Ras Association (RalGDS/AF-6) Domain Family Member 1 Proteine (RASSF1)

RASSF1 encodes a protein similar to the RAS effector proteins. Zusätzlich bieten wir Ihnen Ras Association (RalGDS/AF-6) Domain Family Member 1 Antikörper (155) und Ras Association (RalGDS/AF-6) Domain Family Member 1 Kits (7) und viele weitere Produktgruppen zu diesem Protein an.

alle Proteine anzeigen Gen GeneID UniProt
RASSF1 11186 Q9NS23
RASSF1 56289 Q99MK9
Ratte RASSF1 RASSF1 363140  
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Katalog Nr. Origin Quelle Konjugat Bilder Menge Anbieter Lieferzeit Preis Details
Insektenzellen Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 50 Days
$6,869.04
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Insektenzellen Maus His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 50 Days
$6,869.04
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Wheat germ Human GST tag 10 μg Anmelden zum Anzeigen 11 bis 12 Tage
$414.29
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Escherichia coli (E. coli) Human His tag 100 μg Anmelden zum Anzeigen 15 bis 19 Tage
$400.00
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RASSF1 Proteine nach Spezies und Herkunft

Origin Exprimiert in Konjugat
Human , ,
,
Mouse (Murine)

Weitere Proteine zu Ras Association (RalGDS/AF-6) Domain Family Member 1 (RASSF1) Interaktionspartnern

Human Ras Association (RalGDS/AF-6) Domain Family Member 1 (RASSF1) Interaktionspartner

  1. Effect of decitabine pretreatment on sensitivity of bladder cancer cells towards chemotherapeutic drugs was also studied. Decitabine treatment leads to restoration of RASSF1A, activation of hippo pathway followed by decreased expression of its oncogenic downstream targets (CTGF (zeige CTGF Proteine) & CYR61 (zeige CYR61 Proteine)).

  2. the use of RASSF1A promoter methylation could distinguish ovarian cancer and low malignant potential tumors. -RASSF1A promoter methylation may not be correlated with the clinical features and the survival of ovarian cancer patients.

  3. the methylation positive rates of SHOX2 (zeige SHOX2 Proteine) with RASSF1A in stage III were both higher than the other stages of lung cancer

  4. Tested if RASSF1A polymorphisms associated with ovarian cancer and with tumor grade and stage. Five tagging single nucleotide polymorphisms (SNPs) (rs4688728G>T, rs72932987C>T, rs1989839C>T, rs2073497A>C, and rs2236947A>C) were evaluated. The CT genotype of rs1989839 was associated with the patients with ovarian cancer (P=0.001), and was significantly correlated with tumor grade and stage (P=0.008).

  5. No significant differences were presented in DNA methylation (zeige HELLS Proteine) levels of RASSF1A and ATM (zeige ATM Proteine) between the sporadic breast cancer cases and the healthy controls.

  6. High Promoter Methylation of RASSF1A gene is associated with Breast Cancer.

  7. Hypermethylation of RASSF1 gene is associated with neuroendocrine tumors.

  8. RACK1 (zeige GNB2L1 Proteine) associates with MOAP-1 (zeige MOAP1 Proteine) via electrostatic associations similar to those observed between MOAP-1 (zeige MOAP1 Proteine)/RASSF1A and MOAP-1 (zeige MOAP1 Proteine)/TNF-R1 (zeige TNFRSF1A Proteine). These events illustrate the complex nature of MOAP-1 (zeige MOAP1 Proteine) regulation and characterizes the important role of the scaffolding protein, RACK1 (zeige GNB2L1 Proteine), in influencing MOAP-1 (zeige MOAP1 Proteine) biology.

  9. The present work proved that there was a higher frequency of RASSF1A methylation and a decrease in its serum level in patients with ovarian cancer compared to controls as well as in the high-grade tumor patients compared to low grade ones and also in advanced ovarian tumor stage compared to early stages.

  10. Promoter methylation of RASSF1A can influence sensitivity to oxaliplatin-based chemotherapy, which can be used to predict outcomes for patients with stage II and III Colorectal Cancer

Mouse (Murine) Ras Association (RalGDS/AF-6) Domain Family Member 1 (RASSF1) Interaktionspartner

  1. RASSF1A is expressed in differentiating stem cells.RASSF1A promotes YAP (zeige YAP1 Proteine) and p73 (zeige ARHGAP24 Proteine) binding to differentiation related genes.RASSF1A uncouples Wnt (zeige WNT2 Proteine) from Hippo signalling and promotes YAP (zeige YAP1 Proteine) mediated differentiation via p73 (zeige ARHGAP24 Proteine).

  2. beta-catenin (zeige CTNNB1 Proteine) was predominantly associated with Na+/H+ exchanger regulating factor 1 (NHERF1 (zeige SLC9A3R2 Proteine)) in a dynamic context and an increase of its oncogenic function through RAS-association domain family 1, isoform A (RASSF1A) inactivation in liver metastases.

  3. essential role of RASSF1A in regulating TNF-alpha (zeige TNF Proteine) signalling in cardiomyocytes, with RASSF1A being key in the formation of the TNFR (zeige TNFRSF1A Proteine) complex and in signal transmission to the downstream targets

  4. RASSF1A may function to interfere and restrict TLR-driven activation of NF-kappaB (zeige NFKB1 Proteine) and is essential for protection against inflammation-induced injury.

  5. nickel-smelting fumes upregulated the expression of RASSF1A. This suggest that nickel-smelting fumes could be toxic to cells, inducing cell apoptosis and necrosis.

  6. Loss of RASSF1A synergizes with deregulated RUNX2 (zeige RUNX2 Proteine) signaling in tumorigenesis.

  7. Concomitant with the loss of Rassf1a, the loss of p53 (zeige TP53 Proteine) (which causes unrestrained propagation of tetraploids into aneuploid cells) further undermines genomic stability and accelerates tumorigenesis.

  8. Data show that methylation of CCND-2 (zeige CCND2 Proteine), p16, RAR-beta (zeige RARB Proteine) and RASSF-1a was significantly more prevalent in tumor than in normal tissue specimens.

  9. Rassf1A acts as a tumor suppressor gene.

  10. cooperation between inactivation of Rassf1a and Apc (zeige APC Proteine) resulting in accelerated intestinal tumourigenesis.

Ras Association (RalGDS/AF-6) Domain Family Member 1 (RASSF1) Protein Überblick

Protein Überblick

This gene encodes a protein similar to the RAS effector proteins. Loss or altered expression of this gene has been associated with the pathogenesis of a variety of cancers, which suggests the tumor suppressor function of this gene. The inactivation of this gene was found to be correlated with the hypermethylation of its CpG-island promoter region. The encoded protein was found to interact with DNA repair protein XPA. The protein was also shown to inhibit the accumulation of cyclin D1, and thus induce cell cycle arrest. Several alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported.

Genbezeichner und Symbole assoziert mit RASSF1

  • NPR2-like, GATOR1 complex subunit (NPRL2)
  • Ras association (RalGDS/AF-6) domain family 1 (rassf1)
  • Ras association domain family member 1 (RASSF1)
  • putative rassf1 (Smp_157340)
  • Ras association domain family member 1 L homeolog (rassf1.L)
  • Ras association (RalGDS/AF-6) domain family member 1 (Rassf1)
  • Ras association domain family member 1 (Rassf1)
  • 123F2 Protein
  • AA536941 Protein
  • AU044980 Protein
  • NORE2A Protein
  • RASSF1 Protein
  • Rassf1A Protein
  • Rassf1B Protein
  • Rassf1C Protein
  • RDA32 Protein
  • REH3P21 Protein
  • wu:fc17f02 Protein
  • zgc:92505 Protein
  • zgc:112224 Protein

Bezeichner auf Proteinebene für RASSF1

Ras association (RalGDS/AF-6) domain family 1 , Ras association (RalGDS/AF-6) domain family member 1 , ras association domain-containing protein 1 , Ras association domain family 1 , rassf1 , WUGSC:H_LUCA12.5 , cardiac-specific ras association domain family 1 protein , pancreas-specific ras association domain family 1 protein , tumor suppressor protein RDA32 , 123F protein , RASSF1A tumor suppressor , protein 123F2

GENE ID SPEZIES
425132 Gallus gallus
447811 Danio rerio
702385 Macaca mulatta
744944 Pan troglodytes
8344706 Schistosoma mansoni
100036863 Xenopus laevis
100302080 Ovis aries
11186 Homo sapiens
56289 Mus musculus
363140 Rattus norvegicus
607929 Canis lupus familiaris
510276 Bos taurus
Ausgewählte Anbieter für Ras Association (RalGDS/AF-6) Domain Family Member 1 Proteine (RASSF1)
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