Sialic Acid Binding Ig-Like Lectin 9 Proteine (SIGLEC9)

Putative adhesion molecule that mediates sialic-acid dependent binding to cells. Zusätzlich bieten wir Ihnen SIGLEC9 Antikörper (172) und SIGLEC9 Kits (4) und viele weitere Produktgruppen zu diesem Protein an.

alle Proteine anzeigen Gen GeneID UniProt
SIGLEC9 27180 Q9Y336
Maus SIGLEC9 SIGLEC9 83382 Q91Y57
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Showing 6 out of 7 products:

Katalog Nr. Origin Quelle Konjugat Bilder Menge Anbieter Lieferzeit Preis Details
Insektenzellen Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 50 Days
$5,960.83
Details
Human Human Fc Tag   10 μg Anmelden zum Anzeigen 15 bis 16 Tage
$212.50
Details
Mammalian Cells Human Fc Tag   50 μg Anmelden zum Anzeigen 4 Days
$360.53
Details
HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Anmelden zum Anzeigen 10 bis 12 Tage
$554.07
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Escherichia coli (E. coli) Human Unkonjugiert 100 μg Anmelden zum Anzeigen 15 bis 18 Tage
$640.00
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Escherichia coli (E. coli) Human Unkonjugiert   100 μg Anmelden zum Anzeigen 11 bis 18 Tage
$596.97
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SIGLEC9 Proteine nach Spezies und Herkunft

Origin Exprimiert in Konjugat
Human , , , ,
, , ,

Weitere Proteine zu Sialic Acid Binding Ig-Like Lectin 9 (SIGLEC9) Interaktionspartnern

Chimpanzee Sialic Acid Binding Ig-Like Lectin 9 (SIGLEC9) Interaktionspartner

  1. Binding studies on recombinant human Siglec-9 show recognition of both Neu5Ac and Neu5Gc; in striking contrast, chimpanzee and gorilla Siglec-9 strongly prefer binding Neu5Gc.

Human Sialic Acid Binding Ig-Like Lectin 9 (SIGLEC9) Interaktionspartner

  1. The SIGLEC9 rs2075803 G/rs2258983 A haplotype, which corresponds to a Siglec-9 variant that is less effective at suppressing inflammatory response, may be a risk factor for the development of emphysema.

  2. Glycophorin A (zeige GYPA Proteine), the most abundant sialoglycoprotein on erythrocytes, engaged neutrophil Siglec-9, a sialic acid-recognizing receptor known to dampen innate immune cell activation. These studies demonstrate a previously unsuspected role for erythrocytes in suppressing neutrophils ex vivo and in vitro and help explain why neutrophils become easily activated after separation from whole blood.

  3. Data suggest that sialic acid-binding Ig-like lectin-9 (Siglec-9)may serve as a potential diagnostic and therapeutic target for rheumatoid arthritis (RA).

  4. The mechanism of the Siglec-9 and AOC3 (zeige AOC2 Proteine) interaction is mediated both by protein-sugar interactions via the V domain and by the protein-protein interactions via the C22 Siglec9 domain.

  5. This work defines a critical role for aberrantly glycosylated MUC1 (zeige MUC1 Proteine) and identifies an activating pathway that follows engagement of Siglec-9.

  6. Constitutively expressed Siglec-9 inhibits LPS (zeige IRF6 Proteine)-induced CCR7 (zeige CCR7 Proteine), but enhances IL-4 (zeige IL4 Proteine)-induced CD200R (zeige CD200R1 Proteine) expression in human macrophages.

  7. Ligands for Siglec-8 (zeige SIGLEC8 Proteine) and Siglec-9 may regulate the function of eosinophils, mast cells, neutrophils, and other cells in sinus mucosa.

  8. Inflammation results in up-regulation of immuneinhibitory Siglec-8 (zeige SIGLEC8 Proteine) and Siglec-9 sialoglycan ligands on human airways.

  9. a polymorphism that reduced Siglec-9 binding to carcinomas was associated with improved early survival in non-small-cell lung ca (zeige CD33 Proteine)ncer patients

  10. Dasatinib enhances migration of monocyte-derived dendritic cells by reducing phosphorylation of inhibitory immune receptors Siglec-9 and Siglec-3 (zeige CD33 Proteine).

Mouse (Murine) Sialic Acid Binding Ig-Like Lectin 9 (SIGLEC9) Interaktionspartner

  1. The Siglec-E-deficient dendritic cells were defective for TRIF (zeige RNF138 Proteine)-mediated IFN-beta (zeige IFNB1 Proteine) production in response to E. coli infection.

  2. This study demonstrated that virulent parasite Leishmania donovani (AG83+Sias) establish a unique sialic acids-mediated binding and subsequent phagocytosis in the host cell through the selective exploitation of siglec-1 (zeige SIGLEC1 Proteine).

  3. new data relating to the structure and function of Siglec-E, the major CD33 (zeige CD33 Proteine)-related Siglec expressed on mouse neutrophils, monocytes, macrophages, and dendritic cells.

  4. indicate that Siglec-9 affects several different signaling pathways in IL-4 (zeige IL4 Proteine)-stimulated macrophages, which resulted in enhanced induction of Arg1 (zeige ARG1 Proteine) in Siglec-9-expressing RAW264 cells

  5. Competitive ELISA assays confirmed the involvement of sulfated (zeige SULF1 Proteine) epitopes in the affinity between Siglec-E and cruzipain, probably modified by natural protein environment

  6. Data indicate a role for neuraminidase 1 (Neu1 (zeige NEU1 Proteine)) in regulating Siglec E protein-toll-like receptor 4 (TLR4 (zeige TLR4 Proteine)) interaction and endotoxemia.

  7. Siglec-E-deficient macrophages showed a propensity toward a tumor-promoting M2 polarization, indicating a secondary role of CD33 (zeige CD33 Proteine)-related Siglecs in limiting cancer-promoting inflammation and tumor growth.

  8. siglec-E functions as an inhibitory receptor of neutrophils via positive regulation of NADPH oxidase (zeige NOX1 Proteine) activation and ROS (zeige ROS1 Proteine) production

  9. These results suggest that sSiglec-9 has an antitumor benefit against MUC1 (zeige MUC1 Proteine)-expressing tumor in the transgenic mice.

  10. Siglec-9 expressed on immune cells may play a role as a potential counterreceptor for MUC1 (zeige MUC1 Proteine) and that this signaling may be another MUC1 (zeige MUC1 Proteine)-mediated pathway and function in parallel with a growth factor-dependent pathway.

SIGLEC9 Protein Überblick

Protein Überblick

Putative adhesion molecule that mediates sialic-acid dependent binding to cells. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. In the immune response, may act as an inhibitory receptor upon ligand induced tyrosine phosphorylation by recruiting cytoplasmic phosphatase(s) via their SH2 domain(s) that block signal transduction through dephosphorylation of signaling molecules.

Genbezeichner und Symbole assoziert mit SIGLEC9

  • sialic acid-binding immunoglobulin-like lectin 9 (SIGLEC9)
  • sialic acid-binding Ig-like lectin 9 (LOC100610476)
  • sialic acid binding Ig like lectin 9 (SIGLEC9)
  • sialic acid binding Ig-like lectin E (Siglece)
  • Cd170 Protein
  • CD329 Protein
  • CDw329 Protein
  • FOAP-9 Protein
  • mSiglec-E Protein
  • OBBP-LIKE Protein
  • siglec-9 Protein
  • Siglec5 Protein
  • Siglec9 Protein
  • Siglec12 Protein
  • Siglecl1 Protein

Bezeichner auf Proteinebene für SIGLEC9

sialic acid-binding immunoglobulin-like lectin 9 , sialic acid binding Ig-like lectin 9 , protein FOAP-9 , sialic acid-binding Ig-like lectin 9 , MIS , SIGLEC-like 1 , myeloid inhibitory siglec , sialic acid binding Ig-like lectin 5 , sialic acid-binding Ig-like lectin 12 , sialic acid-binding Ig-like lectin 5 , sialic acid-binding Ig-like lectin E , sialic acid-binding Ig-like lectin-like 1 , sialic acid-binding immunoglobulin-like lectin E , siglec-12 , siglec-5 , siglec-E , siglec-L1

GENE ID SPEZIES
497116 Pan troglodytes
100610476 Pan troglodytes
27180 Homo sapiens
83382 Mus musculus
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