Sema Domain, Immunoglobulin Domain (Ig), Transmembrane Domain (TM) and Short Cytoplasmic Domain, (Semaphorin) 4A Proteine (Sema4a)

Sema4a encodes a member of the semaphorin family of soluble and transmembrane proteins. Zusätzlich bieten wir Ihnen Sema4a Antikörper (107) und Sema4a Kits (8) und viele weitere Produktgruppen zu diesem Protein an.

alle Proteine anzeigen Gen GeneID UniProt
Sema4a 64218 Q9H3S1
Sema4a 20351 Q62178
Ratte Sema4a Sema4a 310630  
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Top Sema4a Proteine auf antikoerper-online.de

Showing 10 out of 15 products:

Katalog Nr. Origin Quelle Konjugat Bilder Menge Anbieter Lieferzeit Preis Details
Human Cells Human Fc Tag 100 μg Anmelden zum Anzeigen 20 bis 21 Tage
$382.80
Details
Insektenzellen Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 60 Days
$9,797.11
Details
Insektenzellen Maus rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Anmelden zum Anzeigen 60 bis 65 Tage
$7,639.51
Details
Wheat germ Human GST tag 2 μg Anmelden zum Anzeigen 11 bis 12 Tage
$338.33
Details
HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Anmelden zum Anzeigen Verfügbar
$814.00
Details
HEK-293 Cells Human His tag Human Semaphorin 4A, His Tag on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 95%. 100 μg Anmelden zum Anzeigen 2 bis 3 Tage
$286.00
Details
HEK-293 Cells Human His tag   0.1 mg Anmelden zum Anzeigen 2 bis 3 Tage
$515.63
Details
CHO Cells Maus Fc Tag   100 μg Anmelden zum Anzeigen 5 bis 8 Tage
$523.25
Details
Mammalian Cells Maus His tag   50 μg Anmelden zum Anzeigen 4 Days
$600.88
Details
Human Maus His tag   10 μg Anmelden zum Anzeigen 15 bis 16 Tage
$300.00
Details

Sema4a Proteine nach Spezies und Herkunft

Origin Exprimiert in Konjugat
Human , , , ,
, , , ,
Mouse (Murine) , , ,
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Am meisten referenzierte Sema4a Proteine

  1. Human Sema4a Protein expressed in Wheat germ - ABIN1319469 : Mogie, Shanks, Nkyimbeng-Takwi, Smith, Davila, Lipsky, DeTolla, Keegan, Chapoval: Neuroimmune semaphorin 4A as a drug and drug target for asthma. in International immunopharmacology 2013 (PubMed)

Weitere Proteine zu Sema Domain, Immunoglobulin Domain (Ig), Transmembrane Domain (TM) and Short Cytoplasmic Domain, (Semaphorin) 4A (Sema4a) Interaktionspartnern

Human Sema Domain, Immunoglobulin Domain (Ig), Transmembrane Domain (TM) and Short Cytoplasmic Domain, (Semaphorin) 4A (Sema4a) Interaktionspartner

  1. Advanced peri (zeige PLIN1 Proteine)-implantitis lesions showed higher levels of gene expression for Sem3A and Sem4D and lower levels of Sem4A in comparison to tissues obtained from a healthy dental implant.

  2. Here we show three families with retinal degeneration in which unaffected family members are either homozygous or heterozygous for the variant. The p.R713Q variant in SEMA4A is insufficient to cause either autosomal recessive or autosomal dominant retinitis pigmentosa and is unlikely to be pathogenic.

  3. ILT-4 (zeige LILRB2 Proteine) is a receptor for hSEMA4A)on activated CD4 (zeige CD4 Proteine)(+) T cells. hSEMA4A is highly expressed in human asthmatic lung tissue.

  4. Suggest a role for Plexin-B1 (zeige PLXNB1 Proteine) as a ligand and Sema4A as a receptor and characterize a reverse signaling pathway downstream of Sema4A regulating cell migration via Scrib (zeige SCRIB Proteine).

  5. SEMA (zeige SEMA3B Proteine) 4A confers doxorubicin resistance on hepatocellular carcinoma by inducing epithelialemesenchymal transition.

  6. In this review, we summarized the current findings on neuroimmune Sema4A and Sema4D (zeige SEMA4D Proteine) molecules in chronic inflammation underlying many diseases and discussed their positive or negative impacts on the implicated molecular and cellular processes

  7. Sema4A activated the Akt (zeige AKT1 Proteine) pathway via Plexin D1 (zeige PLXND1 Proteine) receptor in lung fibroblasts.Lung fibroblasts show elevated levels of Sema4A expression in systemic sclerosis patients.

  8. Data suggest that increased expression of semaphorin 4A (Sema4A) is required to promote inflammation of rheumatoid arthritis (RA).

  9. Germline variants in SEMA4A predispose to familial colorectal cancer type X.

  10. PACAP (zeige ADCYAP1 Proteine) released from retinal neural cells (photoreceptors or optic nerve cells) may regulate Sema4A expression in retinal pigment epithelial cells and thereby contribute to the maintenance of retinal structure and function.

Mouse (Murine) Sema Domain, Immunoglobulin Domain (Ig), Transmembrane Domain (TM) and Short Cytoplasmic Domain, (Semaphorin) 4A (Sema4a) Interaktionspartner

  1. Suggest a role for Plexin-B1 (zeige PLXNB1 Proteine) as a ligand and Sema4A as a receptor and characterize a reverse signaling pathway downstream of Sema4A regulating cell migration via Scrib (zeige SCRIB Proteine).

  2. SEMA4A is required for optimal activation of mTORC1 in CD8 (zeige CD8A Proteine)+ T cells.

  3. Treg-cell stability can be subverted in certain inflammatory sites, but is maintained by a Sema4a-Nrp1 (zeige NRP1 Proteine) axis-- this pathway is a potential therapeutic target that could limit Treg-cell-mediated tumour-induced tolerance without inducing autoimmunity

  4. Data indicate that both semaphorin 4A mRNA and protein were clearly detected on the earliest progenitors and were downregulated through thymic development.

  5. These results indicate the importance of the Sema4A protein conformation in human and mouse retina homeostasis.

  6. A fraction of Sema4a-deficient transgenic BALB/c mice spontaneously develop skin lesions resembling atopic dermatitis (AD) in humans.

  7. These data provide a new insight into Sema4A biology and define Sema4A as an important regulator of Th2-driven lung pathophysiology.

  8. Sema4A activates a specialized and restricted genetic program in macrophages able to sustain angiogenesis and participates in their recruitment and activation in inflammatory injuries.

  9. Sema4A regulates two distinct endosomal-sorting pathways that are critical for photoreceptor survival and phototransduction during the transition between daylight and darkness.

  10. experiments using knockout mice revealed that Sema4A but not Sema7A (zeige SEMA7A Proteine) was required for the effect produced by Th1 (zeige HAND1 Proteine) cells on neurite outgrowth from cortical neurons.

Sema4a Protein Überblick

Protein Überblick

This gene encodes a member of the semaphorin family of soluble and transmembrane proteins. Semaphorins are involved in numerous functions, including axon guidance, morphogenesis, carcinogenesis, and immunomodulation. The encoded protein is a single-pass type I membrane protein containing an immunoglobulin-like C2-type domain, a PSI domain and a sema domain. It inhibits axonal extension by providing local signals to specify territories inaccessible for growing axons. It is an activator of T-cell-mediated immunity and suppresses vascular endothelial growth factor (VEGF)-mediated endothelial cell migration and proliferation in vitro and angiogenesis in vivo. Mutations in this gene are associated with retinal degenerative diseases including retinitis pigmentosa type 35 (RP35) and cone-rod dystrophy type 10 (CORD10). Multiple alternatively spliced transcript variants encoding different isoforms have been identified.

Genbezeichner und Symbole assoziert mit Sema4a

  • semaphorin 4A (SEMA4A)
  • sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A (sema4a)
  • sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A (Sema4a)
  • semaphorin 4A (Sema4a)
  • AI132332 Protein
  • CORD10 Protein
  • RP35 Protein
  • SEMA4A Protein
  • Semab Protein
  • SemB Protein

Bezeichner auf Proteinebene für Sema4a

semaphorin B , sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A , semaphorin-4A , semaphorin-4A-like , sema B , semaphorin-B , semaphorin 4A

GENE ID SPEZIES
457386 Pan troglodytes
718191 Macaca mulatta
100064005 Equus caballus
100135101 Xenopus (Silurana) tropicalis
100172970 Pongo abelii
100342051 Oryctolagus cuniculus
100401951 Callithrix jacchus
100465692 Ailuropoda melanoleuca
64218 Homo sapiens
490416 Canis lupus familiaris
20351 Mus musculus
310630 Rattus norvegicus
510239 Bos taurus
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