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SUMO/sentrin Specific Peptidase Family Member 8 Proteine (SENP8)

SENP8 encodes a cysteine protease that is a member of the sentrin-specific protease family. Zusätzlich bieten wir Ihnen SUMO/sentrin Specific Peptidase Family Member 8 Antikörper (75) und SUMO/sentrin Specific Peptidase Family Member 8 Kits (1) und viele weitere Produktgruppen zu diesem Protein an.

alle Proteine anzeigen Gen GeneID UniProt
SENP8 71599 Q9D2Z4
SENP8 123228 Q96LD8
SENP8 315723 Q5FVJ8
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Top SUMO/sentrin Specific Peptidase Family Member 8 Proteine auf antikoerper-online.de

Showing 10 out of 14 products:

Katalog Nr. Origin Quelle Konjugat Bilder Menge Anbieter Lieferzeit Preis Details
Insektenzellen Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 50 Days
$6,749.58
Details
Insektenzellen Maus His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 50 Days
$6,749.58
Details
Escherichia coli (E. coli) Human His tag Validation with Western Blot 10 μg Anmelden zum Anzeigen 4 bis 8 Tage
$394.90
Details
Escherichia coli (E. coli) Human His tag   50 μg Anmelden zum Anzeigen 4 Days
$115.50
Details
HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Anmelden zum Anzeigen 11 Days
$888.80
Details
Escherichia coli (E. coli) Human His-SUMO Tag 100 μg Anmelden zum Anzeigen 11 Days
$411.40
Details
Wheat germ Human GST tag 10 μg Anmelden zum Anzeigen 11 bis 12 Tage
$414.29
Details
Hefe Ratte His tag   1 mg Anmelden zum Anzeigen 60 bis 71 Tage
$2,539.17
Details
Hefe Arabidopsis thaliana His tag   1 mg Anmelden zum Anzeigen 60 bis 71 Tage
$2,566.67
Details
Escherichia coli (E. coli) Human His tag   10 μg Anmelden zum Anzeigen 15 bis 16 Tage
$100.00
Details

SENP8 Proteine nach Spezies und Herkunft

Origin Exprimiert in Konjugat
Mouse (Murine)

Human , , ,
, , ,
Rat (Rattus)

Weitere Proteine zu SUMO/sentrin Specific Peptidase Family Member 8 (SENP8) Interaktionspartnern

Arabidopsis thaliana SUMO/sentrin Specific Peptidase Family Member 8 (SENP8) Interaktionspartner

  1. DENEDDYLASE1 functions to maintain NEDD8 pathway activity by recovering diverted NEDD8 moieties from proteins of the NEDD8 conjugation machinery. [DEN1]

  2. mutants of a DEN1 homolog from Arabidopsis thaliana have no detectable defects in NEDD8 processing but do accumulate a broad range of NEDD8 conjugates. Neddylation may serve as a regulatory mechanism for cullin and non-cullin proteins. [DEN1]

Human SUMO/sentrin Specific Peptidase Family Member 8 (SENP8) Interaktionspartner

  1. Impairment of NEDDylation by Ubc12 knockout enhances PCNA ubiquitination and promotes PCNA-poleta interaction, while up-regulation of NEDDylation by NEDD8 overexpression or NEDP1 deletion reduces the excessive accumulation of ubiquitinated PCNA. Moreover, Ubc12 knockout decreases cell sensitivity to H2O2-induced oxidative stress, but NEDP1 deletion aggravates this sensitivity

  2. Furthermore, the authors characterized SENP8/DEN1 as the protease that counteracts Ubc12 auto-neddylation, and observed aberrant neddylation of Ubc12 and other NEDD8 conjugation pathway components in SENP8-deficient cells.

  3. In endothelial dysfunction, HDAC2 levels were reciprocally regulated by ectopic expression of NEDD8 and the de-NEDDylating enzyme SENP8.

  4. the expression of SENP8, SAE1, PIAS1, PIAS2 and ZMIZ1 is deregulated in the majority of PTC tissues, likely contributing to the PTC phenotype.

  5. Data indicate that overexpression of SENP8, a NEDD8-specific cysteine protease, resulted in deNEDDylation of E2F1 and promoted its transactivation activity at the p73 gene.

  6. We analyzed whether CSN1 alone can increase DEN1 degradation in HeLa cells.these data suggest that the COP9 signalosome supports proteasome-dependent protein degradation of DEN1/DenA in fungi and in human cells.

  7. A role for SENP8 as a central regulator of the inflammatory process is identified using knockdown and overexpression approaches.

  8. the specificity of NEDD8-specific peptidase SENP8

  9. Data show that the stability of MDM2 is regulated by NEDD8 pathway and identify NEDP1 that deneddylates MDM2, resulting in MDM2 destabilization concomitant with p53 activation.

  10. NEDP1 is likely to play an important role in ubiquitin-mediated proteolysis by controlling the activity of SCF complexes

  11. results suggest a unique role for NEDD8-specific protease 1(DEN1) in regulating the modification of cullin 1 by Nedd8 protein

  12. X-ray structures of the human Nedd8-specific protease, Den1, in a complex with the inhibitor Nedd8 aldehyde, thus revealing a model for the tetrahedral transition state intermediate generated during proteolysis

SUMO/sentrin Specific Peptidase Family Member 8 (SENP8) Protein Überblick

Protein Überblick

This gene encodes a cysteine protease that is a member of the sentrin-specific protease family. The encoded protein is involved in processing and deconjugation of the ubiquitin-like protein termed, neural precursor cell expressed developmentally downregulated 8. Alternate splicing results in multiple transcript variants.

Genbezeichner und Symbole assoziert mit SENP8

  • SUMO/sentrin peptidase family member, NEDD8 specific L homeolog (senp8.L)
  • Cysteine proteinases superfamily protein (AT5G60190)
  • SUMO/sentrin specific peptidase 8 (Senp8)
  • SUMO/sentrin peptidase family member, NEDD8 specific (SENP8)
  • SUMO/sentrin peptidase family member, NEDD8 specific (Senp8)
  • 9130010J17Rik Protein
  • AU020827 Protein
  • DEN1 Protein
  • F15L12.8 Protein
  • F15L12_8 Protein
  • MGC84956 Protein
  • NEDP1 Protein
  • PRSC2 Protein

Bezeichner auf Proteinebene für SENP8

SUMO/sentrin specific peptidase family member 8 , NEDD8-specific protease 1 , SUMO/sentrin specific protease 8 , SUMO/sentrin specific protease family member 8 , deneddylase-1 , protease, cysteine, 2 (NEDD8 specific) , sentrin-specific protease 8 , sentrin/SUMO-specific protease SENP8 , NEDD8 specific-protease cysteine 2 , SUMO sentrin specific protease family member 8 , deneddylase 1 , protease, cysteine 2 , SUMO/sentrin specific peptidase 8 , Sumo1/sentrin/SMT3 specific peptidase 8

GENE ID SPEZIES
735058 Xenopus laevis
836141 Arabidopsis thaliana
71599 Mus musculus
123228 Homo sapiens
315723 Rattus norvegicus
487631 Canis lupus familiaris
Ausgewählte Anbieter für SUMO/sentrin Specific Peptidase Family Member 8 Proteine (SENP8)
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