anti-Receptor Protein Tyrosine Phosphatase (PTPRT) Antikörper

Human Receptor Protein Tyrosine Phosphatase (PTPRT) Interaktionspartner

1. The single cell genotyping not only confirmed the co-occurrence of the PTPRT, CAND1 (zeige CAND1 Antikörper) and DOCK6 (zeige DOCK6 Antikörper) mutations in the same AML (zeige RUNX1 Antikörper) clone but also revealed a clonal hierarchy, as the PTPRT mutation was likely acquired after the CAND1 (zeige CAND1 Antikörper) and DOCK6 (zeige DOCK6 Antikörper) mutations.

2. PTPRT promoter methylation is significantly associated with sensitivity to STAT3 (zeige STAT3 Antikörper) inhibition in HNSCC cells, suggesting that PTPRT promoter methylation may serve as a predictive biomarker for responsiveness to STAT3 (zeige STAT3 Antikörper) inhibitors in clinical development

3. Data reported evidence that rs2866943 polymorphism in PTPRT 3'-UTR (zeige UTS2R Antikörper) was involved in the occurrence of esophageal squamous cell carcinoma by acting as a protective factor while rs6029959 acts as a risk factor.

4. Data show that hepatitis B virus X protein mutant HBxDelta127 enhances proliferation of hepatoma cells through up-regulating miR (zeige MLXIP Antikörper)-215 targeting protein tyrosine phosphatase (zeige ACP1 Antikörper), receptor type T (PTPRT).

5. tumor-specific mutational events in the PTPRT gene can serve as direct drivers for tumor growth by inducing hyperactivation of STAT3 (zeige STAT3 Antikörper), a potent oncogenic transcription factor and PTPRT substrate

6. [review] High-throughput mutational analysis identifies loss-of-function mutations in six PTPs (zeige PTS Antikörper) in human colon cancers, providing critical cancer genetics evidence that PTPs (zeige PTS Antikörper) can act as tumour suppressor genes.

7. Data show that paxillin (zeige PXN Antikörper) is a direct substrate of PTPRT and that PTPRT specifically regulates paxillin (zeige PXN Antikörper) phosphorylation at tyrosine residue 88(Y88).

8. alterations of the PTPRT-mediated signaling pathway by PTPRT phosphatase domain mutation may not play a critical role in the development of common human cancers

9. STAT3 (zeige STAT3 Antikörper) is a substrate of receptor protein tyrosine phosphatase T

10. brain-specific (zeige CALY Antikörper) PTPRT regulates synapse formation through interaction with cell adhesion molecules, and this function and the phosphatase activity are attenuated through tyrosine phosphorylation by the synaptic tyrosine kinase (zeige TXK Antikörper) Fyn (zeige FYN Antikörper).

Mouse (Murine) Receptor Protein Tyrosine Phosphatase (PTPRT) Interaktionspartner

1. Receptor protein tyrosine phosphatase rho (RPTPrho, gene symbol PTPRT) is a transmembrane protein expressed at high levels in the developing hippocampus, olfactory bulb, cortex, and cerebellum.

2. These studies implicate PTPRT-modulated STAT3 (zeige STAT3 Antikörper) signaling in the regulation of high-fat diet-induced obesity

3. BCR (zeige BCR Antikörper) is a novel substrate of PTPRT .

4. Data show that paxillin (zeige PXN Antikörper) is a direct substrate of PTPRT and that PTPRT specifically regulates paxillin (zeige PXN Antikörper) phosphorylation at tyrosine residue 88(Y88).