anti-Platelet Factor 4 (PF4) Antikörper

PF4 encodes a member of the CXC chemokine family. Zusätzlich bieten wir Ihnen Platelet Factor 4 Proteine (74) und Platelet Factor 4 Kits (35) und viele weitere Produktgruppen zu diesem Protein an.

Alle Antikörper anzeigen Gen GeneID UniProt
PF4 5196 P02776
PF4 56744 Q9Z126
PF4 360918 P06765
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Top anti-Platelet Factor 4 Antikörper auf antikoerper-online.de

Showing 10 out of 155 products:

Katalog Nr. Reaktivität Wirt Konjugat Applikation Bilder Menge Lieferzeit Preis Details
Human Kaninchen Unkonjugiert IHC (p), WB Anti-PF4 antibody, IHC(P) IHC(P): Human Lung Cancer Tissue Anti-PF4 antibody, Western blotting Lane 1: Recombinant Human CXCL4 Protein 10ng Lane 2: Recombinant Human CXCL4 Protein 5ng Lane 3: Recombinant Human CXCL4 Protein 2.5ng 100 μg 4 bis 6 Tage
$280.00
Details
Human Kaninchen Unkonjugiert ELISA, WB Western blot analysis of PF4 expression in 293T whole cell lysates ( Lane 1) and A549 whole cell lysates ( Lane 2). PF4 at 26KD was detected using rabbit anti- PF4 Antigen Affinity purified polyclonal antibody (Catalog # ) at 0.5 ??g/mL. The blot was developed using chemiluminescence (ECL) method (Catalog # EK1002). 100 μg 4 bis 6 Tage
$240.00
Details
Maus Kaninchen Unkonjugiert ELISA, IHC (p), WB Western blot analysis of PF4 expression in mouse skeletal muscle extract ( Lane 1). PF4 at 26KD was detected using rabbit anti- PF4 Antigen Affinity purified polyclonal antibody (Catalog # ) at 0.5 µg/mL. The blot was developed using chemiluminescence (ECL) method (Catalog # EK1002). PF4 was detected in paraffin-embedded sections of mouse spleen tissues using rabbit anti- PF4 Antigen Affinity purified polyclonal antibody (Catalog # ) at 1 µg/mL. The immunohistochemical section was developed using SABC method (Catalog # SA1022). 100 μg 4 bis 6 Tage
$280.00
Details
Human Kaninchen Unkonjugiert ICC, IHC, WB Figure. DAB staining on IHC-P; Samples: Human Stomach Cancer Tissue. 100 μL 15 bis 18 Tage
$196.00
Details
Ratte Kaninchen Unkonjugiert ICC, IHC, WB 100 μL 15 bis 18 Tage
$239.00
Details
Human Kaninchen Unkonjugiert ELISA, WB 100 μg 11 bis 14 Tage
$493.17
Details
Human Maus Unkonjugiert EIA, WB   0.2 mg 6 bis 8 Tage
$550.00
Details
Human Maus Biotin EIA, WB   0.1 mg 6 bis 8 Tage
$451.00
Details
Human Kaninchen Unkonjugiert WB Western Blot at 1:2000 dilution + human spleen lysate Lysates/proteins at 20 ug per lane. 200 μL 2 bis 3 Tage
$550.00
Details
Human Schaf Unkonjugiert ELISA, IHC, IHC (p) Human Placenta (formalin-fixed, paraffin-embedded) stained with PF4 antibody ABIN351496 at 5 ug/ml followed by biotinylated secondary antibody, alkaline phosphatase-streptavidin and chromogen. Anti-PF4 antibody IHC of human placenta. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml. 50 μg 11 bis 14 Tage
$484.00
Details

Am meisten referenzierte anti-Platelet Factor 4 Antikörper

  1. Human Monoclonal PF4 Primary Antibody für CyTOF, FACS - ABIN4900200 : Dubrac, Quemener, Lacazette, Lopez, Zanibellato, Wu, Bikfalvi, Prats: Functional divergence between 2 chemokines is conferred by single amino acid change. in Blood 2010 (PubMed)
    Show all 2 Pubmed References

  2. Human Polyclonal PF4 Primary Antibody für ELISA, IHC (p) - ABIN4265396 : Zhang, Mercado-Uribe, Liu: Tumor stroma and differentiated cancer cells can be originated directly from polyploid giant cancer cells induced by paclitaxel. in International journal of cancer 2013 (PubMed)

  3. Human Monoclonal PF4 Primary Antibody für FACS - ABIN4897342 : van Bon, Affandi, Broen, Christmann, Marijnissen, Stawski, Farina, Stifano, Mathes, Cossu, York, Collins, Wenink, Huijbens, Hesselstrand, Saxne, DiMarzio, Wuttge, Agarwal, Reveille, Assassi, Mayes et al.: Proteome-wide analysis and CXCL4 as a biomarker in systemic sclerosis. ... in The New England journal of medicine 2014 (PubMed)

  4. Human Monoclonal PF4 Primary Antibody für FACS - ABIN4897341 : Alshareeda, Rakha, Alghwainem, Alrfaei, Alsowayan, Albugami, Alsubayyil, Abomraee, Mohd Zin: The effect of human placental chorionic villi derived mesenchymal stem cell on triple-negative breast cancer hallmarks. in PLoS ONE 2018 (PubMed)

Weitere Antikörper gegen Platelet Factor 4 Interaktionspartner

Human Platelet Factor 4 (PF4) Interaktionspartner

  1. Findings demonstrate a novel T-cell regulatory function of non-platelet-derived CXCL4 that colon cancer cells may hijack to evade the host immune system.

  2. CXCL4 inhibits endothelial cell proliferation and migration, leading to suppression of angiogenesis.

  3. CXCL4 induced CCR1 endocytosis and could induce monocyte chemotaxis in a CCR1 antagonist-sensitive manner.

  4. Cellular immune sensitization to PF4-heparin complexes occurs before heparin exposure, and immune dysregulation can contribute to heparin-induced thrombocytopenia.

  5. Platelets are able to kill bacteria directly after recognizing anti-PF4/P IgG opsonized bacteria in the presence of PF4 via their FcgammaRIIA.

  6. Observations suggest the crucial role of platelet cytokine PF4 as the rapid enhancer of replication as well as propagation of both observations together suggest the crucial role of platelet cytokine PF4 as the rapid enhancer of replication as well as propagation of both Dengue virus and Japanese Encephalitis virus in host cells including monocytes by inhibiting IFN response of these immune cells.

  7. Study elucidate an unanticipated mechanism for CXCL4-mediated immune amplification in systemic sclerosis, in which CXCL4 organizes "self" and microbial DNA into liquid crystalline immune complexes that amplify TLR9-mediated plasmacytoid dendritic cell hyperactivation and interferon-alpha production. Surprisingly, this activity does not require CXCR3, the CXCL4 receptor.

  8. Urinary angiostatin, CXC chemokine ligand 4 (CXCL4) and vascular cell adhesion molecule-1 (VCAM-1) were significantly higher in patients with active renal disease than in patients with active non-renal disease.

  9. results identify PF4 as a ligand for the integrin Mac-1 and suggest that many immune-modulating effects previously ascribed to PF4 are mediated through its interaction with Mac-1

  10. Bacteremia/sepsis was associated with higher anti-PF4/heparin antibody titers. There was no difference between Gram negative/positive bacteremia and antibody titer.

  11. CXCL4 boosts pro-inflammatory cytokine production especially IL-17 by CD4(+) T cells, either by acting directly or indirectly via myeloid antigen presenting cells, implicating a role for CXCL4 in psoriatic arthritis pathology.

  12. The data show that antibodies magnify immune responses induced in PBMCs by PF4 alone or in complex with heparin or LMWH. Authors propose that following induction of HIT antibodies by heparin-PF4 complexes, binding of the antibodies to PF4 is sufficient to induce a local pro-inflammatory response which may play a role in the progression of HIT.

  13. Report anti-PF4/H monoclonal antibody with a human Fc fragment, which induces similar cellular activation as heparin-induced thrombocytopenia antibodies.

  14. PF4 was produced by Ly6G+CD11b+ immature myeloid cells in the early stage premetastatic lungs, and decreased during metastatic progression.

  15. The CXCL4 monomer acts as the minimal active unit for interacting with CXCR3 N-Terminal Sulfated Peptide, and sulfation of N-terminal tyrosine residues on the receptor is important for binding.

  16. These findings support PF4 as a cancer-enhancing endocrine signal that controls discrete aspects of bone marrow hematopoiesis and tumor microenvironment.

  17. data support that increased levels of circulating CXCL4 may contribute to immune dysregulation through the modulation of dendritic cell differentiation

  18. Endometrial CXCL4 mRNA concentrations were significantly increased during menstruation. In women with heavy menstrual bleeding, CXCL4 was reduced in endothelial cells during the menstrual phase compared with women with normal menstrual bleeding. These data implicate CXCL4 in endometrial repair after menses.

  19. Two haplotype blocks, one upstream to the coding region of UGT2A1 (rs146712414, P = 9.1 x 10(-5); odds ratio [OR], 1.34; 95% confidence interval [CI], 1.16-1.56) and one downstream of the genes PF4/PPBP/CXCL5 (rs1595009, P = 1.3 x 10(-4); OR, 1.32; 95% CI, 1.15-1.52), were associated with AgP.

  20. These data demonstrate that the CXCR2 network and CXCL4 play a role in the maintenance of normal HSC/HPC cell fates, including survival and self-renewal.

Mouse (Murine) Platelet Factor 4 (PF4) Interaktionspartner

  1. ELF4 binds to the promoter of genes of two C-X-C chemokines, Pf4 and pro-platelet basic protein (Ppbp), initiating the transcription of these two genes, thereby enhancing PF4-mediated killing of parasites from infected erythrocytes.

  2. Platelets are activated during P. aeruginosa infection, and mice depleted of platelets display markedly increased mortality and impaired bacterial clearance. CXCL4 deficiency impairs bacterial clearance and lung epithelial permeability. CXCL4 deficiency selectively regulates chemokine production. CXCL4 deficiency reduces platelet-neutrophil interactions in blood following P. aeruginosa infection.

  3. these data demonstrate that PF4 has an important role in increasing B cell differentiation in the bone marrow environment

  4. these results identify CXCL4 as a vital immunoregulatory chemokine essential for protecting mice against influenza A virus infection, especially as it affects the development of lung injury and neutrophil mobilization to the inflamed lung

  5. These results indicate that CXCL4 is a novel Ni-binding protein that augments Ni allergy at the elicitation and sensitization phases. This is the first study to demonstrate that the Ni-binding protein augments Ni allergy in vivo.

  6. PF4 was produced by Ly6G+CD11b+ immature myeloid cells in the early stage premetastatic lungs, and decreased during metastatic progression.

  7. These data demonstrate that the CXCR2 network and CXCL4 play a role in the maintenance of normal HSC/HPC cell fates, including survival and self-renewal.

  8. Platelet-derived CXCL7 and CXCL4 contribute to the pathogenesis of acute lung injury.

  9. CXCL4 plays an important role in pancreatic inflammation

  10. Platelet secretion of CXCL4 is Rac1-dependent and regulates neutrophil infiltration and tissue damage in septic lung damage

  11. PF4 has a complex intramedullary life cycle with important implications in megakaryopoiesis and hematopoietic stem cell replication not seen with other tested alpha granule proteins.

  12. Heparin enhances antigen uptake and activation of the initial steps in the cellular immune response to PF4-containing complexes.

  13. Data indicate that platelet factor 4 (PF4) is involved directly in liver innate immune response against ischaemia-reperfusion injury (IRI) by regulating Th17 cell differentiation.

  14. CXCL4 regulates hematopoietic stem cell cell cycle activity.

  15. Platelet factor 4 has a role in regulating Th17 differentiation and cardiac allograft rejection

  16. Histones regulate activated protein C formation in a manner similar to PF4 and suggest heparinoids may be benificial in sepsis.

  17. PF4 drives a vascular smooth muscle inflammatory phenotype including a decline in differentiation markers, increased cytokine production, and cell proliferation.

  18. Peptide inhibition of CXCL4-CCL5 interactions may represent a viable translational strategy to limit progression of abdominal aortic aneurysms.

  19. PF4 expression on intestinal epithelial cells is increased after IR at both the mRNA and protein levels. In conclusion, these findings demonstrate that may PF4 represent an important mediator of local and remote tissue damage.

  20. These results suggest that Cxcl4 and Cxcl7 play a role in the development of neurobehavioral alterations that are triggered by in utero TCDD exposure and later surface in adults.

Platelet Factor 4 (PF4) Antigen-Profil

Protein Überblick

This gene encodes a member of the CXC chemokine family. This chemokine is released from the alpha granules of activated platelets in the form of a homotetramer which has high affinity for heparin and is involved in platelet aggregation. This protein is chemotactic for numerous other cell type and also functions as an inhibitor of hematopoiesis, angiogenesis and T-cell function.

Genbezeichner und Symbole assoziert mit PF4

  • platelet factor 4 (PF4) Antikörper
  • platelet factor 4 (Pf4) Antikörper
  • platelet factor 4 (LOC703451) Antikörper
  • platelet factor 4 (LOC100524373) Antikörper
  • platelet factor 4 (LOC102181854) Antikörper
  • platelet factor 4 (LOC100630489) Antikörper
  • Cxcl4 Antikörper
  • PF-4 Antikörper
  • PF4 Antikörper
  • Pf4a Antikörper
  • RATPF4A Antikörper
  • Scyb4 Antikörper

Bezeichner auf Proteinebene für PF4

C-X-C motif chemokine 4 , chemokine (C-X-C motif) ligand 4 , iroplact , oncostatin-A , PF-4 , platelet factor 4 (chemokine (C-X-C motif) ligand 4) , platelet factor 4

GENE ID SPEZIES
5196 Homo sapiens
56744 Mus musculus
360918 Rattus norvegicus
507790 Bos taurus
703451 Macaca mulatta
740477 Pan troglodytes
101104401 Ovis aries
102181854 Capra hircus
100630489 Equus caballus
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