anti-Runt-Related Transcription Factor 1 (RUNX1) Antikörper

Mouse (Murine) Runt-Related Transcription Factor 1 (RUNX1) Interaktionspartner

1. Deletion of Runx1 in mouse T-ALL impairs cell growth. RUNX1 depletion consistently resulted in reduced cell proliferation and increased apoptosis.

2. Ezh2 and Runx1 mutations collaborate to initiate lympho-myeloid leukemia in early thymic progenitors

3. RUNX1 promoted TGF-beta-induced partial EMT by increasing transcription of the PI3K subunit p110delta, which mediated Akt activation.

4. The promoter regions of Runx1 is targets of STAT4 and that STAT4 binding during NK cell activation induces epigenetic modifications of Runx1 gene loci resulting in increased expression.

5. Results suggest that AML1/ETO expression determines a more mobile and less adherent phenotype in preleukemic cells, therefore altering the interaction with the hematopoietic niche, potentially leading to the migration across the bone marrow barrier and to disease progression

6. Gene expression profiling of HEPs revealed a RUNX1c-induced proinflammatory molecular signature, supporting previous studies demonstrating proinflammatory signaling as a regulator of HSC emergence.

7. In the Title.

8. Histones showed limited activation in regions of single TF binding, while enhancers that bind NF-E2 and either RUNX1, FLI1 or both TFs gave the highest signals for TF occupancy and H3K4me2; these enhancers associated best with genes activated late in MK maturation.

9. the ability of Runx1 to induce endothelial-to-hematopoietic transition (EHT) in non-hemogenic endothelial cells depends on the anatomical location of the cell and the developmental age of the conceptus

10. CDK6 kinase activity negatively regulates the conversion of fat-storing cells into fat-burning cells by suppressing RUNX1, and may be a therapeutic target for the treatment of obesity and related metabolic diseases

11. RUNX1 dosage plays a pivotal role in hemogenic endothelium maturation and the establishment of the hematopoietic system.

12. These results suggest that RUNX1 may be an essential modulator in BMP9- induced osteogenic differentiation of mesenchymal stem cells.

13. Loss of Runx1 and Runx2 inhibits prostate cell motility.

14. In vivo, in vitro and systems biology results show that Runx1 exerts a pro-neurogenic function in neural precursor cells in vitro, while in vivo data remained inconclusive.

15. High RUNX1 expression is associated with lymphoma.

16. Specific Runx1-bound enhancer elements critically modulate lineage-dependent expressions of PLZF.

17. Study reveals a previously unrecognized synergism between ETV6/RUNX1 and BCL2 impacting on malignant disease and autoimmunity.

18. Data provide evidence that Runx1 plays a role in regulating the sphingolipid rheostat in normal development and that perturbation of this cell fate regulator contributes to Runx-driven lymphomagenesis.

19. The findings suggest that the absence of uPA correlates with increased levels of Runx transcriptional regulators in a way that promotes inflammation-associated carcinogenesis.

20. Flt3 and cooperating Flt3/Runx1 mutations cause hematopoietic stem cell depletion and myeloid progenitor expansion during adult but not fetal stages of murine development.

Human Runt-Related Transcription Factor 1 (RUNX1) Interaktionspartner

1. Knockdown of RUNX1 in human T-cell acute lymphoblastic leukemia impairs cell growth and survival.RUNX1 depletion consistently resulted in reduced cell proliferation and increased apoptosis.RUNX1 has a net positive effect on cell growth in the context of established T-ALL.

2. A microdeletion encompassing exons 1-2 of RUNX1 (outside the cluster region of the Runt Homology domain and the transactivation domain) was detected in six family members using array-CGH and MLPA validation

3. The number of RUNX1mut, RUNX1 WT loss and the number and type of additional mutations is biologically and clinically relevant.

4. In this study, the presence of clonal heterogeneity and impaired FCM-MRD clearance among ETV6/RUNX1-positive patients, ultimately influenced prognosis.

5. Results show that Runx1 associates with c-Abl kinase through its C-terminal inhibitory domain which directly binds to c-Abl. Also, Runx1 is phosphorylated by c-Abl kinase modulating its transcriptional activity and megakaryocyte maturation.

6. DEGs and pathways identified in the present study will help understand the molecular mechanisms underlying RUNX1 mutations in AML and develop effective therapeutic strategies for RUNX1-mutation AML.

7. RUNX1 regulates ITGA6 through a consensus RUNX1 binding motif in its promoter

8. Loss of RUNX1 resulted in enhanced proliferation, migration, and invasion of lung adenocarcinomas

9. In the Title.

10. Ezh2 and Runx1 mutations collaborate to initiate lympho-myeloid leukemia in early thymic progenitors

11. miR-144 mimics can inhibit the proliferation and migration of ovarian cancer cells though regulating the expression of RUNX1.

12. The effect of FENDRR on cell proliferation, apoptosis and invasion and migration ability in protate cancer cells was suppressed by silence of RUNX1.

13. KSRP, miR-129, and RUNX1 participate in a regulatory axis to control the outcome of myeloid differentiation.

14. PKM2 as a novel target of RUNX1-ETO and is specifically downregulated in RUNX1-ETO positive AML patients, indicating that PKM2 level might have a diagnostic potential in RUNX1-ETO associated AML.

15. specific type of RUNX1 mutation did not affect its association pattern with trisomy 21

16. High RUNX1 expression is associated with prostatic cancer.

17. RUNX1 Mutation is associated with acute myeloid leukemia.

18. The specific association of ZBTB7A mutations with t(8;21) rearranged acute myeloid leukaemia points towards leukemogenic cooperativity between mutant ZBTB7A and the RUNX1/RUNX1T1 fusion protein has been reported.

19. miR-216a-3p can promote gastric cancer cell proliferation, migration, and invasion via targeting RUNX1 and activating the NF-kappaB signaling pathway

20. the t(5;21)(p15;q22) translocation could be identified only when what had seemed like a del(21)(qq) in G-banded preparations was examined using FISH and RNA-sequencing directed at finding out what lay behind the 21q-.

Zebrafish Runt-Related Transcription Factor 1 (RUNX1) Interaktionspartner

1. Our data suggest that runx1 and cbfb are required at 2 different steps during early hematopoietic stem cell development

2. We propose that cohesin and CTCF have distinct functions in the regulation of runx1 during zebrafish embryogenesis.

3. Morpholino knockdown of Myef2 or Runx1 in zebrafish results in reduced numbers of hematopoietic stem cells, suggesting that these two factors also interact in vivo to regulate hematopoiesis.

4. Runx1 is induced by high Pu.1 level and in turn transrepresses pu.1 expression, thus constituting a negative feedback loop that fashions a favorable Pu.1 level required for balanced fate commitment to neutrophils versus macrophages.

5. hematopoietic stem cell numbers depended on activity of the transcription factor Runx1, on blood flow, and on proper development of the dorsal aorta

6. in zebrafish adult HSCs can be formed without an intact runx1.

7. isolation and characterization by spatiotemporal expression detected in the developing zebrafish

8. Zebrafish embryos lacking Rad21, or cohesin subunit Smc3, fail to express runx3 and lose hematopoietic runx1 expression in early embryonic development.

Xenopus laevis Runt-Related Transcription Factor 1 (RUNX1) Interaktionspartner

1. Xaml1/Runx1 is required for the specification of Rohon-Beard sensory neurons in Xenopus.

2. ETV6-RUNX1 (TEL-AML1) fusion and hyperdiploidy (>50 chromosomes) are favorable genetic features in childhood acute lymphoblastic leukemia (ALL).

3. reveal a shift in Runx2 function protein during vertebrate evolution towards its exclusive roles in cartilage hypertrophy and bone differentiation within the amniote lineage