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RSPO3 encodes a member of the thrombospondin type 1 repeat supergene family. Zusätzlich bieten wir Ihnen R-Spondin 3 Antikörper (50) und R-Spondin 3 Kits (11) und viele weitere Produktgruppen zu diesem Protein an.
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For liver transplant-free survival, a genome-wide significant signal was identified and expression of the candidate gene RSPO3 was demonstrated in key liver-resident effector cells and may play a role in primary sclerosing cholangitis disease progression.
The present study identified RSPO (zeige RSPO1 Proteine) fusion transcripts, including three novel transcripts, in one-third of colorectal Traditional serrated adenoma (TSA (zeige PRDX2 Proteine)) and showed that PTPRK (zeige PTPRK Proteine)-RSPO3 fusions were the predominant cause of RSPO (zeige RSPO1 Proteine) overexpression in colorectal TSA (zeige PRDX2 Proteine).
RSPOs facilitate HSC (zeige FUT1 Proteine) activation and promote liver fibrogenesis by enhancing the Wnt (zeige WNT2 Proteine) pathway
Colorectal cancer cell lines identified VACO6 cells as a carrier of a canonical PTPRK (zeige PTPRK Proteine)(e1)-RSPO3(e2) fusion; cell line displayed marked in vitro and in vivo sensitivity to WNT (zeige WNT2 Proteine) blockade by the porcupine (zeige PORCN Proteine) inhibitor LGK974. Long-term treatment of VACO6 cells with LGK974 led to the emergence of a resistant population carrying two frameshift deletions of the WNT (zeige WNT2 Proteine) pathway inhibitor AXIN1 (zeige AXIN1 Proteine), with consequent protein loss.
PTPRK (zeige PTPRK Proteine)-RSPO3 fusions and RNF43 (zeige RNF43 Proteine) mutations were found to be characteristic genetic features of traditional serrated adenomas (TSAs).
Using C-mannosylation-defective Rspo3 mutant-overexpressing cell lines, we found that C-mannosylation of Rspo3 promotes its secretion and activates Wnt (zeige WNT2 Proteine)/beta-catenin (zeige CTNNB1 Proteine) signaling.
High RSPO3 expression is associated with breast cancer.
A genome-wide association study of bone mineral density (BMD (zeige BEST1 Proteine)) found a new BMD (zeige BEST1 Proteine) locus that harbors the PTCH1 (zeige PTCH1 Proteine) gene, that associates with reduced spine BMD (zeige BEST1 Proteine) and the RSPO3 associates with increased spine BMD (zeige BEST1 Proteine).
results suggest that the expression of RSPO (zeige RSPO1 Proteine) fusion transcripts is related to a subset of colorectal cancers arising in the Japanese population
These findings suggest that aberrant RSPO3-LGR4 (zeige LGR4 Proteine) signaling potentially acts as a driving mechanism in the aggressiveness of Keap1 (zeige KEAP1 Proteine)-deficient lung ADs (zeige AGPS Proteine).
These results shed new light on the role of Rspo3 in heart development and demonstrate that LGR4 (zeige LGR4 Proteine) is the principal R-spondin 3 receptor in the heart.
Results identify a mechanism through which localized expression of RSPO3 induces proliferation of the coronary arteries at their stems and permits their formation.
Rspo3-LGR4 (zeige LGR4 Proteine) axis protects hepatocytes from hypoxia/reoxygenation injury via activating beta-catenin (zeige CTNNB1 Proteine).
H. pylori infection increases stromal R-spondin 3 expression and expands the Axin2 (zeige AXIN2 Proteine)(+) cell pool to cause hyperproliferation and gland hyperplasia; the ability of stromal niche cells to control and adapt epithelial stem cell dynamics constitutes a sophisticated mechanism that orchestrates epithelial regeneration and maintenance of tissue integrity
We provide in vivo evidence that RSPO3 stimulates the crypt stem cell and niche compartments and drives rapid intestinal tumorigenesis.
Rspo3 function remains essential in adult life to ensure replenishment of lost cells and maintain the properties of the zona glomerulosa
Conditional deletion of Rspo3 in mice disrupts activation of central fate, demonstrating its crucial role in determining and maintaining beta-catenin (zeige CTNNB1 Proteine)-dependent zonation.
data identify endothelial RSPO3-driven non-canonical WNT (zeige WNT2 Proteine)/Ca(2 (zeige CA2 Proteine)+)/NFAT (zeige NFATC1 Proteine) signaling as a critical maintenance pathway of the remodeling vasculature
Nkx2-5 (zeige NKX2-5 Proteine) has a role in regulating cardiac growth through modulation of Wnt (zeige WNT2 Proteine) signaling by R-spondin3
Rspo3 loss of function mutation in combination with Rspo2 (zeige RSPO2 Proteine) mutation,but not on its own, causes severe limb truncation.
This gene encodes a member of the thrombospondin type 1 repeat supergene family. In addition, the protein contains a furin-like cysteine-rich region. Furin-like repeat domains have been found in a variety of eukaryotic proteins involved in the mechanism of signal transduction by receptor tyrosine kinases.
, R-spondin 3 homolog
, protein with TSP type-1 repeat
, roof plate-specific spondin-3
, thrombospondin type-1 domain-containing protein 2
, thrombospondin, type I, domain containing 2
, R-spondin 3-like protein
, cristin 1
, cysteine-rich and single thrombospondin domain-containing protein 1
, thrombospondin, type I, domain 2