Sialic Acid Binding Ig-Like Lectin 9 Proteine (SIGLEC9)

Putative adhesion molecule that mediates sialic-acid dependent binding to cells. Zusätzlich bieten wir Ihnen und und viele weitere Produktgruppen zu diesem Protein an.

alle Proteine anzeigen Gen GeneID UniProt
SIGLEC9 27180 Q9Y336
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Showing 6 out of 8 products:

Katalog Nr. Origin Quelle Konjugat Bilder Menge Anbieter Lieferzeit Preis Details
Insektenzellen Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 50 Days
$6,749.58
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Baculovirus infected Insect Cells Human hIgG-His-tag 50 μg Anmelden zum Anzeigen 13 bis 16 Tage
$400.00
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Human Cells Human Fc Tag   50 μg Anmelden zum Anzeigen 4 Days
$313.50
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Human Cells Human Fc Tag   10 μg Anmelden zum Anzeigen 15 bis 16 Tage
$212.50
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HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Anmelden zum Anzeigen 11 Days
$547.80
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Escherichia coli (E. coli) Human Unkonjugiert SDS-PAGE analysis of Human SIGLEC9 Protein. 100 μg Anmelden zum Anzeigen 11 bis 18 Tage
$668.03
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SIGLEC9 Proteine nach Spezies und Herkunft

Origin Exprimiert in Konjugat
Human , , , ,
, , , ,

Weitere Proteine zu Sialic Acid Binding Ig-Like Lectin 9 (SIGLEC9) Interaktionspartnern

Human Sialic Acid Binding Ig-Like Lectin 9 (SIGLEC9) Interaktionspartner

  1. The SIGLEC9 rs2075803 G/rs2258983 A haplotype, which corresponds to a Siglec-9 variant that is less effective at suppressing inflammatory response, may be a risk factor for the development of emphysema.

  2. Glycophorin A, the most abundant sialoglycoprotein on erythrocytes, engaged neutrophil Siglec-9, a sialic acid-recognizing receptor known to dampen innate immune cell activation. These studies demonstrate a previously unsuspected role for erythrocytes in suppressing neutrophils ex vivo and in vitro and help explain why neutrophils become easily activated after separation from whole blood.

  3. Data suggest that sialic acid-binding Ig-like lectin-9 (Siglec-9)may serve as a potential diagnostic and therapeutic target for rheumatoid arthritis (RA).

  4. The mechanism of the Siglec-9 and AOC3 interaction is mediated both by protein-sugar interactions via the V domain and by the protein-protein interactions via the C22 Siglec9 domain.

  5. This work defines a critical role for aberrantly glycosylated MUC1 and identifies an activating pathway that follows engagement of Siglec-9.

  6. Constitutively expressed Siglec-9 inhibits LPS-induced CCR7, but enhances IL-4-induced CD200R expression in human macrophages.

  7. Ligands for Siglec-8 and Siglec-9 may regulate the function of eosinophils, mast cells, neutrophils, and other cells in sinus mucosa.

  8. Inflammation results in up-regulation of immuneinhibitory Siglec-8 and Siglec-9 sialoglycan ligands on human airways.

  9. a polymorphism that reduced Siglec-9 binding to carcinomas was associated with improved early survival in non-small-cell lung cancer patients

  10. Dasatinib enhances migration of monocyte-derived dendritic cells by reducing phosphorylation of inhibitory immune receptors Siglec-9 and Siglec-3.

  11. Expression of Siglec-7 and -9 ligands was associated with susceptibility of NK cell-sensitive tumor cells and, unexpectedly, of presumably NK cell-resistant tumor cells to NK cell-mediated cytotoxicity.

  12. Protein degradation of focal adhesion kinase and related molecules was induced by Siglec-9 binding to its counterreceptors via sialylglycoconjugates, leading to the modulation of adhesion kinetics of cancer cells.

  13. Siglec-9 expressed on immune cells may play a role as a potential counterreceptor for MUC1 and that this signaling may be another MUC1-mediated pathway and function in parallel with a growth factor-dependent pathway.

  14. The Siglec-9 peptide binding to the enzymatic groove of VAP-1 can be used for imaging conditions, such as inflammation and cancer.

  15. Siglec-9 A391C was the only polymorphism related to TCR-mediated signaling in human Siglec-9, resulting in less inhibition compared to the wild type.

  16. These results suggest that Siglec-9 expressed on DCs is involved in immunoregulation through ligation with mucins in an epithelial cancer patient.

  17. MUC16-Siglec-9 binding likely mediates inhibition of anti-tumor immune responses.

  18. Septic shock patients exhibit different ex vivo death responses of blood neutrophils after Siglec-9 ligation early in shock.

  19. Binding studies on recombinant human Siglec-9 show recognition of both Neu5Ac and Neu5Gc; in striking contrast, chimpanzee and gorilla Siglec-9 strongly prefer binding Neu5Gc.

  20. Siglec-7 and Siglec-9 are capable of negative regulation of TCR signaling and ligand binding is required for optimal activity

Chimpanzee Sialic Acid Binding Ig-Like Lectin 9 (SIGLEC9) Interaktionspartner

  1. Binding studies on recombinant human Siglec-9 show recognition of both Neu5Ac and Neu5Gc; in striking contrast, chimpanzee and gorilla Siglec-9 strongly prefer binding Neu5Gc.

SIGLEC9 Protein Überblick

Protein Überblick

Putative adhesion molecule that mediates sialic-acid dependent binding to cells. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. In the immune response, may act as an inhibitory receptor upon ligand induced tyrosine phosphorylation by recruiting cytoplasmic phosphatase(s) via their SH2 domain(s) that block signal transduction through dephosphorylation of signaling molecules.

Genbezeichner und Symbole assoziert mit SIGLEC9

  • sialic acid binding Ig like lectin 9 (SIGLEC9)
  • sialic acid-binding immunoglobulin-like lectin 9 (SIGLEC9)
  • CD329 Protein
  • CDw329 Protein
  • FOAP-9 Protein
  • OBBP-LIKE Protein
  • siglec-9 Protein
  • siglec9 Protein

Bezeichner auf Proteinebene für SIGLEC9

protein FOAP-9 , sialic acid-binding Ig-like lectin 9 , sialic acid-binding immunoglobulin-like lectin 9 , sialic acid binding Ig-like lectin 9

GENE ID SPEZIES
27180 Homo sapiens
497116 Pan troglodytes
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