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The protein encoded by PAIP1 interacts with poly(A)-binding protein and with the cap-binding complex eIF4A. Zusätzlich bieten wir Ihnen Poly(A) Binding Protein Interacting Protein 1 Proteine (6) und und viele weitere Produktgruppen zu diesem Protein an.
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Cow (Bovine) Polyclonal PAIP1 Primary Antibody für WB - ABIN2778987
Fortna, Kim, MacLaren, Marshall, Hahn, Meltesen, Brenton, Hink, Burgers, Hernandez-Boussard, Karimpour-Fard, Glueck, McGavran, Berry, Pollack, Sikela: Lineage-specific gene duplication and loss in human and great ape evolution. in PLoS biology 2004
Results showed that mRNA and protein expression of PAIP1, a miRNA-340 target gene, were down-regulated in women with gestational diabetes.
Data provide evidence that the stability of Paip1 can be regulated by ubiquitin-mediated degradation, thus highlighting the importance of WWP2 as a suppressor of translation.
The Paip1-eIF3 interaction is impaired by the mTORC1 inhibitors.
the crystal structure of the middle domain of Paip1 isoform 2 (Paip1M) as determined by single-wavelength anomalous dispersion phasing is reported.
Paip1 is translational activator in 5' cap-dependent translation by interacting with PABP & initiation factors eIF4A & eIF3. Crystallization & preliminary diffraction analysis of middle domain of Paip1 gives crystals that diffract to resolution of 2.2 A.
Paip1 interacts with poly(A) binding protein through two independent binding motifs.
eIF3-Paip1 stabilizes the interaction between PABP and eIF4G, which brings about the circularization of the mRNA.
The protein encoded by this gene interacts with poly(A)-binding protein and with the cap-binding complex eIF4A. It is involved in translational initiation and protein biosynthesis. Overexpression of this gene in COS7 cells stimulates translation. Alternative splicing occurs at this locus and three transcript variants encoding three distinct isoforms have been identified.
PABC1-interacting protein 1
, PABP-interacting protein 1
, poly(A)-binding protein-interacting protein 1
, polyadenylate binding protein-interacting protein 1
, polyadenylate-binding protein-interacting protein 1
, poly(A) binding protein interacting protein 1
, polyadenylate-binding protein-interacting protein 1-like