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Relaxins are known endocrine and autocrine/paracrine hormones, belonging to the insulin gene superfamily. Zusätzlich bieten wir Ihnen Relaxin 1 Antikörper (93) und Relaxin 1 Kits (44) und viele weitere Produktgruppen zu diesem Protein an.
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Results indicate that serum relaxin may be a clinically useful indicator for diagnostic and prognostic evaluation in epithelial ovarian cancer (EOC) patients.
In a population of acute HF patients, admission relaxin serum levels were associated with clinical and echocardiographic markers of pulmonary hypertension, RV dysfunction, and overload, suggesting a role for circulating relaxin as a biomarker in this setting.
The digestive tract has been shown to express relaxin receptors; the hormone appears to exert site-specific effects acting at the neural or at the smooth muscle level, mainly by a nitric oxide-mediated mechanism. (Review)
a novel fusion transcript comprising the RLN1 and RLN2 genes, was identified.
Although serum relaxin level is not a causative factor for benign hypermobility syndrome, the significant increases in patients with hyperkyphosis and pes planus suggest the hypothesis that relaxin has a limited and indefinite role in patients with BJHS.
Serum concentrations of relaxin showed a positive association to duration of gestation among women with miscarriage but no association to duration of gestation among women with spontaneous onset of labour.
Rln enhanced synergistically BMP-2 (zeige BMP2 Proteine)-induced osteoblast differentiation and bone formation.
Relaxin actions in pregnancy include increasing cervical pro-MMP-1 (zeige MMP1 Proteine) and pro-MMP-3 (zeige MMP3 Proteine) and decreasing TIMP-1 (zeige TIMP1 Proteine), changes which soften the cervix.
For the first time, we bring together the systemic (ovarian) and autocrine/paracrine (intrauterine) sources of RLN, in an attempt to understand how RLN contributes to premature birth in women.
Notch (zeige NOTCH1 Proteine) signaling can down-regulate TGF-beta1 (zeige TGFB1 Proteine)/Smad3 (zeige SMAD3 Proteine)-induced fibroblast-myofibroblast transition and that RLX could exert its well known anti-fibrotic action through the up-regulation of this pathway.
the data demonstrate that pregnant Rln(-/-) mice do not have the typical characteristics of preeclampsia. However, these mice show evidence of proteinuria, but we suggest that this results from systemic renal vascular dysfunction before pregnancy.
Infusion of AngII reduced, but relaxin increased, MMP-9 (zeige MMP9 Proteine) mRNA in macrophages.
This study tested the hypothesis that functional adaptation of the mesenteric and uterine arteries during pregnancy will be compromised in relaxin-deficient mice.
Passive mechanical wall properties differed at younger ages, suggesting that Relaxin expression has only minor effects on vascular aging.
we demonstrate endothelial dysfunction and impaired arterial wall remodeling in male mice deficient in relaxin. Thus, our results highlight a role for endogenous relaxin in the maintenance of normal mesenteric artery structure and function in males.
data suggest a novel role for Rln in craniofacial skeletal development and metabolism through Rxfp2 (zeige RXFP2 Proteine)
Relaxin and estrogen enhance matrix loss in the temporomandibular joint disc.
Relaxin deficiency compromises uterine artery remodeling in older pregnant females.
RLX improves impaired wound healing, enhances staining of MMP-11 (matrix metalloproteinase-11 (zeige MMP11 Proteine)) and increases wound-breaking strength at day 12 in diabetic mice.
Relaxins are known endocrine and autocrine/paracrine hormones, belonging to the insulin gene superfamily. In the human there are three non-allelic relaxin genes, RLN1, RLN2 and RLN3. RLN1 and RLN2 share high sequence homology. This encoded protein is synthesized as a single-chain polypeptide but the active form consists of an A chain and a B chain linked by disulfide bonds; however, their exact cleavage sites have not been described. Relaxin is produced by the ovary, and targets the mammalian reproductive system to ripen the cervix, elongate the pubic symphysis and inhibit uterine contraction. It may have additional roles in enhancing sperm motility, regulating blood pressure, controlling heart rate and releasing oxytocin and vasopressin. This gene has multiple polyadenylation sites. There are multiple alternatively spliced transcript variants described for this gene but their full length nature is not known yet.
, prorelaxin H1
, prorelaxin 1
, Relaxin 1 (H1)
, relaxin 1