Plectin (PLEC) ELISA Kits

Plectin is a prominent member of an important family of structurally and in part functionally related proteins, termed plakins or cytolinkers, that are capable of interlinking different elements of the cytoskeleton. Zusätzlich bieten wir Ihnen Plectin Antikörper (54) und und viele weitere Produktgruppen zu diesem Protein an.

list all ELISA KIts Gen GeneID UniProt
PLEC 5339 Q15149
PLEC 18810 Q9QXS1
PLEC 64204  
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Katalog Nr. Reaktivität Sensitivität Bereich Bilder Menge Anbieter Lieferzeit Preis Details
Human 0.58 ng/mL 1.56 ng/mL - 100 ng/mL 96 Tests Anmelden zum Anzeigen 13 bis 16 Tage
Maus 0.78-50 ng/mL   96 Tests Anmelden zum Anzeigen 2 bis 3 Tage
  96 Tests Anmelden zum Anzeigen 15 bis 18 Tage

Weitere ELISA Kits für Plectin Interaktionspartner

Human Plectin (PLEC) Interaktionspartner

  1. These findings extend current knowledge of the mutation spectrum of the PLEC gene associated with limbgirdle muscular dystrophy 2Q.

  2. The Structure of the Plakin Domain of Plectin Reveals an Extended Rod-like Shape.

  3. We present two cases of Epidermolysis bullosa with significant urologic involvement resulting from mutations in plectin.

  4. lectin and cytoskeletons were not detected in the nuclei of liver cells compared to the results of confocal microscopy. Despite the absence of nuclear plectin and cytoskeletal filaments, the evidence provided support that nuclear pleomorphism of cancer cells is correlated with the cytoplasmic disorganization of cytoskeleton.

  5. data demonstrate that plectin is an essential regulator of nuclear morphology in vitro and in vivo and protects the nucleus from mechanical deformation.

  6. The dominant expression of the P1a isoform in epidermal basal cell layer and cultured keratinocytes suggests that mutations in the first exon of isoform 1a cause skin-only epidermolysis bullosa simplex without extracutaneous involvement.

  7. plectin interacts with keratins 5 and 14 in a process associated with epidermolysis bullosa simplex

  8. Six of sicteen epidermolysis bullosa simplex probands had dominant PLEC missense mutations.

  9. Mislocated Plectin is necessary for exosome formation and produces exosomes that are capable of promoting pancreatic tumor growth and aggression.

  10. this study is the first to demonstrate that up-regulation of vimentin and plectin expression positively correlates with the invasion and metastasis of androgen-independent PCA

Mouse (Murine) Plectin (PLEC) Interaktionspartner

  1. data demonstrate that plectin is an essential regulator of nuclear morphology in vitro and in vivo and protects the nucleus from mechanical deformation.

  2. Data demonstrate that rodless plectin can functionally compensate for the loss of full-length plectin in mice.

  3. results show that the depletion of distinct plectin isoforms affects mitochondrial network organization and function in different ways.

  4. Binding of calcium-calmodulin (Ca(2 (zeige CA2 ELISA Kits)+)-CaM) to P1a together with phosphorylation of integrin beta 4 (zeige ITGB4 ELISA Kits) disrupts the complex, resulting in disassembly of hemidesmosomes.

  5. Plectin bridges acetylcholine receptors and intermediate filaments via direct interaction with the AChR-scaffolding protein rapsyn (zeige RAPSN ELISA Kits) in an isoform-specific manner.

  6. the lack of plectin has divergent implications on biomechanical properties depending on the respective cell type.

  7. Ablation of plectin in myelinating Schwann cells is found not to affect myelin sheath formation.

  8. Nesprin-3 is critical for the localization of plectin to the nuclear perimeter of Sertoli cells.

  9. findings suggest a mechanism for microtubule(MT)destabilization in which isoform-specific binding of P1c to MTs (zeige NEU2 ELISA Kits) antagonizes the MT-stabilizing and assembly-promoting function of MT-associated proteins through an inhibitory function exerted by plectin's SH3 domain (zeige ITSN1 ELISA Kits)

  10. plectin 1a, the major isoform expressed in epidermal keratinocytes, is proteolytically degraded, supporting the notion that degradation of hemidesmosome-anchored plectin is spatially controlled.

Plectin (PLEC) Antigen-Profil

Beschreibung des Gens

Plectin is a prominent member of an important family of structurally and in part functionally related proteins, termed plakins or cytolinkers, that are capable of interlinking different elements of the cytoskeleton. Plakins, with their multi-domain structure and enormous size, not only play crucial roles in maintaining cell and tissue integrity and orchestrating dynamic changes in cytoarchitecture and cell shape, but also serve as scaffolding platforms for the assembly, positioning, and regulation of signaling complexes (reviewed in PMID: 9701547, 11854008, and 17499243). Plectin is expressed as several protein isoforms in a wide range of cell types and tissues from a single gene located on chromosome 8 in humans (PMID: 8633055, 8698233). Until 2010, this locus was named plectin 1 (symbol PLEC1 in human\; Plec1 in mouse and rat) and the gene product had been referred to as 'hemidesmosomal protein 1' or 'plectin 1, intermediate filament binding 500kDa'. These names were superseded by plectin. The plectin gene locus in mouse on chromosome 15 has been analyzed in detail (PMID: 10556294, 14559777), revealing a genomic exon-intron organization with well over 40 exons spanning over 62 kb and an unusual 5' transcript complexity of plectin isoforms. Eleven exons (1-1j) have been identified that alternatively splice directly into a common exon 2 which is the first exon to encode plectin's highly conserved actin binding domain (ABD). Three additional exons (-1, 0a, and 0) splice into an alternative first coding exon (1c), and two additional exons (2alpha and 3alpha) are optionally spliced within the exons encoding the acting binding domain (exons 2-8). Analysis of the human locus has identified eight of the eleven alternative 5' exons found in mouse and rat (PMID: 14672974)\; exons 1i, 1j and 1h have not been confirmed in human. Furthermore, isoforms lacking the central rod domain encoded by exon 31 have been detected in mouse (PMID:10556294), rat (PMID: 9177781), and human (PMID: 11441066, 10780662, 20052759). The short alternative amino-terminal sequences encoded by the different first exons direct the targeting of the various isoforms to distinct subcellular locations (PMID: 14559777). As the expression of specific plectin isoforms was found to be dependent on cell type (tissue) and stage of development (PMID: 10556294, 12542521, 17389230) it appears that each cell type (tissue) contains a unique set (proportion and composition) of plectin isoforms, as if custom-made for specific requirements of the particular cells. Concordantly, individual isoforms were found to carry out distinct and specific functions (PMID: 14559777, 12542521, 18541706). In 1996, a number of groups reported that patients suffering from epidermolysis bullosa simplex with muscular dystrophy (EBS-MD) lacked plectin expression in skin and muscle tissues due to defects in the plectin gene (PMID: 8698233, 8941634, 8636409, 8894687, 8696340). Two other subtypes of plectin-related EBS have been described: EBS-pyloric atresia (PA) and EBS-Ogna. For reviews of plectin-related diseases see PMID: 15810881, 19945614. Mutations in the plectin gene related to human diseases should be named based on the position in NM_000445 (variant 1, isoform 1c), unless the mutation is located within one of the other alternative first exons, in which case the position in the respective Reference Sequence should be used.

Genbezeichner und Symbole assoziert mit Plectin (PLEC) ELISA Kits

  • plectin (LOC100481602) Antikörper
  • plectin L homeolog (plec.L) Antikörper
  • plectin (PLEC) Antikörper
  • plectin (Plec) Antikörper
  • plectin (LOC786966) Antikörper
  • AA591047 Antikörper
  • AU042537 Antikörper
  • EBS1 Antikörper
  • EBSO Antikörper
  • HD1 Antikörper
  • IFAP300 Antikörper
  • LGMD2Q Antikörper
  • Pcn Antikörper
  • Plec1 Antikörper
  • PLEC1b Antikörper
  • Plectin-1 Antikörper
  • Pltn Antikörper

Bezeichner auf Proteinebene für Plectin (PLEC) ELISA Kits

plectin , plectin-1-like , hemidesmosomal protein 1 , plectin 1, intermediate filament binding protein 500kDa , plectin-1 , plectin 1 , plectin-6 , 300 kDa intermediate filament-associated protein

100481602 Ailuropoda melanoleuca
398587 Xenopus laevis
5339 Homo sapiens
18810 Mus musculus
64204 Rattus norvegicus
100682530 Cricetulus griseus
786966 Bos taurus
482083 Canis lupus familiaris
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