Protease, serine, 8 Proteine (PRSS8)

Human Protease, serine, 8 (PRSS8) Interaktionspartner

1. limited role for HAI-2 (zeige SPINT2 Proteine) in the inhibition of matriptase (zeige ST14 Proteine) and prostasin is the result of its primarily intracellular localization in basal and spinous layer keratinocytes, which probably prevents the Kunitz inhibitor from interacting with active prostasin or matriptase (zeige ST14 Proteine)

2. PRSS8 was downregulated in glioma tissues.PRSS8 role in the glioma cell proliferation, migration, and invasion.

3. PRSS8 acts as a tumor suppressor in colorectal cancer

4. Data show that PRSS8 was reduced in esophageal squamous cell carcinomas (ESCC) tissues and the reduction of PRSS8 was associated with poor differentiation and shorter survival time.

5. Studies in colonic T84 cell monolayers revealed that barrier disruption by the colitis-associated Th2-type cytokines, IL-4 (zeige IL4 Proteine) and IL-13 (zeige IL13 Proteine), down-regulates matriptase (zeige ST14 Proteine) as well as prostasin through phosphorylation of the transcriptional regulator STAT6 (zeige STAT6 Proteine)

6. PRSS8 may serve as a tumour suppressor in hepatocellular carcinoma progression.

7. Overexpression of PRSS8 mRNA and high levels of prostasin in multiple subtypes of early stage ovarian tumors may provide clinical biomarkers for early detection of ovarian cancer.

8. It is concluded that prostasin protein level change is less likely to be causally involved in placental dysfunction in preeclampsia.

9. In urinary exosomes, NCC (zeige SLC12A3 Proteine) and prostasin had a diurnal pattern parallel to ADH (zeige AVP Proteine) and aquaporin 2 (zeige AQP2 Proteine), confirming that, in healthy subjects, both prostasin and NCC (zeige SLC12A3 Proteine) relate to water balance.

10. Polymorphism of the prostasin gene is closely associated with poor pregnancy outcomes of early-onset severe preeclampsia.

Mouse (Murine) Protease, serine, 8 (PRSS8) Interaktionspartner

1. Studies in colonic T84 cell monolayers revealed that barrier disruption by the colitis-associated Th2-type cytokines, IL-4 (zeige IL4 Proteine) and IL-13 (zeige IL13 Proteine), down-regulates matriptase (zeige ST14 Proteine) as well as prostasin through phosphorylation of the transcriptional regulator STAT6 (zeige STAT6 Proteine)

2. a proteolysis-dependent function of activated prostasin in hair follicles, dependent on zymogen conversion by matriptase (zeige ST14 Proteine).

3. The claudin-4 (zeige CLDN4 Proteine)-mediated chloride conductance can be regulated endogenously by a protease-channel-activating protease 1 (cap1).

4. HAI-1 (zeige SPINT1 Proteine) regulates the activity of activated matriptase (zeige ST14 Proteine), whereas HAI-2 (zeige SPINT2 Proteine) has an essential role in regulating prostasin-dependent matriptase (zeige ST14 Proteine) zymogen activation.

5. a novel inhibitory interaction between CAP1/Prss8 and nexin-1 (zeige SERPINE2 Proteine), opening the search for specific CAP1/Prss8 antagonists that are independent of its catalytic activity

6. Data indicate that liver-specific serine protease (zeige F2 Proteine) prostasin (PRSS8) knockout (LKO) mice develop insulin (zeige INS Proteine) resistance associated with the increase in hepatic Toll-like receptor 4 (TLR4 (zeige TLR4 Proteine)).

7. Data indicate that serine protease (zeige F2 Proteine) prostasin (CAP1/PRSS8) supports terminal epidermal differentiation through a non-catalytic mechanism.

8. mutations in Prss8 restored placentation and normal development of HAI-1 (zeige SPINT1 Proteine)-deficient embryos and prevented early embryonic lethality, mid-gestation lethality due to placental labyrinth failure, and neural tube defects in HAI-2 (zeige SPINT2 Proteine)-deficient embryos.

9. Mutations of the serine protease (zeige F2 Proteine) CAP1/Prss8 lead to reduced embryonic viability, skin defects, and decreased ENaC (zeige SCNN1A Proteine) activity.

10. The T to A mutation at residue 170 (Val to Asp (zeige C3 Proteine)) in Prss8 is responsible for the mutant frizzy (fr) phenotype.