anti-Runt-Related Transcription Factor 1 (RUNX1) Antikörper

Mouse (Murine) Runt-Related Transcription Factor 1 (RUNX1) Interaktionspartner

1. RUNX1 is found only in the relatively rare wave 2 and 3 progenitors in the embryo.RUNX1 loss blocked the formation of wave 2 and 3 progenitors from this rare population of "hemogenic" endothelial cells (HE). RUNX1 was required for blood cell formation from HE. Review.

2. RUNX1 may be involved in the transition of the myometrium from a quiescent into a contractile state in preparation for labor.

3. B7-H4 enhances the differentiation of murine leukemia-initiating cells via the PTEN/AKT/RCOR2/RUNX1 pathways.

4. Reducing Runx1 function drives increased contractility after myocardial infarction, thereby preserving LV systolic function and preventing adverse cardiac remodeling.

5. Runx/Cbfb complexes protect group 2 innate lymphoid cells from exhausted-like hyporesponsiveness during allergic airway inflammation.

6. Deletion of Runx1 in mouse T-ALL impairs cell growth. RUNX1 depletion consistently resulted in reduced cell proliferation and increased apoptosis.

7. Ezh2 and Runx1 mutations collaborate to initiate lympho-myeloid leukemia in early thymic progenitors

8. RUNX1 promoted TGF-beta-induced partial EMT by increasing transcription of the PI3K subunit p110delta, which mediated Akt activation.

9. The promoter regions of Runx1 is targets of STAT4 and that STAT4 binding during NK cell activation induces epigenetic modifications of Runx1 gene loci resulting in increased expression.

10. Results suggest that AML1/ETO expression determines a more mobile and less adherent phenotype in preleukemic cells, therefore altering the interaction with the hematopoietic niche, potentially leading to the migration across the bone marrow barrier and to disease progression

11. Gene expression profiling of HEPs revealed a RUNX1c-induced proinflammatory molecular signature, supporting previous studies demonstrating proinflammatory signaling as a regulator of HSC emergence.

12. Histones showed limited activation in regions of single TF binding, while enhancers that bind NF-E2 and either RUNX1, FLI1 or both TFs gave the highest signals for TF occupancy and H3K4me2; these enhancers associated best with genes activated late in MK maturation.

13. the ability of Runx1 to induce endothelial-to-hematopoietic transition (EHT) in non-hemogenic endothelial cells depends on the anatomical location of the cell and the developmental age of the conceptus

14. CDK6 kinase activity negatively regulates the conversion of fat-storing cells into fat-burning cells by suppressing RUNX1, and may be a therapeutic target for the treatment of obesity and related metabolic diseases

15. RUNX1 dosage plays a pivotal role in hemogenic endothelium maturation and the establishment of the hematopoietic system.

16. These results suggest that RUNX1 may be an essential modulator in BMP9- induced osteogenic differentiation of mesenchymal stem cells.

17. Loss of Runx1 and Runx2 inhibits prostate cell motility.

18. In vivo, in vitro and systems biology results show that Runx1 exerts a pro-neurogenic function in neural precursor cells in vitro, while in vivo data remained inconclusive.

19. High RUNX1 expression is associated with lymphoma.

20. Specific Runx1-bound enhancer elements critically modulate lineage-dependent expressions of PLZF.

Human Runt-Related Transcription Factor 1 (RUNX1) Interaktionspartner

1. RUNX1 regulates the oncogene KIT, by binding to its enhancer, and through interaction with FUBP1.

2. Serum NEF is a sensitive diagnostic and prognostic marker for gastric carcinoma. NEF siRNA silencing promoted, and overexpression inhibited, gastric carcinoma proliferation. In addition, NEF overexpression promoted, and NEF siRNA silencing inhibited, Runx1 expression. Therefore, it was concluded that lncRNA NEF may participate in the regulation of cancer cell proliferation by regulating Runx1 expression

3. identified RNF38 as a novel E3 ligase that modifies RUNX1 function without inducing its degradation

4. These data indicate that RUNX1 regulates A4GALT and thereby the expression of clinically important glycosphingolipids implicated in blood group incompatibility and host-pathogen interactions.

5. The human RUNX1 gene was cloned as one of a pair of genes disrupted by the (8;21)(q22;q22) translocation in acute myeloid leukemia. The human RUNX1 protein binds the "core-binding" DNA motif. The inv(16)(p13.1;q22) mutation associated with AML created a chimeric protein that fused the non-DNA-binding CBFbeta subunit to the coiled-coil tail region of a smooth muscle myosin heavy chain. Review.

6. RUNX1 may be involved in the transition of the myometrium from a quiescent into a contractile state in preparation for labor.

7. High frequency of RUNX1 mutation in myelodysplastic syndrome patients with whole-arm translocation of der(1;7)(q10;p10).

8. ZFP36L2 could be transactivated by AML1, which subsequently induced cell-cycle arrest and apoptosis of leukemia cells

9. Study reports differential regulation of gene expression by RUNX1-RUNX1T1 oncoprotein and MAPK1 as determined by genome-wide expression analysis responsible for the phenotypic features of acute myeloid leukaemia with karyotypic discernible translocation (t)(8;21)(q22;q22).

10. identified most of these factors as RUNX1-RUNX1T1 targets, with Ras Homolog Family Member (RHOB) overexpression being the core of this network

11. Upregulated CASC2 may inhibit cell proliferation, migration, and invasion through regulating miR-18a-5p and its target gene RUNX1 in MM.

12. The authors demonstrate that the transcriptional regulator Runx1 is essential for the generation of ROR-gammat expressing iNKT17 cells.

13. As most transcriptional repressor proteins do not comprise tetramerization domains, our results provide a possible explanation as to the reason that RUNX1 is recurrently found translocated to ETO family members

14. ransplant age (>45 years) and complex chromosome karyotype abnormality were negative prognostic factors in allogeneic hematopoietic stem-cell transplantation for myeloid neoplasms patients with RUNX1 mutations

15. the effect of RUNX1 inhibition on the endothelial vascular niche cells

16. Knockdown of RUNX1 in human T-cell acute lymphoblastic leukemia impairs cell growth and survival.RUNX1 depletion consistently resulted in reduced cell proliferation and increased apoptosis.RUNX1 has a net positive effect on cell growth in the context of established T-ALL.

17. A microdeletion encompassing exons 1-2 of RUNX1 (outside the cluster region of the Runt Homology domain and the transactivation domain) was detected in six family members using array-CGH and MLPA validation

18. The number of RUNX1mut, RUNX1 WT loss and the number and type of additional mutations is biologically and clinically relevant.

19. In this study, the presence of clonal heterogeneity and impaired FCM-MRD clearance among ETV6/RUNX1-positive patients, ultimately influenced prognosis.

20. Results show that Runx1 associates with c-Abl kinase through its C-terminal inhibitory domain which directly binds to c-Abl. Also, Runx1 is phosphorylated by c-Abl kinase modulating its transcriptional activity and megakaryocyte maturation.

Zebrafish Runt-Related Transcription Factor 1 (RUNX1) Interaktionspartner

1. Our data suggest that runx1 and cbfb are required at 2 different steps during early hematopoietic stem cell development

2. We propose that cohesin and CTCF have distinct functions in the regulation of runx1 during zebrafish embryogenesis.

3. Morpholino knockdown of Myef2 or Runx1 in zebrafish results in reduced numbers of hematopoietic stem cells, suggesting that these two factors also interact in vivo to regulate hematopoiesis.

4. Runx1 is induced by high Pu.1 level and in turn transrepresses pu.1 expression, thus constituting a negative feedback loop that fashions a favorable Pu.1 level required for balanced fate commitment to neutrophils versus macrophages.

5. hematopoietic stem cell numbers depended on activity of the transcription factor Runx1, on blood flow, and on proper development of the dorsal aorta

6. in zebrafish adult HSCs can be formed without an intact runx1.

7. isolation and characterization by spatiotemporal expression detected in the developing zebrafish

8. Zebrafish embryos lacking Rad21, or cohesin subunit Smc3, fail to express runx3 and lose hematopoietic runx1 expression in early embryonic development.

Xenopus laevis Runt-Related Transcription Factor 1 (RUNX1) Interaktionspartner

1. Xaml1/Runx1 is required for the specification of Rohon-Beard sensory neurons in Xenopus.

2. ETV6-RUNX1 (TEL-AML1) fusion and hyperdiploidy (>50 chromosomes) are favorable genetic features in childhood acute lymphoblastic leukemia (ALL).

3. reveal a shift in Runx2 function protein during vertebrate evolution towards its exclusive roles in cartilage hypertrophy and bone differentiation within the amniote lineage