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PADI4 is a member of a gene family which encodes enzymes responsible for the conversion of arginine residues to citrulline residues. Zusätzlich bieten wir Ihnen PADI4 Antikörper (117) und PADI4 Kits (20) und viele weitere Produktgruppen zu diesem Protein an.
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Meta-analysis indicated a significantly increased association between PADI -104C/T polymorphism and rheumatoid arthritis (RA) in Chinese and Japanese populations (which were the majority of included populations in the analysis).
PADI4 interacted with SYVN1 (zeige SYVN1 Proteine) directly and that overexpression of PADI4 suppressed the ubiquitination of proteins. Thus, a reduction in ER stress induced by PADI4 may abrogate the initiation of chronic RA by suppressing the proliferative signals of RA synoviocytes.
mRNA expression of PADI2 (zeige PADI2 Proteine), PADI4 and Sp1 (zeige PSG1 Proteine) is upregulated in rheumatoid arthritis bone marrow CD34 (zeige CD34 Proteine)+ cells independently of the systemic inflammation or treatment regimen.
this study in a Southern Mexican population suggests that PADI4 individual polymorphisms and the related susceptibility haplotype (GTG (zeige GGT1 Proteine)) are also genetic risk markers for rheumatoid arthritis
The T allele of PADI4 rs2240340 is associated with Rheumatoid Arthritis in Asians.
PADI4 contributes to gastric tumorigenesis by upregulating CXCR2 (zeige CXCR2 Proteine), KRT14 (zeige KRT14 Proteine) and TNF-alpha (zeige TNF Proteine) expression.
In this case-control study with sufficient sample size to detect associations, we observed that PADI4 SNPS rs11203367 and rs874881 do not significantly determine RA susceptibility
SNPs of PADI4 may be a risk factor for airway abnormalities in RA.
this meta-analysis suggested that PADI4 -92C/G polymorphism may be associated with the rheumatoid arthritis incidence in the Chinese population, especially for South China. Further studies conducted on other ethnic groups are required for definite conclusions.
PADI4 contributes to the pathogenesis of RA by protecting FLSs from apoptosis. PADI4 suppresses p21 (zeige CDKN1A Proteine) transcription through altering histone H3 (zeige HIST3H3 Proteine) arginine modifications on p21 (zeige CDKN1A Proteine) promoter region.
PADi4 is critical for neutrophil extracellular traps formation, but is dispensable for generalized citrullination
sFlt-1 overexpression in Padi4(-/-) mice resulted in dramatically lower inflammatory and thrombotic response, which was accompanied by significant reduction in pregnancy losses. Inhibition of NETosis may serve as a novel target in disorders of impaired placentation.
a role for NETs in cardiac fibrosis and conclude that PAD4 regulates age-related organ fibrosis and dysfunction.
PADI4 exacerbates arthritis with diverse immunological modifications.
Selective inhibition of peptidylarginine deiminase IV with Cl-amidine blocked NET formation, reduced atherosclerotic lesion area, and delayed time to carotid artery thrombosis in a photochemical injury model.
Padi4 is part of the pluripotency transcriptional network, binding to regulatory elements of key stem-cell genes and activating their expression
PAD4 regulates the proliferation of multipotent progenitors in the bone marrow by controlling c-myc (zeige MYC Proteine) expression.
PAD4-mediated chromatin decondensation in the neutrophil is crucial for pathological venous thrombosis and present neutrophil activation and PAD4 as potential drug targets for deep vein thrombosis.
PAD4 is dispensable in this effector phase model of arthritis
analysis of regulation of histone modification and chromatin structure by the p53 (zeige TP53 Proteine)-PADI4 pathway
This gene is a member of a gene family which encodes enzymes responsible for the conversion of arginine residues to citrulline residues. This gene may play a role in granulocyte and macrophage development leading to inflammation and immune response.
peptidyl arginine deiminase, type IV
, protein-arginine deiminase type-4-like
, HL-60 PAD
, PADI-H protein
, peptidyl arginine deiminase, type V
, protein-arginine deiminase type IV
, protein-arginine deiminase type-4
, PAD type IV
, peptidylarginine deiminase IV
, peptidyl arginine deiminase, type 4
, peptidylarginine deiminase type alpha