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May have a role in the regulation of spermatogenesis.. Zusätzlich bieten wir Ihnen PD-1 Antikörper (653) und PD-1 Proteine (93) und viele weitere Produktgruppen zu diesem Protein an.
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Human PD-1 ELISA Kit für Sandwich ELISA - ABIN417517
Li, Zhou, Li, Sang, Han, Lv, Zhao, Li, Liu et al.: Circulating soluble programmed death-1 levels may differentiate immune-tolerant phase from other phases and hepatocellular carcinoma from other clinical diseases in chronic hepatitis B virus ... in Oncotarget 2017
Human PD-1 ELISA Kit für Sandwich ELISA - ABIN2703394
Yanaba, Hayashi, Yoshihara, Nakagawa: Serum levels of soluble programmed death-1 and programmed death ligand-1 in systemic sclerosis: Association with extent of skin sclerosis. in The Journal of dermatology 2016
These results demonstrate the involvement of sPD-1 in the disease course of chronic HBV infection and indicate the potential to apply sPD-1 as a biomarker for differentiating IT from other phases and HCC from other disease conditions in chronic HBV infection.
summarizes the latest research on PD-1 in infectious diseases and discusses its role in acute and chronic viral infection[review]
Our study demonstrates a cross-talk between PARPi and tumor-associated immunosuppression and provides evidence to support the combination of PARPi and PD-L1 (zeige CD274 ELISA Kits) or PD-1 immune checkpoint blockade as a potential therapeutic approach to treat breast cancer
Results show that high programmed cell death 1 (PDCD1, PD-1)methylation (mPDCD1) was associated with a significantly shorter overall survival after surgical resection.
Suggest that genetic polymorphisms of PD-1 function as sex-dependent risk factors for development of acute rejection in an Iranian kidney transplant population.
downregulation in PD-1 inhibitory signaling in RA could be attributed to increased serum sPD-1 and decreased synovial tissue PD-L1 (zeige CD274 ELISA Kits) levels
PD1 polymorphisms are associated with susceptibility to chronic hepatitis B infection in the Chinese population.
PD-1 seems to correlate with disease progression in epitheliotropic T cell dyscrasias ranging from minimal staining in prelymphomatous dyscrasias to significant staining in mycosis fungoides
in some tumor types, PD-L2 (zeige PDCD1LG2 ELISA Kits) expression is more closely linked to Th1 (zeige TH1L ELISA Kits)/IFNG (zeige IFNG ELISA Kits) expression and PD-1 and CD8 (zeige CD8A ELISA Kits) signaling than PD-L1 (zeige CD274 ELISA Kits)
Although mutational and immunologic differences have been proposed as the primary determinants of heterogeneous response/resistance to targeted therapies and immunotherapies, respectively, differential lesional gene expression profiles may also dictate anti-PD-1 outcomes
An examination of the mechanisms of immunity behind this long-term protection in PD-1 knockout mice showed a key role for parasite-specific CD8 (zeige CD8A ELISA Kits)(+) T cells even when CD4 (zeige CD4 ELISA Kits)(+) T cells and B cells responded to re-infection.
To test the in vivo activity of REGN2810, which does not cross-react with murine PD-1, knock-in mice were generated to express a hybrid protein containing the extracellular domain of human PD-1, and transmembrane and intracellular domains of mouse PD-1
The combination of tumor vaccination to induce high avidity tumor specific T cell responses and PD-1 blockade synergises to provide tumor therapy and 85% survival in the aggressive B16 melanoma model.
Blockade of PD-1 with monoclonal antibody may be an effective treatment during the postoperative period for restoring surgery-induced immunosuppression.
Data suggest that genetic or environmental factors that even moderately affect the expression of both PD-1 and FoxP3 (zeige FOXP3 ELISA Kits) can cause life-threatening autoimmune diseases by disrupting the T-cell homeostasis.
Data (including data from studies in transgenic/knockout mice) suggest that T-cell expression of Mirn155 is required to limit melanoma growth; miR (zeige MLXIP ELISA Kits)-155, Pdcd1, Pdcd1l1 (zeige CD274 ELISA Kits), and Ctla4 (zeige CTLA4 ELISA Kits) appear to regulate overlapping pathways promoting antitumor immunity. [Mirn155 = microRNA 155; Pdcd1 = programmed cell death 1 protein; Pdcd1l1 (zeige CD274 ELISA Kits) = programmed cell death 1 ligand 1 (zeige CD274 ELISA Kits) protein; Ctla4 (zeige CTLA4 ELISA Kits) = cytotoxic T-lymphocyte-associated protein 4 (zeige CTLA4 ELISA Kits)]
PD-1 plays a vital role in brain inflammation via regulation of Fgl-2 (zeige FGL2 ELISA Kits) after ICH (zeige ACE ELISA Kits), and that manipulation of PD-1 might be a promising therapeutical target in ICH (zeige ACE ELISA Kits).
We identified PD-1 to be specifically expressed in PLZF(+) ILCp and revealed that the timing and order of expression of the transcription factors NFIL3 (zeige NFIL3 ELISA Kits), ID2, and TCF-1 (zeige HNF1A ELISA Kits) was critical. Importantly, induction of ILC (zeige CCL27 ELISA Kits) lineage commitment required only transient expression of NFIL3 (zeige NFIL3 ELISA Kits) prior to ID2 and TCF-1 (zeige HNF1A ELISA Kits) expression.
The identification of the role for PD-1 in regulating B cell-dependent antitumor immunity to Tn antigen highlights an opportunity to develop new therapeutic strategies targeting tumor-associated carbohydrate antigens
These findings suggest that PD-1 pathway blockade may reverse adaptive immune resistance following cyclic dinucleotide treatment, enhancing both local and systemic antitumor immunity.
Data show that CTLA-4 (zeige CTLA4 ELISA Kits)(+)PD-1(-) memory CD4 (zeige CD4 ELISA Kits)(+) T cells, which share phenotypic markers with regulatory T cells, were enriched in SIV DNA in blood, lymph nodes (LN), spleen, and gut (zeige GUSB ELISA Kits), and contained replication-competent and infectious virus.
Compared to before immunosuppression, PD-1 expression increased at reactivation. Increased T cells before zoster is likely due to virus reactivation.
A PD-1(high) phenotype is associated with accelerated in vivo CD8 (zeige CD8A ELISA Kits) T cell turnover in SIV-infections, especially within the SIV-specific CD8 (zeige CD8A ELISA Kits) T cell pool.
High levels of PD-1 expression on CD4 (zeige CD4 ELISA Kits)(+) T cells in lymph nodes of rhesus macaques can serve as a valuable marker to identify T follicular helper cells.
Data indicate that PD-1 expression is increased as a result of T cell activation during a primary immune response as well as during persistent immune activation in macaques.
PD-1 can serve as a sensitive indicator of persistent, low-level virus replication
This gene encodes a cell surface membrane protein of the immunoglobulin superfamily. This protein is expressed in pro-B-cells and is thought to play a role in their differentiation. In mice, expression of this gene is induced in the thymus when anti-CD3 antibodies are injected and large numbers of thymocytes undergo apoptosis. Mice deficient for this gene bred on a BALB/c background developed dilated cardiomyopathy and died from congestive heart failure. These studies suggest that this gene product may also be important in T cell function and contribute to the prevention of autoimmune diseases.
programmed cell death protein 1
, protein PD-1
, programmed cell death 1
, programmed death 1