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SENP8 encodes a cysteine protease that is a member of the sentrin-specific protease family. Zusätzlich bieten wir Ihnen SUMO/sentrin Specific Peptidase Family Member 8 Antikörper (73) und SUMO/sentrin Specific Peptidase Family Member 8 Kits (1) und viele weitere Produktgruppen zu diesem Protein an.
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DENEDDYLASE1 functions to maintain NEDD8 pathway activity by recovering diverted NEDD8 moieties from proteins of the NEDD8 conjugation machinery. [DEN1]
mutants of a DEN1 homolog from Arabidopsis thaliana have no detectable defects in NEDD8 processing but do accumulate a broad range of NEDD8 conjugates. Neddylation may serve as a regulatory mechanism for cullin and non-cullin proteins. [DEN1]
Furthermore, the authors characterized SENP8/DEN1 as the protease that counteracts Ubc12 auto-neddylation, and observed aberrant neddylation of Ubc12 and other NEDD8 conjugation pathway components in SENP8-deficient cells.
In endothelial dysfunction, HDAC2 levels were reciprocally regulated by ectopic expression of NEDD8 and the de-NEDDylating enzyme SENP8.
the expression of SENP8, SAE1, PIAS1, PIAS2 and ZMIZ1 is deregulated in the majority of PTC tissues, likely contributing to the PTC phenotype.
Data indicate that overexpression of SENP8, a NEDD8-specific cysteine protease, resulted in deNEDDylation of E2F1 and promoted its transactivation activity at the p73 gene.
We analyzed whether CSN1 alone can increase DEN1 degradation in HeLa cells.these data suggest that the COP9 signalosome supports proteasome-dependent protein degradation of DEN1/DenA in fungi and in human cells.
A role for SENP8 as a central regulator of the inflammatory process is identified using knockdown and overexpression approaches.
the specificity of NEDD8-specific peptidase SENP8
Data show that the stability of MDM2 is regulated by NEDD8 pathway and identify NEDP1 that deneddylates MDM2, resulting in MDM2 destabilization concomitant with p53 activation.
NEDP1 is likely to play an important role in ubiquitin-mediated proteolysis by controlling the activity of SCF complexes
results suggest a unique role for NEDD8-specific protease 1(DEN1) in regulating the modification of cullin 1 by Nedd8 protein
X-ray structures of the human Nedd8-specific protease, Den1, in a complex with the inhibitor Nedd8 aldehyde, thus revealing a model for the tetrahedral transition state intermediate generated during proteolysis
This gene encodes a cysteine protease that is a member of the sentrin-specific protease family. The encoded protein is involved in processing and deconjugation of the ubiquitin-like protein termed, neural precursor cell expressed developmentally downregulated 8. Alternate splicing results in multiple transcript variants.
SUMO/sentrin specific peptidase family member 8
, NEDD8-specific protease 1
, SUMO/sentrin specific protease 8
, SUMO/sentrin specific protease family member 8
, protease, cysteine, 2 (NEDD8 specific)
, sentrin-specific protease 8
, sentrin/SUMO-specific protease SENP8
, NEDD8 specific-protease cysteine 2
, SUMO sentrin specific protease family member 8
, deneddylase 1
, protease, cysteine 2
, SUMO/sentrin specific peptidase 8
, Sumo1/sentrin/SMT3 specific peptidase 8