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SOX13 encodes a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic development and in the determination of cell fate.
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the interaction between Hhex (zeige HHEX Antikörper) and SOX13 may contribute to control Wnt (zeige WNT2 Antikörper)/TCF1 (zeige HNF1A Antikörper) signaling in the early embryo.
This study demonstrated that Sox13 functionally complements the related Sox5 and Sox6 as important developmental modulators in mouse spinal cord oligodendrocytes.
Results show that Sox9 (zeige SOX9 Antikörper), Sox5 (zeige SOX5 Antikörper), and Sox13 transcription factors are expressed in postnatal testis and may regulate multiple functions such as steroidogenesis and spermatogenesis.
Data indicate that sox13-mutant CD45.1(+) congenic mice were protected from psoriasis-like skin changes, which identified a role for Sox13-dependent gammadeltaT17 cells in the inflammatory condition.
Our data suggest a role for SOX13 in the specification and/or differentiation of a specific subset of neurons in the developing central nervous system.
The temporal and spatial expression of SOX13 protein during mouse organogenesis.
Sox13 identified as a gammadelta-specific gene in the immune system; it promotes gammadelta T cell development while opposing alphabeta T cell differentiation
This gene encodes a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic development and in the determination of cell fate. The encoded protein may act as a transcriptional regulator after forming a protein complex with other proteins. It has also been determined to be a type-1 diabetes autoantigen, also known as islet cell antibody 12.
SRY (sex determining region Y)-box 11 b
, Transcription factor Sox-13
, transcription factor Sox-11-B
, SRY-box 13
, SRY-related HMG-box gene 13
, islet cell antibody 12
, islet cell antigen 12
, transcription factor SOX-13
, type 1 diabetes autoantigen ICA12
, SRY-box containing gene 13
, SRY (Sex determining region Y)-box 13