Sema Domain, Immunoglobulin Domain (Ig), Transmembrane Domain (TM) and Short Cytoplasmic Domain, (Semaphorin) 4A Proteine (Sema4a)

Sema4a encodes a member of the semaphorin family of soluble and transmembrane proteins. Zusätzlich bieten wir Ihnen Sema4a Antikörper (106) und Sema4a Kits (9) und viele weitere Produktgruppen zu diesem Protein an.

alle Proteine anzeigen Gen GeneID UniProt
Sema4a 64218 Q9H3S1
Sema4a 20351 Q62178
Ratte Sema4a Sema4a 310630  
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Showing 10 out of 15 products:

Katalog Nr. Origin Quelle Konjugat Bilder Menge Anbieter Lieferzeit Preis Details
Human Cells Human Fc Tag 100 μg Anmelden zum Anzeigen 14 bis 16 Tage
$382.80
Details
Insektenzellen Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 60 Days
$9,626.73
Details
Insektenzellen Maus rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Anmelden zum Anzeigen 60 bis 65 Tage
$7,506.65
Details
Wheat germ Human GST tag 2 μg Anmelden zum Anzeigen 11 bis 12 Tage
$338.33
Details
HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Anmelden zum Anzeigen Verfügbar
$814.00
Details
Human Cells Maus His tag   50 μg Anmelden zum Anzeigen 4 Days
$590.43
Details
HEK-293 Cells Human His tag Human Semaphorin 4A, His Tag on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 95%. 100 μg Anmelden zum Anzeigen 2 bis 3 Tage
$286.00
Details
Human Cells Maus His tag   10 μg Anmelden zum Anzeigen 15 bis 16 Tage
$300.00
Details
HEK-293 Cells Human His tag   0.1 mg Anmelden zum Anzeigen 2 bis 3 Tage
$550.00
Details
CHO Cells Maus Fc Tag   100 μg Anmelden zum Anzeigen 5 bis 8 Tage
$642.69
Details

Sema4a Proteine nach Spezies und Herkunft

Origin Exprimiert in Konjugat
Human , , , ,
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Mouse (Murine) , ,
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Am meisten referenzierte Sema4a Proteine

  1. Human Sema4a Protein expressed in Wheat germ - ABIN1319469 : Mogie, Shanks, Nkyimbeng-Takwi, Smith, Davila, Lipsky, DeTolla, Keegan, Chapoval: Neuroimmune semaphorin 4A as a drug and drug target for asthma. in International immunopharmacology 2013 (PubMed)

Weitere Proteine zu Sema Domain, Immunoglobulin Domain (Ig), Transmembrane Domain (TM) and Short Cytoplasmic Domain, (Semaphorin) 4A (Sema4a) Interaktionspartnern

Human Sema Domain, Immunoglobulin Domain (Ig), Transmembrane Domain (TM) and Short Cytoplasmic Domain, (Semaphorin) 4A (Sema4a) Interaktionspartner

  1. Human oligodendrocytes undergo apoptosis when exposed to Sema4A and take up H-ferritin for meeting iron requirements and that these functions are mediated via the Tim-1 receptor. H-ferritin can block Sema4A-mediated cytotoxicity. Sema4A is detectable in the CSF of multiple sclerosis patients and HIV-seropositive persons and can induce oligodendrocyte cell death.

  2. Advanced peri-implantitis lesions showed higher levels of gene expression for Sem3A and Sem4D and lower levels of Sem4A in comparison to tissues obtained from a healthy dental implant.

  3. Here we show three families with retinal degeneration in which unaffected family members are either homozygous or heterozygous for the variant. The p.R713Q variant in SEMA4A is insufficient to cause either autosomal recessive or autosomal dominant retinitis pigmentosa and is unlikely to be pathogenic.

  4. ILT-4 is a receptor for hSEMA4A)on activated CD4(+) T cells. hSEMA4A is highly expressed in human asthmatic lung tissue.

  5. Suggest a role for Plexin-B1 as a ligand and Sema4A as a receptor and characterize a reverse signaling pathway downstream of Sema4A regulating cell migration via Scrib.

  6. SEMA 4A confers doxorubicin resistance on hepatocellular carcinoma by inducing epithelialemesenchymal transition.

  7. In this review, we summarized the current findings on neuroimmune Sema4A and Sema4D molecules in chronic inflammation underlying many diseases and discussed their positive or negative impacts on the implicated molecular and cellular processes

  8. Sema4A activated the Akt pathway via Plexin D1 receptor in lung fibroblasts.Lung fibroblasts show elevated levels of Sema4A expression in systemic sclerosis patients.

  9. Data suggest that increased expression of semaphorin 4A (Sema4A) is required to promote inflammation of rheumatoid arthritis (RA).

  10. Germline variants in SEMA4A predispose to familial colorectal cancer type X.

  11. PACAP released from retinal neural cells (photoreceptors or optic nerve cells) may regulate Sema4A expression in retinal pigment epithelial cells and thereby contribute to the maintenance of retinal structure and function.

  12. These results indicate the importance of the Sema4A protein conformation in human and mouse retina homeostasis.

  13. Sema4A plays an inhibitory role in T helper (Th)2-type allergic diseases, such as allergic asthma, in a fraction of Sema4a-deficient transgenic mice.

  14. mutations in SEMA4A may cause susceptibility to light exposure, oxidative stress, and ER stress, which may be involved in the progression and pathology of RP.

  15. Dendritic cell-derived SEM4A is not only critical for T helper type (Th)1 cells but also for Th17 cell differentiation, and multiple sclerosis patients with high Sema4A levels exhibit Th17 cell skewing.

  16. Mutations within the SEMA4A gene cause various retinal degnerative diseases.

Sema4a Protein Überblick

Protein Überblick

This gene encodes a member of the semaphorin family of soluble and transmembrane proteins. Semaphorins are involved in numerous functions, including axon guidance, morphogenesis, carcinogenesis, and immunomodulation. The encoded protein is a single-pass type I membrane protein containing an immunoglobulin-like C2-type domain, a PSI domain and a sema domain. It inhibits axonal extension by providing local signals to specify territories inaccessible for growing axons. It is an activator of T-cell-mediated immunity and suppresses vascular endothelial growth factor (VEGF)-mediated endothelial cell migration and proliferation in vitro and angiogenesis in vivo. Mutations in this gene are associated with retinal degenerative diseases including retinitis pigmentosa type 35 (RP35) and cone-rod dystrophy type 10 (CORD10). Multiple alternatively spliced transcript variants encoding different isoforms have been identified.

Genbezeichner und Symbole assoziert mit Sema4a

  • semaphorin 4A (SEMA4A)
  • sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A (sema4a)
  • sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A (Sema4a)
  • semaphorin 4A (Sema4a)
  • AI132332 Protein
  • CORD10 Protein
  • RP35 Protein
  • SEMA4A Protein
  • Semab Protein
  • SemB Protein

Bezeichner auf Proteinebene für Sema4a

semaphorin B , sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A , semaphorin-4A , semaphorin-4A-like , sema B , semaphorin-B , semaphorin 4A

GENE ID SPEZIES
457386 Pan troglodytes
718191 Macaca mulatta
100064005 Equus caballus
100135101 Xenopus (Silurana) tropicalis
100172970 Pongo abelii
100342051 Oryctolagus cuniculus
100401951 Callithrix jacchus
100465692 Ailuropoda melanoleuca
64218 Homo sapiens
490416 Canis lupus familiaris
20351 Mus musculus
310630 Rattus norvegicus
510239 Bos taurus
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