anti-Potassium Channel, Subfamily K, Member 2 (KCNK2) Antikörper

KCNK2 encodes one of the members of the two-pore-domain background potassium channel protein family. Zusätzlich bieten wir Ihnen KCNK2 Proteine (4) und viele weitere Produktgruppen zu diesem Protein an.

Alle Antikörper anzeigen Gen GeneID UniProt
KCNK2 3776 O95069
KCNK2 16526 P97438
KCNK2 170899  
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Top anti-KCNK2 Antikörper auf antikoerper-online.de

Showing 10 out of 44 products:

Katalog Nr. Reaktivität Wirt Konjugat Applikation Bilder Menge Anbieter Lieferzeit Preis Details
Human Kaninchen Unkonjugiert WB Western blot analysis of Trek-1 in Jurkat cell lysantes (Lane 1, 2). 3T3 cell Lysante (Lane 3), and rat kidney tissue lysante (Lane 4). 100 μg Anmelden zum Anzeigen 2 bis 3 Tage
$245.00
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Rind (Kuh) Kaninchen Unkonjugiert WB Detection of TREK 1 in human brain membrane lysate using ABIN188929. 0.1 mL Anmelden zum Anzeigen 7 bis 9 Tage
$446.35
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Human Kaninchen Unkonjugiert IHC, WB IHC on paraffin sections of rat DRG tissue using Rabbit antibody to KCNK2: .HIER: 1 mM EDTA, pH 8 for 20 min using Thermo PT Module.Blocking: 0.2% LFDM in TBST filtered thru 0.2 µm.Detection was done using Novolink HRP polymer from Leica following manufacturer's instructions.Primary antibody: dilution 1: 1000, incubated 30 min at RT (using Autostainer).Sections were counterstained with Harris Hematoxylin. 100 μL Anmelden zum Anzeigen 7 bis 8 Tage
$454.67
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Maus Kaninchen Unkonjugiert ELISA, WB   100 μg Anmelden zum Anzeigen 11 bis 14 Tage
$419.83
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Human Kaninchen Unkonjugiert WB Detection of KCNK2 in human brain membrane lysate using KCNK2 polyclonal antibody . 100 μL Anmelden zum Anzeigen 11 bis 12 Tage
$452.00
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Human Kaninchen Unkonjugiert ELISA, WB   100 μg Anmelden zum Anzeigen 11 bis 14 Tage
$793.83
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Human Kaninchen Unkonjugiert WB   100 μL Anmelden zum Anzeigen 11 bis 14 Tage
$859.83
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Human Kaninchen Unkonjugiert WB   200 μL Anmelden zum Anzeigen 11 bis 16 Tage
$1,147.14
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Human Kaninchen Unkonjugiert WB   100 μL Anmelden zum Anzeigen 11 bis 16 Tage
$638.00
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Rind (Kuh) Kaninchen Biotin WB   0.1 mL Anmelden zum Anzeigen 8 bis 11 Tage
$559.35
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Am meisten referenzierte anti-KCNK2 Antikörper

  1. Cow (Bovine) Polyclonal KCNK2 Primary Antibody für WB - ABIN188929 : Zhang, Yin, Wang, Li, Wang: Over-expressed human TREK-1 inhibits CHO cell proliferation via inhibiting PKA and p38 MAPK pathways and subsequently inducing G1 arrest. in Acta pharmacologica Sinica 2016 (PubMed)

Weitere Antikörper gegen KCNK2 Interaktionspartner

Cow (Bovine) Potassium Channel, Subfamily K, Member 2 (KCNK2) Interaktionspartner

  1. ANG II inhibits bTREK-1 K(+) channels by a Ca(2+)-dependent mechanism that does not require the depletion of membrane-associated PIP(2).

  2. Metabolites of cAMP stimulate TREK-1 expression in adrenal cortex cells by activation of a novel cAMP-independent mechanism.

  3. TREK-1 channels may function as sensors that couple the metabolic state of the cell to membrane potential, perhaps through an associated ATP-binding protein

  4. These results identify bTREK-1 K(+) channels as a pivotal control point where ANG II receptor activation is transduced to depolarization-dependent Ca(2+) entry and aldosterone secretion.

  5. Data show that angiotensin II and paracrine factors that act through phospholipase C inhibit bTREK-1 in adrenocortical cells through simultaneous activation of separate Ca2+- and ATP hydrolysis-dependent signaling pathways.

  6. Angiotensin II (ANGII) inhibits adrenocortical cell KCNK2 in an ATP dependent, PLC/PKC independent manner.

  7. These findings demonstrate that, in addition to the well-described PKA-dependent TREK-1 inhibition, ACTH, NPS-ACTH, forskolin, and 8-pCPT-2'-O-Me-cAMP also inhibit these K(+) channels by a PKA-independent signaling pathway.

Human Potassium Channel, Subfamily K, Member 2 (KCNK2) Interaktionspartner

  1. data reveal a druggable K2P site that stabilizes the C-type gate 'leak mode' and provide direct evidence for K2P selectivity filter gating

  2. decreased TREK-1 expression in the aganglionic and ganglionic bowel observed in Hirschsprung's disease may alter intestinal epithelial barrier function leading to the development of enterocolitis

  3. Atrial TREK-1 expression was reduced in atrial fibrillation patients with concomitant severe heart failure

  4. The authors identified a heterozygous point mutation in the selectivity filter of the stretch-activated K2P potassium channel TREK-1 (KCNK2 or K2P2.1). This mutation introduces abnormal sodium permeability and stretch-activation hypersensitivity to TREK-1.

  5. downregulated in overactive detrusor

  6. The M2-glycine hinge controls the macroscopic currents of TREK1 channels.

  7. TREK-1 overexpression suppresses CHO cell proliferation by inhibiting the activity of PKA and p38/MAPK signaling pathways and subsequently inducing G1 phase cell arrest.

  8. Trek1 expression facilitates the restoration of intestinal epithelial barrier functions in an allergic environment.

  9. presence of TREK-1 variants correlated to reduced TREK-1 activity, suggesting a pathological role for TREK-1 variants in preterm labor

  10. Data suggest that potassium channel protein TREK-1 (TREK-1) might be a biomarker in castration resistance free survival (CRFS) judgment of prostate cancer (PCa), as well as a potential therapeutic target.

  11. During conductance simulation experiments, both TASK-3 and TREK-1 channels were able to repolarise the membrane once AP threshold was reached

  12. How ion channels sense mechanical force: insights from mechanosensitive K2P channels TRAAK, TREK1, and TREK2.

  13. We conclude that Trek1 is critical to maintain the nasal epithelial barrier function.

  14. Nasal epithelia express Trek1 that can be suppressed by allergic response.

  15. Modulation of K2P 2.1 and K2P 10.1 K(+) channel sensitivity to carvedilol by alternative mRNA translation initiation

  16. Response of the human detrusor to stretch is regulated by TREK-1

  17. PLD2, but not PLD1, directly binds to the C terminus of TREK1 and TREK2.

  18. results suggest that the TREK-1e splice variant may interfere with the vesicular traffic of full-length TREK-1 channels from the ER to the plasma membrane.

  19. TREK-1 deficient alveolar epithelial cells have less F-actin and are more deformable making them more resistant to stretch-induced injury.

  20. Activation of K(2)P channel-TREK1 mediates the neuroprotection induced by sevoflurane preconditioning.

Mouse (Murine) Potassium Channel, Subfamily K, Member 2 (KCNK2) Interaktionspartner

  1. Data demonstrate that inhibition of TWIK-related K(+) channel-1 (TREK-1) protects mice from cognitive impairment induced by anesthesia and TREK-1 is a potential therapeutic target against memory impairment induced by volatile anesthetics.

  2. data reveal a druggable K2P site that stabilizes the C-type gate 'leak mode' and provide direct evidence for K2P selectivity filter gating

  3. Hyperoxia treatment of TREK-1/TREK-2/TRAAK-deficient mice is associated with a reduction in surfactant proteins

  4. TREK-1 deficiency promoted neurons and oligodendrocytes apoptosis, aggravated demyelination and retarded motor recovery following spinal cord injury.

  5. essential for normal sinoatrial node cell excitability

  6. Formation of TREK-1/TREK-2 channels was also demonstrated in native dorsal root ganglion neurons indicating that heterodimerization may provide greater diversity of leak K(+) conductances also in native tissues.

  7. Trek1 expression facilitates the restoration of intestinal epithelial barrier functions in an allergic environment.

  8. Data suggest that porosome-associated proteins SNAP25, TREK-1, syntaxin-1A, and Gai3 exhibit stability and functionality such that isolated proteins can be reconstituted as insulin-secreting porosomes in cell membrane of live cells.

  9. Data indicate that arginine vasopressin (AVP) and corticotropin-releasing hormone (CRH) show additive effects on the suppression of the potassium channel subfamily K member 2 TREK-1 current via protein kinase C.

  10. TWIK-1/TREK-1 heterodimers mediate astrocytic passive conductance and cannabinoid-induced glutamate release from astrocytes.

  11. In TREK1-deficient mice, brain endothelial cells displayed an inflammatory phenotype.

  12. provide new insight into membrane targeting of TREK-1 in the heart and establish a broader role for beta(IV)-spectrin in organizing functional membrane domains critical for normal heart function

  13. TREK-1 channels significantly contribute to the responsiveness of Grueneberg ganglion neurons to cool temperatures.

  14. direct activation of the TREK-1 K(+) channel, acting downstream from the mu opioid receptor, might have strong analgesic effects without opioid-like adverse effects

  15. TREK-M inhibits neuronal firing by hyperpolarizing the resting membrane potential and decreasing input resistance. Delivery of TREK-M could reduce the duration of status epilepticus and reduce neuronal death.

  16. TREK1 knockout mice exhibit altered retinal waves.

  17. TREK-1 is directly sensitive to membrane tension.

  18. study analyzed the role of TWIK-related potassium channel-1 (TREK1)in endothelial cells and the blood-brain barrier(BBB); blocking TREK1 increased leukocyte transmigration; TREK1 activation had the opposite effect; results suggest an ion channel expressed by endothelial cells at the BBB regulates immune cell trafficking into the inflamed CNS

  19. Polycystins protect renal epithelial cells against apoptosis in response to mechanical stress, and this function is mediated through the opening of stretch-activated K(2P) channels.

  20. Trek-1 deficiency decreased IL-6 secretion from mouse and human alveolar epithelial cells at both transcriptional and translational levels

KCNK2 Antigen-Profil

Protein Überblick

This gene encodes one of the members of the two-pore-domain background potassium channel protein family. This type of potassium channel is formed by two homodimers that create a channel that leaks potassium out of the cell to control resting membrane potential. The channel can be opened, however, by certain anesthetics, membrane stretching, intracellular acidosis, and heat. Three transcript variants encoding different isoforms have been found for this gene.

Genbezeichner und Symbole assoziert mit KCNK2

  • potassium two pore domain channel subfamily K member 2 (KCNK2) Antikörper
  • potassium channel, two pore domain subfamily K, member 2 (kcnk2) Antikörper
  • potassium channel, subfamily K, member 2 (Kcnk2) Antikörper
  • potassium two pore domain channel subfamily K member 2 (Kcnk2) Antikörper
  • A430027H14Rik Antikörper
  • AI848635 Antikörper
  • hTREK-1c Antikörper
  • hTREK-1e Antikörper
  • K2p2.1 Antikörper
  • KCNK2 Antikörper
  • rTREK1d Antikörper
  • TPKC1 Antikörper
  • TREK Antikörper
  • Trek-1 Antikörper
  • TREK1 Antikörper

Bezeichner auf Proteinebene für KCNK2

potassium channel subfamily K member 2 , potassium channel, subfamily K, member 2 , potassium channel subfamily K member 2-like , K2P2.1 potassium channel , TREK-1 K(+) channel subunit , TWIK-related potassium channel 1 , outward rectifying potassium channel protein TREK-1 , potassium inwardly-rectifying channel, subfamily K, member 2 , tandem-pore-domain potassium channel TREK-1 , two pore domain potassium channel TREK-1 , two pore potassium channel TPKC1 , two-pore potassium channel 1 , arachidonic acid sensitive tandem pore domain potassium channel , ion transport membrane protein

GENE ID SPEZIES
282590 Bos taurus
457734 Pan troglodytes
490295 Canis lupus familiaris
708705 Macaca mulatta
770954 Gallus gallus
100023531 Monodelphis domestica
100050114 Equus caballus
100356478 Oryctolagus cuniculus
100400002 Callithrix jacchus
100435329 Pongo abelii
100481291 Ailuropoda melanoleuca
100495685 Xenopus (Silurana) tropicalis
100601855 Nomascus leucogenys
3776 Homo sapiens
16526 Mus musculus
170899 Rattus norvegicus
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