Runt-Related Transcription Factor 1, Translocated To, 1 (Cyclin D-Related) (RUNX1T1) ELISA Kits

RUNX1T1 encodes a member of the myeloid translocation gene family which interact with DNA-bound transcription factors and recruit a range of corepressors to facilitate transcriptional repression.

list all ELISA KIts Gen GeneID UniProt
Anti-Human RUNX1T1 RUNX1T1 862 Q06455
Anti-Maus RUNX1T1 RUNX1T1 12395 Q61909
Anti-Ratte RUNX1T1 RUNX1T1 362489  
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Katalog Nr. Reaktivität Sensitivität Bereich Bilder Menge Anbieter Lieferzeit Preis Details
Human
  96 Tests Anmelden zum Anzeigen 15 bis 18 Tage
$875.60
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Maus
  96 Tests Anmelden zum Anzeigen 15 bis 18 Tage
$875.60
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Weitere ELISA Kits für RUNX1T1 Interaktionspartner

Human Runt-Related Transcription Factor 1, Translocated To, 1 (Cyclin D-Related) (RUNX1T1) Interaktionspartner

  1. Data indicate miR (zeige MLXIP ELISA Kits)-29b-1 as a regulator of the AML1 (zeige RUNX1 ELISA Kits)-ETO protein (RUNX1 (zeige RUNX1 ELISA Kits)-RUNX1T1), and that miR (zeige MLXIP ELISA Kits)-29b-1 expression in t(8;21)-carrying leukemic cell lines partially rescues the leukemic phenotype.

  2. Altogether, these results revealed an unexpected and important epigenetic mini-circuit of AML1-ETO/THAP10/miR-383 in t(8;21) acute myeloid leukaemia, in which epigenetic suppression of THAP10 predicts a poor clinical outcome and represents a novel therapeutic target.

  3. RUNX1 (zeige RUNX1 ELISA Kits)-RUNX1T1 transcript levels were measured in bone marrow samples collected from 208 patients at scheduled time points after transplantation. Over 90% of the 175 patients who were in continuous complete remission had a >/=3-log reduction in RUNX1 (zeige RUNX1 ELISA Kits)-RUNX1T1 transcript levels from the time of diagnosis at each time point after transplantation and a >/=4-log reduction at >/=12 months.

  4. The data suggest that the tumor suppressor activity of both RUNX1t1 and TFF1 (zeige TFF1 ELISA Kits) are mechanistically connected to CEBPB (zeige CEBPB ELISA Kits) and that cross-regulation between CEBPB (zeige CEBPB ELISA Kits)-RUNX1t1-TFF1 (zeige TFF1 ELISA Kits) plays an important role in gastric carcinogenesis.

  5. RUNX1T1 serves as a common angiogenic driver for vaculogenesis and functionality of endothelial lineage cells

  6. Leukaemogenesis by AML1-ETO requires enhanced C/D box snoRNA/RNP formation.

  7. Study demonstrated that TRiC's contribution to the activity of the DNA-binding domain (AML1 (zeige RUNX1 ELISA Kits)-175) of AML1 (zeige RUNX1 ELISA Kits)-ETO is consistent with its contribution to the activity of full-length AML1 (zeige RUNX1 ELISA Kits)-ETO and is mediated through its direct association with the DNA-binding domain

  8. the AML1 (zeige RUNX1 ELISA Kits)-ETO fusion protein increases the expression of SIRT1 (zeige SIRT1 ELISA Kits), possibly by binding to the promoter region of SIRT1 (zeige SIRT1 ELISA Kits) to activate its transcription in t(8;21) AML (zeige RUNX1 ELISA Kits).

  9. A feedback circuitry involving miR (zeige MLXIP ELISA Kits)-9-1 and RUNX1 (zeige RUNX1 ELISA Kits)-RUNX1T1.

  10. The role of RUNX1T1 in t(8;21) acute myeloid leukemia (zeige BCL11A ELISA Kits) and miRNA expression regulation

Mouse (Murine) Runt-Related Transcription Factor 1, Translocated To, 1 (Cyclin D-Related) (RUNX1T1) Interaktionspartner

  1. Results suggest that AML1 (zeige RUNX1 ELISA Kits)/ETO expression determines a more mobile and less adherent phenotype in preleukemic cells, therefore altering the interaction with the hematopoietic niche, potentially leading to the migration across the bone marrow barrier and to disease progression

  2. The data suggest that the tumor suppressor activity of both RUNX1t1 and TFF1 (zeige TFF1 ELISA Kits) are mechanistically connected to CEBPB (zeige CEBPB ELISA Kits) and that cross-regulation between CEBPB (zeige CEBPB ELISA Kits)-RUNX1t1-TFF1 (zeige TFF1 ELISA Kits) plays an important role in gastric carcinogenesis.

  3. RUNX1T1 serves as a common angiogenic driver for vaculogenesis and functionality of endothelial lineage cells

  4. Leukaemogenesis by AML1-ETO requires enhanced C/D box snoRNA/RNP formation.

  5. Data show that RUNX1 (zeige RUNX1 ELISA Kits)-ETO;c-Kit (zeige KIT ELISA Kits)(T417IDelta418-419) coexpression promoted exclusively acute myeloid leukemia (zeige BCL11A ELISA Kits) (AML (zeige RUNX1 ELISA Kits)) in a fraction (51%) of reconstituted mice.

  6. Self-renewal induced by AML1 (zeige RUNX1 ELISA Kits)/ETO in primary murine progenitors was inhibited when Aes (zeige AES ELISA Kits) was decreased or absent.

  7. AML1 (zeige RUNX1 ELISA Kits)-ETO synergizes with an ICSBP (zeige IRF8 ELISA Kits) deficiency to induce myeloblastic transformation in the bone marrow, reminiscent of acute myelogenous leukemia

  8. molecular role for ETO in normal physiology as an inhibitor of C/EBPbeta (zeige CEBPB ELISA Kits) and a novel regulator of early adipogenesis

  9. the loss of the molecular events of AML1 (zeige RUNX1 ELISA Kits)-ETO C-terminal NCoR (zeige NCOR1 ELISA Kits)/SMRT-interacting domain transforms AML1 (zeige RUNX1 ELISA Kits)-ETO into a potent leukemogenic protein

  10. p15(Ink4b (zeige CDKN2B ELISA Kits)) loss must be accompanied by additional oncogenic changes for RUNX1 (zeige RUNX1 ELISA Kits)-ETO-associated AML (zeige RUNX1 ELISA Kits) to develop

RUNX1T1 Antigen-Profil

Beschreibung des Gens

This gene encodes a member of the myeloid translocation gene family which interact with DNA-bound transcription factors and recruit a range of corepressors to facilitate transcriptional repression. The t(8\;21)(q22\;q22) translocation is one of the most frequent karyotypic abnormalities in acute myeloid leukemia. The translocation produces a chimeric gene made up of the 5'-region of the runt-related transcription factor 1 gene fused to the 3'-region of this gene. The chimeric protein is thought to associate with the nuclear corepressor/histone deacetylase complex to block hematopoietic differentiation. Alternative splicing results in multiple transcript variants.

Genbezeichner und Symbole assoziert mit RUNX1T1

  • runt-related transcription factor 1; translocated to, 1 (cyclin D-related) (runx1t1) Antikörper
  • RUNX1 translocation partner 1 L homeolog (runx1t1.L) Antikörper
  • RUNX1 translocation partner 1 (RUNX1T1) Antikörper
  • runt-related transcription factor 1; translocated to, 1 (cyclin D-related) (Runx1t1) Antikörper
  • RUNX1 translocation partner 1 (Runx1t1) Antikörper
  • AML1T1 Antikörper
  • Cbfa2t1 Antikörper
  • Cbfa2t1h Antikörper
  • CDR Antikörper
  • ETO Antikörper
  • MTG8 Antikörper
  • si:ch211-232j17.1 Antikörper
  • wu:fi14b07 Antikörper
  • zgc:154044 Antikörper
  • ZMYND2 Antikörper

Bezeichner auf Proteinebene für RUNX1T1

protein CBFA2T1 , MTG8 , MTG8/ETOb , expressed during postmitotic spinal neurons, most likely in motorneurons , acute myelogenous leukemia 1 translocation 1, cyclin-D related , core-binding factor, runt domain, alpha subunit 2; translocated to, 1; cyclin D-related , eight twenty one protein , myeloid translocation gene on 8q22 , zinc finger MYND domain-containing protein 2 , CBFA2T1 identified gene homolog , acute myelogenous leukemia 1 translocation 1 protein , core-binding factor, runt domain, alpha subunit 2 , cyclin D-related , translocated to, 1

GENE ID SPEZIES
767809 Danio rerio
733153 Xenopus laevis
395503 Gallus gallus
862 Homo sapiens
487044 Canis lupus familiaris
12395 Mus musculus
362489 Rattus norvegicus
100155449 Sus scrofa
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