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Poly(ADP-ribose) glycohydrolase (PARG) is the major enzyme responsible for the catabolism of poly(ADP-ribose), a reversible covalent-modifier of chromosomal proteins. Zusätzlich bieten wir Ihnen PARG Antikörper (50) und PARG Proteine (5) und viele weitere Produktgruppen zu diesem Protein an.
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PARG is acetylated at multiple sites.PARG interacts with PCNA (zeige PCNA ELISA Kits) via a non-canonical PIP (zeige PIP ELISA Kits)-box.
PARG inhibition leads to stalled replication forks and increased homologous recombination (HRR). The lack of HRR proteins at PARG inhibitor-induced replication stalling that induces cell death.
Data show that poly-(ADP-ribose) polymerase 1 (PARP1 (zeige PARP1 ELISA Kits)) opposes the function of poly-(ADP-ribose) glycohydrolase (PARG) during regulation of bone morphogenetic protein target gene expression.
Poly(ADP-ribosyl) glycohydrolase (PARG) is involved in cell proliferation and DNA synthesis, with depletion leading to replication-coupled H2AX (zeige H2AFX ELISA Kits) phosphorylation. In addition, PARG depletion or inhibition slows down individual replication forks similarly to mild chemotherapeutic treatment.
Studies indicate that poly (ADP-ribose) glycohydrolase (PARG) and terminal ADP-ribose glycohydrolase 1 (TARG1 (zeige NDRG1 ELISA Kits)) are key enzymes in poly(ADP-ribose) polymerases (PARPs)-mediated ADP-ribosylation.
Nuclear Smad (zeige SMAD1 ELISA Kits) function is negatively regulated by PARP-1 (zeige PARP1 ELISA Kits) that is assisted by PARP-2 (zeige PARP2 ELISA Kits) and positively regulated by PARG during the course of TGFB (zeige TGFB1 ELISA Kits) signaling.
Radiation-induced G2/M arrest was largely suppressed by PARG siRNA in PC-14 and A427 cells, which exhibited significantly enhanced radiosensitivity in response to PARG knockdown.
The amount of poly(ADP-ribose) in a cell is regulated under the control of PARP1 (zeige PARP1 ELISA Kits)/PARG gene expression balance.
PARG knockdown enhances sensitivity to MMS in MIAPaCa2 and RKO tumor cell lines.
poly(ADP-ribose) glycohydrolase is crucial for Trypanosoma cruzi infection cycle.
This study contributes to the understanding of PARG catalytic and regulatory mechanisms as well as the rational design of PARG inhibitors.
PARG110 knockout retinal explants were highly resistant to cyclic GMP (zeige NT5C2 ELISA Kits) toxicity.
we investigated the role of PARG in photoreceptor degeneration using the PARG-110 knock out mouse and report for the first time on PARG expression in wild-type and knock-out retina.
PARG release of PAR attached to nuclear proteins, followed by ARH3 cleavage of PAR, is essential in regulating PAR-dependent apoptosis-inducing factor (zeige AIFM1 ELISA Kits) release from mitochondria and parthanatos.
Data indicate that poly(ADP-ribose) glycohydrolase Parg(-/-) cells were more sensitive to gamma-irradiation than poly(ADP-ribose) polymerase-1 Parp-1 (zeige PARP1 ELISA Kits)(-/-) cells.
Results define PARG as a coactivator regulating chromatin remodeling during retinoic acid receptor (zeige RARA ELISA Kits)-dependent gene expression.
Results demonstrate nuclear AIF (zeige AIFM1 ELISA Kits) translocation only in PARG-null TS cells, which demonstrates the presence of AIF (zeige AIFM1 ELISA Kits)-mediated cell death.
PARP-1 (zeige PARP1 ELISA Kits)/PARG control a cell death signal pathway that operates between five different cell compartments and communicates via three types of chemical messengers: a nucleotide, a cation, and proteins
PARG-deficient cells showed a compromised DNA repair and increased genomic instability.
Hydrolysis of PARP (zeige PARP1 ELISA Kits) requires PARG.
Poly(ADP-ribose) glycohydrolase (PARG) is the major enzyme responsible for the catabolism of poly(ADP-ribose), a reversible covalent-modifier of chromosomal proteins. The protein is found in many tissues and may be subject to proteolysis generating smaller, active products.
mitochondrial poly(ADP-ribose) glycohydrolase
, poly(ADP-ribose) glycohydrolase
, poly(ADP-ribose) glycohydrolase 60 kDa isoform
, cytosolic poly(ADP-ribose) glycohydrolase
, mitochondrial poly(ADP-ribose) glycohydrolase 63 kDa isoform