Parkinson Protein 2, E3 Ubiquitin Protein Ligase (Parkin) Proteine (PARK2)

The precise function of PARK2 is unknown\; however, the encoded protein is a component of a multiprotein E3 ubiquitin ligase complex that mediates the targeting of substrate proteins for proteasomal degradation. Zusätzlich bieten wir Ihnen PARK2 Antikörper (192) und PARK2 Kits (22) und viele weitere Produktgruppen zu diesem Protein an.

alle Proteine anzeigen Gen GeneID UniProt
PARK2 5071 O60260
PARK2 56816 Q9JK66
PARK2 50873 Q9WVS6
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Showing 10 out of 12 products:

Katalog Nr. Origin Quelle Konjugat Bilder Menge Anbieter Lieferzeit Preis Details
Insektenzellen Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 60 Days
$9,797.11
Details
Insektenzellen Maus His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 60 Days
$9,797.11
Details
Escherichia coli (E. coli) Human His tag 100 μg Anmelden zum Anzeigen 13 bis 16 Tage
$400.00
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Wheat germ Human GST tag 10 μg Anmelden zum Anzeigen 11 bis 12 Tage
$414.29
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Hefe Ratte His tag   1 mg Anmelden zum Anzeigen 60 bis 71 Tage
$3,309.17
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Insect cells (Sf21) Human Unkonjugiert   25 μg Anmelden zum Anzeigen 5 bis 8 Tage
$791.20
Details
Escherichia coli (E. coli) Human S tag,His tag 100 μg Anmelden zum Anzeigen 15 bis 18 Tage
$624.00
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Escherichia coli (E. coli) Human His tag   10 μg Anmelden zum Anzeigen 15 bis 16 Tage
$225.00
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Escherichia coli (E. coli) Human Unkonjugiert   5 applications Anmelden zum Anzeigen 1 bis 2 Tage
$318.85
Details
Baculovirus infected Insect Cells Human GST tag   50 μg Anmelden zum Anzeigen 10 bis 12 Tage
$624.55
Details

PARK2 Proteine nach Spezies und Herkunft

Origin Exprimiert in Konjugat
Human , , , ,
, ,
Rat (Rattus)

Mouse (Murine)

Weitere Proteine zu Parkinson Protein 2, E3 Ubiquitin Protein Ligase (Parkin) (PARK2) Interaktionspartnern

Fruit Fly (Drosophila melanogaster) Parkinson Protein 2, E3 Ubiquitin Protein Ligase (Parkin) (PARK2) Interaktionspartner

  1. Loss of parkin is associated with nuclear clustering and morphology defects in larval muscles and thus developing aortic aneurysms.

  2. This study found learning and memory abnormalities in Parkin mutant genotypes in Drosophila.

  3. parkin mutants have a longer lifespan when fed the 1:16 P:C compared to those fed the 1:2 P:C diet. Parkin mutants fed the 1:16 P:C diet have delayed climbing deficit, increased resistance to starvation. Mutant flies fed the 1:16 P:C diet also have improved mitochondrial functions as evidenced by increased respiratory control ratio

  4. Drosophila CHIP protects against mitochondrial dysfunction by acting downstream of Pink1 (zeige PINK1 Proteine) in parallel with Parkin

  5. Maintenance of tissue homeostasis upon reduction of Pink1 (zeige PINK1 Proteine) or Parkin appears to result from reduction of age- and stress-induced intestinal stem cell proliferation, in part, through induction of ISC senescence.

  6. activation of endoplasmic reticulum stress by defective mitochondria is neurotoxic in pink1 (zeige PINK1 Proteine) and parkin flies and that the reduction of this signalling is neuroprotective, independently of defective mitochondria.

  7. Pharmacological or genetic activation of heat shock protein 70 (Hsp70) protects against loss of parkin Function. Heat shock protein members may act as compensatory factors for parkin loss of function and that the exploitation of these factors may be of potential therapeutic value.

  8. autophosphorylation of PINK1 (zeige PINK1 Proteine) is essential for the mitochondrial translocation of Parkin and for subsequent phosphorylation and activation of Parkin.

  9. Our data indicate that PINK1 (zeige PINK1 Proteine) and Parkin play an important role in FUS (zeige FUS Proteine)-induced neurodegeneration. This study has uncovered a previously unknown link between FUS (zeige FUS Proteine) proteinopathy and PINK1 (zeige PINK1 Proteine)/Parkin genes, providing new insights into the pathogenesis of FUS (zeige FUS Proteine) proteinopathy.

  10. Clu (zeige CLU Proteine) is upstream of and binds to VCP (zeige vcp Proteine) in vivo and promotes VCP (zeige vcp Proteine)-dependent Marf (zeige MFN2 Proteine) degradation in vitro Marf (zeige MFN2 Proteine) accumulates in whole muscle lysates of clu (zeige CLU Proteine)-deficient flies and is destabilized upon Clu (zeige CLU Proteine) overexpression. Thus, Clu (zeige CLU Proteine) is essential for mitochondrial homeostasis and functions in concert with Parkin and VCP (zeige vcp Proteine) for Marf (zeige MFN2 Proteine) degradation to promote damaged mitochondrial clearance.

Human Parkinson Protein 2, E3 Ubiquitin Protein Ligase (Parkin) (PARK2) Interaktionspartner

  1. Studies indicate a functional PTEN-induced putative kinase 1)(PINK1 (zeige PINK1 Proteine))/E3 ubiquitin protein ligase (parkin) mitophagy pathway in neurons [Review].

  2. parkin deficiency induces synaptotagmin-11 (zeige SYT11 Proteine) accumulation and PD-like neurotoxicity in mouse models, which is reversed by SYT11 (zeige SYT11 Proteine) knockdown in the SNpc or knockout of SYT11 (zeige SYT11 Proteine) restricted to dopaminergic neuron

  3. Parkin expression is inversely correlated with HIF-1alpha (zeige HIF1A Proteine) expression and metastasis in breast cancer. Results reveal an important mechanism for Parkin in tumor suppression and HIF-1alpha (zeige HIF1A Proteine) regulation.

  4. mitochondrial dysfunction activates the PINK1 (zeige PINK1 Proteine)/Parkin signaling and mitophagy in renal tubular epithelial cells under albumin (zeige ALB Proteine) overload condition.

  5. The authors demonstrate that RABGEF1 (zeige RABGEF1 Proteine), the upstream factor of the endosomal Rab GTPase (zeige RAB6A Proteine) cascade, is recruited to damaged mitochondria via ubiquitin binding downstream of Parkin. RABGEF1 (zeige RABGEF1 Proteine) directs the downstream Rab (zeige HRB Proteine) proteins, RAB5 (zeige RAB5A Proteine) and RAB7A (zeige RAB7A Proteine), to damaged mitochondria, whose associations are further regulated by mitochondrial Rab (zeige HRB Proteine)-GAPs.

  6. DNAJ (zeige DNAJB6 Proteine) proteins keep Parkin C289G mutant protein in a soluble, degradation-competent form.

  7. S-nitrosylated PINK1 (zeige PINK1 Proteine) decreases Parkin translocation to mitochondrial membranes

  8. Parkinsonism associated with Parkin gene mutation is one of the most common familial forms of Parkinson Disease, which is characterized by early onset of symptoms, slow progression, elective dopaminergic neuronal loss and the absence of Lewy bodies.

  9. A transcriptional repressor network including THAP domain containing 11 protein (THAP11) was identified and negatively regulates endogenous PARKIN abundance.

  10. Study explored the role of parkin proteins in Parkinson's disease (PD) neurodegeneration by analyzing their expression profile in an in vitro model exposed to divers neurotoxins. Results showed that up- or down-regulation of specific splice isoforms may be a direct effect of toxin exposure. Moreover, the isoforms may exert different actions in neurodegeneration via modulation of different molecular pathways.

Zebrafish Parkinson Protein 2, E3 Ubiquitin Protein Ligase (Parkin) (PARK2) Interaktionspartner

  1. Melatonin, added together with MPTP (zeige PTPN2 Proteine) or added once MPTP (zeige PTPN2 Proteine) was removed, prevented and recovered, respectively, the parkinsonian phenotype once it was established, restoring gene expression and normal function of the parkin/PINK1 (zeige PINK1 Proteine)/DJ-1 (zeige PARK7 Proteine)/MUL1 loop and also the normal motor activity of the embryos.

Pig (Porcine) Parkinson Protein 2, E3 Ubiquitin Protein Ligase (Parkin) (PARK2) Interaktionspartner

  1. Single nucleotide polymorphism (SNP) analysis revealed seven SNPs in the porcine PARK2 gene, one missense and one silent mutation in exon 7 and five SNPs in intron 7

Mouse (Murine) Parkinson Protein 2, E3 Ubiquitin Protein Ligase (Parkin) (PARK2) Interaktionspartner

  1. Overexpression of parkin resulted in a significant reduction of total-eNOS (zeige NOS3 Proteine) and p-eNOS (zeige NOS3 Proteine) in parallel with the downregulation of ERRalpha (zeige ESRRA Proteine) (a regulator of eNOS (zeige NOS3 Proteine)) protein and the enhancement of ERRalpha (zeige ESRRA Proteine) ubiquitination.

  2. Parkin mice carrying a deletion in exon 3 display impairments in the main pathway responsible for maintaining BH4 levels in the CNS, an essential cofactor for dopamine synthesis, under inflammatory conditions. Concomitant to this alteration, striatum cells do not upregulate BDNF (zeige BDNF Proteine) to confer neuroprotection in LPS (zeige TLR4 Proteine)-exposed mice, displaying an increased number of mitochondria of smaller size with perinuclear clustering.

  3. the results indicate that PICK1 (zeige PICK1 Proteine) is a potent inhibitor of Parkin, and the reduction of PICK1 (zeige PICK1 Proteine) enhances the protective effect of Parkin.

  4. PINK1 (zeige PINK1 Proteine) and PARK2 suppress pancreatic tumorigenesis through control of mitochondrial iron-mediated immunometabolism

  5. When fed with iron-supplemented diet, DMT1 (zeige SLC11A2 Proteine)-expressing mice exhibit rather selective accumulation of iron in the substantia nigra but otherwise seem normal. Parkin expression is also enhanced, likely as a neuroprotective response. When DMT1 (zeige SLC11A2 Proteine) is overexpressed against a Parkin null background, the double-mutant mice similarly resisted a disease phenotype when fed with iron or manganese, but greater susceptibility to 6-OHDA.

  6. Bnip3l (zeige BNIP3L Proteine) knockout (bnip3l (zeige BNIP3L Proteine)(-/-)) impaired mitophagy and aggravated cerebral I-R (ischemia-reperfusion) injury in mice, which can be rescued by BNIP3L (zeige BNIP3L Proteine) overexpression. The rescuing effects of BNIP3L (zeige BNIP3L Proteine) overexpression can be observed in park2(-/-) mice, which showed mitophagy deficiency after I-R.

  7. Parkin acts as a regulator of microtubule system during neuronal aging.

  8. The expression of PINK1 (zeige PINK1 Proteine) and Parkin were elevated in white adipose tissue in obese mice.

  9. crossed Parkin knockouts to the Twinkle-TG mouse in which mtDNA deletions are increased specifically in substantia nigra to determine the effect of increased deletion mutagenesis in the absence of mitochondrial quality control

  10. These findings reveal parkin-mediated cytoprotective mechanisms against misfolded SOD1 (zeige SOD1 Proteine) toxicity.

PARK2 Protein Überblick

Protein Überblick

The precise function of this gene is unknown\; however, the encoded protein is a component of a multiprotein E3 ubiquitin ligase complex that mediates the targeting of substrate proteins for proteasomal degradation. Mutations in this gene are known to cause Parkinson disease and autosomal recessive juvenile Parkinson disease. Alternative splicing of this gene produces multiple transcript variants encoding distinct isoforms. Additional splice variants of this gene have been described but currently lack transcript support.

Genbezeichner und Symbole assoziert mit PARK2

  • parkin (park)
  • parkin RBR E3 ubiquitin protein ligase (PRKN)
  • parkin RBR E3 ubiquitin protein ligase (Prkn)
  • parkin RBR E3 ubiquitin protein ligase (prkn)
  • parkin (CpipJ_CPIJ014867)
  • Parkinson disease (autosomal recessive, juvenile) 2, parkin (Park2)
  • AR-JP Protein
  • CG10523 Protein
  • Dmel\\CG10523 Protein
  • Dpark Protein
  • dpk Protein
  • LPRS2 Protein
  • Park Protein
  • PARK2 Protein
  • PDJ Protein
  • pdr-1 Protein
  • Prkn Protein
  • SD01679 Protein
  • si:ch211-123f21.1 Protein
  • zgc:112390 Protein

Bezeichner auf Proteinebene für PARK2

CG10523-PB , CG10523-PC , D-parkin , dparkin , park-PB , park-PC , E3 ubiquitin-protein ligase parkin , Parkinson disease (autosomal recessive, juvenile) 2, parkin , parkinson juvenile disease protein 2 , parkin variant SV5DEL , parkin , parkin protein , parkinson protein 2, E3 ubiquitin protein ligase (parkin)

GENE ID SPEZIES
40336 Drosophila melanogaster
5071 Homo sapiens
56816 Rattus norvegicus
550328 Danio rerio
733673 Sus scrofa
741350 Pan troglodytes
6049109 Culex quinquefasciatus
50873 Mus musculus
612316 Canis lupus familiaris
100724550 Cavia porcellus
530858 Bos taurus
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