Runt-Related Transcription Factor 2 Proteine (RUNX2)

RUNX2 is a member of the RUNX family of transcription factors and encodes a nuclear protein with an Runt DNA-binding domain. Zusätzlich bieten wir Ihnen RUNX2 Antikörper (253) und RUNX2 Kits (60) und viele weitere Produktgruppen zu diesem Protein an.

alle Proteine anzeigen Gen GeneID UniProt
RUNX2 860 Q13950
RUNX2 12393 Q08775
RUNX2 367218  
Direkt bei antikoerper-online bestellen
  • +1 877 302 8632
  • +1 888 205 9894 (toll-free)
  • Online bestellen
  • orders@antikoerper-online.de

Top RUNX2 Proteine auf antikoerper-online.de

Showing 9 out of 12 products:

Katalog Nr. Origin Quelle Konjugat Bilder Menge Anbieter Lieferzeit Preis Details
Insektenzellen Maus His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 60 Days
$9,797.11
Details
Escherichia coli (E. coli) Human His tag 100 μg Anmelden zum Anzeigen 15 bis 18 Tage
$746.00
Details
Escherichia coli (E. coli) Maus His tag 100 μg Anmelden zum Anzeigen 15 bis 18 Tage
$784.00
Details
Wheat germ Human GST tag 10 μg Anmelden zum Anzeigen 11 bis 12 Tage
$414.29
Details
Escherichia coli (E. coli) Human His tag Validation with Western Blot 50 μg Anmelden zum Anzeigen Verfügbar
$284.90
Details
Hefe Pferd His tag   1 mg Anmelden zum Anzeigen 60 bis 71 Tage
$2,271.50
Details
Hefe Ratte His tag   1 mg Anmelden zum Anzeigen 60 bis 71 Tage
$2,541.00
Details
Escherichia coli (E. coli) Maus Unkonjugiert   100 μg Anmelden zum Anzeigen 11 bis 18 Tage
$582.75
Details
Escherichia coli (E. coli) Rind (Kuh) Unkonjugiert   5 applications Anmelden zum Anzeigen 1 bis 2 Tage
$318.85
Details

RUNX2 Proteine nach Spezies und Herkunft

Origin Exprimiert in Konjugat
Human ,
,
Mouse (Murine) ,

Rat (Rattus)

Weitere Proteine zu Runt-Related Transcription Factor 2 (RUNX2) Interaktionspartnern

Human Runt-Related Transcription Factor 2 (RUNX2) Interaktionspartner

  1. Knockdown of RUNX2 significantly inhibited TE-1 and EC-109 cell viability, repressed TE-1 cell migration and invasion, and increased TE-1 cell apoptosis and were associated with the activation of the PI3K (zeige PIK3CA Proteine)/AKT (zeige AKT1 Proteine) and ERK (zeige EPHB2 Proteine) pathways.

  2. Results show that RUNX2 gene silencing increased gemcitabine (GEM (zeige GEM Proteine)) sensitivity of p53mutated pancreatic cancer (PaCa) MiaPaCa2 spheres suggesting that RUNX2 is involved in PaCa-GEM (zeige GEM Proteine) resistance in presence of mutated p53 (zeige TP53 Proteine).

  3. Runx2 overexpression effectively decreased TNF-alpha (zeige TNF Proteine)-induced Bax (zeige BAX Proteine) and cleaved caspase-3 (zeige CASP3 Proteine) expression levels

  4. RUNX2 is one of the promising molecular targets for the treatment of the patients with pancreatic cancer regardless of their p53 (zeige TP53 Proteine) status[review]

  5. we identified a novel missense mutation of RUNX2 in 2 patients by Whole exome sequencing and showed potential correlations between facial phenotypes and missense mutations in Runt (zeige RUNX1 Proteine) domain through a mini-meta analysis.

  6. Mutant Runx2 regulates amelogenesis and osteogenesis through a miR-185-5p-Dlx2 axis.

  7. Results show that RUNX2 is highly expressed in bladder cancer tissues and are negatively correlated with miR (zeige MLXIP Proteine)-154 levels. This is likely through miR (zeige MLXIP Proteine)-154 binding the 3'-UTR of RUNX2 mRNA, promoting its degradation.

  8. Results identified a novel mutation besides the previously known in one patient with cleidocranial dysplasia (CCD). G462X mutation in exon 8 is located in the C-terminus of proline/serine/threonine-rich (PST (zeige SULT1A1 Proteine)) domain. It might reduce the Runx2 transacting activity, lower the protein stability, downgrade the expression of bone marker genes, and eventually diminish osteoblast differentiation in CCD patients.

  9. Findings reveal a novel mechanism that Runx2 is transcriptionally regulated by HSP90 (zeige HSP90 Proteine) via the AKT (zeige AKT1 Proteine)/GSK-3beta/beta-catenin (zeige CTNNB1 Proteine) signaling pathway, and by which leads to apoptosis of osteosarcoma cells.

  10. Increased baseline gene expressions of RUNX2, p21 (zeige CDKN1A Proteine) and caspase 3 (zeige CASP3 Proteine) in the peripheral blood might predict better responses to methotrexate therapy.

Zebrafish Runt-Related Transcription Factor 2 (RUNX2) Interaktionspartner

  1. Runx2 may have an evolutionarily conserved role in axis formation

Mouse (Murine) Runt-Related Transcription Factor 2 (RUNX2) Interaktionspartner

  1. Results indicate that Dlx5 (zeige DLX5 Proteine) and Runx2 are critical factors for the upregulated Osterix (zeige SP7 Proteine) expression in shPP2A cells, which is considered to be important for the accelerated osteoblast differentiation in these cells.

  2. the expression of mouse Amtn gene in amelogenesis is mediated by Runx2/Cbfbeta complex. Runx2/Cbfbeta can bind to the two Runx2 binding motifs AACCACT (-1342/-1336) and AACCAAA (-98/-92) in the Amtn promoter and regulate Amtn gene expression.

  3. Mutant Runx2 regulates amelogenesis and osteogenesis through a miR-185-5p-Dlx2 axis.

  4. Puerarin may promote MC3T3E1 osteoblastlike cell viability and differentiation, which may be related to the downregulation of miR204 and the following activation of Runx2.

  5. mTOR (zeige FRAP1 Proteine)/Raptor (zeige RPTOR Proteine) signaling is essential for bone formation in vivo through the regulation of Runx2 expression.

  6. these findings provide evidence that Cx43 (zeige GJA1 Proteine) and Runx2 functionally intersect in vivo to regulate cortical bone properties and affect osteoblast differentiation and proliferation

  7. miR (zeige MLXIP Proteine)-133a-5p targets the 3' UTR of RUNX2 mRNA to regulate the expression of RUNX2 negatively.

  8. muramyl dipeptide directly augmented osteoblast differentiation and bone-forming gene expression by Runx2 activation.

  9. Loss of Runx1 (zeige RUNX1 Proteine) and Runx2 inhibits prostate cell motility.

  10. fetal administration of Entinostat/MS-275, a class I histone deacetylase (HDAC (zeige HDAC1 Proteine))-specific inhibitor, partially prevents delayed closure of cranial sutures in Runx2(+/-) mice strain of C57BL/6J by two mechanisms: 1) posttranslational acetylation of Runx2 protein, which stabilized the protein and activated its transcriptional activity; and 2) epigenetic regulation of Runx2 and other bone marker genes

Rabbit Runt-Related Transcription Factor 2 (RUNX2) Interaktionspartner

  1. The results suggest that gene therapy using Runx2-modi fi ed dental pulp stem cells was more effective during bone deposition and new bone formation in tibia Distraction osteogenesis.

  2. Runx2-modified adipose-derived stem cells promote tendon graft integration in anterior cruciate ligament reconstruction.

  3. The OPG (zeige TNFSF11 Proteine) expression levels decreased while those of RANKL (zeige TNFSF11 Proteine) and RUNX2 increased during orthodontic tooth movement, which suggested that they play a role in the osteogenesis process and the reconstruction of periodontal tissue.

Xenopus laevis Runt-Related Transcription Factor 2 (RUNX2) Interaktionspartner

  1. These data also indicate that MGP (zeige MGP Proteine) is under dual regulation by runx2 through the use of various isoforms and context-dependent formation of transcriptional complexes.

Pig (Porcine) Runt-Related Transcription Factor 2 (RUNX2) Interaktionspartner

  1. Klotho (zeige KL Proteine) gene deficiency promotes high-fat diet-induced fibrosis in aortic valves, likely through the AMPKalpha (zeige GRK4 Proteine)-RUNX2 pathway.

RUNX2 Protein Überblick

Protein Überblick

This gene is a member of the RUNX family of transcription factors and encodes a nuclear protein with an Runt DNA-binding domain. This protein is essential for osteoblastic differentiation and skeletal morphogenesis and acts as a scaffold for nucleic acids and regulatory factors involved in skeletal gene expression. The protein can bind DNA both as a monomer or, with more affinity, as a subunit of a heterodimeric complex. Mutations in this gene have been associated with the bone development disorder cleidocranial dysplasia (CCD). Transcript variants that encode different protein isoforms result from the use of alternate promoters as well as alternate splicing.

Genbezeichner und Symbole assoziert mit RUNX2

  • runt related transcription factor 2 (RUNX2)
  • runt-related transcription factor 2a (runx2a)
  • runt related transcription factor 2 (Runx2)
  • runt-related transcription factor 2 (Runx2)
  • runt related transcription factor 2 (runx2)
  • runt-related transcription factor 2 (LOC703331)
  • runt-related transcription factor 2 (LOC100549663)
  • runt related transcription factor 2 L homeolog (runx2.L)
  • runt-related transcription factor 2 (RUNX2)
  • aml3 Protein
  • Cbf Protein
  • CBF-alpha-1 Protein
  • Cbfa-1 Protein
  • cbfa1 Protein
  • ccd Protein
  • ccd1 Protein
  • CLCD Protein
  • LS3 Protein
  • OSF-2 Protein
  • osf2 Protein
  • pea2aa Protein
  • pebp2a1 Protein
  • pebp2a2 Protein
  • pebp2aa Protein
  • pebp2aa1 Protein
  • Pebpa2a Protein
  • RUNX2 Protein

Bezeichner auf Proteinebene für RUNX2

PEA2-alpha A , PEBP2-alpha A , SL3-3 enhancer factor 1 alpha A subunit , SL3/AKV core-binding factor alpha A subunit , acute myeloid leukemia 3 protein , core-binding factor, runt domain, alpha subunit 1 , oncogene AML-3 , osteoblast-specific transcription factor 2 , polyomavirus enhancer-binding protein 2 alpha A subunit , runt-related transcription factor 2 , transcription factor Runx2a , AKV core binding factor , CBF-alpha-1 , PEBP2 alpha A , core binding factor alpha 1 , runt domain, alpha subunit 1 , core-binding factor subunit alpha-1 , runt related transcription factor 2 , transcription factor Cbfa1 , runt-related factor 2 , core binding factor alpha 1 subunit , runt-related transcription factor 2-like , Runx2 spliced isoform , runt-related transcription factor 2 type I , runt-related transcription factor 2 type II

GENE ID SPEZIES
860 Homo sapiens
405784 Danio rerio
12393 Mus musculus
367218 Rattus norvegicus
373919 Gallus gallus
445986 Takifugu rubripes
472017 Pan troglodytes
703331 Macaca mulatta
100008943 Oryctolagus cuniculus
100033890 Equus caballus
100080409 Ornithorhynchus anatinus
100189546 Xenopus (Silurana) tropicalis
100222668 Taeniopygia guttata
100406564 Callithrix jacchus
100453201 Pongo abelii
100549663 Meleagris gallopavo
100555776 Anolis carolinensis
100619969 Monodelphis domestica
100037059 Xenopus laevis
536911 Bos taurus
100737965 Sus scrofa
474923 Canis lupus familiaris
100734175 Cavia porcellus
100861217 Capra hircus
101115489 Ovis aries
Ausgewählte Anbieter für RUNX2 Proteine (RUNX2)
Haben Sie etwas anderes gesucht?