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RARRES1 was identified as a retinoid acid (RA) receptor-responsive gene.
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Data show that retinoic acid receptor (zeige RARA Proteine) responder 1 (RARRES1) expression is subtype-dependent and regulated by DNA methylation (zeige HELLS Proteine) and the expression of aldehyde dehydrogenase 1A3 (ALDH1A3 (zeige ALDH1A3 Proteine)).
Data suggest that Retinoic Acid Receptor (zeige RARA Proteine) Responder (RARRES1)/ Tazarotene-induced gene-1 (TIG-1) may serve as a target for therapeutic intervention both in cancer and in angiogenesis-related disorders.
Authors found that transmembrane protein 192 (TMEM192) interacted with TIG1. Authors also found that both TIG1A and TIG1B isoforms interacted and co-localized with TMEM192 in HtTA cervical cancer cells. The expression of TIG1 induced the expression of autophagy-related proteins.
All-trans retinoic acid modulated secretion of RARRES1 in a dose dependent manner.
our data suggested that epigenetic silencing of TIG1 gene expression by promoter hypermethylation may play an important role in hepatocellular carcinoma .
High TIG1 expression is associated with inflammatory breast cancer through activation of Axl (zeige AXL Proteine) kinase.
Analysis of a standard liver fibrosis model (CCl(4 (zeige CCL4 Proteine))) demonstrated an early induction of RARRES1 mRNA and protein expression.
genotype-associated hypermethylation of the ETS (zeige ETS1 Proteine)-family target gene RARRES1 influences methylation at its neighbor gene LXN (zeige LXN Proteine) and could be useful as a prognostic biomarker.
Knocking-down CTCF (zeige CTCF Proteine) expression hampered RARRES1 expression.
TIG1 suppressed PGE2-stimulated Wnt (zeige WNT2 Proteine) and cAMP signaling pathways in colon cancer cells through GRK5 (zeige GRK5 Proteine).
This gene was identified as a retinoid acid (RA) receptor-responsive gene. It encodes a type 1 membrane protein. The expression of this gene is upregulated by tazarotene as well as by retinoic acid receptors. The expression of this gene is found to be downregulated in prostate cancer, which is caused by the methylation of its promoter and CpG island. Alternatively spliced transcript variant encoding distinct isoforms have been observed.
tazarotene-induced protein 1
, retinoic acid receptor responder (tazarotene induced) 1
, retinoic acid receptor responder protein 1
, ovocalyxin 32
, RAR-responsive protein TIG1
, tazarotene-induced gene 1 protein
, 32 kDa eggshell matrix protein