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RSPO3 encodes a member of the thrombospondin type 1 repeat supergene family. Zusätzlich bieten wir Ihnen R-Spondin 3 Antikörper (49) und R-Spondin 3 Kits (11) und viele weitere Produktgruppen zu diesem Protein an.
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Knockdown of RSPO3 resulted in significantly increased mRNA expression levels of RUNX2, ALP and OCN and no effects on the proliferation of human adipose-derived stem cells.
For liver transplant-free survival, a genome-wide significant signal was identified and expression of the candidate gene RSPO3 was demonstrated in key liver-resident effector cells and may play a role in primary sclerosing cholangitis disease progression.
The present study identified RSPO fusion transcripts, including three novel transcripts, in one-third of colorectal Traditional serrated adenoma (TSA) and showed that PTPRK-RSPO3 fusions were the predominant cause of RSPO overexpression in colorectal TSA.
RSPOs facilitate HSC activation and promote liver fibrogenesis by enhancing the Wnt pathway
Colorectal cancer cell lines identified VACO6 cells as a carrier of a canonical PTPRK(e1)-RSPO3(e2) fusion; cell line displayed marked in vitro and in vivo sensitivity to WNT blockade by the porcupine inhibitor LGK974. Long-term treatment of VACO6 cells with LGK974 led to the emergence of a resistant population carrying two frameshift deletions of the WNT pathway inhibitor AXIN1, with consequent protein loss.
PTPRK-RSPO3 fusions and RNF43 mutations were found to be characteristic genetic features of traditional serrated adenomas (TSAs).
Using C-mannosylation-defective Rspo3 mutant-overexpressing cell lines, we found that C-mannosylation of Rspo3 promotes its secretion and activates Wnt/beta-catenin signaling.
High RSPO3 expression is associated with breast cancer.
A genome-wide association study of bone mineral density (BMD) found a new BMD locus that harbors the PTCH1 gene, that associates with reduced spine BMD and the RSPO3 associates with increased spine BMD.
results suggest that the expression of RSPO fusion transcripts is related to a subset of colorectal cancers arising in the Japanese population
These findings suggest that aberrant RSPO3-LGR4 signaling potentially acts as a driving mechanism in the aggressiveness of Keap1-deficient lung ADs.
using RNA-seq data, identification of multiple fusion transcripts including recurrent gene fusions involving R-spondin family members RSPO2 and RSPO3 that together occur in 10% of colon tumours
the gene is a novel member of thrombospondin type I repeat supergene family (hPWTSR)
a polymorphism in thrombospondin subtly but significantly sensitizes the calcium-binding repeats to removal of Ca2+ and thermal denaturation
This gene encodes a member of the thrombospondin type 1 repeat supergene family. In addition, the protein contains a furin-like cysteine-rich region. Furin-like repeat domains have been found in a variety of eukaryotic proteins involved in the mechanism of signal transduction by receptor tyrosine kinases.
, R-spondin 3 homolog
, protein with TSP type-1 repeat
, roof plate-specific spondin-3
, thrombospondin type-1 domain-containing protein 2
, thrombospondin, type I, domain containing 2
, R-spondin 3-like protein
, cristin 1
, cysteine-rich and single thrombospondin domain-containing protein 1
, thrombospondin, type I, domain 2