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The protein encoded by PTK6 is a cytoplasmic nonreceptor protein kinase which may function as an intracellular signal transducer in epithelial tissues. Zusätzlich bieten wir Ihnen PTK6 Proteine (15) und PTK6 Kits (13) und viele weitere Produktgruppen zu diesem Protein an.
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Human Polyclonal PTK6 Primary Antibody für IF, WB - ABIN519483
Foudah, Sallam, Akl, El Sayed: Optimization, pharmacophore modeling and 3D-QSAR studies of sipholanes as breast cancer migration and proliferation inhibitors. in European journal of medicinal chemistry 2014
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Human Monoclonal PTK6 Primary Antibody für IHC (p), ELISA - ABIN519484
Akl, Ayoub, Mohyeldin, Busnena, Foudah, Liu, Sayed: Olive phenolics as c-Met inhibitors: (-)-Oleocanthal attenuates cell proliferation, invasiveness, and tumor growth in breast cancer models. in PLoS ONE 2014
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Human Polyclonal PTK6 Primary Antibody für IHC (p), WB - ABIN392105
Derry, Prins, Ray, Tyner: Altered localization and activity of the intracellular tyrosine kinase BRK/Sik in prostate tumor cells. in Oncogene 2003
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Human Monoclonal PTK6 Primary Antibody für ELISA - ABIN966923
Ottilie, Raulf, Barnekow, Hannig, Schartl: Multiple src-related kinase genes, srk1-4, in the fresh water sponge Spongilla lacustris. in Oncogene 1992
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Human Polyclonal PTK6 Primary Antibody für IF (p), IHC (p) - ABIN1713614
Akl, Foudah, Ebrahim, Meyer, El Sayed: The marine-derived sipholenol A-4-O-3',4'-dichlorobenzoate inhibits breast cancer growth and motility in vitro and in vivo through the suppression of Brk and FAK signaling. in Marine drugs 2014
Human Monoclonal PTK6 Primary Antibody für ELISA, WB - ABIN969373
Wilks: Two putative protein-tyrosine kinases identified by application of the polymerase chain reaction. in Proceedings of the National Academy of Sciences of the United States of America 1989
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Human Monoclonal PTK6 Primary Antibody für ELISA, WB - ABIN2869234
Liu, Zhang, Zhong, Li, Liu, Lin, Wu, Zeng: Low expression of PTK6/Brk predicts poor prognosis in patients with laryngeal squamous cell carcinoma. in Journal of translational medicine 2013
In prostate tumor tissue microarrays, loss of PTEN phosphohydrolase (PTEN) correlates with increased tyrosine kinase (zeige TXK Antikörper) 6 PTK6 tyrosine 342 (PY342) phosphorylation and poor outcome.
These results indicate that plasma-membrane-associated PTK6 phosphorylates Eps8 (zeige EPS8 Antikörper), which promotes cell proliferation, adhesion, and migration
Expression of PTK6 in established tumors may maintain the epithelial phenotype, preventing tumor progression.
analysis of recombinant PTK6 kinase domain by x-ray crystallography reveals details of its binding to inhibitors
The crystal structure of the kinase domain of human PTK6 has been reported.
PTK6 mRNA and protein levels were elevated in cervical squamous cell cancer and the elevated cytoplasmic expression of PTK6 was associated with tumor grade and short patient survival.
PELP1 (zeige PELP1 Antikörper) interacted with GR to activate Brk expression.
PTK6 prolongs S-phase and increases the ability of gemcitabine to cause DNA damage in vitro and in vivo
BRK expression in a majority of CC can interact with RTK, augmenting growth and interfering with proliferation inhibitors (SAM68 (zeige KHDRBS1 Antikörper)). Therapeutically targeting BRK function (in addition to RTK) should be of benefit for CC treatment.
Additive impact of HER2 (zeige ERBB2 Antikörper)-/PTK6-RNAi on interactions with HER3 (zeige ERBB3 Antikörper) or IGF-1R (zeige IGF1R Antikörper) leads to reduced breast cancer progression
PTK6 may act as a novel mediator of TNFalpha (zeige TNF Antikörper)/IFNgamma intestinal epithelial permeability during inflammatory injury, and miR (zeige MLXIP Antikörper)-93 may protect intestinal epithelial barrier function, at least in part, by targeting PTK6
Ptk6 promotes ERBB2 (zeige ERBB2 Antikörper)-induced mammary gland tumorigenesis in the mouse.
Protein tyrosine kinase 6 has a role in mediating TNFalpha (zeige TNF Antikörper)-induced endothelial barrier dysfunction
Protein tyrosine kinase 6 protects cells from anoikis by directly phosphorylating focal adhesion kinase and activating AKT (zeige AKT1 Antikörper).
expression of Brk/PTK6 in non-transformed mammary epithelial cells mediates p38 MAPK (zeige MAPK14 Antikörper) phosphorylation and promotes increased cellular survival, delayed involution, and latent tumor formation.
a novel function for PTK6 at the plasma membrane
PTK6 promotes STAT3 (zeige STAT3 Antikörper) activation in the colon following injection of the carcinogen azoxymethane and regulates STAT3 (zeige STAT3 Antikörper) activity in mouse colon tumors.
AKT (zeige AKT1 Antikörper) is a direct substrate of PTK6 and AKT (zeige AKT1 Antikörper) tyrosine residues 315 and 326 are phosphorylated by PTK6.
PTK6 associates with nuclear and cytoplasmic beta-catenin (zeige CTNNB1 Antikörper) and inhibits beta-catenin (zeige CTNNB1 Antikörper)- and T-cell factor (TCF (zeige HNF4A Antikörper))-mediated transcription.
The protein encoded by this gene is a cytoplasmic nonreceptor protein kinase which may function as an intracellular signal transducer in epithelial tissues. Overexpression of this gene in mammary epithelial cells leads to sensitization of the cells to epidermal growth factor and results in a partially transformed phenotype. Expression of this gene has been detected at low levels in some breast tumors but not in normal breast tissue. The encoded protein has been shown to undergo autophosphorylation. Alternative splicing results in multiple transcript variants.
PTK6 protein tyrosine kinase 6
, breast tumor kinase
, protein-tyrosine kinase 6
, protein-tyrosine kinase BRK
, tyrosine-protein kinase BRK
, protein tyrosine kinase 6
, src-related intestinal kinase
, tyrosine kinase identified from skin
, protein-tyrosine kinase 6-like