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PGC encodes an aspartic proteinase that belongs to the peptidase family A1. Zusätzlich bieten wir Ihnen PGC Antikörper (178) und PGC Kits (68) und viele weitere Produktgruppen zu diesem Protein an.
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Recombinant pepsin C and pepsinogen C were purified from transgenic rice culture medium, and the NH2-terminal 5-residue sequences were verified by amino acid sequencing.
Pepsinogen-II 100 bp ins (zeige INS Proteine)/del gene polymorphism and its elevated circulating levels are associated with gastric cancer, particularly with Helicobacter pylori infection and intestinal metaplasia.
Results suggest that rs9471643 CG and rs6458238 AG/AA genotypes have important roles in up-regulating PGC expression, which may partially explain why individuals with these favorable genotypes have decreased risks of getting gastric cancer.
Data show that SNP interactions among H. pylori-related genes PGC, PTPN11 (zeige PTPN11 Proteine), and IL1B (zeige IL1B Proteine), are associated with susceptibility to gastric carcinogenesis.
Serum pepsinogens I (PGI (zeige BGN Proteine)) and II (PGII (zeige DCN Proteine)), gastrin (zeige GAST Proteine) 17 (G-17), and antibodies against whole H. pylori, or cytotoxin-associated gene A (CagA (zeige S100A8 Proteine)) antigen among 309 consecutive patients, were measured.
The results highlight an important role of PGC rs3789210 and rs6939861 in altering susceptibility to atrophic gastritis and/or gastric cancer.
Pepsinogen II is a good marker of corpus morphological changes before and after H. pylori eradication.
High serum Pepsinogen II level is associ9ated with the progression of gastric precancerous lesions.
An interaction effect of pri-let-7a-1 rs10739971 polymorphism with ERCC6 (zeige ERCC6 Proteine) rs1917799 polymorphism was observed for the risk of gastric cancer.
Pepsin and pepsinogen in middle ear effusion are probably caused by LPR (zeige FAS Proteine) and may be involved in the pathogenesis of OME.
This gene encodes an aspartic proteinase that belongs to the peptidase family A1. The encoded protein is a digestive enzyme that is produced in the stomach and constitutes a major component of the gastric mucosa. This protein is also secreted into the serum. This protein is synthesized as an inactive zymogen that includes a highly basic prosegment. This enzyme is converted into its active mature form at low pH by sequential cleavage of the prosegment that is carried out by the enzyme itself. Polymorphisms in this gene are associated with susceptibility to gastric cancers. Serum levels of this enzyme are used as a biomarker for certain gastric diseases including Helicobacter pylori related gastritis. Alternate splicing results in multiple transcript variants. A pseudogene of this gene is found on chromosome 1.
, pepsinogen C
, pepsin C
, pepsinogen group II
, urinary pepsinogen 1
, Urinary pepsinogen 1