anti-SMAD Family Member 9 (SMAD9) Antikörper

Human SMAD Family Member 9 (SMAD9) Interaktionspartner

1. Mutations in SMAD9 gene encoding for transforming growth factor (TGF)-[beta] superfamily have been identified in Pulmonary Arterial Hypertension.

2. Phosphorylated Smad1/5/8/9 specifically bound to the BREs of Smad8/9 gene. The present study reveals that Smad8/9 is a unique R-Smad regulated through the BMP pathway at the mRNA level.

3. Case Report: hamartomatous olyposis and gastrointestinal ganglioneuromas with SMAD9 germline mutation that reduces PTEN expression.

4. a detailed computational model for TGF-beta (zeige TGFB1 Antikörper) signalling that incorporates elements of previous models together with crosstalking between Smad1 (zeige GARS Antikörper)/5/8 and Smad2 (zeige SMAD2 Antikörper)/3 channels through a negative feedback loop dependent on Smad7 (zeige SMAD7 Antikörper).

5. ATP production by NaF (zeige IL8 Antikörper) promotes hypertrophy-like changes via activation of phospho-Smad8

6. TNF (zeige TNF Antikörper) activated NF-kappaB (zeige NFKB1 Antikörper) pathway and inhibited the phosphorylation of Smad 1 (zeige GARS Antikörper)/5/8 and BMP-2 (zeige BMP2 Antikörper)-induced osteoblastic differentiation in BMMSCs

7. CREBZF (zeige CREBZF Antikörper), a novel Smad8-binding protein.

8. Data suggest that Smads 1, 5 and 8 as potential prognostic markers and therapeutic targets for mTOR (zeige FRAP1 Antikörper) inhibition therapy of prostate cancer.

9. Endoglin (zeige ENG Antikörper) promotes transforming growth factor beta-mediated Smad 1 (zeige GARS Antikörper)/5/8 signaling and inhibits endothelial cell migration through its association with GIPC (zeige GIPC1 Antikörper)

10. Study described the first mutation in SMAD8 in a patient with IPAH, and suggested the involvement of SMAD8 in the pathogenesis of PAH.

Mouse (Murine) SMAD Family Member 9 (SMAD9) Interaktionspartner

1. Sphingosine 1 phosphate also up-regulated runt-related transcription factor 2 (Runx2 (zeige RUNX2 Antikörper)) expression through S1PR2 (zeige S1PR2 Antikörper)/RhoA (zeige RHOA Antikörper)/ROCK/Smad1 (zeige SMAD1 Antikörper)/5/8 signaling.

2. Phosphorylated Smad1/5/8/9 specifically bound to the BREs of Smad8/9 gene. The present study reveals that Smad8/9 is a unique R-Smad regulated through the BMP pathway at the mRNA level.

3. BetA can enhance in vivo osteogenic potentials of BMP2 (zeige BMP2 Antikörper), possibly via stimulating Smad 1 (zeige SMAD1 Antikörper)/5/8 and p38 (zeige CRK Antikörper) pathways, and combination of both agents can be considered as a therapeutic strategy for bone diseases.

4. findings suggest that Smad9 is a new type of transcriptional regulator in BMP signaling.

5. The findings demonstrate for the first time that KMUP-1 can promote osteoblast maturation and differentiation in vitro via BMP-2 (zeige BMP2 Antikörper)/Smad1 (zeige SMAD1 Antikörper)/5/8 and Wnt (zeige WNT2 Antikörper)/beta-catenin (zeige CTNNB1 Antikörper) pathways.

6. Data indicate that PDGF (zeige PDGFA Antikörper)-AA promotes mesenchymal stem cel migration via bone morphogenetic protein 2 (BMP2 (zeige BMP2 Antikörper))-smad (zeige SMAD1 Antikörper) proteins smad1 (zeige SMAD1 Antikörper)/5/8 activation requires lysosome-mediated degradation of PDGF (zeige PDGFA Antikörper) alpha Receptor (PDGFRalpha).

7. our data suggest a pivotal role for canonical BMP signaling demonstrating distinguished nonoverlapping function of pSmad8 with pSmad1 and pSmad5 in hfSCs regulation and hair morphogenesis but a redundant role in adult hair progenitors differentiation.

8. Data show that HtrA1 (zeige HTRA1 Antikörper) is produced during osteoclastogenesis, and negatively regulates osteoblast differentiation, osteoblast differentiation and BMP2 (zeige BMP2 Antikörper)-induced Smad1 (zeige SMAD1 Antikörper)/5/8, ERK1/2 and p38 (zeige CRK Antikörper) phosphorylation in pre-osteoblasts.

9. FGF2 (zeige FGF2 Antikörper) inhibited BMP9 (zeige GDF2 Antikörper)-induced osteogenic differentiation by blocking BMP9 (zeige GDF2 Antikörper)-induced Smads signaling and subsequently reducing Smads dependent up-regulation of ALK1 (zeige ACVRL1 Antikörper) and ALK2 (zeige ACRV1 Antikörper) in mesenchymal stem cells.

10. a detailed computational model for TGF-beta (zeige TGFB1 Antikörper) signalling that incorporates elements of previous models together with crosstalking between Smad1 (zeige SMAD1 Antikörper)/5/8 and Smad2 (zeige SMAD2 Antikörper)/3 channels through a negative feedback loop dependent on Smad7 (zeige SMAD7 Antikörper).

Cow (Bovine) SMAD Family Member 9 (SMAD9) Interaktionspartner

1. a detailed computational model for TGF-beta (zeige TGFB1 Antikörper) signalling that incorporates elements of previous models together with crosstalking between Smad1 (zeige SMAD1 Antikörper)/5/8 and Smad2 (zeige SMAD2 Antikörper)/3 channels through a negative feedback loop dependent on Smad7 (zeige SMAD7 Antikörper).