Sialidase 1 (Lysosomal Sialidase) Proteine (NEU1)

The protein encoded by NEU1 is a lysosomal enzyme that cleaves terminal sialic acid residues from substrates such as glycoproteins and glycolipids. Zusätzlich bieten wir Ihnen NEU1 Antikörper (62) und viele weitere Produktgruppen zu diesem Protein an.

alle Proteine anzeigen Gen GeneID UniProt
NEU1 4758 Q99519
NEU1 18010 O35657
NEU1 24591  
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Showing 10 out of 13 products:

Katalog Nr. Origin Quelle Konjugat Bilder Menge Anbieter Lieferzeit Preis Details
Insektenzellen Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 50 Days
Insektenzellen Maus His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 50 Days
Human Cells Human His tag   50 μg Anmelden zum Anzeigen 4 Days
Wheat germ Human GST tag 10 μg Anmelden zum Anzeigen 11 bis 12 Tage
HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Anmelden zum Anzeigen 11 Days
Escherichia coli (E. coli) Human His tag 100 μg Anmelden zum Anzeigen 15 bis 19 Tage
Human Cells Human His tag   10 μg Anmelden zum Anzeigen 15 bis 16 Tage
Hefe Rind (Kuh) His tag   1 mg Anmelden zum Anzeigen 60 bis 71 Tage
Hefe Wildschwein His tag   1 mg Anmelden zum Anzeigen 60 bis 71 Tage
Hefe Ratte His tag   1 mg Anmelden zum Anzeigen 60 bis 71 Tage

NEU1 Proteine nach Spezies und Herkunft

Origin Exprimiert in Konjugat
Human , , , ,
, ,
Mouse (Murine)

Rat (Rattus)

Weitere Proteine zu Sialidase 1 (Lysosomal Sialidase) (NEU1) Interaktionspartnern

Human Sialidase 1 (Lysosomal Sialidase) (NEU1) Interaktionspartner

  1. Binding of elastin-derived peptides (EDP) to the elastin receptor complex (ERC) indirectly modulates CD36 sialylation level and regulates oxidized LDL uptake through NEU1 sialidase.

  2. Association of TRPV1 and TLR4 through the interleukin-1 receptor domain potentiates TRPV1 activity by blocking activation-induced desensitization

  3. in monocytes/macrophages, NEU1 is interconnected in a positive feedback loop with lipopolysaccharides and IL-1beta as enhancers of inflammation, and may therefore promote atherosclerosis and plaque instability

  4. Patients with minimally invasive and lepidic adenocarcinomas were categorized as low-risk group with high EGFR mutation rate; Patients with micro-papillary and solid adenocarcinomas were categorized as high-risk with lower EGFR mutation rate

  5. Transmembrane topology and dimerization ability of NEU1 have been reported.

  6. this work identified NEU1 as a novel biomarker for both diagnosis and prognosis in hepatocellular carcinoma

  7. Our combined data indicate that as HPMECs achieve confluence and CD31 ectodomains become homophilically engaged, multiple SFKs are activated to increase tyrosine phosphorylation of p120ctn, which in turn, functions as a cross-bridging adaptor molecule that physically couples NEU1 to CD31, permitting NEU1-mediated desialylation of CD31.

  8. TLR4 protein

  9. neuraminidase-1 (Neu1) in complex with matrix metalloproteinase-9 and G protein-coupled receptor tethered to RTKs and TLRs is identified as a major target in multistage tumorigenesis [review]

  10. EGFR protein, human is predictive of adjuvant chemo response. Also, It is a prognostic factor.

  11. Data suggest that mutations c.90delC (p.Tyr30Ter) and c.572A>T (p.Asp191Val) of the NFU1 gene probably underlie the pathogenesis of multiple mitochondrial dysfunction syndrome (MMDS).

  12. Elevated NEU1 expression alters functional activities of distinct lung cell types in vitro and recapitulates lymphocytic infiltration and collagen accumulation in vivo, consistent with mechanisms implicated in lung fibrosis.

  13. initial treatment with an EGFR-TKI is a reasonable option for patients presenting with EGFR mutation-positive NSCLC and a CM.

  14. miR-125b functions as an oncogene in gastric cancer and represents a new potential therapeutic target for gastric cancer.

  15. NEU1 siRNA can effectively inhibit proliferation, apoptosis, and invasion of human ovarian cancer cells by targeting lysosome and oxidative phosphorylation signaling, which can serve as a new target ovarian cancer treatment

  16. How the point mutations of the neuraminidase sequences affected the susceptibility of H9N2 virus to oseltamivir is still to be determined and deserve further investigations

  17. Our study shows that the 340-cavity is not an occasional or atypical domain in NA subtypes, and it has potential to function as a new hotspot for influenza drug binding.

  18. Basal Neu-1 catalytic activity is strongly increased in aged cells.

  19. Neu1 desialylation is a mechanism of Fc-independent platelet clearance in immune thrombocytopenia.

  20. Flagellin drives NEU1 to desialylate MUC1, thereby increasing its adhesiveness for Pseudomonas aeruginosa and its shedding

Cow (Bovine) Sialidase 1 (Lysosomal Sialidase) (NEU1) Interaktionspartner

  1. NEU1 gene is not responsible for the lysosomal storage disease of Japanese Black cattle.

Mouse (Murine) Sialidase 1 (Lysosomal Sialidase) (NEU1) Interaktionspartner

  1. The NEU1 exists on the cell surface of mouse thymocytes and CD5 is a natural substrate for it.

  2. Neu1 inhibits lipolysis induced by beta-adrenergic stimulation in adipocytes via interactions with Plin1 on lipid drops.

  3. Neu1 is the only lysosomal multienzyme complex gene underexpressed in mucopolysaccharidosis type I mice.

  4. Neu1 desialylation is a mechanism of Fc-independent platelet clearance in immune thrombocytopenia.

  5. Data indicate a role for neuraminidase 1 (Neu1) in regulating Siglec E protein-toll-like receptor 4 (TLR4) interaction and endotoxemia.

  6. elastin-derived peptides as an enhancer of atherogenesis and defines the Neuraminidase 1/PI3Kgamma signalling pathway as a key mediator

  7. significant increases in Col1a1, serine/threonine-protein kinase 1, Ctnnb1, CSRNP1, Ddit4, Cyp2e1, and Krit1 expressions and great decreases inreceptor D2, Neu1, and Dhcr7 expressions following long-term exposure to TiO2 NPs

  8. NEU1 deficiency has a role in determining amyloid precursor protein levels and amyloid-beta secretion via deregulated lysosomal exocytosis

  9. Neu1 sialidase and matrix metalloproteinase-9 cross-talk regulates nucleic acid-induced endosomal TOLL-like receptor-7 and -9 activation, cellular signaling and pro-inflammatory responses.

  10. The activity of NEU1 was preferentially higher in epididymal fat and lower in the livers of two strains of obese and diabetic mice.

  11. these studies identify Neu1 as a novel component of the signaling pathways of energy metabolism and glucose uptake.

  12. The rescue of sialidase activity in hypomorphic sialidase mice using helper-dependent adenovirus resulted in increased VLDL production and an increase in MTP levels.

  13. Data indicate that sialidases Neu1 and Neu3 are present on sperm, and their activity is required for capacitation and zona pellucida binding.

  14. Neuraminidase 1 as a modulator of cell receptors. (Review)

  15. a novel Neu1 and MMP9 cross-talk in alliance with TLR4 on the cell surface that is essential for ligand activation of TLRs and subsequent cellular signaling.

  16. The deficiency of lysosomal neuraminidase may result in a serious hearing loss and morphological alterations of ear.

  17. desialylation of both IR and IGF-1R by Neu1 controls the net proliferative response of skeletal myoblasts to insulin

  18. Hyaluronan receptor activity of CD44 and acute asthmatic reactions, including Th2-mediated airway inflammation and airway hyperresponsiveness, are dependent upon Neu1 enzymatic activity.

  19. A potential role of NEU1 in cell proliferation and extracellular matrix remodeling.

  20. The neuraminidase-1 (Neu1) knockout mouse model is a phenocopy of the lysosomal storage disease sialidosis, characterized by neuropathic symptoms, including hearing loss.

NEU1 Protein Überblick

Protein Überblick

The protein encoded by this gene is a lysosomal enzyme that cleaves terminal sialic acid residues from substrates such as glycoproteins and glycolipids. In the lysosome, this enzyme is part of a heterotrimeric complex together with beta-galactosidase and cathepsin A (the latter is also referred to as 'protective protein'). Mutations in this gene can lead to sialidosis, a lysosomal storage disease that can be type 1 (cherry red spot-myoclonus syndrome or normosomatic type), which is late-onset, or type 2 (the dysmorphic type), which occurs at an earlier age with increased severity.

Genbezeichner und Symbole assoziert mit NEU1

  • neuraminidase 1 (NEU1)
  • neuraminidase 1 (lysosomal sialidase) L homeolog (neu1.L)
  • neuraminidase 1 (neu1)
  • neuraminidase 1 (Neu1)
  • AA407268 Protein
  • AA407316 Protein
  • Aglp Protein
  • Apl Protein
  • Bat-7 Protein
  • Bat7 Protein
  • G9 Protein
  • Map-2 Protein
  • MGC81958 Protein
  • NANH Protein
  • Neu Protein
  • Neu-1 Protein
  • SIAL1 Protein

Bezeichner auf Proteinebene für NEU1

G9 sialidase , N-acetyl-alpha-neuraminidase 1 , acetylneuraminyl hydrolase , exo-alpha-sialidase , lysosomal sialidase , sialidase-1 , sialidase 1 (lysosomal sialidase) , neuraminidase , isotocin , Isotocin-neurophysin IT 1 , neuraminidase 1 , sialidase-1-like , HLA-B-associated transcript 7 , sialidase 1

4758 Homo sapiens
444511 Xenopus laevis
471968 Pan troglodytes
481717 Canis lupus familiaris
505554 Bos taurus
716740 Macaca mulatta
100124381 Sus scrofa
100136555 Salmo salar
100342130 Oryctolagus cuniculus
100408501 Callithrix jacchus
100595428 Nomascus leucogenys
18010 Mus musculus
24591 Rattus norvegicus
100728899 Cavia porcellus
Ausgewählte Anbieter für NEU1 Proteine (NEU1)
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