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SETBP1 encodes a protein which contains a several motifs including a ski homology region and a SET-binding region in addition to three nuclear localization signals. Zusätzlich bieten wir Ihnen SETBP1 Antikörper (36) und und viele weitere Produktgruppen zu diesem Protein an.
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SETBP1 mutations were a rare molecular event in acute myeloid leukemia (zeige BCL11A Proteine) and myelodysplastic syndrome patients
we report here for the first time changes in the allele frequencies of CSF3R (zeige CSF3R Proteine)-T618I and SETBP1-G870S with response to ruxolitnib as well as insights into the clonal evolution of CNL under selective pressure from ruxolitinib.
we report the results of a screening for mutations in SETBP1 and JAK3 (zeige JAK3 Proteine) of a cohort of seventy Italian patients with juvenile myelomonocytic leukemia, identifying 11.4% of them harboring secondary mutations in these two genes and discovering two new mutations in the SKI (zeige SKI Proteine) domain of SETBP1
Patients with SETBP1 hotspot mutations suffered from aggressive disease with rapid evolution and inferior overall survival. Patients with SETBP1 non-hotspot mutations had less aggressive disease and a more favorable prognosis.
SETBP1 mutation is associated with chronic myelomonocytic leukemia.
Somatic c.2608G > A (p.Gly870Ser) in the SETBP1 gene identified in a patient with Fnaconi anemia.
Current evidence shows that SETBP1 mutation is associated with a poor prognosis in patients with MDS (zeige PAFAH1B1 Proteine) and CMML, but not in patients with chronic neutrophilic leukemia.
SETBP1 is a major oncogene (zeige RAB1A Proteine) in myeloid neoplasms, which cooperates with various genetic events and causes distinct phenotypes of myelodysplastic/myeloproliferative neoplasms and secondary acute myeloid leukemia (zeige BCL11A Proteine).
Results indicate a genotype-phenotype correlation in germline SET binding protein 1 (SETBP1) mutations spanning a molecular, cellular and clinical phenotype.
AML (zeige RUNX1 Proteine) with RUNX1 (zeige RUNX1 Proteine)/RUNX1T1 (zeige RUNX1T1 Proteine) rearrangement displayed c.2903C>T alteration in the mutational hotspot of SETBP1.
Myb (zeige MYB Proteine) knockdown in Setbp1 and Setbp1 missense mutations-induced AML (zeige RUNX1 Proteine) cells also efficiently induced their differentiation in culture and significantly prolonged the survival of their secondary recipient mice.
We demonstrated that Nup98 (zeige NUP98 Proteine)-TopIIbeta and Nup98 (zeige NUP98 Proteine)-SETBP1 negatively regulate the XPO1 (zeige XPO1 Proteine)-mediated protein export. Our results will contribute to the understanding of the molecular mechanism by which the Nup98 (zeige NUP98 Proteine)-fusion proteins induce tumorigenesis.
Setbp1 overexpression also causes transcriptional repression of critical hematopoiesis regulator gene Runx1 (zeige RUNX1 Proteine)
Setbp1 promotes the self-renewal of murine myeloid progenitors via activation of Hoxa9 (zeige HOXA9 Proteine) and Hoxa10 (zeige HOXA10 Proteine).
This gene encodes a protein which contains a several motifs including a ski homology region and a SET-binding region in addition to three nuclear localization signals. The encoded protein has been shown to bind the SET nuclear oncogene which is involved in DNA replication. Mutations in this gene are associated with Schinzel-Giedion midface retraction syndrome. Multiple transcript variants encoding different isoforms have been found for this gene.
A20-binding inhibitor of NF-kappaB activation 2
, SET-binding protein
, SET binding protein 1
, SET-binding protein-like