Runt-Related Transcription Factor 2 Proteine (RUNX2)

RUNX2 is a member of the RUNX family of transcription factors and encodes a nuclear protein with an Runt DNA-binding domain. Zusätzlich bieten wir Ihnen RUNX2 Antikörper (250) und RUNX2 Kits (60) und viele weitere Produktgruppen zu diesem Protein an.

alle Proteine anzeigen Gen GeneID UniProt
RUNX2 860 Q13950
RUNX2 12393 Q08775
RUNX2 367218  
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Showing 9 out of 12 products:

Katalog Nr. Origin Quelle Konjugat Bilder Menge Anbieter Lieferzeit Preis Details
Insektenzellen Maus His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 60 Days
Escherichia coli (E. coli) Human His tag 100 μg Anmelden zum Anzeigen 15 bis 18 Tage
Escherichia coli (E. coli) Maus His tag 100 μg Anmelden zum Anzeigen 15 bis 18 Tage
Wheat germ Human GST tag 10 μg Anmelden zum Anzeigen 11 bis 12 Tage
Escherichia coli (E. coli) Human His tag Validation with Western Blot 50 μg Anmelden zum Anzeigen Verfügbar
Hefe Pferd His tag   1 mg Anmelden zum Anzeigen 60 bis 71 Tage
Hefe Ratte His tag   1 mg Anmelden zum Anzeigen 60 bis 71 Tage
Escherichia coli (E. coli) Maus Unkonjugiert   100 μg Anmelden zum Anzeigen 11 bis 18 Tage
Escherichia coli (E. coli) Rind (Kuh) Unkonjugiert   5 applications Anmelden zum Anzeigen 1 bis 2 Tage

RUNX2 Proteine nach Spezies und Herkunft

Origin Exprimiert in Konjugat
Human ,
Mouse (Murine) ,

Rat (Rattus)

Weitere Proteine zu Runt-Related Transcription Factor 2 (RUNX2) Interaktionspartnern

Human Runt-Related Transcription Factor 2 (RUNX2) Interaktionspartner

  1. that cross-talk between cAMP/PKA signaling and RUNX2 promotes a malignant phenotype of glioma cells

  2. Study identified RUNX2 to be targeted by miR-217 which directly bound to RUNX2 mRNA and inhibited its expression in bladder cancer cells. Also, findings demonstrated that RUNX2 expression was upregulated by hsa_circ_0000144. Moreover, rescue assays demonstrated that RUNX2 was a downstream effector molecule of hsa_circ_0000144/miR-217 network. These results revealed the oncogenic role of RUNX2 in bladder neoplasm.

  3. In summary, these results reveal that PTHLH expression is a poor prognosis marker in head and neck squamous cell carcinoma patients, and RUNX2-PTHLH axis contributes to head and neck squamous cell carcinoma tumor growth.

  4. Knockdown of RUNX2 significantly inhibited TE-1 and EC-109 cell viability, repressed TE-1 cell migration and invasion, and increased TE-1 cell apoptosis and were associated with the activation of the PI3K/AKT and ERK pathways.

  5. Results show that RUNX2 gene silencing increased gemcitabine (GEM) sensitivity of p53mutated pancreatic cancer (PaCa) MiaPaCa2 spheres suggesting that RUNX2 is involved in PaCa-GEM resistance in presence of mutated p53.

  6. Runx2 overexpression effectively decreased TNF-alpha-induced Bax and cleaved caspase-3 expression levels

  7. RUNX2 is one of the promising molecular targets for the treatment of the patients with pancreatic cancer regardless of their p53 status[review]

  8. we identified a novel missense mutation of RUNX2 in 2 patients by Whole exome sequencing and showed potential correlations between facial phenotypes and missense mutations in Runt domain through a mini-meta analysis.

  9. Mutant Runx2 regulates amelogenesis and osteogenesis through a miR-185-5p-Dlx2 axis.

  10. Results show that RUNX2 is highly expressed in bladder cancer tissues and are negatively correlated with miR-154 levels. This is likely through miR-154 binding the 3'-UTR of RUNX2 mRNA, promoting its degradation.

  11. Results identified a novel mutation besides the previously known in one patient with cleidocranial dysplasia (CCD). G462X mutation in exon 8 is located in the C-terminus of proline/serine/threonine-rich (PST) domain. It might reduce the Runx2 transacting activity, lower the protein stability, downgrade the expression of bone marker genes, and eventually diminish osteoblast differentiation in CCD patients.

  12. Findings reveal a novel mechanism that Runx2 is transcriptionally regulated by HSP90 via the AKT/GSK-3beta/beta-catenin signaling pathway, and by which leads to apoptosis of osteosarcoma cells.

  13. Increased baseline gene expressions of RUNX2, p21 and caspase 3 in the peripheral blood might predict better responses to methotrexate therapy.

  14. Study identifies a novel missense mutation (c.895 T>C, Y299H) in exon 5 of Runx2 gene in patients with cleidocranial dysplasia (CCD). This mutation results in an amino acid change at codon 895 (P.Tyr 299 His.) from a tryptophan codon (TAT) to a histidine codon (CAT).

  15. miR-539 functions as a tumor suppressor in colorectal cance, at least in part, by targeting RUNX2.

  16. These results indicate activation of DLX5 and RUNX2 via its distal promoter represents a unique feature of GFs, and is important for ECM regulation. Down-regulation of these transcription factors in PAFs could be associated with their property to degrade collagen, which may impact on the process of periodontitis.

  17. down-regulated miR-143-5p promotes the differentiation of DPSCs into odontoblasts by enhancing Runx2 expression via the OPG/RANKL signaling pathway.

  18. Three novel mutations (R193G, 258fs, Y400X) in cleidocranial dysplasia.

  19. The Runx2 is one of the genes responsible for the pathogenesis of osteoarthritis (OA) because RUNX2 is up-regulated in chondrocytes in OA cartilage and a germline haplodeficiency or deletion of Runx2 in articular chondrocytes decelerates OA progression.

  20. application of dexamethasone reduced the expression of RUNX2 and beta-catenin in human gingiva-derived mesenchymal stem cells

Zebrafish Runt-Related Transcription Factor 2 (RUNX2) Interaktionspartner

  1. quantitative data on the kinetics of gene expression is presented; new splice forms reported

  2. Runx2 may have an evolutionarily conserved role in axis formation

Mouse (Murine) Runt-Related Transcription Factor 2 (RUNX2) Interaktionspartner

  1. Findings suggest that inhibition of Runx2 in chondrocytes could at least partially rescue destabilization of the medial meniscus (DMM) surgery-induced osteoarthritis (OA)-like defects.

  2. This study reveals that RUNX2 is differentially expressed in ATII cells vs. fibroblasts in lung fibrosis, which contributes to profibrotic cell function. Cell-specific targeting of RUNX2 pathways may represent a therapeutic approach for IPF.

  3. we have identified novel interaction between p38 MAPK and Runx2 enhances Runx2 transactivity, thus promoting vascular smooth muscle cells calcification

  4. By using microRNA array, we identified a large number of microRNAs that showed different expression between wild-type Runx2 group and mutant groups. The aim of this study is to find out the effect of mmu-miR-1963, which was downregulated in all mutant Runx2 groups, on the ameloblast differentiation of LS8 cells

  5. Results indicate that Dlx5 and Runx2 are critical factors for the upregulated Osterix expression in shPP2A cells, which is considered to be important for the accelerated osteoblast differentiation in these cells.

  6. the expression of mouse Amtn gene in amelogenesis is mediated by Runx2/Cbfbeta complex. Runx2/Cbfbeta can bind to the two Runx2 binding motifs AACCACT (-1342/-1336) and AACCAAA (-98/-92) in the Amtn promoter and regulate Amtn gene expression.

  7. Mutant Runx2 regulates amelogenesis and osteogenesis through a miR-185-5p-Dlx2 axis.

  8. Puerarin may promote MC3T3E1 osteoblastlike cell viability and differentiation, which may be related to the downregulation of miR204 and the following activation of Runx2.

  9. mTOR/Raptor signaling is essential for bone formation in vivo through the regulation of Runx2 expression.

  10. these findings provide evidence that Cx43 and Runx2 functionally intersect in vivo to regulate cortical bone properties and affect osteoblast differentiation and proliferation

  11. miR-133a-5p targets the 3' UTR of RUNX2 mRNA to regulate the expression of RUNX2 negatively.

  12. muramyl dipeptide directly augmented osteoblast differentiation and bone-forming gene expression by Runx2 activation.

  13. Loss of Runx1 and Runx2 inhibits prostate cell motility.

  14. fetal administration of Entinostat/MS-275, a class I histone deacetylase (HDAC)-specific inhibitor, partially prevents delayed closure of cranial sutures in Runx2(+/-) mice strain of C57BL/6J by two mechanisms: 1) posttranslational acetylation of Runx2 protein, which stabilized the protein and activated its transcriptional activity; and 2) epigenetic regulation of Runx2 and other bone marker genes

  15. These data suggest that NaF promotes the osteoblastic differentiation of MC3T3-E1 cells through the Runx2/Osterix pathway and may be effective for the treatment of bone-related disorders.

  16. results suggest that Edil3 may stimulate osteoblast differentiation and matrix mineralization by increasing expression of Runx2 through alpha5beta1 integrin /ERK pathway

  17. Taken together, these results demonstrate that piperine enhance osteoblast differentiation through AMPK phosphorylation in MC3T3-E1 cells.

  18. Sphingosine 1 phosphate also up-regulated runt-related transcription factor 2 (Runx2) expression through S1PR2/RhoA/ROCK/Smad1/5/8 signaling.

  19. Nearly half of all DNase hypersensitivity sites (both constitutive and dynamic) overlap binding events of the bone-essential RUNX2 and/or the chromatin-related CTCF transcription factors.

  20. The findings suggest that the absence of uPA correlates with increased levels of Runx transcriptional regulators in a way that promotes inflammation-associated carcinogenesis.

Rabbit Runt-Related Transcription Factor 2 (RUNX2) Interaktionspartner

  1. The results suggest that gene therapy using Runx2-modi fi ed dental pulp stem cells was more effective during bone deposition and new bone formation in tibia Distraction osteogenesis.

  2. Runx2-modified adipose-derived stem cells promote tendon graft integration in anterior cruciate ligament reconstruction.

  3. The OPG expression levels decreased while those of RANKL and RUNX2 increased during orthodontic tooth movement, which suggested that they play a role in the osteogenesis process and the reconstruction of periodontal tissue.

Xenopus laevis Runt-Related Transcription Factor 2 (RUNX2) Interaktionspartner

  1. These data also indicate that MGP is under dual regulation by runx2 through the use of various isoforms and context-dependent formation of transcriptional complexes.

Pig (Porcine) Runt-Related Transcription Factor 2 (RUNX2) Interaktionspartner

  1. Klotho gene deficiency promotes high-fat diet-induced fibrosis in aortic valves, likely through the AMPKalpha-RUNX2 pathway.

RUNX2 Protein Überblick

Protein Überblick

This gene is a member of the RUNX family of transcription factors and encodes a nuclear protein with an Runt DNA-binding domain. This protein is essential for osteoblastic differentiation and skeletal morphogenesis and acts as a scaffold for nucleic acids and regulatory factors involved in skeletal gene expression. The protein can bind DNA both as a monomer or, with more affinity, as a subunit of a heterodimeric complex. Mutations in this gene have been associated with the bone development disorder cleidocranial dysplasia (CCD). Transcript variants that encode different protein isoforms result from the use of alternate promoters as well as alternate splicing.

Genbezeichner und Symbole assoziert mit RUNX2

  • runt related transcription factor 2 (RUNX2)
  • runt-related transcription factor 2a (runx2a)
  • runt related transcription factor 2 (Runx2)
  • runt-related transcription factor 2 (Runx2)
  • runt related transcription factor 2 (runx2)
  • runt-related transcription factor 2 (LOC703331)
  • runt-related transcription factor 2 (LOC100549663)
  • runt related transcription factor 2 L homeolog (runx2.L)
  • runt-related transcription factor 2 (RUNX2)
  • aml3 Protein
  • Cbf Protein
  • CBF-alpha-1 Protein
  • Cbfa-1 Protein
  • cbfa1 Protein
  • ccd Protein
  • ccd1 Protein
  • CLCD Protein
  • LS3 Protein
  • OSF-2 Protein
  • osf2 Protein
  • pea2aa Protein
  • pebp2a1 Protein
  • pebp2a2 Protein
  • pebp2aa Protein
  • pebp2aa1 Protein
  • Pebpa2a Protein
  • RUNX2 Protein

Bezeichner auf Proteinebene für RUNX2

PEA2-alpha A , PEBP2-alpha A , SL3-3 enhancer factor 1 alpha A subunit , SL3/AKV core-binding factor alpha A subunit , acute myeloid leukemia 3 protein , core-binding factor, runt domain, alpha subunit 1 , oncogene AML-3 , osteoblast-specific transcription factor 2 , polyomavirus enhancer-binding protein 2 alpha A subunit , runt-related transcription factor 2 , transcription factor Runx2a , AKV core binding factor , CBF-alpha-1 , PEBP2 alpha A , core binding factor alpha 1 , runt domain, alpha subunit 1 , core-binding factor subunit alpha-1 , runt related transcription factor 2 , transcription factor Cbfa1 , runt-related factor 2 , core binding factor alpha 1 subunit , runt-related transcription factor 2-like , Runx2 spliced isoform , runt-related transcription factor 2 type I , runt-related transcription factor 2 type II

860 Homo sapiens
405784 Danio rerio
12393 Mus musculus
367218 Rattus norvegicus
373919 Gallus gallus
445986 Takifugu rubripes
472017 Pan troglodytes
703331 Macaca mulatta
100008943 Oryctolagus cuniculus
100033890 Equus caballus
100080409 Ornithorhynchus anatinus
100189546 Xenopus (Silurana) tropicalis
100222668 Taeniopygia guttata
100406564 Callithrix jacchus
100453201 Pongo abelii
100549663 Meleagris gallopavo
100555776 Anolis carolinensis
100619969 Monodelphis domestica
100037059 Xenopus laevis
536911 Bos taurus
100737965 Sus scrofa
474923 Canis lupus familiaris
100734175 Cavia porcellus
100861217 Capra hircus
101115489 Ovis aries
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