anti-Sialic Acid Binding Ig-Like Lectin 8 (SIGLEC8) Antikörper

Sialic acid-binding immunoglobulin (Ig)-like lectins, or SIGLECs (e.g., CD33 (MIM 159590)), are a family of type 1 transmembrane proteins each having a unique expression pattern, mostly in hemopoietic cells. Zusätzlich bieten wir Ihnen SIGLEC8 Kits (20) und SIGLEC8 Proteine (8) und viele weitere Produktgruppen zu diesem Protein an.

Alle Antikörper anzeigen Gen GeneID UniProt
SIGLEC8 27181 Q9NYZ4
SIGLEC8    
SIGLEC8    
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Top anti-SIGLEC8 Antikörper auf antikoerper-online.de

Showing 10 out of 65 products:

Katalog Nr. Reaktivität Wirt Konjugat Applikation Bilder Menge Lieferzeit Preis Details
Human Ziege Unkonjugiert ELISA, WB ABIN308467 (0.3µg/ml) staining of MOLT4 lysate (35µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence. 100 μg 6 bis 7 Tage
$429.84
Details
Human Kaninchen Unkonjugiert EIA, IHC (p), WB 0.4 mL 6 bis 8 Tage
$484.00
Details
Human Ziege Unkonjugiert ELISA, WB 100 μg 11 bis 14 Tage
$610.50
Details
Human Kaninchen Unkonjugiert IHC (p), WB Antibody is used in Western blot to detect Siglec8 in mouse liver tissue lysate (lnae 1) and in HL60 cell lysate (lane 2). Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. BC = breast carcinoma; HC = hepatocarcinoma. 400 μL 2 bis 3 Tage
$515.63
Details
Human Kaninchen Unkonjugiert IHC (p), WB Western blot analysis in HepG2 cell line lysates (35ug/lane). SIGLEC8 Antibody immunohistochemistry analysis in formalin fixed and paraffin embedded human liver tissue followed by peroxidase conjugation of the secondary antibody and DAB staining. 400 μL 2 bis 3 Tage
$515.63
Details
Human Kaninchen Unkonjugiert ICC, IHC, WB Figure.DAB staining on IHC-P. Samples: Human Tissue 100 μg 13 bis 16 Tage
$332.00
Details
Human Maus Unkonjugiert ELISA, WB Western Blot detection against Immunogen (37.55 KDa) . 50 μL 11 bis 12 Tage
$305.71
Details
Human Ziege Unkonjugiert WB   0.1 mg 4 bis 8 Tage
$462.00
Details
Human Kaninchen Unkonjugiert ELISA, IHC 200 μL 12 bis 14 Tage
$438.90
Details
Human Maus Unkonjugiert ELISA, WB Detection limit for recombinant GST tagged SIGLEC8 is approximately 3ng/ml as a capture antibody. Western Blot detection against Immunogen (37.18 KDa) . 100 μg 11 bis 12 Tage
$440.00
Details

Am meisten referenzierte anti-SIGLEC8 Antikörper

  1. Human Polyclonal SIGLEC8 Primary Antibody für IHC (p), ELISA - ABIN544598 : Foussias, Yousef, Diamandis: Molecular characterization of a Siglec8 variant containing cytoplasmic tyrosine-based motifs, and mapping of the Siglec8 gene. in Biochemical and biophysical research communications 2000 (PubMed)
    Show all 3 Pubmed References

  2. Human Polyclonal SIGLEC8 Primary Antibody für ELISA, WB - ABIN449557 : Nutku, Aizawa, Hudson, Bochner: Ligation of Siglec-8: a selective mechanism for induction of human eosinophil apoptosis. in Blood 2003 (PubMed)
    Show all 2 Pubmed References

  3. Polyclonal SIGLEC8 Primary Antibody für ELISA, WB - ABIN539676 : Yokoi, Choi, Hubbard, Lee, Canning, Lee, Ryu, von Gunten, Bickel, Hudson, Macglashan, Bochner: Inhibition of FcepsilonRI-dependent mediator release and calcium flux from human mast cells by sialic acid-binding immunoglobulin-like lectin 8 engagement. in The Journal of allergy and clinical immunology 2008 (PubMed)
    Show all 2 Pubmed References

  4. Human Polyclonal SIGLEC8 Primary Antibody für ELISA, WB - ABIN565353 : von Gunten, Vogel, Schaub, Stadler, Miescher, Crocker, Simon: Intravenous immunoglobulin preparations contain anti-Siglec-8 autoantibodies. in The Journal of allergy and clinical immunology 2007 (PubMed)

Weitere Antikörper gegen SIGLEC8 Interaktionspartner

Human Sialic Acid Binding Ig-Like Lectin 8 (SIGLEC8) Interaktionspartner

  1. These data demonstrate that Siglec-8 functions uniquely as an activating receptor on IL-5-primed eosinophils through a novel pathway involving regulation of beta2-integrin-dependent adhesion, NADPH oxidase, and a subset of protein kinases

  2. Targeting saporin to Siglec-8 consistently caused extensive cell death.

  3. In differentiating ,eosinophils, SIGLEC-8 messenger RNA and protein were markedly down-regulated in parallel with OLIG2 by an OLIG2 small interfering RNA or a short hairpin RNA. An E-box in the first intron was found to stimulate SIGLEC-8 gene transcription and to bind OLIG2.

  4. miR-215 acts in concert with the host gene IARS2 to affect neuron migration and proliferation through the target gene SIGLEC-8.

  5. Our study suggested that intratumoral Siglec-8 expression was an independent prognostic factor for overall survival of patients with gastric cancer

  6. Ligands for Siglec-8 and Siglec-9 may regulate the function of eosinophils, mast cells, neutrophils, and other cells in sinus mucosa.

  7. Inflammation results in up-regulation of immuneinhibitory Siglec-8 and Siglec-9 sialoglycan ligands on human airways.

  8. Siglec-8 expression is sensitive to tiotropium and formoterol, indicating that it may be involved in COPD pathogenesis and may influence COPD phenotyping

  9. In activated eosinophils ligation of Siglec-8 leads to ROS-dependent enhancement of IL-5-induced ERK phosphorylation, which results in a novel mode of biochemically regulated eosinophil cell death.

  10. Engagement of Siglec-8 on blood eosinophils results in caspase- and mitochondria-dependent apoptosis.

  11. Report the development of a sensitive competitive ELISA to detect sSiglec-8 in human serum samples obtained from patients with various forms of eosinophilia.

  12. Eosinophils primed by IL-33 and/or IL-5 in vivo would be expected to display enhanced susceptibility to undergoing Siglec-8-induced apoptosis.

  13. expressed on eosinophils and basophils from subjects with chronic eosinophilic leukemia, chronic myelogenous leukemia, and on malignant and non-malignant bone marrow mast cells

  14. The Siglec-8 gene may be a susceptibility locus for asthma.

  15. Sialic acid binding immunoglobulin-like lectin 8 (Siglec-8) cross-linking with antibodies rapidly generated caspase-3-like activity and reduced eosinophil viability through induction of apoptosis

  16. Siglec-8 binds preferentially to a sLex structure bearing an additional sulfate ester on the galactose 6-hydroxyl

  17. Siglec-8-induced apoptosis in eosinophils occurs through the sequential production of reactive oxygen species, followed by induction of mitochondrial injury and caspase cleavage.

  18. IL-5 priming enhances Siglec-8-mediated mitochondrial and ROS-dependent eosinophil apoptosis and eliminates caspase dependence.

  19. First reported inhibitory effects of Siglec engagement on human mast cells.

  20. A review of the cytotoxic effects of natural anti-Siglec8 autoantibodies on both neutrophils and eosinophils.

SIGLEC8 Antigen-Profil

Protein Überblick

Sialic acid-binding immunoglobulin (Ig)-like lectins, or SIGLECs (e.g., CD33 (MIM 159590)), are a family of type 1 transmembrane proteins each having a unique expression pattern, mostly in hemopoietic cells. SIGLEC8 is a member of the CD33-like subgroup of SIGLECs, which are localized to 19q13.3-q13.4 and have 2 conserved cytoplasmic tyrosine-based motifs: an immunoreceptor tyrosine-based inhibitory motif, or ITIM (see MIM 604964), and a motif homologous to one identified in signaling lymphocyte activation molecule (SLAM\\\\; MIM 603492) that mediates an association with SLAM-associated protein (SAP\\\\; MIM 300490) (summarized by Foussias et al., 2000

Genbezeichner und Symbole assoziert mit SIGLEC8

  • sialic acid binding Ig like lectin 8 (SIGLEC8) Antikörper
  • sialic acid-binding Ig-like lectin 8 (LOC506364) Antikörper
  • SAF2 Antikörper
  • SIGLEC-8 Antikörper
  • SIGLEC8 Antikörper
  • SIGLEC8L Antikörper

Bezeichner auf Proteinebene für SIGLEC8

CDw329 , SAF-2 , sialic acid-binding Ig-like lectin 8 , sialoadhesin family member 2 , sialic acid binding Ig-like lectin 8

GENE ID SPEZIES
27181 Homo sapiens
456249 Pan troglodytes
506364 Bos taurus
100595640 Nomascus leucogenys
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