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PBKs encodes a serine/threonine kinase related to the dual specific mitogen-activated protein kinase kinase (MAPKK) family. Zusätzlich bieten wir Ihnen PDZ Binding Kinase Proteine (14) und PDZ Binding Kinase Kits (6) und viele weitere Produktgruppen zu diesem Protein an.
Showing 10 out of 153 products:
Human Monoclonal PBK Primary Antibody für ICC, FACS - ABIN969345
Oh, Zhu, Cho, Lee, Kang, Kim, Zykova, Bode, Dong: T-lymphokine-activated killer cell-originated protein kinase functions as a positive regulator of c-Jun-NH2-kinase 1 signaling and H-Ras-induced cell transformation. in Cancer research 2007
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Human Polyclonal PBK Primary Antibody für WB - ABIN1881635
Zykova, Zhu, Lu, Higgins, Tatsumi, Abe, Bode, Dong: Lymphokine-activated killer T-cell-originated protein kinase phosphorylation of histone H2AX prevents arsenite-induced apoptosis in RPMI7951 melanoma cells. in Clinical cancer research : an official journal of the American Association for Cancer Research 2006
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Human Polyclonal PBK Primary Antibody für ICC, IF - ABIN4343992
Mulder, Björling, Jonasson, Wernérus, Hober, Hökfelt, Uhlén: Tissue profiling of the mammalian central nervous system using human antibody-based proteomics. in Molecular & cellular proteomics : MCP 2009
Results found that PBK/TOPK was upregulated and phosphorylated in HTLV1-transformed Tcell lines and ATLLderived Tcell lines. In addition, HTLV1 infection upregulated PBK/TOPK expression in PBMCs, suggesting that this kinase increases the rate of mitosis and expands malignant T cells.
Findings strongly suggest that phosphorylated T-lymphokine-activated killer cell-originated protein kinase may be a potent biomarker to determine the outcome of patients with primary central nervous system lymphoma and to develop novel drugs to treat primary central nervous system lymphoma.
the expression of TOPK be a novel alternative biomarker to categorize the malignancy of gliomas.
CDK1 (zeige CDK1 Antikörper)-mediated mitotic phosphorylation of PDZ-binding kinase is involved in cytokinesis and inhibits its oncogenic activity.
Data suggest that T-LAK cell-originated protein kinase (TOPK) might play a pivotal role in breast cancer invasion and metastasis.
our study provide convincing evidences that FoxM1 (zeige FOXM1 Antikörper)-regulated PBK exerts oncogenic activities towards HCC (zeige FAM126A Antikörper) via the activation of beta-Catenin (zeige CTNNB1 Antikörper) pathway.
High TOPK expression is associated with liver cancer.
The role of T-LAK cell-originated protein kinase directly promotes metastasis of colorectal cancer by modulating p53-related protein kinase (zeige TP53RK Antikörper).
TOPK protein and transcriptional levels of FOXM1 (zeige FOXM1 Antikörper) were reduced by TOPK inhibitor treatment.
Results indicate that src (zeige SRC Antikörper)-family kinase (Src (zeige SRC Antikörper)) is a upstream kinase of T-LAK cell-originated protein kinase (TOPK).
this study shows that remote ischemic postconditioning protects against renal ischemia/reperfusion injury via activation of TOPK/PTEN/Akt (zeige AKT1 Antikörper) signaling pathway
T-LAK cell-originated protein kinase (TOPK) phosphorylation of MKP1 (zeige DUSP1 Antikörper) protein prevents solar ultraviolet light-induced inflammation through inhibition of the p38 protein (zeige RNF19A Antikörper) signaling pathway.
The TOPK protein is expressed mainly in the cytosol of spermatocytes and spermatids, but not in spermatids and spermatogonia in situ.
Melanoma cell lines expressing with high levels of TOPK are more resistant to As(3+)-induced apoptosis. Therefore, inhibition of TOPK activity combined with As(3+) treatment may be helpful in the treatment of melanomas.
This genes encodes a serine/threonine kinase related to the dual specific mitogen-activated protein kinase kinase (MAPKK) family. Evidence suggests that mitotic phosphorylation is required for its catalytic activity. This mitotic kinase may be involved in the activation of lymphoid cells and support testicular functions, with a suggested role in the process of spermatogenesis.
PDZ binding kinase
, T-LAK cell-originated protein kinase
, MAPKK-like protein kinase
, cancer/testis antigen 84
, lymphokine-activated killer T-cell-originated protein kinase
, serine/threonine protein kinase
, spermatogenesis-related protein kinase
, PDZ-binding kinase
, PBK, PDZ-binding kinase
, lymphokine-activated killer T-cell-originated protein kinase homolog