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Relaxin 1 Protein (RLN1) (His tag)

RLN1 Spezies: Human Wirt: HEK-293 Cells Recombinant > 82 % as determined by reducing SDS-PAGE.
Produktnummer ABIN7317519
  • Target Alle Relaxin 1 (RLN1) Proteine anzeigen
    Relaxin 1 (RLN1)
    Protein-Typ
    Recombinant
    Spezies
    • 2
    • 1
    • 1
    Human
    Quelle
    • 1
    • 1
    • 1
    HEK-293 Cells
    Aufreinigungstag / Konjugat
    Dieses Relaxin 1 Protein ist gelabelt mit His tag.
    Verwendungszweck
    Recombinant Human Relaxin-1/RLN1 Protein (His Tag)
    Sequenz
    Met 1-Cys 185
    Produktmerkmale
    A DNA sequence encoding the human RLN1 (NP_008842.1) (Met 1-Cys 185) was fused with a polyhistidine tag at the C-terminus.
    Reinheit
    > 82 % as determined by reducing SDS-PAGE.
    Endotoxin-Niveau
    < 1.0 EU per μg as determined by the LAL method.
    Top Product
    Discover our top product RLN1 Protein
  • Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Lyophilized
    Rekonstitution
    Please refer to the printed manual for detailed information.
    Buffer
    Lyophilized from sterile PBS, pH 7.4
    Lagerung
    4 °C,-20 °C,-80 °C
    Informationen zur Lagerung
    Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
  • Target
    Relaxin 1 (RLN1)
    Andere Bezeichnung
    Relaxin-1/RLN1 (RLN1 Produkte)
    Synonyme
    H1 Protein, H1RLX Protein, RLXH1 Protein, bA12D24.3.1 Protein, bA12D24.3.2 Protein, Rln Protein, rlx Protein, RELAX Protein, RLX1 Protein, RNL1 Protein, RLN1 Protein, RLX Protein, relaxin 1 Protein, RLN1 Protein, Rln1 Protein
    Hintergrund

    Background: Relaxin-1, also known as Prorelaxin H1 and RLN1, is a secreted protein which belongs to the insulin family. It is a peptide hormone that was first described in 1926 by Frederick Hisaw. Since its discovery as a reproductive hormone 80 years ago, relaxin has been implicated in a number of pregnancy-related functions involving extracellular matrix (ECM) turnover and collagen degradation. It is now becoming evident that relaxin's ability to reduce matrix synthesis and increase ECM degradation has important implications in several nonreproductive organs, including the heart, lung, kidney, liver and skin. The relaxin-like peptide family belongs in the insulin superfamily and consists of 7 peptides of high structural but low sequence similarity; relaxin-1 (RNL1), relaxin-2 (RNL2) and relaxin-3 ( RNL3), and the insulin-like (INSL) peptides, INSL3, INSL4, INSL5 and INSL6. The functions of relaxin-3, INSL4, INSL5, INSL6 remain uncharacterised. Relaxin-1 / RLN1 is an ovarian hormone that acts with estrogen to produce dilatation of the birth canal in many mammals. Relaxin-1 / RLN1 may be involved in remodeling of connective tissues during pregnancy, promoting growth of pubic ligaments and ripening of the cervix. Relaxin and estrogen appear to play protective roles against airway fibrosis, airway SM thickening, and cardiac hypertrophy. Relaxin may also provide a means to regulate excessive collagen deposition during kidney development and in diseased states characterized by renal fibrosis.

    Synonym: bA12D24.3.1;bA12D24.3.2;H1;H1RLX;RLN1;RLXH1

    Molekulargewicht
    20 kDa
    NCBI Accession
    NP_008842
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