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Protein-lysine N-methyltransferase that monomethylates both histones and non-histone proteins. Zusätzlich bieten wir Ihnen SETD8 Antikörper (126) und viele weitere Produktgruppen zu diesem Protein an.
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Protein-lysine N-methyltransferase that monomethylates both histones and non-histone proteins. Specifically monomethylates 'Lys-20' of histone H4 (H4K20me1). H4K20me1 is enriched during mitosis and represents a specific tag for epigenetic transcriptional repression. Mainly functions in euchromatin regions, thereby playing a central role in the silencing of euchromatic genes. Required for cell proliferation, probably by contributing to the maintenance of proper higher order structure of DNA during mitosis. Involved in chromosome condensation and proper cytokinesis. Nucleosomes are preferred as substrate compared to free histones. Mediates monomethylation of p53/TP53 at 'Lys-382', leading to repress p53/TP53-target genes (By similarity).
, H4-K20-specific histone methyltransferase
, H4K20-specific histone methyltransferase splice variant Set8b
, N-lysine methyltransferase SETD8
, PR/SET domain containing protein 8
, PR/SET domain-containing protein 07
, SET domain-containing protein 8
, histone-lysine N-methyltransferase SETD8
, lysine N-methyltransferase 5A
, SET domain-containing 8