CD31 (zeige HBA1 Proteine) ectodomains become homophilically engaged, multiple SFKs are activated to increase tyrosine phosphorylation of p120ctn (zeige CTNND1 Proteine), which in turn, functions as a cross-bridging adaptor molecule that physically couples NEU1 to CD31 (zeige HBA1 Proteine), permitting NEU1-mediated desialylation of CD31 (zeige HBA1 Proteine).
TLR4 (zeige TLR4 Proteine) protein
NEURL (zeige NEURL Proteine) rs12415501 and CAND2 (zeige CAND2 Proteine) rs4642101 are significantly associated with postoperative atrial fibrillation susceptibility after coronary artery bypass grafting among Chinese population
neuraminidase-1 (Neu1) in complex with matrix metalloproteinase-9 (zeige MMP9 Proteine) and G protein-coupled receptor (zeige ADRA1A Proteine) tethered to RTKs and TLRs is identified as a major target in multistage tumorigenesis [review]
EGFR (zeige EGFR Proteine) protein, human is predictive of adjuvant chemo response. Also, It is a prognostic factor.
Data suggest that mutations c.90delC (p.Tyr30Ter) and c.572A>T (p.Asp191Val) of the NFU1 (zeige NFU1 Proteine) gene probably underlie the pathogenesis of multiple mitochondrial dysfunction syndrome (MMDS).
Elevated NEU1 expression alters functional activities of distinct lung cell types in vitro and recapitulates lymphocytic infiltration and collagen accumulation in vivo, consistent with mechanisms implicated in lung fibrosis.
initial treatment with an EGFR (zeige EGFR Proteine)-TKI is a reasonable option for patients presenting with EGFR (zeige EGFR Proteine) mutation-positive NSCLC and a CM.
NEU1 gene is not responsible for the lysosomal storage disease of Japanese Black cattle.
Neu1 (zeige NEURL Proteine) inhibits lipolysis induced by beta-adrenergic stimulation in adipocytes via interactions with Plin1 (zeige PLIN1 Proteine) on lipid drops.
Neu1 (zeige NEURL Proteine) is the only lysosomal multienzyme complex gene underexpressed in mucopolysaccharidosis type I mice.
Neu1 (zeige NEURL Proteine) desialylation is a mechanism of Fc-independent platelet clearance in immune thrombocytopenia.
Data indicate a role for neuraminidase 1 (Neu1) in regulating Siglec E protein-toll-like receptor 4 (TLR4 (zeige TLR4 Proteine)) interaction and endotoxemia.
elastin (zeige ELN Proteine)-derived peptides as an enhancer of atherogenesis and defines the Neuraminidase 1/PI3Kgamma (zeige PIK3CG Proteine) signalling pathway as a key mediator
significant increases in Col1a1 (zeige COL1A1 Proteine), serine/threonine-protein kinase 1, Ctnnb1 (zeige CTNNB1 Proteine), CSRNP1 (zeige CSRNP1 Proteine), Ddit4 (zeige DDIT4 Proteine), Cyp2e1 (zeige CYP2E1 Proteine), and Krit1 (zeige KRIT1 Proteine) expressions and great decreases inreceptor D2, Neu1 (zeige NEURL Proteine), and Dhcr7 (zeige DHCR7 Proteine) expressions following long-term exposure to TiO2 NPs (zeige NPS Proteine)
NEU1 (zeige NEURL Proteine) deficiency has a role in determining amyloid precursor protein (zeige APP Proteine) levels and amyloid-beta secretion via deregulated lysosomal exocytosis
Neu1 (zeige NEURL Proteine) sialidase and matrix metalloproteinase-9 (zeige MMP9 Proteine) cross-talk regulates nucleic acid-induced endosomal TOLL-like receptor-7 (zeige TLR7 Proteine) and -9 activation, cellular signaling and pro-inflammatory responses.
The activity of NEU1 (zeige NEURL Proteine) was preferentially higher in epididymal fat and lower in the livers of two strains of obese and diabetic mice.
these studies identify Neu1 (zeige NEURL Proteine) as a novel component of the signaling pathways of energy metabolism and glucose uptake.
The protein encoded by this gene is a lysosomal enzyme that cleaves terminal sialic acid residues from substrates such as glycoproteins and glycolipids. In the lysosome, this enzyme is part of a heterotrimeric complex together with beta-galactosidase and cathepsin A (the latter is also referred to as 'protective protein'). Mutations in this gene can lead to sialidosis, a lysosomal storage disease that can be type 1 (cherry red spot-myoclonus syndrome or normosomatic type), which is late-onset, or type 2 (the dysmorphic type), which occurs at an earlier age with increased severity.
, N-acetyl-alpha-neuraminidase 1
, acetylneuraminyl hydrolase
, lysosomal sialidase
, sialidase 1 (lysosomal sialidase)
, Isotocin-neurophysin IT 1
, neuraminidase 1
, HLA-B-associated transcript 7
, sialidase 1
, RING finger protein 67
, h-neuralized 1
, neuralized-like protein 1A