ST8 alpha-N-Acetyl-Neuraminide alpha-2,8-Sialyltransferase 1 Proteine (ST8SIA1)

Gangliosides are membrane-bound glycosphingolipids containing sialic acid. Zusätzlich bieten wir Ihnen ST8SIA1 Antikörper (16) und ST8SIA1 Kits (2) und viele weitere Produktgruppen zu diesem Protein an.

alle Proteine anzeigen Gen GeneID UniProt
ST8SIA1 6489 Q92185
ST8SIA1 20449 Q64687
Ratte ST8SIA1 ST8SIA1 25280  
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Top ST8SIA1 Proteine auf antikoerper-online.de

Showing 7 out of 9 products:

Katalog Nr. Origin Quelle Konjugat Bilder Menge Anbieter Lieferzeit Preis Details
Insektenzellen Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 50 Days
$6,869.04
Details
Insektenzellen Maus rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Anmelden zum Anzeigen 50 bis 55 Tage
$5,355.45
Details
Mammalian Cells Human His tag   50 μg Anmelden zum Anzeigen 4 Days
$600.88
Details
Human Cells Human His tag 100 μg Anmelden zum Anzeigen 20 bis 21 Tage
$547.80
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Wheat germ Human GST tag 10 μg Anmelden zum Anzeigen 11 bis 12 Tage
$414.29
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HEK-293 Cells Human His tag   10 μg Anmelden zum Anzeigen 8 bis 11 Tage
$297.00
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Human Human His tag   10 μg Anmelden zum Anzeigen 15 bis 16 Tage
$300.00
Details

ST8SIA1 Proteine nach Spezies und Herkunft

Origin Exprimiert in Konjugat
Human , , , , ,
, ,
Mouse (Murine)
,

Weitere Proteine zu ST8 alpha-N-Acetyl-Neuraminide alpha-2,8-Sialyltransferase 1 (ST8SIA1) Interaktionspartnern

Xenopus laevis ST8 alpha-N-Acetyl-Neuraminide alpha-2,8-Sialyltransferase 1 (ST8SIA1) Interaktionspartner

  1. Results report the sequences of two ST8Sia I mRNAs found in Xenopus laevis and their genomic organization; the canonical form resulted constituted of 5 exons and 4 introns, while the "short" mRNA lacks of the exon 2.

  2. Maternal Xlgd3 synthase mRNA could not be detected and showed a steady-state expression from gastrula to late tailbud stage.

Human ST8 alpha-N-Acetyl-Neuraminide alpha-2,8-Sialyltransferase 1 (ST8SIA1) Interaktionspartner

  1. These results from genotype-phenotype analysis might suggest a possible link between the ST8SIA1 functional promoter haplotype and the clinical severity of TAO [thyroid-associated ophthalmopathy].

  2. altered expression of miR (zeige MLXIP Proteine)-33a/let-7e was correlated with ST8SIA1 level, which might contribute to CRC (zeige CALR Proteine) progression

  3. Data suggest that ganglioside glycosyltransferases ST3GAL5 (zeige ST3GAL5 Proteine), ST8SIA1, and B4GALNT1 (zeige B4GALNT1 Proteine) are S-acylated at conserved cysteine residues located close to cytoplasmic border of their transmembrane domains; ST3Gal-II (zeige ST3GAL2 Proteine) is acylated at conserved cysteine residue in N-terminal cytoplasmic tail; for B4GALNT1 (zeige B4GALNT1 Proteine) and ST3Gal-II (zeige ST3GAL2 Proteine), dimer formation controls their S-acylation status.

  4. GD3 and GD3S are highly expressed in glioblastoma multiforme (GBM) stem cell, play a key role in glioblastoma tumorigenicity, and are potential therapeutic targets against GBM.

  5. Results show that GD3S regulates stem cell function via c-Met and the expression of GD3S is regulated by FOXC2 (zeige FOXC2 Proteine), a transcription factor functioning downstream of several epithelial-mesenchymal transition signaling pathways.

  6. Though results are limited by the small sample size, variants in BDNF (zeige BDNF Proteine) and ST8SIA may slow down the early response to antidepressants in subjects non-exposed to stressors at the illness onset, with a remarkable gene-environment interaction

  7. TNF-alpha (zeige TNF Proteine) and IL-6 (zeige IL6 Proteine) secreted from keratinocytes enhanced ST8SIA1 expression in melanocytes.

  8. This indicates that ST8Sia I is able to act as an oligosialyltransferase in a cellular context.

  9. Results show that G(D3) synthase expression is sufficient to enhance the tumorigenicity of MDA-MB-231 breast cancer cells through a ganglioside-dependent activation of the c-Met receptor.

  10. GD3 has a role in hypoxia susceptibility by disabling the c-Src (zeige SRC Proteine)/NF-kappaB (zeige NFKB1 Proteine) survival pathway resulting in lower Mn-SOD (zeige SOD2 Proteine) expression

Mouse (Murine) ST8 alpha-N-Acetyl-Neuraminide alpha-2,8-Sialyltransferase 1 (ST8SIA1) Interaktionspartner

  1. Targeted deletion of GD3S protects substantia nigra degeneration and prevents motor deficits associated with MPTP (zeige PTPN2 Proteine)-poisoning.

  2. leptin (zeige LEP Proteine)/ObRb (zeige LEPR Proteine)-mediated signals were enhanced in hypothalamus of GD3S KO mice due to increased a-series gangliosides, leading to the apparently similar features of energy expenditure between the KO and wild type mice

  3. role of GD3 synthase in sciatic nerve and neuronal morphology during peripheral nerve regeneration

  4. This study demonistrated that Ganglioside deficiency(B4galnt1 (zeige B4GALNT1 Proteine) and ST8SIA1 knockout mice causes inflammation and neurodegeneration via the activation of complement system in the spinal cord.

  5. Interaction of ganglioside GD3 with an EGF receptor (zeige EGFR Proteine) sustains the self-renewal ability of mouse neural stem cells in vitro.

  6. This study showed that NMJs of old mice lacking GD3-synthase (expressing only O- and a-series gangliosides), which do not show an overt neurological phenotype but may develop subclinical synaptic deficits

  7. GD3 has a role in hypoxia susceptibility by disabling the c-Src (zeige SRC Proteine)/NF-kappaB (zeige NFKB1 Proteine) survival pathway resulting in lower Mn-SOD (zeige SOD2 Proteine) expression

  8. alpha2,8-sialyltransferase has roles in cell proliferation and mobility

ST8SIA1 Protein Überblick

Protein Überblick

Gangliosides are membrane-bound glycosphingolipids containing sialic acid. Ganglioside GD3 is known to be important for cell adhesion and growth of cultured malignant cells. The protein encoded by this gene is a type II membrane protein that catalyzes the transfer of sialic acid from CMP-sialic acid to GM3 to produce gangliosides GD3 and GT3. The encoded protein may be found in the Golgi apparatus and is a member of glycosyltransferase family 29.

Genbezeichner und Symbole assoziert mit ST8SIA1

  • ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1 (ST8SIA1)
  • ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1 L homeolog (st8sia1.L)
  • ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1 (st8sia1)
  • ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1 (St8sia1)
  • 9330109E03Rik Protein
  • GD3S Protein
  • Sia-T Protein
  • SIAL-T2 Protein
  • Siat8 Protein
  • SIAT8-A Protein
  • Siat8a Protein
  • ST8SIA-IV Protein
  • St8sia1 Protein
  • ST8SiaI Protein
  • st8sial Protein
  • Xlgd3 Protein

Bezeichner auf Proteinebene für ST8SIA1

CMP-NeuAc:GM3 sialyltransferase , alpha-N-acetylneuraminide alpha-2,8-sialyltransferase , Alpha-2,8-sialyltransferase 8A , GD3 synthase , Ganglioside GD3 synthase , SIAT8-A , ST8Sia I , ST8SiaI , XLGD3 synthase , alpha-2,8-sialyltransferase ST8Sia-I , sialyltransferase 8A , sialyltransferase St8Sia I , sialytransferase St8Sia I , alpha-2,8-sialyltransferase 8A , sialytransferase St8SiaI , ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1 , Alpha-N-acetylneuraminide alpha-2,8-sialyltransferase , alpha-2,8-sialyltransferase 1 , alpha-N-acetylneuraminide alpha-2,8-sialyltransferase-like , disialoganglioside (GD3) synthase , ganglioside GD3 synthase , ganglioside GT3 synthase , ganglioside-specific alpha-2,8-polysialyltransferase , sialyltransferase 8 (alpha-N-acetylneuraminate: alpha-2,8-sialytransferase, GD3 synthase) A , sialyltransferase 8A (alpha-N-acetylneuraminate: alpha-2,8-sialyltransferase, GD3 synthase) , alpha-2, 8-sialyltransferase , sialyltransferase 8 A , alpha-N-acetylneuraminate: alpha-2,8-sialytransferase , sialytransferase St8Sia-I , Sialyltransferase 8 (alpha-N-acetylneuraminate: alpha-28-sialytransferase GD3 synthase) , Sialyltransferase 8 A (alpha-N-acetylneuraminate: alpha-28-sialytransferase GD3 synthase) GenBank no: U53883 , alpha-2, 8-sialytransferase , alpha-2,8-sialyltransferase , sialyltransferase 8 (alpha-2 8-sialytransferase) A

GENE ID SPEZIES
395860 Gallus gallus
398735 Xenopus laevis
444887 Xenopus (Silurana) tropicalis
477672 Canis lupus familiaris
706707 Macaca mulatta
100011205 Monodelphis domestica
100049518 Oryzias latipes
100351155 Oryctolagus cuniculus
100464397 Ailuropoda melanoleuca
100588840 Nomascus leucogenys
6489 Homo sapiens
20449 Mus musculus
282352 Bos taurus
25280 Rattus norvegicus
465341 Pan troglodytes
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