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Plxna2 encodes a member of the plexin-A family of semaphorin co-receptors.
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used Sema6A (zeige SEMA6A ELISA Kits)-deficient and PlxnA2-deficient zebrafish embryos in a microarray analysis to identify genes that were differentially expressed when this signaling pathway was disrupted.
Sema6a (zeige SEMA6A ELISA Kits) and Plxna2 have roles in promoting eye vesicle cohesion through mediating spatially regulated repulsion within the developing zebrafish eye
Data indicate that plexin A1-4 (PLXNA1-4) mediation of neuroanatomical traits can be detected using in vivo neuroimaging techniques.
although plexin-A4 (zeige PLXNA4 ELISA Kits) overexpression restored Sema3A (zeige SEMA3A ELISA Kits) signaling in plexin-A1-silenced cells, it failed to restore Sema3B (zeige SEMA3B ELISA Kits) signaling in plexin-A2-silenced cells.
PLXNA2 upregulation contributes to TMPRSS2 (zeige TMPRSS2 ELISA Kits):ERG (zeige ERG ELISA Kits)-mediated enhancements of PC3c cell migration and invasion.
PLXNA2 has been identified as a new rare copy number variations gene for tetralogy of Fallot.
results of our study reveal that PlxnA2 has a pro-osteogenic function by modulating BMP2 (zeige BMP2 ELISA Kits) signaling
PLXNA2 polymorphisms show association with ankylosing spondylitis.
in vitro analysis of PLXNA2 revealed that the gene has higher expression in more aggressive breast cancer cell types.
An association is identified between variants in the PLXNA2 gene and schizophrenia in two collections of schizophrenia cases and controls. High-density SNP mapping showed that the region of association spans approximately 60 kb of the PLXNA2 gene.
results suggest that PLXNA2 may not play a major role in the development of schizophrenia in our Japanese sample
PLXNA2 confers a varying genetic risk for schizophrenia among different populations.
These findings implicate Semaphorin-6A (zeige SEMA6A ELISA Kits) - Plexin-A2/Plexin-A4 (zeige PLXNA4 ELISA Kits) interactions in dorsal lateral geniculate nucleus axon guidance and in the spatiotemporal organization of guidepost cell populations in the mammalian subpallium.
describe procedures for protein production and purification that we utilized in the crystallographic study of the mouse Plexin A2 (mPlxnA2) extracellular fragment, including the sema (zeige SEMA3B ELISA Kits) domain
Using time-lapse videomicroscopy we provide evidence that Sema6A (zeige SEMA6A ELISA Kits)/PlexinA2 signaling participates to interkinetic nuclear migration of retinal progenitor cell
Plexin A2 is expressed in both On and Off starburst amacrine cell.
crystal structures of cognate complexes of the semaphorin-binding regions of plexins B1 and A2 with semaphorin ectodomains (human PLXNB1(1-2)-SEMA4D(ecto) and murine PlxnA2(1-4)-Sema6A(ecto)), plus unliganded structures of PlxnA2(1-4) and Sema6A(ecto)
crystal structures of the semaphorin 6A (Sema6A (zeige SEMA6A ELISA Kits)) receptor-binding fragment and the plexin A2 (PlxnA2) ligand-binding fragment in both their pre-signalling (that is, before binding) and signalling (after complex formation) states
This study demonstrated that Sema6B (zeige SEMA6B ELISA Kits), another class 6 transmembrane semaphorin, is expressed in CA3 (zeige CA3 ELISA Kits) and repels mossy fibers in a PlxnA4 (zeige PLXNA4 ELISA Kits)-dependent manner in vitro.
In plexin-A2-deficient mice many granule cells remained in the molecular layer; mouse chimera studies further suggested that plexin-A2 acts in a cell-autonomous manner.
mutations in GATA6 (zeige GATA6 ELISA Kits) are genetic causes of congenital heart diseases involving outflow tract defects, as a result of the disruption of the direct regulation of semaphorin 3C (zeige SEMA3C ELISA Kits)-plexin A2 signaling
This gene encodes a member of the plexin-A family of semaphorin co-receptors. Semaphorins are a large family of secreted or membrane-bound proteins that mediate repulsive effects on axon pathfinding during nervous system development. A subset of semaphorins are recognized by plexin-A/neuropilin transmembrane receptor complexes, triggering a cellular signal transduction cascade that leads to axon repulsion. This plexin-A family member is thought to transduce signals from semaphorin-3A and -3C.
, plexin A2
, plexin 2
, semaphorin receptor OCT
, transmembrane protein OCT
, plex 2