anti-Sestrin 2 (SESN2) Antikörper

SESN2 encodes a member of the sestrin family of PA26-related proteins. Zusätzlich bieten wir Ihnen Sestrin 2 Kits (21) und Sestrin 2 Proteine (7) und viele weitere Produktgruppen zu diesem Protein an.

Alle Antikörper anzeigen Gen GeneID UniProt
SESN2 83667 P58004
SESN2 230784 P58043
SESN2 502988  
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Top anti-Sestrin 2 Antikörper auf

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Katalog Nr. Reaktivität Wirt Konjugat Applikation Bilder Menge Anbieter Lieferzeit Preis Details
Rind (Kuh) Kaninchen Unkonjugiert WB WB Suggested Anti-SESN2 Antibody Titration: 0.2-1 ug/ml ELISA Titer: 1:62500 Positive Control: MCF7 cell lysate 100 μL Anmelden zum Anzeigen 2 bis 3 Tage
Rind (Kuh) Kaninchen Unkonjugiert WB 100 μL Anmelden zum Anzeigen 2 bis 3 Tage
Human Kaninchen Unkonjugiert FACS, WB Western blot analysis of Sestrin-2 Antibody (Center) (ABIN652222) in 293 cell line lysates (35 µg/lane). Sestrin-2 (arrow) was detected using the purified polyclonal antibody. Sestrin-2 Antibody (Center) (ABIN652222) flow cytometric analysis of 293 cells (right histogram) compared to a negative control cell (left histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis. 400 μL Anmelden zum Anzeigen 10 bis 11 Tage
Human Kaninchen Unkonjugiert ICC, IF, IHC, IHC (p) Immunocytochemistry/Immunofluorescence: SESN2 Antibody [NBP1-85029] - Immunofluorescent staining of human cell line A-431 shows positivity in cytoplasm. Immunohistochemistry-Paraffin: SESN2 Antibody [NBP1-85029] - Staining of human colon shows strong cytoplasmic positivity in glandular cells. 0.1 mL Anmelden zum Anzeigen 10 bis 13 Tage
Human Maus Unkonjugiert IF, ELISA, WB 100 μg Anmelden zum Anzeigen 7 bis 9 Tage
Human Maus Unkonjugiert IF, IHC (p), IP, ELISA, WB Immunoperoxidase of monoclonal antibody to SESN2 on formalin-fixed paraffin-embedded human ovary, clear cell carcinoma. [antibody concentration 3 ug/ml] SESN2 monoclonal antibody (M03), clone 3B8 Western Blot analysis of SESN2 expression in K-562 100 μg Anmelden zum Anzeigen 11 bis 12 Tage
Human Kaninchen Unkonjugiert EIA, WB (LEFT) Western blot analysis of Sestrin-2 Antibody (Center) in 293 cell line lysates (35ug/lane). Sestrin-2 (arrow) was detected using the purified Pab. (RIGHT) Western blot analysis of SESN2 (arrow) using rabbit polyclonal Sestrin-2 Antibody (Center) . 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected with the SESN2 gene (Lane 2). 0.4 mL Anmelden zum Anzeigen 6 bis 8 Tage
Human Kaninchen Unkonjugiert WB 50 μg Anmelden zum Anzeigen 7 bis 9 Tage
Rind (Kuh) Kaninchen Unkonjugiert WB 50 μg Anmelden zum Anzeigen 7 bis 9 Tage
Maus Kaninchen Unkonjugiert ICC, IHC, WB Figure. Western Blot; Sample: Recombinant protein. Figure.DAB staining on IHC-P. Samples: Mouse Tissue 100 μg Anmelden zum Anzeigen 13 bis 16 Tage

SESN2 Antikörper nach Reaktivität, Anwendung, Klonalität and Konjugat

Attribute Applikationen Wirt Klonalität Konjugat
Human , , ,
, , , , ,
Mouse (Murine) ,

Rat (Rattus) ,


Am meisten referenzierte anti-Sestrin 2 Antikörper

  1. Human Monoclonal Sestrin 2 Primary Antibody für IF, IHC (p) - ABIN566510 : Liu, Lee, Lee: Association of platelet-derived growth factor receptor ? accumulation with increased oxidative stress and cellular injury in sestrin 2 silenced human glioblastoma cells. in FEBS letters 2011 (PubMed)
    Show all 2 Pubmed References

  2. Human Polyclonal Sestrin 2 Primary Antibody für ICC, IF - ABIN4353033 : Stadler, Rexhepaj, Singan, Murphy, Pepperkok, Uhlén, Simpson, Lundberg: Immunofluorescence and fluorescent-protein tagging show high correlation for protein localization in mammalian cells. in Nature methods 2013 (PubMed)

Weitere Antikörper gegen Sestrin 2 Interaktionspartner

Human Sestrin 2 (SESN2) Interaktionspartner

  1. This study shows that differential Sestrin2-mediated regulation of mTORC1 and mTORC2 (zeige CRTC2 Antikörper) is necessary for the survival of glutamine (zeige GFPT1 Antikörper)-depleted lung cancer cells.

  2. There was significant overexpression of serum sesn2 protein and mRNA levels in the Alzheimer's Disease group compared to Mild Cognitive Impairment and the control group.

  3. isorhapontigenin treatment induces autophagy and inhibits bladder cancer growth through MAPK8 (zeige MAPK8 Antikörper)-JUN (zeige JUN Antikörper)-dependent transcriptional induction of SESN2

  4. The results suggest that SESN2 increases degradation of HIF-1A (zeige HIF1A Antikörper) via AMPK (zeige PRKAA1 Antikörper)-PHD (zeige PDC Antikörper) regulation that contributes to inhibition of in vitro and in vivo tumorigenesis.

  5. simple analysis of the reported "apo (zeige C9orf3 Antikörper)"-Sestrin2 structure reveals the clear presence of prominent, unmodeled electron density in the leucine-binding pocket that exactly accommodates the leucine observed in the higher resolution structure.

  6. Mass spectrometry analysis, western blot and surface plasmon resonance (SPR (zeige SPR Antikörper)) of affinity purified sesn1 (zeige SESN1 Antikörper) and sesn2 proteins confirmed their identity; biophysical characteristics were observed using circular dichroism (CD) showing that sesn1 (zeige SESN1 Antikörper) and sesn2 have a predominant a-helical structure.

  7. The data are the first to indicate that SESN2 might be a novel prognostic marker for hepatocellular carcinoma

  8. The up-regulation of SESN2 by mitochondrial dysfunction requires binding to ATF4 (zeige ATF4 Antikörper).

  9. Sesn2 has two subdomains. The N-terminal domain reduces alkylhydroperoxide radicals through its helix-turn-helix oxidoreductase (zeige TXNRD1 Antikörper) motif, and the C-terminal domain interacts with GATOR2 and subsequently inhibits mTORC1.

  10. SESN2-AMPK (zeige PRKAA1 Antikörper) signaling could exert a protective effect against glucose deprivation-induced cell death and that this effect is mediated by restoration of mitochondrial function.

Mouse (Murine) Sestrin 2 (SESN2) Interaktionspartner

  1. While acute aerobic exercise increased Sesn1 (zeige SESN1 Antikörper) accumulation and induced a discrete augment of Sesn2 protein content and AMPK (zeige PRKAA1 Antikörper) threonine phosphorylation, chronic exercise reduced the basal levels of Sesn1 (zeige SESN1 Antikörper) and Sesn2 as well as of AMPK (zeige PRKAA1 Antikörper) threonine phosphorylation in the quadriceps muscles of C57BL/6J mice.

  2. sestrin2 has a role in suppressing sepsis by inducing mitophagy and inhibiting NLRP3 (zeige NLRP3 Antikörper) activation in macrophages

  3. SESN2 suppressed ER stress-mediated apoptosis. SESN2 attenuated hepatic injury in mice.

  4. Decreased Sesn2 levels in aging lead to a blunted ischemic AMPK (zeige PRKAA1 Antikörper) activation, alterations in substrate metabolism, and an increased sensitivity to ischemic insults.

  5. p53 (zeige TP53 Antikörper)-dependent coordination with SESN2 regulates AMPK (zeige PRKAA1 Antikörper) and mTORC1 signaling and controls parturition timing

  6. Our findings further revealed that Sesn2-induced autophagy contributed to restore the impaired insulin (zeige INS Antikörper) signaling through the activation of AMPK (zeige PRKAA1 Antikörper) signal. Even in the presence of palmitate, Sesn2 up-regulation maintained insulin (zeige INS Antikörper) sensitivity and glucose metabolism via AMPK (zeige PRKAA1 Antikörper)-dependent autophagic activation.

  7. Oleanolic acid can attenuate hepatic ischemia reperfusion injury via HO-1 (zeige HMOX1 Antikörper)/Sesn2 signaling pathway.

  8. suggest that TLR-mediated Sesn2 induction is dependent on AP-1 (zeige JUN Antikörper), Nrf2 (zeige NFE2L2 Antikörper), and the inhibition of ubiquitin-mediated degradation of Sesn2 and might protect cells against endotoxin toxicity

  9. an AMPK (zeige PRKAA1 Antikörper)-independent mechanism of mTORC1 inhibition by Sestrins mediated by their interaction with GATOR2, is reported.

  10. Study found that Sestrins (1,2 and 3) can inhibit mTORC1 signaling in the absence of AMPK (zeige PRKAA1 Antikörper) or TSC2 (zeige TSC2 Antikörper). Surprisingly, when coexpressed with a GTP (zeige AK3 Antikörper)-bound constitutively active form of RagB (zeige RRAGB Antikörper) (RagBQ99L), Sestrins potentiate mTORC1 signaling in the absence of amino acids.

Sestrin 2 (SESN2) Antigen-Profil

Protein Überblick

This gene encodes a member of the sestrin family of PA26-related proteins. The encoded protein may function in the regulation of cell growth and survival. This protein may be involved in cellular response to different stress conditions.

Genbezeichner und Symbole assoziert mit anti-Sestrin 2 (SESN2) Antikörper

  • sestrin 2 (SESN2) Antikörper
  • sestrin 2 (Sesn2) Antikörper
  • sestrin 2 L homeolog (sesn2.L) Antikörper
  • sestrin 2 (sesn2) Antikörper
  • hi95 Antikörper
  • MGC81239 Antikörper
  • RGD1566319 Antikörper
  • ses2 Antikörper
  • SESN2 Antikörper
  • sest2 Antikörper
  • Sestrin-2 Antikörper

Bezeichner auf Proteinebene für anti-Sestrin 2 (SESN2) Antikörper

hypoxia induced gene 95 , sestrin-2 , sestrin 2 , sestrin-2-like

83667 Homo sapiens
230784 Mus musculus
414641 Xenopus laevis
469167 Pan troglodytes
487335 Canis lupus familiaris
509863 Bos taurus
716904 Macaca mulatta
733499 Xenopus (Silurana) tropicalis
100056552 Equus caballus
100172219 Pongo abelii
100353543 Oryctolagus cuniculus
100397149 Callithrix jacchus
100469808 Ailuropoda melanoleuca
100592235 Nomascus leucogenys
502988 Rattus norvegicus
100719606 Cavia porcellus
100149745 Danio rerio
Ausgewählte Anbieter für anti-Sestrin 2 (SESN2) Antikörper
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