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PER3 is a member of the Period family of genes and is expressed in a circadian pattern in the suprachiasmatic nucleus, the primary circadian pacemaker in the mammalian brain.
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data suggest that, PER3(4/4) genotype may accelerate the course of disease in multiple sclerosis susceptible individuals especially in women
The impact of PER3 polymorphisms on sleep cycle and insomnia in older adults is reported.
there is a significant association between the PER3 polymorphism and the extraversion personality trait
CLOCK rs1801260*C and PER3(4/4) influence myelination processes by regulating sleep quality and quantity.
TFEB regulates PER3 expression via glucose-dependent effects on CLOCK/BMAL1 (zeige ARNTL ELISA Kits)
Data suggest that three E box-like response elements are located upstream of PER3 transcription start sites; these response elements appear to additively contribute to cell-autonomous transcriptional oscillation of PER3 and other circadian proteins.
This study showed that Lack of Association between Genetic Polymorphism of PER3 gene with Late Onset Depression and Alzheimer's Disease in a Sample of a Brazilian Population
This study shown a possible association between Per3 polymorphism and consciousness recovery level in Disorders of Consciousness patients.
PER3 variants may be associated with decreased risk for depressive symptoms, including subthreshold levels of depressive symptoms, in older adults.
The PER1 c.2884C > G polymorphism and PER3 54bp VNTR were associated with annual percent changes in bone mineral density of femoral neck after 1 year of hormone therapy.
The findings demonstrate that Per3 has a major role in the APC (zeige APC ELISA Kits) clock and regulates adipogenesis in vivo.
Per3 is involved in the suppression of behavioural activity in direct response to light.
evidence for an association of PER3 polymorphisms with juvenile myoclonic epilepsy.
Our data provide strong evidence that variation in the Per3 transcript is causally associated with and also responsive to stress and alcohol.
We found that both the methamphetamine sensitive oscillator and food entrained oscillator in Per1(-/-)/Per2(-/-)/Per3(-/-) mice are circadian oscillators with unusually short ( approximately 21 h) periods.
Per3 exists as homodimers, which are mediated by interactions of the PAS-B beta-sheet surface including a highly conserved tryptophan Trp 359. PER3 homodimers are additionally stabilized by an N-terminal region including a predicted helix-loop-helix motif.
Per3 is a key player in the mammalian circadian system.
Per3(-/-) mice spent less time in wakefulness and more time in NREM sleep in the light period immediately after sleep deprivation and REM sleep accumulated more slowly during the recovery showing a role for PER3 in sleep-wake timing and sleep homeostasis.
Data show that S100a9 (zeige S100A9 ELISA Kits), Mmp10 (zeige MMP10 ELISA Kits) and Ang2 (zeige ANGPT2 ELISA Kits) were among the most downregulated genes, whereas Per3, Tef (zeige TEF ELISA Kits) and Prdx6 (zeige PRDX6 ELISA Kits) were significantly upregulated in the DMH (zeige DST ELISA Kits) + Calcium group.
This gene is a member of the Period family of genes and is expressed in a circadian pattern in the suprachiasmatic nucleus, the primary circadian pacemaker in the mammalian brain. Genes in this family encode components of the circadian rhythms of locomotor activity, metabolism, and behavior. Circadian expression in the suprachiasmatic nucleus continues in constant darkness, and a shift in the light/dark cycle evokes a proportional shift of gene expression in the suprachiasmatic nucleus. The specific function of this gene is not yet known.
circadian clock protein PERIOD 3
, period circadian protein homolog 3
, period homolog 3
, cell growth-inhibiting gene 13 protein
, growth-inhibiting protein 13
, period 3
, period circadian protein 3