SET Domain Containing (Lysine Methyltransferase) 8 Proteine (SETD8)

Protein-lysine N-methyltransferase that monomethylates both histones and non-histone proteins. Zusätzlich bieten wir Ihnen SETD8 Antikörper (143) und und viele weitere Produktgruppen zu diesem Protein an.

alle Proteine anzeigen Gen GeneID UniProt
SETD8 387893 Q9NQR1
SETD8 67956 Q2YDW7
Ratte SETD8 SETD8 689820  
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Top SETD8 Proteine auf antikoerper-online.de

Showing 10 out of 10 products:

Katalog Nr. Origin Quelle Konjugat Bilder Menge Anbieter Lieferzeit Preis Details
Insektenzellen Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 50 Days
$6,869.04
Details
Insektenzellen Maus His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 50 Days
$6,869.04
Details
Escherichia coli (E. coli) Human Unkonjugiert 100 μg Anmelden zum Anzeigen 20 bis 21 Tage
$382.80
Details
Escherichia coli (E. coli) Human His tag Validation with Western Blot 50 μg Anmelden zum Anzeigen Verfügbar
$284.90
Details
Hefe Xenopus tropicalis His tag   1 mg Anmelden zum Anzeigen 60 bis 71 Tage
$2,907.67
Details
Hefe Rind (Kuh) His tag   1 mg Anmelden zum Anzeigen 60 bis 71 Tage
$2,959.00
Details
Hefe Schizosaccharomyces pombe His tag   1 mg Anmelden zum Anzeigen 60 bis 71 Tage
$3,197.33
Details
Baculovirus infected Insect Cells Human His tag   50 μg Anmelden zum Anzeigen 13 bis 16 Tage
$400.00
Details
Escherichia coli (E. coli) Human His tag   10 μg Anmelden zum Anzeigen 1 bis 2 Tage
$460.83
Details
Escherichia coli (E. coli) Human His tag   10 μg Anmelden zum Anzeigen 1 bis 2 Tage
$460.83
Details

SETD8 Proteine nach Spezies und Herkunft

Origin Exprimiert in Konjugat
Human , ,

Mouse (Murine)

Weitere Proteine zu SET Domain Containing (Lysine Methyltransferase) 8 (SETD8) Interaktionspartnern

Human SET Domain Containing (Lysine Methyltransferase) 8 (SETD8) Interaktionspartner

  1. that oncogenic SETD8 was regulated by miR (zeige MLXIP Proteine)-382 and involved glioma progression

  2. Data found that KMT5A was overexpressed in papillary thyroid carcinoma (PTC (zeige F9 Proteine)) tumors. Its knockdown revealed that KMT5A participated in the proliferation, apoptosis, cell cycle, migration and invasion of PTC (zeige F9 Proteine) cells as well as attenuated fatty acid metabolism. These results provide mounting evidence of KMT5A as an oncogenic mediator in fatty acid metabolism of PTC (zeige F9 Proteine).

  3. Authors demonstrated that PR-Set7, an epigenetic regulator for H4K20me1 modification, was extensively expressed in the postnatal uteri, and its conditional deletion resulted in a complete lack of endometrial glands and infertility in mice.

  4. MiR (zeige MLXIP Proteine)-502 medaited histone methyltransferase SET8 expression is associated with outcome of esophageal squamous cell carcinoma.

  5. these date elucidated that NT21MP and miR335 mediated PR of breast cancer cells partly through regulation of Wnt (zeige WNT2 Proteine)/betacatenin signaling pathway. Activation of miR335 or inactivation of SETD8 could be a novel approach for the treatment of breast cancer.

  6. High expression of SET8 is associated with cervical cancer.

  7. This improves the binding of SAM (zeige TTN Proteine), SAH (zeige ACSM3 Proteine), and sinefungin by up to 10,000-fold. A small collection of inhibitors structurally related to SAM (zeige TTN Proteine) were screened and 40 compounds were identified that only inhibit SETD8 when a nucleosome substrate is used

  8. We demonstrated the expression levels of SET8 in TT genotype were higher than in CC genotypes, and high levels of SET8 were associated with poor survival in breast cancer

  9. Lysine methylation represses p53 (zeige TP53 Proteine) activity in teratocarcinoma cancer cells via up-regulation of SMYD2 (zeige SMYD2 Proteine) and PR-Set7 and perpetuation of cancer cells proliferation.

  10. The loss of SETD8 concurrently stimulated nucleolar function.

Mouse (Murine) SET Domain Containing (Lysine Methyltransferase) 8 (SETD8) Interaktionspartner

  1. Authors demonstrated that PR-Set7, an epigenetic regulator for H4K20me1 modification, was extensively expressed in the postnatal uteri, and its conditional deletion resulted in a complete lack of endometrial glands and infertility in mice.

  2. PR-Set7 is a direct target of Cul4A (zeige CUL4A Proteine) for degradation and involved in the formation of lung tumors in the conditional Cul4A (zeige CUL4A Proteine) transgenic mouse model.

  3. These results suggest that Setd8 is an important regulator of erythroid maturation that works in part through repression of Gata2 (zeige GATA2 Proteine) expression.

  4. These results establish SetD8 as a determinant of erythroid cell maturation and provide a framework for understanding how a broadly expressed histone-modifying enzyme mediates cell-type-specific GATA factor function.

  5. all of the H3K36-specific methyltransferases, including ASH1L (zeige ASH1L Proteine), HYPB, NSD1, and NSD2 (zeige WHSC1 Proteine) were inhibited by ubH2A, whereas the other histone methyltransferases, including PRC2, G9a (zeige EHMT2 Proteine), and Pr-Set7 were not affected by ubH2A.

  6. Data indicate a vital link between GATA-1 (zeige GATA1 Proteine) and the histone H4 lysine 20 methyltransferase PR-Set7/SetD8 (SetD8).

  7. Pr-set7 knockdown caused increased gammaH2AX (zeige H2AFX Proteine) foci on chromosomes indicating DNA damage on chromosomes.

  8. Setd8 is a crucial inhibitor of apoptosis in skin and its activity is essential for epidermal stem cell survival, proliferation and differentiation

  9. the SET8 and PCNA (zeige PCNA Proteine) interaction couples H4-K20 (zeige KRT20 Proteine) methylation with DNA replication

  10. PR-Set7 enzymatic activity is essential for mammalian cell cycle progression and for the maintenance of genomic stability, most likely by monomethylating histone H4K20.

SETD8 Protein Überblick

Protein Überblick

Protein-lysine N-methyltransferase that monomethylates both histones and non-histone proteins. Specifically monomethylates 'Lys-20' of histone H4 (H4K20me1). H4K20me1 is enriched during mitosis and represents a specific tag for epigenetic transcriptional repression. Mainly functions in euchromatin regions, thereby playing a central role in the silencing of euchromatic genes. Required for cell proliferation, probably by contributing to the maintenance of proper higher order structure of DNA during mitosis. Involved in chromosome condensation and proper cytokinesis. Nucleosomes are preferred as substrate compared to free histones. Mediates monomethylation of p53/TP53 at 'Lys-382', leading to repress p53/TP53-target genes (By similarity).

Genbezeichner und Symbole assoziert mit SETD8

  • lysine methyltransferase 5A (KMT5A)
  • lysine methyltransferase 5A (Kmt5a)
  • lysine methyltransferase 5Ab (kmt5ab)
  • lysine methyltransferase 5A S homeolog (kmt5a.S)
  • 2410195B05Rik Protein
  • AA617402 Protein
  • AW536475 Protein
  • kmt5a Protein
  • kmt5a-a Protein
  • Pr-set7 Protein
  • RGD1305893 Protein
  • SET07 Protein
  • SET8 Protein
  • setd8 Protein
  • setd8-a Protein
  • setd8b Protein
  • wu:fc23f12 Protein
  • zgc:171649 Protein

Bezeichner auf Proteinebene für SETD8

H4-K20-HMTase SETD8 , H4-K20-specific histone methyltransferase , H4K20-specific histone methyltransferase splice variant Set8b , N-lysine methyltransferase SETD8 , PR/SET domain containing protein 8 , PR/SET domain-containing protein 07 , PR/SET07 , SET domain-containing protein 8 , histone-lysine N-methyltransferase SETD8 , lysine N-methyltransferase 5A , PR-Set7 , SET domain-containing 8 , SET domain containing (lysine methyltransferase) 8b , SET domain containing 8b , N-lysine methyltransferase KMT5A , SET domain containing (lysine methyltransferase) 8 , histone methyltransferase Pr-set7/Set8 , lysine (K)-specific methyltransferase 5A , Histone-lysine N-methyltransferase KMT5A-A , Lysine-specific methylase 5A-A , N-lysine methyltransferase KMT5A-A , N-lysine methyltransferase SETD8-A , SET domain-containing protein 8-A , histone-lysine N-methyltransferase KMT5A-A , histone-lysine N-methyltransferase SETD8-A , lysine (K)-specific methyltransferase 5A S homeolog , lysine-specific methylase 5A-A

GENE ID SPEZIES
387893 Homo sapiens
67956 Mus musculus
532622 Bos taurus
100004770 Danio rerio
689820 Rattus norvegicus
100158384 Xenopus laevis
Ausgewählte Anbieter für SETD8 Proteine (SETD8)
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