Ras Association (RalGDS/AF-6) Domain Family Member 1 Proteine (RASSF1)

RASSF1 encodes a protein similar to the RAS effector proteins. Zusätzlich bieten wir Ihnen Ras Association (RalGDS/AF-6) Domain Family Member 1 Antikörper (150) und Ras Association (RalGDS/AF-6) Domain Family Member 1 Kits (7) und viele weitere Produktgruppen zu diesem Protein an.

alle Proteine anzeigen Gen GeneID UniProt
RASSF1 11186 Q9NS23
RASSF1 56289 Q99MK9
Ratte RASSF1 RASSF1 363140  
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Katalog Nr. Origin Quelle Konjugat Bilder Menge Anbieter Lieferzeit Preis Details
Insektenzellen Maus His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 50 Days
Insektenzellen Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 50 Days
Wheat germ Human GST tag 10 μg Anmelden zum Anzeigen 11 bis 12 Tage
Escherichia coli (E. coli) Human His tag 100 μg Anmelden zum Anzeigen 15 bis 19 Tage

RASSF1 Proteine nach Spezies und Herkunft

Origin Exprimiert in Konjugat
Human , ,
Mouse (Murine)

Weitere Proteine zu Ras Association (RalGDS/AF-6) Domain Family Member 1 (RASSF1) Interaktionspartnern

Human Ras Association (RalGDS/AF-6) Domain Family Member 1 (RASSF1) Interaktionspartner

  1. Study found reduced expression of RASSF1A with significant hypermethylation of its promoter region and its inactivation through epigenetic regulation may be important factor in tumorigenesis in substantial proportion of parathyroid adenomas.

  2. Tissues from patients with serous and non-serous EOC showed significantly higher promoter methylation of EGFL7 and RASSF1 compared to benign cases.

  3. Transcriptome assay unclosed that RASSF1A promoted IL-6 expression in A375 cells, which in turn activate JAK2/STAT3 signaling.

  4. Rassf1a rs2236947 is a promising biomarker for patients treated with cetuximab plus chemotherapy.

  5. Low RASSF1A expression is associated with gastric cancer.

  6. methylation of BRCA1, RASSF1A and GSTP1 was found in 58.23 %, 74.68 % and 59.49 % of tumor tissues and 51.90 %, 63.29 % and 35.44 % of corresponding adjacent tissues, respectively

  7. Our study established that RASSF1A hypermethylation might have a potential value in the clinical diagnosis of colorectal cancer

  8. Effect of decitabine pretreatment on sensitivity of bladder cancer cells towards chemotherapeutic drugs was also studied. Decitabine treatment leads to restoration of RASSF1A, activation of hippo pathway followed by decreased expression of its oncogenic downstream targets (CTGF & CYR61).

  9. the use of RASSF1A promoter methylation could distinguish ovarian cancer and low malignant potential tumors. -RASSF1A promoter methylation may not be correlated with the clinical features and the survival of ovarian cancer patients.

  10. the methylation positive rates of SHOX2 with RASSF1A in stage III were both higher than the other stages of lung cancer

  11. Tested if RASSF1A polymorphisms associated with ovarian cancer and with tumor grade and stage. Five tagging single nucleotide polymorphisms (SNPs) (rs4688728G>T, rs72932987C>T, rs1989839C>T, rs2073497A>C, and rs2236947A>C) were evaluated. The CT genotype of rs1989839 was associated with the patients with ovarian cancer (P=0.001), and was significantly correlated with tumor grade and stage (P=0.008).

  12. No significant differences were presented in DNA methylation levels of RASSF1A and ATM between the sporadic breast cancer cases and the healthy controls.

  13. High Promoter Methylation of RASSF1A gene is associated with Breast Cancer.

  14. Hypermethylation of RASSF1 gene is associated with neuroendocrine tumors.

  15. RACK1 associates with MOAP-1 via electrostatic associations similar to those observed between MOAP-1/RASSF1A and MOAP-1/TNF-R1. These events illustrate the complex nature of MOAP-1 regulation and characterizes the important role of the scaffolding protein, RACK1, in influencing MOAP-1 biology.

  16. The present work proved that there was a higher frequency of RASSF1A methylation and a decrease in its serum level in patients with ovarian cancer compared to controls as well as in the high-grade tumor patients compared to low grade ones and also in advanced ovarian tumor stage compared to early stages.

  17. Promoter methylation of RASSF1A can influence sensitivity to oxaliplatin-based chemotherapy, which can be used to predict outcomes for patients with stage II and III Colorectal Cancer

  18. The meta-analysis indicates a role of the RASSF1A promoter hypermethylation from peripheral blood in testicular germ cell tumors.

  19. RASSF1A is a tumour suppressor gene epigenetically dysregulated in NET. Aberrant methylation of RASSF1A has been reported in various tumours, but this is the first report of RASSF1A hypermethylation in TETs.

  20. Study shows that recombinant human bone morphogenetic protein-2 activates hippo signaling through RASSF1 in esophageal cancer cells

Mouse (Murine) Ras Association (RalGDS/AF-6) Domain Family Member 1 (RASSF1) Interaktionspartner

  1. RASSF1A is expressed in differentiating stem cells.RASSF1A promotes YAP and p73 binding to differentiation related genes.RASSF1A uncouples Wnt from Hippo signalling and promotes YAP mediated differentiation via p73.

  2. beta-catenin was predominantly associated with Na+/H+ exchanger regulating factor 1 (NHERF1) in a dynamic context and an increase of its oncogenic function through RAS-association domain family 1, isoform A (RASSF1A) inactivation in liver metastases.

  3. essential role of RASSF1A in regulating TNF-alpha signalling in cardiomyocytes, with RASSF1A being key in the formation of the TNFR complex and in signal transmission to the downstream targets

  4. RASSF1A may function to interfere and restrict TLR-driven activation of NF-kappaB and is essential for protection against inflammation-induced injury.

  5. nickel-smelting fumes upregulated the expression of RASSF1A. This suggest that nickel-smelting fumes could be toxic to cells, inducing cell apoptosis and necrosis.

  6. Loss of RASSF1A synergizes with deregulated RUNX2 signaling in tumorigenesis.

  7. Concomitant with the loss of Rassf1a, the loss of p53 (which causes unrestrained propagation of tetraploids into aneuploid cells) further undermines genomic stability and accelerates tumorigenesis.

  8. Data show that methylation of CCND-2, p16, RAR-beta and RASSF-1a was significantly more prevalent in tumor than in normal tissue specimens.

  9. Deletion of this gene increases cancer susceptibility in mice.

  10. Rassf1A acts as a tumor suppressor gene.

  11. cooperation between inactivation of Rassf1a and Apc resulting in accelerated intestinal tumourigenesis.

  12. RASSF1A mediates p21Cip1/Waf1-dependent cell cycle arrest and senescence through modulation of the Raf-MEK-ERK pathway and inhibition of Akt.

  13. data establish RASSF1A as a novel inhibitor of cardiac hypertrophy by modulating the extracellular regulated kinase 1/2 pathway.

Ras Association (RalGDS/AF-6) Domain Family Member 1 (RASSF1) Protein Überblick

Protein Überblick

This gene encodes a protein similar to the RAS effector proteins. Loss or altered expression of this gene has been associated with the pathogenesis of a variety of cancers, which suggests the tumor suppressor function of this gene. The inactivation of this gene was found to be correlated with the hypermethylation of its CpG-island promoter region. The encoded protein was found to interact with DNA repair protein XPA. The protein was also shown to inhibit the accumulation of cyclin D1, and thus induce cell cycle arrest. Several alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported.

Genbezeichner und Symbole assoziert mit RASSF1

  • NPR2-like, GATOR1 complex subunit (NPRL2)
  • Ras association (RalGDS/AF-6) domain family 1 (rassf1)
  • Ras association domain family member 1 (RASSF1)
  • putative rassf1 (Smp_157340)
  • Ras association domain family member 1 L homeolog (rassf1.L)
  • Ras association (RalGDS/AF-6) domain family member 1 (Rassf1)
  • Ras association domain family member 1 (Rassf1)
  • 123F2 Protein
  • AA536941 Protein
  • AU044980 Protein
  • NORE2A Protein
  • RASSF1 Protein
  • Rassf1A Protein
  • Rassf1B Protein
  • Rassf1C Protein
  • RDA32 Protein
  • REH3P21 Protein
  • wu:fc17f02 Protein
  • zgc:92505 Protein
  • zgc:112224 Protein

Bezeichner auf Proteinebene für RASSF1

Ras association (RalGDS/AF-6) domain family 1 , Ras association (RalGDS/AF-6) domain family member 1 , ras association domain-containing protein 1 , Ras association domain family 1 , rassf1 , WUGSC:H_LUCA12.5 , cardiac-specific ras association domain family 1 protein , pancreas-specific ras association domain family 1 protein , tumor suppressor protein RDA32 , 123F protein , RASSF1A tumor suppressor , protein 123F2

425132 Gallus gallus
447811 Danio rerio
702385 Macaca mulatta
744944 Pan troglodytes
8344706 Schistosoma mansoni
100036863 Xenopus laevis
100302080 Ovis aries
11186 Homo sapiens
56289 Mus musculus
363140 Rattus norvegicus
607929 Canis lupus familiaris
510276 Bos taurus
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