anti-Proprotein Convertase Subtilisin/kexin Type 9 (PCSK9) Antikörper

PCSK9 encodes a proprotein convertase belonging to the proteinase K subfamily of the secretory subtilase family. Zusätzlich bieten wir Ihnen PCSK9 Kits (78) und PCSK9 Proteine (64) und viele weitere Produktgruppen zu diesem Protein an.

Alle Antikörper anzeigen Gen GeneID UniProt
PCSK9 255738 Q8NBP7
PCSK9 100102 Q80W65
PCSK9 298296 P59996
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Top anti-PCSK9 Antikörper auf antikoerper-online.de

Showing 10 out of 159 products:

Katalog Nr. Reaktivität Wirt Konjugat Applikation Bilder Menge Anbieter Lieferzeit Preis Details
Human Ziege Unkonjugiert ChIP, IHC (p), IHC, ELISA, WB Western Blot: PCSK9 Antibody [ABIN268772] - Analysis of PCSK9 in McA cell lysates: untransfected (1), transfected with wild type human PCSK9 (2), transfected with S127R human PCSK9 (3) using ABIN268772 (0.2ug/ml). Data kindly provided by Dr. X-M Sun, Hammersmith Hospital, London. Western Blot: PCSK9 Antibody [ABIN268772] - (0.3ug/ml) staining of Human Adipose lysate (35ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence. 0.1 mg Anmelden zum Anzeigen 7 bis 9 Tage
$485.88
Details
Human Ziege Unkonjugiert IHC, ELISA, WB ABIN185371 staining (0.2 µg/mL) of McA cell lysates: untransfected (1), transfected with wild type human pcsk9 (2), transfected with S127R human pcsk9 (3). Data kindly provided by Dr. X-M Sun, Hammersmith Hospital, London. ABIN185371 (0.3 µg/mL) staining of Human Adipose lysate (35 µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence. 100 μg Anmelden zum Anzeigen 6 bis 7 Tage
$358.02
Details
Human Kaninchen Unkonjugiert IHC (p), WB 100 μg Anmelden zum Anzeigen 2 bis 3 Tage
$325.00
Details
Human Ziege Unkonjugiert ELISA, WB 0.1 mg Anmelden zum Anzeigen 2 bis 3 Tage
$481.25
Details
Human Kaninchen Unkonjugiert FACS, IHC (p), WB Western blot analysis of PCSK9 Antibody (N-term) (ABIN652320) in Jurkat cell line lysates (35 µg/lane). PCSK9 (arrow) was detected using the purified polyclonal antibody. PCSK9 Antibody (N-term) (ABIN652320) IHC analysis in formalin fixed and paraffin embedded human brain tissue followed by peroxidase conjugation of the secondary antibody and DAB staining 400 μL Anmelden zum Anzeigen 10 bis 11 Tage
$324.50
Details
Human Kaninchen Unkonjugiert FACS, IHC (p), WB Western blot analysis of PCSK9 antibody (C-term) (ABIN391505) in Hela cell line lysates (35 µg/lane). PCSK9 (arrow) was detected using the purified polyclonal antibody. PCSK9 Antibody (C-term) (ABIN391505) IHC analysis in formalin fixed and paraffin embedded human Colon carcinoma followed by peroxidase conjugation of the secondary antibody and DAB staining 400 μL Anmelden zum Anzeigen 10 bis 11 Tage
$324.50
Details
Human Ziege Unkonjugiert EIA, WB HEK293 lysate (10 µg protein in RIPA buffer) overexpressing Human PCSK9 with C-terminal MYC tag probed with AP22408PU-N (1 µg/ml) in Lane A and probed with anti-MYC Tag (1/1000) in lane C. Mock-transfected HEK293 probed with AP22408PU-N (1mg/ml) in Lane B. Primary incubations were for 1 hour. Detected by chemiluminescence. 0.1 mg Anmelden zum Anzeigen 6 bis 8 Tage
$390.50
Details
Human Kaninchen Unkonjugiert EIA, WB Western blot analysis of PCSK9 Antibody (N-term) in Jurkat cell line lysates (35ug/lane). PCSK9 (arrow) was detected using the purified Pab. 0.4 mL Anmelden zum Anzeigen 6 bis 8 Tage
$390.50
Details
Human Kaninchen Unkonjugiert ICC, IHC, WB Used in DAB staining on fromalin fixed paraffin- embedded liver cancer tissue 100 μg Anmelden zum Anzeigen 15 bis 18 Tage
$350.00
Details
Human Ziege Unkonjugiert EIA, WB HEK293 lysate (10 µg protein in RIPA buffer) overexpressing Human PCSK9 with C-terminal MYC tag probed with AP22407PU-N (0.5 µg/ml) in Lane A and probed with anti-MYC Tag (1/1000) in lane C. Mock-transfected HEK293 probed with AP22407PU-N(1mg/ml) in Lane B. Primary incubations were for 1 hour. Detected by chemiluminescence. 0.1 mg Anmelden zum Anzeigen 6 bis 8 Tage
$390.50
Details

PCSK9 Antikörper nach Reaktivität, Anwendung, Klonalität and Konjugat

Attribute Applikationen Wirt Klonalität Konjugat
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Am meisten referenzierte anti-PCSK9 Antikörper

  1. Human Polyclonal PCSK9 Primary Antibody für ChIP, IHC (p) - ABIN268772 : Cohen, Pertsemlidis, Kotowski, Graham, Garcia, Hobbs: Low LDL cholesterol in individuals of African descent resulting from frequent nonsense mutations in PCSK9. in Nature genetics 2005 (PubMed)
    Show all 10 Pubmed References

  2. Human Polyclonal PCSK9 Primary Antibody für IF (p), IHC (p) - ABIN761831 : Jia, Song, Yang, Ma, Li, Lu, Cao, Zhang, Zhu, Wang, Leng, Cao, Du, Xu: Effects of Tanshinone IIA on the modulation of miR‑33a and the SREBP‑2/Pcsk9 signaling pathway in hyperlipidemic rats. in Molecular medicine reports 2016 (PubMed)

  3. Human Polyclonal PCSK9 Primary Antibody für ELISA, IP - ABIN4347755 : Lalanne, Lambert, Amar, Chétiveaux, Zaïr, Jarnoux, Ouguerram, Friburg, Seidah, Brewer, Krempf, Costet: Wild-type PCSK9 inhibits LDL clearance but does not affect apoB-containing lipoprotein production in mouse and cultured cells. in Journal of lipid research 2005 (PubMed)

  4. Human Polyclonal PCSK9 Primary Antibody für ELISA, WB - ABIN4347756 : Kwon, Lagace, McNutt, Horton, Deisenhofer: Molecular basis for LDL receptor recognition by PCSK9. in Proceedings of the National Academy of Sciences of the United States of America 2008 (PubMed)

Weitere Antikörper gegen PCSK9 Interaktionspartner

Human Proprotein Convertase Subtilisin/kexin Type 9 (PCSK9) Interaktionspartner

  1. Circulating PCSK9 concentration as a continuous variable was not significantly associated with the risk of cardiovascular events. More well-designed studies are needed to clarify the role of PCSK9 in cardiovascular risk.

  2. Data indicate that the elevation in plasma apoB-48 (zeige APOB Antikörper) levels associated with FH is independent of PCSK9 levels.

  3. we discuss current experimental and clinical evidence of the role of PCSK9 and its inhibition on lipid metabolism and several pathologic conditions with a focus on clinical outcomes--{REVIEW}

  4. The E670G polymorphism of the PCSK9 gene is associated with the lipid levels and risk for coronary heart disease.

  5. Here, we assess the available evidence for the association of PCSK9 status with the incidence and control of diabetes mellitus in preclinical and clinical studies, and identify molecular mechanisms regulating PCSK9 expression in the diabetic state. [Review]

  6. These results demonstrated the molecular mechanisms of how HCV modulates PCSK9 promoter activity and advanced our understanding on the mutual interactions between HCV and PCSK9.

  7. These findings provide useful information for researchers interested in the fields of PCSK9 genetics and cardiovascular risk prediction not only for designing future studies, but also for clinical and public health applications

  8. Circulating PCSK9 is significantly related to arterial stiffness, independent of sex and menopausal status in women.

  9. Study demonstrated PCSK9 as a direct target of miR (zeige MLXIP Antikörper)-224 and increased miR (zeige MLXIP Antikörper)-224 or decreased PCSK9 could promote apoptosis and suppress proliferation, invasion of tumor cell line in pancreatic neuroendocrine neoplasms.

  10. There are no associations between PCSK9 levels and either glucose or lipid homeostasis parameters. Nevertheless, a statistically significant link was observed between PCSK9 and markers of insulin (zeige INS Antikörper) homeostasis, solely in CF patients who presented normal glucose tolerance.

Mouse (Murine) Proprotein Convertase Subtilisin/kexin Type 9 (PCSK9) Interaktionspartner

  1. present anti-PCSK9 vaccine induced long-lasting anti-PCSK9 antibody production and improved lipoprotein profiles. Thus, anti-PCSK9 vaccine could become a new option for the treatment of dyslipidemia as a long-acting therapy in future

  2. PCSK9 may act as an inflammatory mediator in the pathogenesis of atherosclerosis via TLR4 (zeige TLR4 Antikörper)/NF-kappaB (zeige NFKB1 Antikörper) signaling pathway.

  3. PCSK9, by sustaining smooth muscle cell synthetic phenotype, proliferation, and migration, may play a pro-atherogenic role in the arterial wall

  4. PCSK9 inhibits lipoprotein(a) clearance through the LDLR (zeige LDLR Antikörper).

  5. Use Crispr-Cas (zeige CTNND1 Antikörper) system to introduce nonsense variants into PCSK9 to lower blood cholesterol levels.

  6. Studied the combination model of a single AAV-PCSK9 injection, high-fat diet, and partial carotid ligation which induces robust atherosclerosis in the flow-disturbed carotid artery within 3 weeks in C57 mice, and results suggest this is a quick and convenient model to study atherosclerosis and mechanisms using any knockout or transgenic mice without having to generate double knockouts.

  7. These observations suggest positive feedback interplay between SMC (zeige DYM Antikörper)-derived PCSK9 and mtDNA damage in the proinflammatory milieu involving mtROS. This interaction results in cellular injury, characterized by apoptosis-a hallmark of atherosclerosis.

  8. AdipoR activation by agonists regulated PCSK9 expression and inhibits atherosclerosis in apoE (zeige APOE Antikörper)(-/-) mice.

  9. Adeno (zeige ADORA2A Antikörper)-associated virus mediated infection with a mouse PCSK9 gain-of-function mutation is a rapid, easy, and efficient approach for inducing hypercholesterolemia and promoting abdominal aortic aneurysms in C57BL/6 mice infused with angiotensin II.

  10. conditions that cause ER stress regardless of their ability to dysregulate ER Ca(2 (zeige CA2 Antikörper)+) inhibit PCSK9 secretion, thereby reducing PCSK9-mediated LDLR (zeige LDLR Antikörper) degradation and promoting LDLR (zeige LDLR Antikörper)-dependent hepatic cholesterol uptake.

PCSK9 Antigen-Profil

Protein Überblick

This gene encodes a proprotein convertase belonging to the proteinase K subfamily of the secretory subtilase family. The encoded protein is synthesized as a soluble zymogen that undergoes autocatalytic intramolecular processing in the endoplasmic reticulum. The protein may function as a proprotein convertase. This protein plays a role in cholesterol homeostasis and may have a role in the differentiation of cortical neurons. Mutations in this gene have been associated with a third form of autosomal dominant familial hypercholesterolemia (HCHOLA3).

Genbezeichner und Symbole assoziert mit PCSK9

  • proprotein convertase subtilisin/kexin type 9 L homeolog (pcsk9.L) Antikörper
  • proprotein convertase subtilisin/kexin type 9 (pcsk9) Antikörper
  • proprotein convertase subtilisin/kexin type 9 (PCSK9) Antikörper
  • proprotein convertase subtilisin/kexin type 9 (Pcsk9) Antikörper
  • AI415265 Antikörper
  • AI747682 Antikörper
  • FH3 Antikörper
  • HCHOLA3 Antikörper
  • LDLCQ1 Antikörper
  • NARC-1 Antikörper
  • Narc1 Antikörper
  • PC9 Antikörper

Bezeichner auf Proteinebene für PCSK9

proprotein convertase subtilisin/kexin type 9 , convertase subtilisin/kexin type 9 preproprotein , neural apoptosis regulated convertase 1 , subtilisin/kexin-like protease PC9 , NARC-1 , convertase subtilisin , neural apoptosis-regulated convertase 1 , proprotein convertase 9 , proprotein convertase PC9 , proprotein convertase subtilisin/kexin type 9 preproprotein , Proprotein convertase 9 , Subtilisin/kexin-like protease PC9

GENE ID SPEZIES
495509 Xenopus laevis
100150316 Danio rerio
100544916 Meleagris gallopavo
255738 Homo sapiens
100102 Mus musculus
298296 Rattus norvegicus
424664 Gallus gallus
100731533 Cavia porcellus
717147 Macaca mulatta
100971792 Pan paniscus
456880 Pan troglodytes
100395116 Callithrix jacchus
100620501 Sus scrofa
Ausgewählte Anbieter für anti-PCSK9 (PCSK9) Antikörper
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