Poly(ADP-ribose) glycohydrolase (PARG) is the major enzyme responsible for the catabolism of poly(ADP-ribose), a reversible covalent-modifier of chromosomal proteins. Zusätzlich bieten wir Ihnen PARG Antikörper (52) und PARG Proteine (5) und viele weitere Produktgruppen zu diesem Protein an.

list all ELISA KIts Gen GeneID UniProt
PARG 8505 Q86W56
PARG 26430  
PARG 83507 Q9QYM2
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Katalog Nr. Reaktivität Sensitivität Bereich Bilder Menge Anbieter Lieferzeit Preis Details
Ratte < 0.094 ng/mL 0.156 ng/mL - 10 ng/mL   96 Tests Anmelden zum Anzeigen 11 bis 18 Tage
Maus < 46.9 pg/mL 78 pg/mL - 5000 pg/mL   96 Tests Anmelden zum Anzeigen 11 bis 18 Tage
Human < 0.188 ng/mL 0.313 ng/mL - 20 ng/mL   96 Tests Anmelden zum Anzeigen 11 bis 18 Tage
Rind (Kuh)
  96 Tests Anmelden zum Anzeigen 15 bis 18 Tage

Weitere ELISA Kits für PARG Interaktionspartner

Human PARG Interaktionspartner

  1. PARG is acetylated at multiple sites.PARG interacts with PCNA via a non-canonical PIP-box.

  2. PARG inhibition leads to stalled replication forks and increased homologous recombination (HRR). The lack of HRR proteins at PARG inhibitor-induced replication stalling that induces cell death.

  3. Data show that poly-(ADP-ribose) polymerase 1 (PARP1) opposes the function of poly-(ADP-ribose) glycohydrolase (PARG) during regulation of bone morphogenetic protein target gene expression.

  4. Poly(ADP-ribosyl) glycohydrolase (PARG) is involved in cell proliferation and DNA synthesis, with depletion leading to replication-coupled H2AX phosphorylation. In addition, PARG depletion or inhibition slows down individual replication forks similarly to mild chemotherapeutic treatment.

  5. Studies indicate that poly (ADP-ribose) glycohydrolase (PARG) and terminal ADP-ribose glycohydrolase 1 (TARG1) are key enzymes in poly(ADP-ribose) polymerases (PARPs)-mediated ADP-ribosylation.

  6. Nuclear Smad function is negatively regulated by PARP-1 that is assisted by PARP-2 and positively regulated by PARG during the course of TGFB signaling.

  7. Radiation-induced G2/M arrest was largely suppressed by PARG siRNA in PC-14 and A427 cells, which exhibited significantly enhanced radiosensitivity in response to PARG knockdown.

  8. The amount of poly(ADP-ribose) in a cell is regulated under the control of PARP1/PARG gene expression balance.

  9. PARG knockdown enhances sensitivity to MMS in MIAPaCa2 and RKO tumor cell lines.

  10. poly(ADP-ribose) glycohydrolase is crucial for Trypanosoma cruzi infection cycle.

  11. Therefore, strategies that target PAR metabolism for the improved treatment of cancer may be required to target PARP-1 and PARG individually in order to optimize cancer cell death.

  12. PARG silencing could inhibit the ability of HUVEC migration and proliferation by downregulating the activity of NF-kappaB in LoVo cells that in turn decreases angiogenic factors such as VEGF, b-FGF, ICAM-1, MMP-9, as well as phosphorylation of p38 and ERK.

  13. Silencing of Apoptosis-Inducing factor and poly(ADP-ribose) glycohydrolase reveals novel roles in breast cancer cell death after chemotherapy.

  14. Results define PARG as a coactivator regulating chromatin remodeling during retinoic acid receptor-dependent gene expression.

  15. inhibition of PARG leads to an accumulation of PAR polymers, the collapse of replication forks and the induction of homologous recombination in wild-type cells.

  16. PARG knockdown, concomitant with inhibition of PARP, suppressed the metastatic potency of colon carcinoma cells by activation of PI3K/Akt signaling pathway.

  17. The identification of a PARG isoform as a component of the mitochondrial matrix raises several interesting possibilities concerning mechanisms of nuclear-mitochondrial cross talk involved in regulation of cell death pathways.

  18. Subcellular localization of human poly(ADP-ribose) glycohydrolase in mammalian cells.

  19. PARG is expressed in alternatiuve splice variants yielding isoforms that localize to different cell compartments.

  20. PARG in modulating chromatin structure, participares in transcription, DNA repair and apoptosis [review].

Mouse (Murine) PARG Interaktionspartner

  1. This study contributes to the understanding of PARG catalytic and regulatory mechanisms as well as the rational design of PARG inhibitors.

  2. PARG110 knockout retinal explants were highly resistant to cyclic GMP toxicity.

  3. we investigated the role of PARG in photoreceptor degeneration using the PARG-110 knock out mouse and report for the first time on PARG expression in wild-type and knock-out retina.

  4. PARG release of PAR attached to nuclear proteins, followed by ARH3 cleavage of PAR, is essential in regulating PAR-dependent apoptosis-inducing factor release from mitochondria and parthanatos.

  5. Data indicate that poly(ADP-ribose) glycohydrolase Parg(-/-) cells were more sensitive to gamma-irradiation than poly(ADP-ribose) polymerase-1 Parp-1(-/-) cells.

  6. Results define PARG as a coactivator regulating chromatin remodeling during retinoic acid receptor-dependent gene expression.

  7. Results demonstrate nuclear AIF translocation only in PARG-null TS cells, which demonstrates the presence of AIF-mediated cell death.

  8. PARP-1/PARG control a cell death signal pathway that operates between five different cell compartments and communicates via three types of chemical messengers: a nucleotide, a cation, and proteins

  9. PARG-deficient cells showed a compromised DNA repair and increased genomic instability.

  10. Hydrolysis of PARP requires PARG.

  11. These data indicate that the poly(ADP-ribose) glycohydrolase 110 kDa isoform plays an important role in DNA damage responses and in pathological processes.

  12. a role for PARG in embryonic development and a protective role in the response to genotoxic stress

  13. endogenous PARG(110) plays a pivotal role in the pathophysiology of ischemia reperfusion injury of the kidney.

  14. PARG has a role in embryonic mouse viability [review]

  15. results suggest that poly (ADP-ribose) glycohydrolase(PARG) activity modulates the inflammatory response in ischemia/reperfusion and participates in end (target) organ damage under these conditions

  16. results suggest that PARG may play an autonomous role in the cellular response to oxidative DNA damage

  17. Our results show that a precise coordination of PARPs and PARG activities is important for normal cellular responses to DNA damage and that this coordination is defective in the absence of the PARG A domain.

  18. The subcellular segregation of PARG in the mitochondria and PARP-1 in the nucleus suggests that PARG translocation is necessary for their functional interaction. This translocation is PARP-1 dependent.

  19. absence of ADP-ribose polymers caused by ectopic over-expression of poly(ADP-ribose) glycohydrolase in mouse fibroblast cells leads to aberrant methylation of the CpG island in the promoter of the Dnmt1 gene, which in turn shuts down its transcription.

  20. knockout mice deficient in PARP1, PARG (110-kDa isoform), or both display morphological and functional sperm abnormalities, including residual DNA strand breaks associated with varying degrees of subfertility.

PARG Antigen-Profil

Beschreibung des Gens

Poly(ADP-ribose) glycohydrolase (PARG) is the major enzyme responsible for the catabolism of poly(ADP-ribose), a reversible covalent-modifier of chromosomal proteins. The protein is found in many tissues and may be subject to proteolysis generating smaller, active products.

Genbezeichner und Symbole assoziert mit PARG (PARG) ELISA Kits

  • poly(ADP-ribose) glycohydrolase (PARG) Antikörper
  • poly (ADP-ribose) glycohydrolase (Parg) Antikörper
  • AI413217 Antikörper
  • PARG99 Antikörper

Bezeichner auf Proteinebene für PARG (PARG) ELISA Kits

mitochondrial poly(ADP-ribose) glycohydrolase , poly(ADP-ribose) glycohydrolase , poly(ADP-ribose) glycohydrolase 60 kDa isoform , cytosolic poly(ADP-ribose) glycohydrolase , mitochondrial poly(ADP-ribose) glycohydrolase 63 kDa isoform

8505 Homo sapiens
26430 Mus musculus
83507 Rattus norvegicus
281377 Bos taurus
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