anti-Peptidyl Arginine Deiminase, Type II (PADI2) Antikörper

Human Peptidyl Arginine Deiminase, Type II (PADI2) Interaktionspartner

1. the mRNA expression of PADI2, PADI4 (zeige PADI4 Antikörper) and Sp1 (zeige PSG1 Antikörper) is upregulated in rheumatoid arthritis bone marrow CD34 (zeige CD34 Antikörper)+ cells independently of the systemic inflammation or treatment regimen.

2. These data suggest that overexpression of the human PAD2 transgene in the epidermis of transgenic mice increases the malignant conversion rate of benign tumors by promoting an inflammatory microenvironment.

3. Brain gene expression of PADI2, ZNF385A (zeige ZNF385A Antikörper), PSD2, and A2ML1 (zeige A2ML1 Antikörper) and DNA methylation (zeige HELLS Antikörper) dysregulations are implicated in the alteration of brain tissue properties associated with late-life cognitive decline above and beyond the influence of common neuropathologic conditions.

4. Peptidyl arginine deiminase 2 (PADI2) is required for activation of androgen receptor (AR (zeige AR Antikörper)) signaling under androgen-deprived condition.

5. Data suggest that protein-arginine deiminase 2 (PADI2) suppresses the proliferation of colonic epithelial cells through catalysis of protein citrullination, and that downregulation of PADI2 expression might therefore contribute to colon carcinogenesis.

6. Downregulation of PADI2 is an early event in the pathogenesis of colorectal cancer associated with poor prognosis and points toward a possible role of citrullination in modulating tumor cells and their microenvironment.

7. Multiple proteins citrullinated by hypoxia-induced PADs were identified. In addition, the extracellular domain of vascular endothelial growth factor receptor 2 was citrullinated by human PAD2 in vitro. CONCLUSION: Our data may contribute to understanding of pathophysiology of malignant gliomas from the aspects of protein citrullination.

8. Deimination of myelin basic protein (MBP) by peptidylarginine deiminase (PAD) prevents its binding to the proteasome and decelerates its degradation by the proteasome in mammalian cells. Potential anticancer drug tetrazole analogue of chloramidine 2, at concentrations greater than 1 microM inhibits the enzymatic activity of PAD in vitro.

9. this study shows that a miR (zeige MLXIP Antikörper)-4728 downregulates PADI2, a novel rheumatoid arthritis risk gene

10. We identified the presence of PADI3 (zeige PADI3 Antikörper) mRNA expression in synovial tissue and PADI2 and PADI4 (zeige PADI4 Antikörper) mRNA expressions in fibroblast-like synoviocytes from patients with rheumatoid arthritis.

Cow (Bovine) Peptidyl Arginine Deiminase, Type II (PADI2) Interaktionspartner

Mouse (Murine) Peptidyl Arginine Deiminase, Type II (PADI2) Interaktionspartner

1. PADi2 contributes to TNFalpha (zeige TNF Antikörper)-induced citrullination and arthritis, but is not required for neutrophil extracellular traps formation

2. Taken together, our study is the first to indicate the potential role of Padi2 as an angiogenesis-regulating gene. The characterization of Padi2 and other genes in associated pathways may provide new understanding of angiogenesis regulation and novel targets for diagnosis and treatment of a wide variety of angiogenesis-dependent diseases.

3. GPx7 (zeige GPX7 Antikörper) is an unusual CysGPx catalyzing the peroxidatic cycle by a one Cys (zeige DNAJC5 Antikörper) mechanism in which GSH and PDI (zeige PDIA3 Antikörper) are alternative substrates.

4. Results suggest that PADI2 may function as an important new biomarker for HER2/ERBB2 (zeige ERBB2 Antikörper)+ tumors and that Cl-amidine represents a new candidate for breast cancer therapy.

5. Activation of the P2X7 purinergic receptor (P2X7 (zeige P2RX7 Antikörper)) by the inflammatory danger signal ATP induces PAD2 activity and robust protein citrullination in mast cells.

6. different subcellular compartmentalization of PADi2 and citrullinated proteins may have different physiological roles in normal and neurodegenerative conditions

7. PAD2 interacts with IKKgamma (zeige IKBKG Antikörper) and suppresses NF-kappaB (zeige NFKB1 Antikörper) activity.

8. Results suggest that peptidylarginine deiminase 2-catalyzed citrullination is not essential to the development of experimental autoimmune encephalomyelitis.

9. An increase in citrullinated proteins resulting from increased PAD2 and 4 is an important change in the pathogenesis of multiple sclerosis.

10. This study suggests that accumulated citrullinated proteins and abnormal activation of PAD2 may function in the pathogenesis of prion (zeige PRNP Antikörper) diseases and serve as potential therapeutic targets.