Palmitoyl-Protein Thioesterase 1 (PPT1) ELISA Kits

The protein encoded by PPT1 is a small glycoprotein involved in the catabolism of lipid-modified proteins during lysosomal degradation. Zusätzlich bieten wir Ihnen PPT1 Antikörper (108) und PPT1 Proteine (14) und viele weitere Produktgruppen zu diesem Protein an.

list all ELISA KIts Gen GeneID UniProt
PPT1 5538 P50897
PPT1 19063 O88531
PPT1 29411 P45479
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Top PPT1 ELISA Kits auf antikoerper-online.de

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Katalog Nr. Reaktivität Sensitivität Bereich Bilder Menge Anbieter Lieferzeit Preis Details
Maus 7 pg/mL 28-1800 pg/mL Typical standard curve 96 Tests Anmelden zum Anzeigen 15 bis 18 Tage
$910.56
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Human
  96 Tests Anmelden zum Anzeigen 2 bis 3 Tage
$867.90
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Ratte
  96 Tests Anmelden zum Anzeigen 15 bis 18 Tage
$875.60
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Rind (Kuh)
  96 Tests Anmelden zum Anzeigen 15 bis 18 Tage
$1,029.60
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Weitere ELISA Kits für PPT1 Interaktionspartner

Human Palmitoyl-Protein Thioesterase 1 (PPT1) Interaktionspartner

  1. the study contributes four novel variants to the spectrum of PPT1 gene mutations and eight novel variants to the TPP1 gene mutation data in neuronal ceroid lipofuscinoses type I and type II

  2. Targeting PPT1 blocks mTOR signaling in a manner distinct from catalytic inhibitors, while concurrently inhibiting autophagy, thereby providing a new strategy for cancer therapy.

  3. the combination of elevated glycolysis and deficient MRPL13 activity was closely linked to CLN1-mediated tumor activity in human hepatoma cells

  4. Proteomics analysis on isolated cilia revealed 660 proteins, which differed in their abundance levels between wild type and Ppt1 knock out.

  5. we reveal the existence of a positive feedback loop, where palmitoylation of PPT1 results in decreased activity and subsequent elevation in the amount of palmitoylated proteins.

  6. analysis of the palmitoyl protein thioesterase 1 interactome in SH-SY5Y human neuroblastoma cells

  7. Data (including data from knockout mice) suggest that deficiency of PPT1 leads to accumulation of granular osmiophilic deposits in many cell types, especially in astrocytes. [review-like article]

  8. Data suggest that human monocytes and macrophages express PPT1; PPT1 appears to contribute 32-40% of 2-arachidonylglycerol hydrolysis activity in THP1 monocyte cell line.

  9. This neuroimaging finding in PPT1-related neuronal ceroid lipofuscinosis was not previously reported.

  10. Stop codon read-through with PTC124 induces palmitoyl-protein thioesterase-1 activity, reduces thioester load and suppresses apoptosis in cultured cells from Infantile neuronal ceroid lipofuscinosis patients.

  11. Results describe the correlation between the three-dimensional structural changes in mutant palmitoyl protein thioesterase 1 and biochemical phenotypes.

  12. mutated in neuronal ceroid lipofuscinosis

  13. The clinical, biochemical, and molecular genetic aspects of lysosomal storage disorders are discussed in this review

  14. The crystal structure of palmitoyl protein thioesterase-2 (PPT2) reveals the basis for divergent substrate specificities of the two lysosomal thioesterases, PPT1 and PPT2.

  15. there is a close correlation between CLN2 and CLN1 expression and colorectal carcinoma progression and metastasis and suggest that they may be potential molecular targets

  16. Results show that PPT1-deficiency causes a defect in fluid-phase and receptor-mediated endocytosis.

  17. ER stress due to PPT1-deficiency increases ROS and disrupts calcium homeostasis activating caspase-9 and caspase-9 activation mediates caspase-3 activation and apoptosis contributing to rapid neurodegeneration in INCL.

  18. Adult neuronal ceroid lipofuscinosis caused by deficiency in palmitoyl protein thioesterase 1.

  19. Palmitoyl protein thioesterase-1 deficiency impairs synaptic vesicle recycling at nerve terminals in humans and mice

  20. study presents clinical and diagnostic investigations in six children with variant late infantile neuronal ceroid lipofuscinosis and mutations in CLN1 including a new large-scale deletion on one allele

Mouse (Murine) Palmitoyl-Protein Thioesterase 1 (PPT1) Interaktionspartner

  1. Our results indicate that PPT1 deficiency causes alterations in the mitochondrial respiratory chain.

  2. Proteomics analysis on isolated cilia revealed 660 proteins, which differed in their abundance levels between wild type and Ppt1 knock out.

  3. In the novel Cln1(R151X) mouse model of INCL.

  4. Parkinson-like motor/sensorimotor deficits in Cln1-/- mice are not mediated by dopamine deficiency.

  5. Data show that Cln1 mutations disrupt the maturation of cathepsin D in lysosome contributing to neuropathology of infantile neuronal ceroid lipofuscinoses and suggest cathepsin D deficiency to be common link between infantile and congenital form.

  6. The authors have generated a Cln1 R151X point mutation mouse model that recapitulates the molecular, neuropathological and behavioral phenotypes of neuronal ceroid lipofuscinoses.

  7. Data (including data from knockout mice) suggest that deficiency of Ppt1 leads to accumulation of granular osmiophilic deposits in many cell types, especially in astrocytes. [review-like article]

  8. Data suggest that mouse macrophages express PPT1; PPT1 appears to contribute to 2-arachidonylglycerol hydrolysis activity in peritoneal macrophages in culture.

  9. The simultaneous loss of both Cln1 and Cln5 genes might enhance the typical pathological phenotypes of these mice by disrupting or downregulating shared or convergent pathogenic pathways.

  10. These results uncover a previously unknown phenotype associated with PPT1 deficiency, that of altered thermoregulation, which is associated with impaired lipolysis and neurotransmitter release to brown adipose tissue during cold exposure.

  11. The addition of the small molecule PPT1 mimetic can further increase that response.

  12. Glutamate receptor 4 (GluR4) AMPA receptor hypofunction and NMDA receptor hyperfunction phenotype show increased sensitivity in Ppt1-deficient neurons.

  13. Data show a progressive breakdown of axons and synapses in the brains of two different models of NCL: Ppt1(-/-) model of infantile NCL and Cln6(nclf) model of variant late-infantile NCL.

  14. The polarized axonal targeting of PPT1 may well indicate a role for PPT1 in the exocytotic pathway of neurons.

  15. was only detected in developing testis not ovary

  16. The severely affected PPT1-/- mouse CNS exhibited reduced volume of both cortical and subcortical regions, but with sparing of the cerebellum

  17. Autopsy of PPT1 mutant mice revealed a severe loss of brain mass and accumulation of autofluorescent granular osmiophilic deposits, both characteristic of Neuronal Ceroid Lipofuscinosis.

  18. We conclude that from an early age, neurons deficient in PPT1 enzyme activity display intrinsically abnormal properties that could potentially explain key features of the clinical disease, such as myoclonus and seizures.

  19. Palmitoyl-protein thioesterase-1 deficiency mediates the activation of the unfolded protein response and neuronal apoptosis in infantile neuronal ceroid lipofuscinosis.

  20. Age-dependent increase in LPC levels in the PPT1-KO mouse brain positively correlates with elevated expression of the genes characteristically associated with phagocytes.

PPT1 Antigen-Profil

Beschreibung des Gens

The protein encoded by this gene is a small glycoprotein involved in the catabolism of lipid-modified proteins during lysosomal degradation. The encoded enzyme removes thioester-linked fatty acyl groups such as palmitate from cysteine residues. Defects in this gene are a cause of infantile neuronal ceroid lipofuscinosis 1 (CLN1, or INCL) and neuronal ceroid lipofuscinosis 4 (CLN4). Two transcript variants encoding different isoforms have been found for this gene.

Genbezeichner und Symbole assoziert mit PPT1

  • palmitoyl-protein thioesterase 1 (PPT1) Antikörper
  • palmitoyl-protein thioesterase 1 (MGYG_00692) Antikörper
  • palmitoyl-protein thioesterase 1 (Ppt1) Antikörper
  • Palmitoyl-protein thioesterase 1 (ppt-1) Antikörper
  • palmitoyl-protein thioesterase 1 (ceroid-lipofuscinosis, neuronal 1, infantile) (ppt1) Antikörper
  • palmitoyl-protein thioesterase 1 L homeolog (ppt1.L) Antikörper
  • 9530043G02Rik Antikörper
  • AA960502 Antikörper
  • C77813 Antikörper
  • CLN1 Antikörper
  • D4Ertd184e Antikörper
  • INCL Antikörper
  • Ppt Antikörper
  • PPT-1 Antikörper
  • ppt1 Antikörper
  • wu:fj17f04 Antikörper
  • zgc:63969 Antikörper

Bezeichner auf Proteinebene für PPT1

ceroid-palmitoyl-palmitoyl-protein thioesterase 1 , palmitoyl-protein hydrolase 1 , palmitoyl-protein thioesterase 1 , PPT-1 , palmitoyl-protein thioesterase 1 (ceroid-lipofuscinosis, neuronal 1, infantile) , palmitoyl protein thioesterase , Palmitoyl-protein hydrolase 1 , palmitoyl-protein thioesterase 1 L homeolog

GENE ID SPEZIES
5538 Homo sapiens
10031925 Arthroderma gypseum CBS 118893
19063 Mus musculus
29411 Rattus norvegicus
419681 Gallus gallus
475316 Canis lupus familiaris
281421 Bos taurus
191744 Caenorhabditis elegans
406648 Danio rerio
100720295 Cavia porcellus
102126191 Macaca fascicularis
100037210 Xenopus laevis
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