Polybromo 1 Proteine (PBRM1)

This locus encodes a subunit of ATP-dependent chromatin-remodeling complexes. Zusätzlich bieten wir Ihnen Polybromo 1 Antikörper (47) und Polybromo 1 Kits (5) und viele weitere Produktgruppen zu diesem Protein an.

alle Proteine anzeigen Gen GeneID UniProt
PBRM1 55193 Q86U86
PBRM1 66923  
Ratte PBRM1 PBRM1 306254  
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Top Polybromo 1 Proteine auf antikoerper-online.de

Showing 4 out of 12 products:

Katalog Nr. Origin Quelle Konjugat Bilder Menge Anbieter Lieferzeit Preis Details
Insektenzellen Maus His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 70 Days
Escherichia coli (E. coli) Human His tag 100 μg Anmelden zum Anzeigen 15 bis 18 Tage
Wheat germ Human GST tag 10 μg Anmelden zum Anzeigen 11 bis 12 Tage
Escherichia coli (E. coli) Human His tag,DYKDDDDK Tag Recombinant PBRM1 (23-156) activity using AlphaScreen. PBRM1 (23-156) was used in an AlphaScreen® assay to generate a titration curve demonstrating the signal response in the presence of modified peptide substrate at increasing protein concentrations. This data was generated and kindly provided courtesy of ChemPartner. Recombinant PBRM1 (23-156) protein gel. PBRM1 (23-156) protein was run on a 10% SDS-PAGE gel and stained with Coomassie blue. 100 μg Anmelden zum Anzeigen 1 bis 2 Tage

PBRM1 Proteine nach Spezies und Herkunft

Origin Exprimiert in Konjugat
Human ,
, , ,
Mouse (Murine)

Weitere Proteine zu Polybromo 1 (PBRM1) Interaktionspartnern

Human Polybromo 1 (PBRM1) Interaktionspartner

  1. Low PBRM1 expression is associated with early stages of clear cell renal cell carcinoma.

  2. Study suggests that reduced expression of PBRM1 and VHL in clear cell renal cell carcinoma is correlated with an increased tumor aggressiveness.

  3. These findings indicate that PBRM1 mutation (and resultant loss of expression) is a late event during biliary carcinogenesis

  4. Clear-cell renal carcinoma cell lines whose ability to proliferate in vitro and in vivo is sensitive to wild-type BAF180, but not a tumor-associated BAF180 mutant, showed that the growth suppression by BAF180 is linked to its ability to form a canonical PBAF complex containing BRG1 that dampens the HIF transcriptional signature.

  5. Knockdown of PBRM1 in colon cancer cells increased the expression of two receptor genes (RIG-I and MDA5) and upregulated interferon (IFN)-related and inflammation-related gene signatures. Lower PBRM1 expression was associated with advanced pathological grade and poorer survival of colorectal cancer (CRC) patients, indicating that PBRM1 could serve as a potential prognostic biomarker for CRC.

  6. kidney-specific deletion of Vhl and Pbrm1, but not either gene alone, results in bilateral, multifocal, transplantable clear cell kidney cancers.

  7. PBRM1 mutation is associated with small Cell Lung Cancer.

  8. These findings indicate that PBRM1 alters cell cycle progression and inhibits proliferation and migration of renal cell carcinoma ACHN cells through the chemokine/chemokine receptor pathway.

  9. our integrative analysis suggested that methylation and miRNA alterations were likely the downstream events associated with PBRM1 truncation mutations. In summary, this study provided some important insights into the understanding of tumorigenesis driven by PBRM1 truncated mutations in Clear cell renal cell carcinoma (ccRCC). The approach may be applied to many driver genes in various cancers.

  10. BAP1 and PBRM1 loss is seen frequently in intrahepatic cholangiocarcinoma

  11. PBRM1 gene deletion is associated with chordoma.

  12. conclude that four of the BDs act together to target PBRM1 to sites on chromatin; when a single BD is mutated, PBRM1 no longer controls gene expression properly, leading to increased cell proliferation

  13. Synthetic lethality screening identifies TIP60-dependent radiation sensitivity in the absence of BAF180.

  14. Functionally, suppression of PBRM1 expression promoted cell proliferation and cell cycle progression

  15. PBRM1 re-expression led to upregulation of genes involved in cellular adhesion, carbohydrate metabolism, apoptotic process and response to hypoxia, and a downregulation of genes involved in different stages of cell division.

  16. Use bioinformatic tools to predict the molecular effects of all mutations lying in PBRM1 genes.

  17. PBRM1 might involve in the development and progression of breast cancer as a tumor suppressor, and thereby may be a valuable prognostic marker for breast cancer patients.

  18. our data describe a close interrelation between p53 and PBRM1 in renal cell carcinomas

  19. PBRM1 expression identified 4 clinical subgroups of patients with clear cell renal cell carcinoma who had divergent clinical outcomes.

  20. PBRM1 could block the G2/M transition by repressing cyclin B1. The data indicated that PBRM1 functions as a tumor suppressor in bladder cancer by repressing cyclin B1 expression.

Polybromo 1 (PBRM1) Protein Überblick

Protein Überblick

This locus encodes a subunit of ATP-dependent chromatin-remodeling complexes. The encoded protein has been identified as in integral component of complexes necessary for ligand-dependent transcriptional activation by nuclear hormone receptors. Mutations at this locus have been associated with primary clear cell renal cell carcinoma.

Genbezeichner und Symbole assoziert mit Polybromo 1 Proteine (PBRM1)

  • polybromo 1 (PBRM1)
  • polybromo 1 L homeolog (pbrm1.L)
  • protein polybromo-1 (LOC100170602)
  • polybromo 1 (pbrm1)
  • polybromo 1 (Pbrm1)
  • 2610016F04Rik Protein
  • AI507524 Protein
  • BAF180 Protein
  • Pb1 Protein
  • RGD1565549 Protein

Bezeichner auf Proteinebene für Polybromo 1 Proteine (PBRM1)

polybromo 1 , protein polybromo-1 , BRG1-associated factor 180 , polybromo-1D , glutamate receptor interacting protein 2 , polybromo 1 protein , 2310032M22Rik

460430 Pan troglodytes
495429 Xenopus laevis
100170602 Xenopus (Silurana) tropicalis
55193 Homo sapiens
565366 Danio rerio
396074 Gallus gallus
476593 Canis lupus familiaris
506557 Bos taurus
66923 Mus musculus
306254 Rattus norvegicus
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