Protease, serine, 8 Proteine (PRSS8)

PRSS8 encodes a trypsinogen, which is a member of the trypsin family of serine proteases. Zusätzlich bieten wir Ihnen Protease, serine, 8 Antikörper (101) und Protease, serine, 8 Kits (40) und viele weitere Produktgruppen zu diesem Protein an.

alle Proteine anzeigen Gen GeneID UniProt
PRSS8 5652 Q16651
PRSS8 192107 Q9ES87
PRSS8 76560  
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Top Protease, serine, 8 Proteine auf antikoerper-online.de

Showing 8 out of 11 products:

Katalog Nr. Origin Quelle Konjugat Bilder Menge Anbieter Lieferzeit Preis Details
Human Cells Human His tag 10 μg Anmelden zum Anzeigen 14 bis 16 Tage
$250.80
Details
Insektenzellen Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Anmelden zum Anzeigen 50 bis 55 Tage
$7,626.01
Details
Insektenzellen Maus rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Anmelden zum Anzeigen 50 bis 55 Tage
$5,355.45
Details
Baculovirus infected Insect Cells Maus His tag 10 μg Anmelden zum Anzeigen 20 bis 21 Tage
$250.80
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Escherichia coli (E. coli) Human His tag 100 μg Anmelden zum Anzeigen 15 bis 18 Tage
$669.00
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Escherichia coli (E. coli) Ratte His tag,GST tag 100 μg Anmelden zum Anzeigen 15 bis 18 Tage
$717.00
Details
Escherichia coli (E. coli) Maus His tag,GST tag 100 μg Anmelden zum Anzeigen 15 bis 18 Tage
$685.00
Details
Wheat germ Human GST tag 10 μg Anmelden zum Anzeigen 11 bis 12 Tage
$414.29
Details

PRSS8 Proteine nach Spezies und Herkunft

Origin Exprimiert in Konjugat
Human , , ,
, ,
Rat (Rattus)

Mouse (Murine) , ,
, ,

Am meisten referenzierte Protease, serine, 8 Proteine

  1. Human PRSS8 Protein expressed in Wheat germ - ABIN1316486 : Svenningsen, Uhrenholt, Palarasah, Skjødt, Jensen, Skøtt: Prostasin-dependent activation of epithelial Na+ channels by low plasmin concentrations. in American journal of physiology. Regulatory, integrative and comparative physiology 2009 (PubMed)

Weitere Proteine zu Protease, serine, 8 (PRSS8) Interaktionspartnern

Human Protease, serine, 8 (PRSS8) Interaktionspartner

  1. limited role for HAI-2 (zeige SPINT2 Proteine) in the inhibition of matriptase (zeige ST14 Proteine) and prostasin is the result of its primarily intracellular localization in basal and spinous layer keratinocytes, which probably prevents the Kunitz inhibitor from interacting with active prostasin or matriptase (zeige ST14 Proteine)

  2. PRSS8 was downregulated in glioma tissues.PRSS8 role in the glioma cell proliferation, migration, and invasion.

  3. PRSS8 acts as a tumor suppressor in colorectal cancer

  4. Data show that PRSS8 was reduced in esophageal squamous cell carcinomas (ESCC) tissues and the reduction of PRSS8 was associated with poor differentiation and shorter survival time.

  5. Studies in colonic T84 cell monolayers revealed that barrier disruption by the colitis-associated Th2-type cytokines, IL-4 (zeige IL4 Proteine) and IL-13 (zeige IL13 Proteine), down-regulates matriptase (zeige ST14 Proteine) as well as prostasin through phosphorylation of the transcriptional regulator STAT6 (zeige STAT6 Proteine)

  6. PRSS8 may serve as a tumour suppressor in hepatocellular carcinoma progression.

  7. Overexpression of PRSS8 mRNA and high levels of prostasin in multiple subtypes of early stage ovarian tumors may provide clinical biomarkers for early detection of ovarian cancer.

  8. It is concluded that prostasin protein level change is less likely to be causally involved in placental dysfunction in preeclampsia.

  9. In urinary exosomes, NCC (zeige SLC12A3 Proteine) and prostasin had a diurnal pattern parallel to ADH (zeige AVP Proteine) and aquaporin 2 (zeige AQP2 Proteine), confirming that, in healthy subjects, both prostasin and NCC (zeige SLC12A3 Proteine) relate to water balance.

  10. Polymorphism of the prostasin gene is closely associated with poor pregnancy outcomes of early-onset severe preeclampsia.

Mouse (Murine) Protease, serine, 8 (PRSS8) Interaktionspartner

  1. Studies in colonic T84 cell monolayers revealed that barrier disruption by the colitis-associated Th2-type cytokines, IL-4 (zeige IL4 Proteine) and IL-13 (zeige IL13 Proteine), down-regulates matriptase (zeige ST14 Proteine) as well as prostasin through phosphorylation of the transcriptional regulator STAT6 (zeige STAT6 Proteine)

  2. a proteolysis-dependent function of activated prostasin in hair follicles, dependent on zymogen conversion by matriptase (zeige ST14 Proteine).

  3. The claudin-4 (zeige CLDN4 Proteine)-mediated chloride conductance can be regulated endogenously by a protease-channel-activating protease 1 (cap1).

  4. HAI-1 (zeige SPINT1 Proteine) regulates the activity of activated matriptase (zeige ST14 Proteine), whereas HAI-2 (zeige SPINT2 Proteine) has an essential role in regulating prostasin-dependent matriptase (zeige ST14 Proteine) zymogen activation.

  5. a novel inhibitory interaction between CAP1/Prss8 and nexin-1 (zeige SERPINE2 Proteine), opening the search for specific CAP1/Prss8 antagonists that are independent of its catalytic activity

  6. Data indicate that liver-specific serine protease (zeige F2 Proteine) prostasin (PRSS8) knockout (LKO) mice develop insulin (zeige INS Proteine) resistance associated with the increase in hepatic Toll-like receptor 4 (TLR4 (zeige TLR4 Proteine)).

  7. Data indicate that serine protease (zeige F2 Proteine) prostasin (CAP1/PRSS8) supports terminal epidermal differentiation through a non-catalytic mechanism.

  8. mutations in Prss8 restored placentation and normal development of HAI-1 (zeige SPINT1 Proteine)-deficient embryos and prevented early embryonic lethality, mid-gestation lethality due to placental labyrinth failure, and neural tube defects in HAI-2 (zeige SPINT2 Proteine)-deficient embryos.

  9. Mutations of the serine protease (zeige F2 Proteine) CAP1/Prss8 lead to reduced embryonic viability, skin defects, and decreased ENaC (zeige SCNN1A Proteine) activity.

  10. The T to A mutation at residue 170 (Val to Asp (zeige C3 Proteine)) in Prss8 is responsible for the mutant frizzy (fr) phenotype.

Protease, serine, 8 (PRSS8) Protein Überblick

Protein Überblick

This gene encodes a trypsinogen, which is a member of the trypsin family of serine proteases. This enzyme is highly expressed in prostate epithelia and is one of several proteolytic enzymes found in seminal fluid. The proprotein is cleaved to produce a light chain and a heavy chain which are associated by a disulfide bond. It is active on peptide linkages involving the carboxyl group of lysine or arginine.

Genbezeichner und Symbole assoziert mit Protease, serine, 8 Proteine (PRSS8)

  • protease, serine 8 (PRSS8)
  • protease, serine, 8 (Prss8)
  • protease, serine 8 (prostasin) (Prss8)
  • protease, serine, 8 (PRSS8)
  • 2410039E18Rik Protein
  • AI313909 Protein
  • C79772 Protein
  • CAP1 Protein
  • fr Protein
  • mCAP1 Protein
  • prostasin Protein

Bezeichner auf Proteinebene für Protease, serine, 8 Proteine (PRSS8)

channel-activating protease 1 , prostasin , serine protease 8 , channel activating protease 1

GENE ID SPEZIES
5652 Homo sapiens
192107 Rattus norvegicus
613506 Bos taurus
76560 Mus musculus
102148278 Equus caballus
102157328 Canis lupus familiaris
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