Sialic Acid Binding Ig-Like Lectin 8 Proteine (SIGLEC8)

Sialic acid-binding immunoglobulin (Ig)-like lectins, or SIGLECs (e.g., CD33 (MIM 159590)), are a family of type 1 transmembrane proteins each having a unique expression pattern, mostly in hemopoietic cells. Zusätzlich bieten wir Ihnen SIGLEC8 Antikörper (79) und SIGLEC8 Kits (15) und viele weitere Produktgruppen zu diesem Protein an.

alle Proteine anzeigen Gen GeneID UniProt
SIGLEC8 27181 Q9NYZ4
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Top SIGLEC8 Proteine auf antikoerper-online.de

Showing 5 out of 7 products:

Katalog Nr. Origin Quelle Konjugat Bilder Menge Anbieter Lieferzeit Preis Details
Insektenzellen Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 50 Days
$5,960.83
Details
Wheat germ Human GST tag 10 μg Anmelden zum Anzeigen 11 bis 12 Tage
$414.29
Details
HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Anmelden zum Anzeigen 10 bis 12 Tage
$860.20
Details
Escherichia coli (E. coli) Human His tag 100 μg Anmelden zum Anzeigen 13 bis 16 Tage
$704.00
Details
Wheat germ Human Unkonjugiert   10 μg Anmelden zum Anzeigen 11 bis 12 Tage
$654.29
Details

SIGLEC8 Proteine nach Spezies und Herkunft

Origin Exprimiert in Konjugat
Human , , ,
, , ,

Am meisten referenzierte SIGLEC8 Proteine

  1. Human SIGLEC8 Protein expressed in Wheat germ - ABIN1320000 : von Gunten, Vogel, Schaub, Stadler, Miescher, Crocker, Simon: Intravenous immunoglobulin preparations contain anti-Siglec-8 autoantibodies. in The Journal of allergy and clinical immunology 2007 (PubMed)

Weitere Proteine zu Sialic Acid Binding Ig-Like Lectin 8 (SIGLEC8) Interaktionspartnern

Human Sialic Acid Binding Ig-Like Lectin 8 (SIGLEC8) Interaktionspartner

  1. In differentiating ,eosinophils, SIGLEC-8 messenger RNA and protein were markedly down-regulated in parallel with OLIG2 (zeige OLIG2 Proteine) by an OLIG2 (zeige OLIG2 Proteine) small interfering RNA or a short hairpin RNA. An E-box in the first intron was found to stimulate SIGLEC-8 gene transcription and to bind OLIG2 (zeige OLIG2 Proteine).

  2. miR (zeige MLXIP Proteine)-215 acts in concert with the host gene IARS2 to affect neuron migration and proliferation through the target gene SIGLEC-8.

  3. Our study suggested that intratumoral Siglec-8 expression was an independent prognostic factor for overall survival of patients with gastric cancer

  4. Ligands for Siglec-8 and Siglec-9 (zeige SIGLEC9 Proteine) may regulate the function of eosinophils, mast cells, neutrophils, and other cells in sinus mucosa.

  5. Inflammation results in up-regulation of immuneinhibitory Siglec-8 and Siglec-9 (zeige SIGLEC9 Proteine) sialoglycan ligands on human airways.

  6. Siglec-8 expression is sensitive to tiotropium and formoterol, indicating that it may be involved in COPD (zeige ARCN1 Proteine) pathogenesis and may influence COPD (zeige ARCN1 Proteine) phenotyping

  7. In activated eosinophils ligation of Siglec-8 leads to ROS (zeige ROS1 Proteine)-dependent enhancement of IL-5 (zeige IL5 Proteine)-induced ERK (zeige EPHB2 Proteine) phosphorylation, which results in a novel mode of biochemically regulated eosinophil cell death.

  8. Engagement of Siglec-8 on blood eosinophils results in caspase (zeige CASP3 Proteine)- and mitochondria-dependent apoptosis.

  9. Eosinophils primed by IL-33 (zeige IL33 Proteine) and/or IL-5 (zeige IL5 Proteine) in vivo would be expected to display enhanced susceptibility to undergoing Siglec-8-induced apoptosis.

  10. The Siglec-8 gene may be a susceptibility locus for asthma.

SIGLEC8 Protein Überblick

Protein Überblick

Sialic acid-binding immunoglobulin (Ig)-like lectins, or SIGLECs (e.g., CD33 (MIM 159590)), are a family of type 1 transmembrane proteins each having a unique expression pattern, mostly in hemopoietic cells. SIGLEC8 is a member of the CD33-like subgroup of SIGLECs, which are localized to 19q13.3-q13.4 and have 2 conserved cytoplasmic tyrosine-based motifs: an immunoreceptor tyrosine-based inhibitory motif, or ITIM (see MIM 604964), and a motif homologous to one identified in signaling lymphocyte activation molecule (SLAM\\\\; MIM 603492) that mediates an association with SLAM-associated protein (SAP\\\\; MIM 300490) (summarized by Foussias et al., 2000

Genbezeichner und Symbole assoziert mit SIGLEC8

  • sialic acid binding Ig like lectin 8 (SIGLEC8)
  • sialic acid-binding Ig-like lectin 8 (LOC506364)
  • SAF2 Protein
  • SIGLEC-8 Protein
  • SIGLEC8 Protein
  • SIGLEC8L Protein

Bezeichner auf Proteinebene für SIGLEC8

CDw329 , SAF-2 , sialic acid-binding Ig-like lectin 8 , sialoadhesin family member 2 , sialic acid binding Ig-like lectin 8

GENE ID SPEZIES
27181 Homo sapiens
456249 Pan troglodytes
506364 Bos taurus
100595640 Nomascus leucogenys
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