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RDH10 encodes a retinol dehydrogenase, which converts all-trans-retinol to all-trans-retinal, with preference for NADP as a cofactor.
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In close proximity to RDH10 gene on human chromosome 8 are located two genes that are phylogenetically related to RDH10. The predicted protein products of these genes, retinol dehydrogenase (zeige ADH7 Antikörper) epidermal 2 (RDHE2 (zeige DHRS9 Antikörper), SDR16C5 (zeige RDHE2 Antikörper)) and retinol dehydrogenase (zeige ADH7 Antikörper) epidermal 2-similar (RDHE2S, SDR16C6), share 59% and 56% sequence similarity with RDH10.
the bifunctional nature of retinoid oxidoreductase (zeige TXNRD1 Antikörper) complex provides the RA-based signaling system with robustness by safeguarding appropriate RA concentration despite naturally occurring fluctuations in RDH10 and DHRS3 (zeige DHRS3 Antikörper).
Taken together, our findings demonstrate that RDH10 is essential during the early stages of facial morphogenesis for the formation of a functional nasal airway, and furthermore establish Rdh10 mutant mice as an important model system to study choanal atresia (CA) .
Insulin (zeige INS Antikörper) inhibits retinoic acid biosynthesis through inhibition of FoxO1 (zeige FOXO1 Antikörper)-induced Rdh10 gene expression.
Data indicate that retinaldehyde reductase (DHRS3 (zeige DHRS3 Antikörper)) requires retinol dehydrogenase 10 (RDH10) for full enzymatic activity and, in turn, activates RDH10.
all three proteins (RDH10, RALDH2 (zeige ALDH1A2 Antikörper), and CRABP2 (zeige CRABP2 Antikörper)) appeared to be required for ATRA production induced by activation of PPARgamma (zeige PPARG Antikörper)
Retinol dehydrogenase 10 but not retinol/sterol dehydrogenase(s) regulates the expression of retinoic acid-responsive genes in human transgenic skin raft culture.
CYP4Z1 (zeige CYP4Z1 Antikörper), KIR (zeige GEM Antikörper) and RDH10 could play a role in non-small-cell lung cancer progression
organization of the gene includes a unique transcriptional start site, a coding region with six translated exons and a 3' UTR (zeige UTS2R Antikörper) containing at least two used polyadenylation sites.
Forced over-expression of the RDH10 gene causes growth arrest of HepG2 cells and could be a possible curative strategy for hepatocellular carcinoma.
Embryonic fibroblasts from Rdh10 heterozygote hypomorphs or with a total Rdh10 knockout exhibit decreased all-trans-retinoic acid biosynthesis and escalated adipogenesis.
Rdh10 null mutant mouse embryos exhibited dorsal pancreas agenesis and a hypoplastic ventral pancreas with retarded tubulogenesis and branching. Conditional disruption of Rdh10 from the endoderm caused increased mortality, reduced body weight, and lowered blood glucose levels after birth. Endodermal Rdh10 deficiency led to a smaller dorsal pancreas with a reduced density of early glucagon (zeige GCG Antikörper)(+) and insulin (zeige INS Antikörper)(+) cells.
Taken together, our findings demonstrate that RDH10 is essential during the early stages of facial morphogenesis for the formation of a functional nasal airway, and furthermore establish Rdh10 mutant mice as an important model system to study choanal atresia (CA)
RDH10 acts in cooperation with other RDH isoforms to produce the 11-cis (zeige CISH Antikörper)-retinal chromophore needed for vision.
Rdh10-/- embryos demonstrate that RA controls hindbrain but not early forebrain patterning, while studies on retinaldehyde-rescued Rdh10-/- embryos show that meningeal RA synthesis is unnecessary to stimulate forebrain cortical expansion.
Retinol dehydrogenase 10 is indispensible for spermatogenesis in juvenile males.
retinol dehydrogenase (zeige ADH7 Antikörper) Rdh10 localizes to lipid droplets during acyl ester biosynthesis
RDH10-mediated oxidation of retinol plays as important a role in the control and regulation of retinoic acid production during embryogenesis as does the subsequent RALDH-mediated reaction.
This gene encodes a retinol dehydrogenase, which converts all-trans-retinol to all-trans-retinal, with preference for NADP as a cofactor. Studies in mice suggest that this protein is essential for synthesis of embryonic retinoic acid and is required for limb, craniofacial, and organ development.
retinol dehydrogenase 10
, retinol dehydrogenase 10-B
, retinol dehydrogenase 10 (all-trans)
, retinol dehydrogenase 10-like
, short chain dehydrogenase/reductase family 16C, member 4