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RASSF1 encodes a protein similar to the RAS effector proteins. Zusätzlich bieten wir Ihnen Ras Association (RalGDS/AF-6) Domain Family Member 1 Antikörper (158) und Ras Association (RalGDS/AF-6) Domain Family Member 1 Kits (7) und viele weitere Produktgruppen zu diesem Protein an.
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No significant differences were presented in DNA methylation (zeige HELLS Proteine) levels of RASSF1A and ATM (zeige ATM Proteine) between the sporadic breast cancer cases and the healthy controls.
High Promoter Methylation of RASSF1A gene is associated with Breast Cancer.
Hypermethylation of RASSF1 gene is associated with neuroendocrine tumors.
RACK1 (zeige GNB2L1 Proteine) associates with MOAP-1 (zeige MOAP1 Proteine) via electrostatic associations similar to those observed between MOAP-1 (zeige MOAP1 Proteine)/RASSF1A and MOAP-1 (zeige MOAP1 Proteine)/TNF-R1 (zeige TNFRSF1A Proteine). These events illustrate the complex nature of MOAP-1 (zeige MOAP1 Proteine) regulation and characterizes the important role of the scaffolding protein, RACK1 (zeige GNB2L1 Proteine), in influencing MOAP-1 (zeige MOAP1 Proteine) biology.
The present work proved that there was a higher frequency of RASSF1A methylation and a decrease in its serum level in patients with ovarian cancer compared to controls as well as in the high-grade tumor patients compared to low grade ones and also in advanced ovarian tumor stage compared to early stages.
Promoter methylation of RASSF1A can influence sensitivity to oxaliplatin-based chemotherapy, which can be used to predict outcomes for patients with stage II and III Colorectal Cancer
The meta-analysis indicates a role of the RASSF1A promoter hypermethylation from peripheral blood in testicular germ cell tumors.
RASSF1A is a tumour suppressor gene epigenetically dysregulated in NET. Aberrant methylation of RASSF1A has been reported in various tumours, but this is the first report of RASSF1A hypermethylation in TETs.
Study shows that recombinant human bone morphogenetic protein-2 (zeige BMP2 Proteine) activates hippo signaling through RASSF1 in esophageal cancer cells
There were significant associations between RASSF1A promoter hypermethylation and Oral Cancer risk.RASSF1A promoter hypermethylation exerted higher frequency in the Tongue Tumor than other site tumor in mouth.
RASSF1A is expressed in differentiating stem cells.RASSF1A promotes YAP (zeige YAP1 Proteine) and p73 (zeige ARHGAP24 Proteine) binding to differentiation related genes.RASSF1A uncouples Wnt (zeige WNT2 Proteine) from Hippo signalling and promotes YAP (zeige YAP1 Proteine) mediated differentiation via p73 (zeige ARHGAP24 Proteine).
beta-catenin (zeige CTNNB1 Proteine) was predominantly associated with Na+/H+ exchanger regulating factor 1 (NHERF1 (zeige SLC9A3R2 Proteine)) in a dynamic context and an increase of its oncogenic function through RAS-association domain family 1, isoform A (RASSF1A) inactivation in liver metastases.
essential role of RASSF1A in regulating TNF-alpha (zeige TNF Proteine) signalling in cardiomyocytes, with RASSF1A being key in the formation of the TNFR (zeige TNFRSF1A Proteine) complex and in signal transmission to the downstream targets
RASSF1A may function to interfere and restrict TLR-driven activation of NF-kappaB (zeige NFKB1 Proteine) and is essential for protection against inflammation-induced injury.
nickel-smelting fumes upregulated the expression of RASSF1A. This suggest that nickel-smelting fumes could be toxic to cells, inducing cell apoptosis and necrosis.
Loss of RASSF1A synergizes with deregulated RUNX2 (zeige RUNX2 Proteine) signaling in tumorigenesis.
Concomitant with the loss of Rassf1a, the loss of p53 (zeige TP53 Proteine) (which causes unrestrained propagation of tetraploids into aneuploid cells) further undermines genomic stability and accelerates tumorigenesis.
Data show that methylation of CCND-2 (zeige CCND2 Proteine), p16, RAR-beta (zeige RARB Proteine) and RASSF-1a was significantly more prevalent in tumor than in normal tissue specimens.
Rassf1A acts as a tumor suppressor gene.
cooperation between inactivation of Rassf1a and Apc (zeige APC Proteine) resulting in accelerated intestinal tumourigenesis.
This gene encodes a protein similar to the RAS effector proteins. Loss or altered expression of this gene has been associated with the pathogenesis of a variety of cancers, which suggests the tumor suppressor function of this gene. The inactivation of this gene was found to be correlated with the hypermethylation of its CpG-island promoter region. The encoded protein was found to interact with DNA repair protein XPA. The protein was also shown to inhibit the accumulation of cyclin D1, and thus induce cell cycle arrest. Several alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported.
Ras association (RalGDS/AF-6) domain family 1
, Ras association (RalGDS/AF-6) domain family member 1
, ras association domain-containing protein 1
, Ras association domain family 1
, cardiac-specific ras association domain family 1 protein
, pancreas-specific ras association domain family 1 protein
, tumor suppressor protein RDA32
, 123F protein
, RASSF1A tumor suppressor
, protein 123F2