Relaxin 1 Proteine (RLN1)

Relaxins are known endocrine and autocrine/paracrine hormones, belonging to the insulin gene superfamily. Zusätzlich bieten wir Ihnen Relaxin 1 Antikörper (78) und und viele weitere Produktgruppen zu diesem Protein an.

alle Proteine anzeigen Gen GeneID UniProt
RLN1 6013 P04808
RLN1 19773  
RLN1 25616 P01347
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Katalog Nr. Origin Quelle Konjugat Bilder Menge Anbieter Lieferzeit Preis Details
Human Cells Human His tag 50 μg Anmelden zum Anzeigen 14 bis 16 Tage
Escherichia coli (E. coli) Maus His tag 100 μg Anmelden zum Anzeigen 15 bis 18 Tage
Wheat germ Human GST tag 10 μg Anmelden zum Anzeigen 11 bis 12 Tage
Escherichia coli (E. coli) Ratte T7 tag,His tag 100 μg Anmelden zum Anzeigen 15 bis 18 Tage
Escherichia coli (E. coli) Maus Unkonjugiert   5 applications Anmelden zum Anzeigen 1 bis 2 Tage

RLN1 Proteine nach Spezies und Herkunft

Origin Exprimiert in Konjugat
Human ,
Mouse (Murine)

Rat (Rattus)

Weitere Proteine zu Relaxin 1 (RLN1) Interaktionspartnern

Human Relaxin 1 (RLN1) Interaktionspartner

  1. Results indicate that serum relaxin may be a clinically useful indicator for diagnostic and prognostic evaluation in epithelial ovarian cancer (EOC) patients.

  2. down-regulated in cord blood by prenatal smoking

  3. In a population of acute HF patients, admission relaxin serum levels were associated with clinical and echocardiographic markers of pulmonary hypertension, RV dysfunction, and overload, suggesting a role for circulating relaxin as a biomarker in this setting.

  4. The digestive tract has been shown to express relaxin receptors; the hormone appears to exert site-specific effects acting at the neural or at the smooth muscle level, mainly by a nitric oxide-mediated mechanism. (Review)

  5. a novel fusion transcript comprising the RLN1 and RLN2 genes, was identified.

  6. Although serum relaxin level is not a causative factor for benign hypermobility syndrome, the significant increases in patients with hyperkyphosis and pes planus suggest the hypothesis that relaxin has a limited and indefinite role in patients with BJHS.

  7. Serum concentrations of relaxin showed a positive association to duration of gestation among women with miscarriage but no association to duration of gestation among women with spontaneous onset of labour.

  8. Rln enhanced synergistically BMP-2-induced osteoblast differentiation and bone formation.

  9. Relaxin actions in pregnancy include increasing cervical pro-MMP-1 and pro-MMP-3 and decreasing TIMP-1, changes which soften the cervix.

  10. For the first time, we bring together the systemic (ovarian) and autocrine/paracrine (intrauterine) sources of RLN, in an attempt to understand how RLN contributes to premature birth in women.

  11. Notch signaling can down-regulate TGF-beta1/Smad3-induced fibroblast-myofibroblast transition and that RLX could exert its well known anti-fibrotic action through the up-regulation of this pathway.

  12. Recombinant human relaxin (RLX) may provide a novel therapy to manage atrial fibrillation in humans by reversing fibrosis and hypertrophy and by modulating cardiac ionic currents.

  13. relaxin may promote the proliferation, invasion and metastasis of osteosarcoma cells by regulating the expression of MMP-9 and facilitating ECM degradation.

  14. [review] This study not only clarifies the role of relaxin in sperm, but could also open avenues of research into its use in fertility treatment.

  15. heterozygous loss at the RLN1 locus is not a genetic factor mediating high population-wide risk for testicular germ cell tumour, but do not exclude a contribution of this aberration in some cases of cancer

  16. Endometrial expression of relaxin and its receptor in endometriosis.

  17. In conclusion, we have identified S100A4 as a major mediator of the actions of relaxin in thyroid carcinoma cell motility and in vivo thyroid tumor angiogenesis.

  18. Relaxin is a potent stimulator of osteoclastogenesis from hematopoietic precursors and regulates the activity of mature osteoclasts.

  19. Women with a history of recurrent pregnancy loss demonstrate attenuated levels of serum relaxin across all pregnancy trimesters.

  20. demonstrated that prorelaxin has the ability to facilitate cell migration processes exclusive of its ability to stimulate cell proliferation

Mouse (Murine) Relaxin 1 (RLN1) Interaktionspartner

  1. the data demonstrate that pregnant Rln(-/-) mice do not have the typical characteristics of preeclampsia. However, these mice show evidence of proteinuria, but we suggest that this results from systemic renal vascular dysfunction before pregnancy.

  2. Infusion of AngII reduced, but relaxin increased, MMP-9 mRNA in macrophages.

  3. SLX has roles in vascular oxidative stress, endothelial dysfunction and atherosclerotic plaque burden

  4. The digestive tract has been shown to express relaxin receptors; the hormone appears to exert site-specific effects acting at the neural or at the smooth muscle level, mainly by a nitric oxide-mediated mechanism. (Review)

  5. This study tested the hypothesis that functional adaptation of the mesenteric and uterine arteries during pregnancy will be compromised in relaxin-deficient mice.

  6. Passive mechanical wall properties differed at younger ages, suggesting that Relaxin expression has only minor effects on vascular aging.

  7. we demonstrate endothelial dysfunction and impaired arterial wall remodeling in male mice deficient in relaxin. Thus, our results highlight a role for endogenous relaxin in the maintenance of normal mesenteric artery structure and function in males.

  8. data suggest a novel role for Rln in craniofacial skeletal development and metabolism through Rxfp2

  9. Relaxin and estrogen enhance matrix loss in the temporomandibular joint disc.

  10. Relaxin deficiency compromises uterine artery remodeling in older pregnant females.

  11. RLX improves impaired wound healing, enhances staining of MMP-11 (matrix metalloproteinase-11) and increases wound-breaking strength at day 12 in diabetic mice.

  12. Relaxin regulates hyaluronan synthesis and aquaporins in the cervix of late pregnant mice

  13. Data suggest that in proximal colon, relaxin affects constitutive nNOS (neuronal nitric oxide synthase) and eNOS (endothelial cell NOS) but not iNOS (inducible NOS), increasing enzyme activity and reducing muscle tone.

  14. Relaxin knockout mice have an age-related progression of pulmonary fibrosis.

  15. Increases in myometrial oxytocin receptor and estrogen receptor alpha expression in late pregnant relaxin+/+ mice were attenuated in relaxin-/- mice. Probably mediated via activation of estrogen receptor-alpha.

  16. structural and functional changes in the kidney of aging relaxin-1 (RLX-/-) deficient mice

  17. neither Insl3 nor Lgr8 contribute to the RLN signaling pathway; Insl3/Lgr8 and Rln1/Lgr7 actions do not overlap in vivo

  18. phenotypic differences in collagen, matrix metalloproteinases (MMP), and estrogen receptors (ERs) in the cervix and vagina of pregnant Rlx+/+ and Rlx-/- mice

  19. Myometrial oxytocin receptors were significantly decreased on gestation day 18.5 in Rlx-/- mice than in Rlx+/+ mice.

  20. findings suggest that relaxin is a naturally occurring inhibitor of collagen deposition during normal development, aging, and pregnancy and can be used to prevent the progression of fibrosis

Relaxin 1 (RLN1) Protein Überblick

Protein Überblick

Relaxins are known endocrine and autocrine/paracrine hormones, belonging to the insulin gene superfamily. In the human there are three non-allelic relaxin genes, RLN1, RLN2 and RLN3. RLN1 and RLN2 share high sequence homology. This encoded protein is synthesized as a single-chain polypeptide but the active form consists of an A chain and a B chain linked by disulfide bonds; however, their exact cleavage sites have not been described. Relaxin is produced by the ovary, and targets the mammalian reproductive system to ripen the cervix, elongate the pubic symphysis and inhibit uterine contraction. It may have additional roles in enhancing sperm motility, regulating blood pressure, controlling heart rate and releasing oxytocin and vasopressin. This gene has multiple polyadenylation sites. There are multiple alternatively spliced transcript variants described for this gene but their full length nature is not known yet.

Genbezeichner und Symbole assoziert mit Relaxin 1 Proteine (RLN1)

  • relaxin 1 (RLN1)
  • relaxin 1 (Rln1)
  • bA12D24.3.1 Protein
  • bA12D24.3.2 Protein
  • H1 Protein
  • H1RLX Protein
  • RELAX Protein
  • Rln Protein
  • RLN1 Protein
  • RLX Protein
  • RLX1 Protein
  • RLXH1 Protein
  • RNL1 Protein

Bezeichner auf Proteinebene für Relaxin 1 Proteine (RLN1)

preprorelaxin H1 , prorelaxin H1 , prorelaxin 1 , Relaxin 1 (H1) , preprorelaxin , relaxin 1

6013 Homo sapiens
19773 Mus musculus
25616 Rattus norvegicus
449632 Pan troglodytes
100127455 Sus scrofa
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