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This locus encodes a subunit of ATP-dependent chromatin-remodeling complexes. Zusätzlich bieten wir Ihnen Polybromo 1 Antikörper (40) und Polybromo 1 Kits (3) und viele weitere Produktgruppen zu diesem Protein an.
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These findings indicate that PBRM1 mutation (and resultant loss of expression) is a late event during biliary carcinogenesis
Clear-cell renal carcinoma cell lines whose ability to proliferate in vitro and in vivo is sensitive to wild-type BAF180, but not a tumor-associated BAF180 mutant, showed that the growth suppression by BAF180 is linked to its ability to form a canonical PBAF complex containing BRG1 (zeige SMARCA4 Proteine) that dampens the HIF transcriptional signature.
Knockdown of PBRM1 in colon cancer cells increased the expression of two receptor genes (RIG-I (zeige DDX58 Proteine) and MDA5 (zeige IFIH1 Proteine)) and upregulated interferon (zeige IFNA Proteine) (IFN)-related and inflammation-related gene signatures. Lower PBRM1 expression was associated with advanced pathological grade and poorer survival of colorectal cancer (CRC (zeige CALR Proteine)) patients, indicating that PBRM1 could serve as a potential prognostic biomarker for CRC (zeige CALR Proteine).
kidney-specific deletion of Vhl (zeige VHL Proteine) and Pbrm1, but not either gene alone, results in bilateral, multifocal, transplantable clear cell kidney cancers.
PBRM1 mutation is associated with small Cell Lung Cancer.
These findings indicate that PBRM1 alters cell cycle progression and inhibits proliferation and migration of renal cell carcinoma (zeige MOK Proteine) ACHN (zeige LARP6 Proteine) cells through the chemokine/chemokine (zeige CCL1 Proteine) receptor pathway.
our integrative analysis suggested that methylation and miRNA alterations were likely the downstream events associated with PBRM1 truncation mutations. In summary, this study provided some important insights into the understanding of tumorigenesis driven by PBRM1 truncated mutations in Clear cell renal cell carcinoma (zeige MOK Proteine) (ccRCC). The approach may be applied to many driver genes in various cancers.
BAP1 (zeige RNF2 Proteine) and PBRM1 loss is seen frequently in intrahepatic cholangiocarcinoma
PBRM1 gene deletion is associated with chordoma.
conclude that four of the BDs act together to target PBRM1 to sites on chromatin; when a single BD is mutated, PBRM1 no longer controls gene expression properly, leading to increased cell proliferation
We conditionally targeted Bap1 (zeige BAP1 Proteine) and Pbrm1 (with Vhl (zeige VHL Proteine)) in the mouse using several Cre drivers.Sglt2 and Villin proximal convoluted tubule drivers failed to cause tumorigenesis, challenging the conventional notion of Clear cell renal cell carcinoma (zeige MOK Proteine) (ccRCC)origins
dual inactivation of Vhl (zeige VHL Proteine) with either Bap1 (zeige BAP1 Proteine) or Pbrm1 results in faithful genetically engineered murine models of clear cell renal cell carcinoma (zeige MOK Proteine) (ccRCC).
Data suggest BAF180 protein as a critical regulator of cellular senescence and HSC (zeige FUT1 Proteine) homeostasis, which is at least partially regulated through BAF180-mediated suppression of cell cycle regulator p21 expression.
Data demonstrate a function for BAF180 in promoting genome stability that is distinct from its well-characterized role in transcriptional regulation.
BAF180 is a repressor of IL-10 (zeige IL10 Proteine) transcription in Th2 cells and suggest that the differential recruitment of different SWI (zeige SMARCA1 Proteine)/SNF (zeige SNRPA Proteine) subtypes can have direct consequences on chromatin structure and gene transcription.
BAF180 is critical for coronary vessel formation.
This locus encodes a subunit of ATP-dependent chromatin-remodeling complexes. The encoded protein has been identified as in integral component of complexes necessary for ligand-dependent transcriptional activation by nuclear hormone receptors. Mutations at this locus have been associated with primary clear cell renal cell carcinoma.
, protein polybromo-1
, BRG1-associated factor 180
, glutamate receptor interacting protein 2
, polybromo 1 protein