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The protein encoded by SMARCA2 is a member of the SWI/SNF family of proteins and is highly similar to the brahma protein of Drosophila. Zusätzlich bieten wir Ihnen SMARCA2 Proteine (5) und viele weitere Produktgruppen zu diesem Protein an.
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Chicken Monoclonal SMARCA2 Primary Antibody für IF, IP - ABIN967938
Muchardt, Yaniv: A human homologue of Saccharomyces cerevisiae SNF2/SWI2 and Drosophila brm genes potentiates transcriptional activation by the glucocorticoid receptor. in The EMBO journal 1993
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Chicken Monoclonal SMARCA2 Primary Antibody für IF, IP - ABIN967939
Singh, Coe, Hong: A role for retinoblastoma protein in potentiating transcriptional activation by the glucocorticoid receptor. in Nature 1995
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Human Polyclonal SMARCA2 Primary Antibody für ICC, IF - ABIN4285267
Van Houdt, Nowakowska, Sousa, van Schaik, Seuntjens, Avonce, Sifrim, Abdul-Rahman, van den Boogaard, Bottani, Castori, Cormier-Daire, Deardorff, Filges, Fryer, Fryns, Gana, Garavelli et al.: Heterozygous missense mutations in SMARCA2 cause Nicolaides-Baraitser syndrome. ... in Nature genetics 2012
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Human Monoclonal SMARCA2 Primary Antibody für ChIP, ICC - ABIN2668505
Okada, Harada, Saiwai, Nakamura, Ohkawa: Generation of a rat monoclonal antibody specific for Brm. in Hybridoma (2005) 2009
two promoter BRM germline variants were associated with worse outcome in our esophageal adenocarcinoma (EAC (zeige CYLD Antikörper)) patients. This significantly poorer outcome was independent of TNM (zeige ODZ1 Antikörper) classification at diagnosis or other clinic-demographic variables.
Epigenetic regulatory molecules bind to two BRM promoter sequence variants but not to their wild-type sequences. These variants are associated with adverse overall and progression-free survival. Decreased BRM gene expression, seen with these variants, is also associated with worse overall survival
We also demonstrate that tazemetostat, a potent and selective EZH2 (zeige EZH2 Antikörper) inhibitor currently in phase II clinical trials, induces potent antiproliferative and antitumor effects in SCCOHT cell lines and xenografts deficient in both SMARCA2 and SMARCA4 (zeige SMARCA4 Antikörper). These results exemplify an additional class of rhabdoid-like tumors that are dependent on EZH2 (zeige EZH2 Antikörper) activity for survival.
Two BRM promoter polymorphisms were strongly associated with hepatocellular carcinoma (HCC (zeige FAM126A Antikörper)) prognosis but were not associated with increased HCC (zeige FAM126A Antikörper) susceptibility.
This de novo SMARCA2 missense mutation c.3721C>G, p.Gln1241Glu is the only reported mutation on exon 26 outside the ATPase (zeige DNAH8 Antikörper) domain of SMARCA2 to be associated with Nicolaides-Baraitser syndrome and adds to chromatin remodeling as a pathway for epileptogenesis.
We conclude that their features better resemble Coffin-Siris syndrome, rather than Nicolaides-Baraitser syndrome and that these features likely arise from SMARCA2 over-dosage. Pure 9p duplications (not caused by unbalanced translocations) are rare. Copy number analysis in patients with features that overlap with Coffin-Siris syndrome is recommended to further determine their genetic aspects.
BRM could activate JAK2 (zeige JAK2 Antikörper)/STAT3 (zeige STAT3 Antikörper) pathway to promote pancreatic cancer growth and chemoresistance.
BRM gene mutation, chromosome 9 monosomy or BRM deletion and CpG methylation contribute collectively to the loss of BRM expression in poorly differentiated clear cell renal cell carcinoma (zeige MOK Antikörper)
BRM-741 and BRM-1321 insertion polymorphisms are associated with susceptibility to cancer.
BRG1 (zeige SMARCA4 Antikörper)/BRM and c-MYC (zeige MYC Antikörper) have an antagonistic relationship regulating the expression of cardiac conduction genes that maintain contractility, which is reminiscent of their antagonistic roles as a tumor suppressor and oncogene (zeige RAB1A Antikörper) in cancer.
SWI (zeige SMARCA1 Antikörper)/SNF (zeige SNRPA Antikörper) chromatin remodeler subunits Brg1 (zeige SMARCA4 Antikörper) and Brm are expressed differentially during drug-induced liver injury and regeneration in a mouse model.
these findings described a role for BRG1 (zeige SMARCA4 Antikörper) and BRM in mitochondrial quality control, by regulating mitochondrial number, mitophagy, and mitochondrial dynamics not previously recognized in the adult cardiomyocyte
BRM depletion enhances the proportion of cells expressing markers of osteoblast precursors at the expense of cells able to differentiate along the adipocyte lineage.
Data show that knockdown of component of chromatin remodeling complex Brm or Baf170 (zeige SMARCC2 Antikörper) at different stages promotes reprogramming.
Data reveal stage-specific roles of Brm during skeletal myogenesis, via formation of repressive and activatory SWI (zeige SMARCA1 Antikörper)/SNF (zeige SNRPA Antikörper) complexes.
Brm protects from UV-induced hyperplastic growth in both cutaneous and corneal keratinocytes
Data suggest that Brg1 (zeige SMARCA4 Antikörper) and Brm integrate various proinflammatory cues into cell adhesion molecule (zeige MCAM Antikörper) transactivation in endothelial injury.
A SMARCA2-containing residual SWI (zeige SMARCA1 Antikörper)/SNF (zeige SNRPA Antikörper) complex underlies the oncogenic activity of SMARCA4 (zeige SMARCA4 Antikörper) mutant cancers.
study identifies NO and HDAC2 (zeige HDAC2 Antikörper) nitrosylation as part of a signaling pathway that regulates cortical development and the expression of Brm in neurons
The protein encoded by this gene is a member of the SWI/SNF family of proteins and is highly similar to the brahma protein of Drosophila. Members of this family have helicase and ATPase activities and are thought to regulate transcription of certain genes by altering the chromatin structure around those genes. The encoded protein is part of the large ATP-dependent chromatin remodeling complex SNF/SWI, which is required for transcriptional activation of genes normally repressed by chromatin. Two transcript variants encoding different isoforms have been found for this gene, which contains a trinucleotide repeat (CAG) length polymorphism.
ATP-dependent helicase SMARCA2
, BRG1-associated factor 190B
, SNF2/SWI2-like protein 2
, SWI/SNF-related matrix-associated actin-dependent regulator of chromatin a2
, global transcription activator homologous sequence
, probable global transcription activator SNF2L2
, protein brahma homolog
, sucrose nonfermenting 2-like protein 2
, SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 2
, subunit of the SWI/SNF chromatin remodeling complex
, phasmid Socket Absent PSA-4