anti-Protein Kinase N1 (PKN1) Antikörper

The protein encoded by PKN1 belongs to the protein kinase C superfamily. Zusätzlich bieten wir Ihnen PKN1 Kits (28) und PKN1 Proteine (11) und viele weitere Produktgruppen zu diesem Protein an.

Alle Antikörper anzeigen Gen GeneID UniProt
PKN1 5585 Q16512
PKN1 320795 P70268
PKN1 29355 Q63433
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Top anti-PKN1 Antikörper auf antikoerper-online.de

Showing 10 out of 38 products:

Katalog Nr. Reaktivität Wirt Konjugat Applikation Bilder Menge Anbieter Lieferzeit Preis Details
Rind (Kuh) Kaninchen Unkonjugiert WB 100 μL Anmelden zum Anzeigen 2 bis 3 Tage
$289.00
Details
Hund Maus Unkonjugiert IF, IP, WB Western blot analysis of PRK1 on Jurkat lysate. Lane 1: 1:1000, lane 2: 1:2000, lane 3: 1:4000 dilution of PRK1. MCF7 cells (ATCC HTB-22) 150 μg Anmelden zum Anzeigen 6 bis 8 Tage
$305.54
Details
Hund Maus Unkonjugiert IF, IP, IHC, WB Western blot analysis of PRK1 on Jurkat lysate. Lane 1: 1:1000, lane 2: 1:2000, lane 3: 1:4000 dilution of PRK1. MCF7 50 μg Anmelden zum Anzeigen 6 bis 8 Tage
$168.74
Details
Human Kaninchen Unkonjugiert ELISA, WB   100 μL Anmelden zum Anzeigen 16 Days
$181.73
Details
Rind (Kuh) Kaninchen Unkonjugiert IC, IF, WB Immunofluorescent analysis of PKN1 staining in HepG2 cells. Formalin-fixed cells were permeabilized with 0.1% Triton X-100 in TBS for 5-10 minutes and blocked with 3% BSA-PBS for 30 minutes at room temperature. Cells were probed with the primary antibody in 3% BSA-PBS and incubated overnight at 4 °C in a humidified chamber. Cells were washed with PBST and incubated with a DyLight 594-conjugated secondary antibody (red) in PBS at room temperature in the dark. DAPI was used to stain the cell nuclei (blue). Western blot analysis of PKN1 expression in HEK293T (A), HepG2 (B), SP2/0 (C), NIH3T3 (D) whole cell lysates. 200 μL Anmelden zum Anzeigen 13 bis 14 Tage
$487.50
Details
Hund Kaninchen Unkonjugiert WB   200 μg Anmelden zum Anzeigen 7 bis 9 Tage
$837.83
Details
Human Kaninchen Unkonjugiert IHC, WB Western blot analysis of extracts of various cells, using PKN1 antibody. Immunohistochemistry of paraffin-embedded mouse brain using PKN1 antibody at dilution of 1:100 (x40 lens). 100 μL Anmelden zum Anzeigen 16 Days
$334.02
Details
Human Maus Unkonjugiert ELISA, FACS, ICC, IHC, WB   100 μL Anmelden zum Anzeigen 8 bis 11 Tage
$550.00
Details
Hund Kaninchen Unkonjugiert IHC (fro), IHC (p), IP, WB   50 μL Anmelden zum Anzeigen 7 bis 9 Tage
$507.83
Details
Human Kaninchen Unkonjugiert WB   100 μL Anmelden zum Anzeigen 7 bis 9 Tage
$837.83
Details

PKN1 Antikörper nach Reaktivität, Anwendung, Klonalität and Konjugat

Attribute Applikationen Wirt Klonalität Konjugat
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Am meisten referenzierte anti-PKN1 Antikörper

  1. Dog (Canine) Monoclonal PKN1 Primary Antibody für IF, IP - ABIN968111 : Flynn, Mellor, Casamassima, Parker: Rho GTPase control of protein kinase C-related protein kinase activation by 3-phosphoinositide-dependent protein kinase. in The Journal of biological chemistry 2000 (PubMed)
    Show all 4 Pubmed References

  2. Dog (Canine) Monoclonal PKN1 Primary Antibody für IF, IP - ABIN968110 : Hughes, Larijani, Parker: Detecting protein-phospholipid interactions. Epidermal growth factor-induced activation of phospholipase D1b in situ. in The Journal of biological chemistry 2002 (PubMed)
    Show all 4 Pubmed References

Weitere Antikörper gegen PKN1 Interaktionspartner

Human Protein Kinase N1 (PKN1) Interaktionspartner

  1. Steady-state kinetic analysis revealed that PKN1-3 follows a sequential ordered Bi-Bi (zeige CACNA1A Antikörper) kinetic mechanism, where peptide substrate binding is preceded by ATP binding. This kinetic mechanism was confirmed by additional kinetic studies for product inhibition and affinity of small molecule inhibitors.

  2. Pkn1 is not required for tumorigenesis initiated by loss of Pten. Triple knockout of Pten, Pkn1, and Pkn2 (zeige PKN2 Antikörper) in mouse prostate results in squamous cell carcinoma, an uncommon but therapy-resistant form of prostate cancer.

  3. PKN1 activity was up-regulated by the active RhoA (zeige RHOA Antikörper) mutant (G14V) and suppressed by RhoA (zeige RHOA Antikörper) T19N. PKN1 siRNA interrupted the ability of RhoA (zeige RHOA Antikörper) to promote ESC proliferation and DNA synthesis. The effect of RhoA (zeige RHOA Antikörper) on ESC proliferation is mediated by activation of the PKN1-cyclin D1 (zeige CCND1 Antikörper) pathway in vitro.

  4. TXA2 (zeige TBXA2R Antikörper)-mediated neoplastic responses in prostate adenocarcinoma PC-3 (zeige PCSK1 Antikörper) cells occur through a PRK1/PRK2 (zeige PKN2 Antikörper)-dependent mechanism.

  5. Transcriptome and interactome analyses uncover that PRK1 regulates expression of migration-relevant genes by interacting with the scaffold protein (zeige HOMER1 Antikörper) sperm-associated antigen 9 (SPAG9/JIP4 (zeige SPAG9 Antikörper)).

  6. Data indicate that Salmonella SspH1 catalyzes the ubiquitination and proteasome-dependent degradation of PKN1 in cells.

  7. Protein kinase N1 inhibits Wnt/b-catenin signaling and apoptosis in melanoma cells.

  8. Protein kinase N1 is a novel substrate of NFATc1 (zeige NFATC1 Antikörper)-mediated cyclin D1 (zeige CCND1 Antikörper)-CDK6 (zeige CDK6 Antikörper) activity and modulates vascular smooth muscle cell division and migration leading to inward blood vessel wall remodeling.

  9. PKN isoforms are not simply redundant in supporting migration, but appear to be linked through isoform specific regulatory domain properties to selective upstream signals. It

  10. Data show that just one contact site as being relevant for binding of RhoA (zeige RHOA Antikörper) and domain from PRK1, and the HR1b domain was found not to contribute to RhoA (zeige RHOA Antikörper) binding.

Mouse (Murine) Protein Kinase N1 (PKN1) Interaktionspartner

  1. Pkn1 is not required for tumorigenesis initiated by loss of Pten. Triple knockout of Pten, Pkn1, and Pkn2 (zeige PKN2 Antikörper) in mouse prostate results in squamous cell carcinoma, an uncommon but therapy-resistant form of prostate cancer.

  2. Mechanistically, Yersinia pseudotuberculosis YopM recruits and activates the mouse host kinases PRK1 and PRK2 (zeige PKN2 Antikörper) to negatively regulate pyrin (zeige MEFV Antikörper) by phosphorylation.

  3. Protein kinase N1, a cell inhibitor of Akt (zeige AKT1 Antikörper) kinase, has a central role in quality control of germinal center formation

  4. PKN is activated by ischemia/reperfusion and inhibits apoptosis of cardiac myocytes, thereby protecting the heart from I/R injury.

  5. Leishmania mexicana infectivity is associated with differential expression of protein kinase C (zeige PKC Antikörper)-like triggered during a cell-cell contact

  6. Pkn1 is involved in ganglioside signals that regulate TNF-alpha (zeige TNF Antikörper) signaling and synthesis.

Fruit Fly (Drosophila melanogaster) Protein Kinase N1 (PKN1) Interaktionspartner

  1. polarity-induced spatiotemporal control of Rok (zeige ROCK1 Antikörper) and Pkn is important for unequal cortical expansion, ensuring correct cleavage furrow positioning and the establishment of physical asymmetry.

  2. The delorean phenotype, with its associated defects in wing morphology, provides evidence of a role for PKN in adult morphogenetic processes.

  3. Drosophila protein kinase N is a negative regulator of actin-myosin activity during oogenesis.

  4. identified a requirement for Pkn in wing morphogenesis, thereby revealing the first postembryonic function for Pkn

PKN1 Antigen-Profil

Protein Überblick

The protein encoded by this gene belongs to the protein kinase C superfamily. This kinase is activated by Rho family of small G proteins and may mediate the Rho-dependent signaling pathway. This kinase can be activated by phospholipids and by limited proteolysis. The 3-phosphoinositide dependent protein kinase-1 (PDPK1/PDK1) is reported to phosphorylate this kinase, which may mediate insulin signals to the actin cytoskeleton. The proteolytic activation of this kinase by caspase-3 or related proteases during apoptosis suggests its role in signal transduction related to apoptosis. Alternatively spliced transcript variants encoding distinct isoforms have been observed.

Genbezeichner und Symbole assoziert mit PKN1

  • protein kinase N1 (PKN1) Antikörper
  • protein kinase N1 (Pkn1) Antikörper
  • protein kinase N1b (pkn1b) Antikörper
  • protein kinase N1 (pkn1) Antikörper
  • Protein kinase N (Pkn) Antikörper
  • 3-2 Antikörper
  • CG2049 Antikörper
  • CG2055 Antikörper
  • CT6637 Antikörper
  • CT6660 Antikörper
  • DBK Antikörper
  • Dmel\\CG2049 Antikörper
  • dPKN Antikörper
  • F730027O18Rik Antikörper
  • l(2)06736 Antikörper
  • l(2)45Ca Antikörper
  • PAK-1 Antikörper
  • PAK1 Antikörper
  • Pk45C Antikörper
  • Pk?3 Antikörper
  • Pkn Antikörper
  • PKN-ALPHA Antikörper
  • PKN1 Antikörper
  • PRK1 Antikörper
  • PRK2 Antikörper
  • Prkcl1 Antikörper
  • Stk3 Antikörper
  • v(2)rG232 Antikörper

Bezeichner auf Proteinebene für PKN1

protease-activated kinase 1 , protein kinase C-like 1 , protein kinase C-like PKN , protein kinase C-related kinase 1 , protein kinase PKN-alpha , protein-kinase C-related kinase 1 , serine-threonine kinase N , serine-threonine protein kinase N , serine/threonine protein kinase N , serine/threonine-protein kinase N1 , serine/threonine kinase 3 , protein kinase N1 , serine/threonine-protein kinase N1-like , protein kinase PKN , CG2049-PB , CG2049-PC , CG2049-PD , CG2049-PE , CG2049-PF , CG2049-PG , CG2049-PH , CG2049-PI , CG2049-PJ , CG2049-PK , CG2049-PL , CG2049-PM , Pkn-PB , Pkn-PC , Pkn-PD , Pkn-PE , Pkn-PF , Pkn-PG , Pkn-PH , Pkn-PI , Pkn-PJ , Pkn-PK , Pkn-PL , Pkn-PM , protein kinase N , protein kinase c related , protein kinase related to protein kinase N , protein kinase-like 45C

GENE ID SPEZIES
5585 Homo sapiens
320795 Mus musculus
455785 Pan troglodytes
509080 Bos taurus
100007897 Danio rerio
100379847 Xenopus (Silurana) tropicalis
100401855 Callithrix jacchus
29355 Rattus norvegicus
35950 Drosophila melanogaster
100713234 Cavia porcellus
101118101 Ovis aries
100856398 Canis lupus familiaris
100515528 Sus scrofa
Ausgewählte Anbieter für anti-PKN1 (PKN1) Antikörper
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