SET Domain Containing (Lysine Methyltransferase) 8 Proteine (SETD8)

Protein-lysine N-methyltransferase that monomethylates both histones and non-histone proteins. Zusätzlich bieten wir Ihnen SETD8 Antikörper (143) und und viele weitere Produktgruppen zu diesem Protein an.

alle Proteine anzeigen Gen GeneID UniProt
SETD8 387893 Q9NQR1
SETD8 67956 Q2YDW7
Ratte SETD8 SETD8 689820  
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Top SETD8 Proteine auf antikoerper-online.de

Showing 10 out of 10 products:

Katalog Nr. Origin Quelle Konjugat Bilder Menge Anbieter Lieferzeit Preis Details
Insektenzellen Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 50 Days
$6,749.58
Details
Insektenzellen Maus His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 50 Days
$6,749.58
Details
Escherichia coli (E. coli) Human Unkonjugiert 100 μg Anmelden zum Anzeigen 14 bis 16 Tage
$382.80
Details
Escherichia coli (E. coli) Human His tag Validation with Western Blot 50 μg Anmelden zum Anzeigen Verfügbar
$284.90
Details
Hefe Xenopus tropicalis His tag   1 mg Anmelden zum Anzeigen 60 bis 71 Tage
$2,907.67
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Hefe Rind (Kuh) His tag   1 mg Anmelden zum Anzeigen 60 bis 71 Tage
$2,959.00
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Hefe Schizosaccharomyces pombe His tag   1 mg Anmelden zum Anzeigen 60 bis 71 Tage
$3,197.33
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Baculovirus infected Insect Cells Human His tag   50 μg Anmelden zum Anzeigen 13 bis 16 Tage
$400.00
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Escherichia coli (E. coli) Human His tag   10 μg Anmelden zum Anzeigen 1 bis 2 Tage
$460.83
Details
Escherichia coli (E. coli) Human His tag   10 μg Anmelden zum Anzeigen 1 bis 2 Tage
$460.83
Details

SETD8 Proteine nach Spezies und Herkunft

Origin Exprimiert in Konjugat
Human , ,

Mouse (Murine)

Weitere Proteine zu SET Domain Containing (Lysine Methyltransferase) 8 (SETD8) Interaktionspartnern

Human SET Domain Containing (Lysine Methyltransferase) 8 (SETD8) Interaktionspartner

  1. Results suggest that SET domain-containing protein 8 (SET8) may be a key mediator in hyperglycemic memory.

  2. that oncogenic SETD8 was regulated by miR-382 and involved glioma progression

  3. Data found that KMT5A was overexpressed in papillary thyroid carcinoma (PTC) tumors. Its knockdown revealed that KMT5A participated in the proliferation, apoptosis, cell cycle, migration and invasion of PTC cells as well as attenuated fatty acid metabolism. These results provide mounting evidence of KMT5A as an oncogenic mediator in fatty acid metabolism of PTC.

  4. Authors demonstrated that PR-Set7, an epigenetic regulator for H4K20me1 modification, was extensively expressed in the postnatal uteri, and its conditional deletion resulted in a complete lack of endometrial glands and infertility in mice.

  5. MiR-502 medaited histone methyltransferase SET8 expression is associated with outcome of esophageal squamous cell carcinoma.

  6. these date elucidated that NT21MP and miR335 mediated PR of breast cancer cells partly through regulation of Wnt/betacatenin signaling pathway. Activation of miR335 or inactivation of SETD8 could be a novel approach for the treatment of breast cancer.

  7. High expression of SET8 is associated with cervical cancer.

  8. This improves the binding of SAM, SAH, and sinefungin by up to 10,000-fold. A small collection of inhibitors structurally related to SAM were screened and 40 compounds were identified that only inhibit SETD8 when a nucleosome substrate is used

  9. We demonstrated the expression levels of SET8 in TT genotype were higher than in CC genotypes, and high levels of SET8 were associated with poor survival in breast cancer

  10. Lysine methylation represses p53 activity in teratocarcinoma cancer cells via up-regulation of SMYD2 and PR-Set7 and perpetuation of cancer cells proliferation.

  11. The loss of SETD8 concurrently stimulated nucleolar function.

  12. The PPARgamma-SETD8 axis constitutes an epigenetic, p53-independent checkpoint on p21-mediated cellular senescence.

  13. rs16917496 polymorphism may be a risk for predisposition to prostate cancer in an Iranian population.

  14. miR-502/SET8 regulatory circuit emerges as a key regulator of the pathobiology of breast cancer and a focal point for possible therapeutic intervention.

  15. In non-small cell lung cancer cells, SETD8 expression suppression is involved in tumorigenesis and metastasis.

  16. SET8 and ZEB1 are functionally interdependent in promoting the epithelial-mesenchymal transition and enhancing the invasive potential of prostate cancer cells in vitro.

  17. SET8 expression is associated with overall survival in gastric cancer

  18. analysis of a structural model for how Set8 uses multivalent interactions to bind and methylate the nucleosome based on crystallographic and solution studies of the Set8/nucleosome complex

  19. This study showed SCF(beta-TRCP) earmarks Set8 for ubiquitination and degradation in a casein kinase I-dependent manner, which is activated by DNA-damaging agents.

  20. Overall, the results revealed that miR-127-3p acts as a tumor suppressor and that its down-regulation in cancer may contribute to OS progression and metastasis.

Mouse (Murine) SET Domain Containing (Lysine Methyltransferase) 8 (SETD8) Interaktionspartner

  1. KMT5a was identified as a target gene that was down-regulated in both mRNA and protein level when miR-127-3p mimics were introduced. miR-127-3p regulates the proliferation of myocytes through KMT5a.

  2. Authors demonstrated that PR-Set7, an epigenetic regulator for H4K20me1 modification, was extensively expressed in the postnatal uteri, and its conditional deletion resulted in a complete lack of endometrial glands and infertility in mice.

  3. PR-Set7 is a direct target of Cul4A for degradation and involved in the formation of lung tumors in the conditional Cul4A transgenic mouse model.

  4. These results suggest that Setd8 is an important regulator of erythroid maturation that works in part through repression of Gata2 expression.

  5. These results establish SetD8 as a determinant of erythroid cell maturation and provide a framework for understanding how a broadly expressed histone-modifying enzyme mediates cell-type-specific GATA factor function.

  6. all of the H3K36-specific methyltransferases, including ASH1L, HYPB, NSD1, and NSD2 were inhibited by ubH2A, whereas the other histone methyltransferases, including PRC2, G9a, and Pr-Set7 were not affected by ubH2A.

  7. Data indicate a vital link between GATA-1 and the histone H4 lysine 20 methyltransferase PR-Set7/SetD8 (SetD8).

  8. Pr-set7 knockdown caused increased gammaH2AX foci on chromosomes indicating DNA damage on chromosomes.

  9. Setd8 is a crucial inhibitor of apoptosis in skin and its activity is essential for epidermal stem cell survival, proliferation and differentiation

  10. the SET8 and PCNA interaction couples H4-K20 methylation with DNA replication

  11. PR-Set7 enzymatic activity is essential for mammalian cell cycle progression and for the maintenance of genomic stability, most likely by monomethylating histone H4K20.

  12. Cell cycle analysis after synchronization indicated that defects at the S and G(2)/M phases were a consequence of decreased H4K20me1 due to the absence of PR-Set7.

  13. Data show that the peroxisome proliferator-activated receptor gamma/retinoid X receptor alpha heterodimer targets the histone modification enzyme PR-Set7/Setd8 gene and regulates adipogenesis through a positive feedback loop.

SETD8 Protein Überblick

Protein Überblick

Protein-lysine N-methyltransferase that monomethylates both histones and non-histone proteins. Specifically monomethylates 'Lys-20' of histone H4 (H4K20me1). H4K20me1 is enriched during mitosis and represents a specific tag for epigenetic transcriptional repression. Mainly functions in euchromatin regions, thereby playing a central role in the silencing of euchromatic genes. Required for cell proliferation, probably by contributing to the maintenance of proper higher order structure of DNA during mitosis. Involved in chromosome condensation and proper cytokinesis. Nucleosomes are preferred as substrate compared to free histones. Mediates monomethylation of p53/TP53 at 'Lys-382', leading to repress p53/TP53-target genes (By similarity).

Genbezeichner und Symbole assoziert mit SETD8

  • lysine methyltransferase 5A (KMT5A)
  • lysine methyltransferase 5A (Kmt5a)
  • lysine methyltransferase 5Ab (kmt5ab)
  • lysine methyltransferase 5A S homeolog (kmt5a.S)
  • 2410195B05Rik Protein
  • AA617402 Protein
  • AW536475 Protein
  • kmt5a Protein
  • kmt5a-a Protein
  • Pr-set7 Protein
  • RGD1305893 Protein
  • SET07 Protein
  • SET8 Protein
  • setd8 Protein
  • setd8-a Protein
  • setd8b Protein
  • wu:fc23f12 Protein
  • zgc:171649 Protein

Bezeichner auf Proteinebene für SETD8

H4-K20-HMTase SETD8 , H4-K20-specific histone methyltransferase , H4K20-specific histone methyltransferase splice variant Set8b , N-lysine methyltransferase SETD8 , PR/SET domain containing protein 8 , PR/SET domain-containing protein 07 , PR/SET07 , SET domain-containing protein 8 , histone-lysine N-methyltransferase SETD8 , lysine N-methyltransferase 5A , PR-Set7 , SET domain-containing 8 , SET domain containing (lysine methyltransferase) 8b , SET domain containing 8b , N-lysine methyltransferase KMT5A , SET domain containing (lysine methyltransferase) 8 , histone methyltransferase Pr-set7/Set8 , lysine (K)-specific methyltransferase 5A , Histone-lysine N-methyltransferase KMT5A-A , Lysine-specific methylase 5A-A , N-lysine methyltransferase KMT5A-A , N-lysine methyltransferase SETD8-A , SET domain-containing protein 8-A , histone-lysine N-methyltransferase KMT5A-A , histone-lysine N-methyltransferase SETD8-A , lysine (K)-specific methyltransferase 5A S homeolog , lysine-specific methylase 5A-A

GENE ID SPEZIES
387893 Homo sapiens
67956 Mus musculus
532622 Bos taurus
100004770 Danio rerio
689820 Rattus norvegicus
100158384 Xenopus laevis
Ausgewählte Anbieter für SETD8 Proteine (SETD8)
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