anti-Nuclear Receptor Binding SET Domain Protein 1 (NSD1) Antikörper

NSD1 encodes a protein containing a SET domain, 2 LXXLL motifs, 3 nuclear translocation signals (NLSs), 4 plant homeodomain (PHD) finger regions, and a proline-rich region. Zusätzlich bieten wir Ihnen und viele weitere Produktgruppen zu diesem Protein an.

Alle Antikörper anzeigen Gen GeneID UniProt
NSD1 64324 Q96L73
NSD1 306764  
NSD1 18193  
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Top anti-NSD1 Antikörper auf antikoerper-online.de

Showing 10 out of 47 products:

Katalog Nr. Reaktivität Wirt Konjugat Applikation Bilder Menge Anbieter Lieferzeit Preis Details
Human Maus Unkonjugiert WB NSD1 monoclonal antibody (M08), clone 4F1. Western Blot analysis of NSD1 expression in human uterus myoma. Antibody Reactive Against Recombinant Protein.Western Blot detection against Immunogen (37.62 KDa) . Dilution: 1:500~1000 100 μg Anmelden zum Anzeigen 8 bis 11 Tage
$461.00
Details
Human Kaninchen Unkonjugiert ICC, IF, IHC, IHC (p) Detection of Human NSD1 by Immunohistochemistry. Samples: FFPE section of human prostate adenocarcinoma. Antibody: Affinity purified rabbit anti-NSD1 ABIN151269 used at a dilution of 1:100. Detection: DAB Immunohistochemistry: KMT3B/NSD1 Antibody  - Sample: FFPE section of human breast carcinoma. Antibody: Affinity purified rabbit anti-NSD1 used at a dilution of 1:250. Detection: DAB staining using Immunohistochemistry Accessory Kit . 0.1 mL Anmelden zum Anzeigen 7 bis 9 Tage
$585.06
Details
Human Kaninchen Unkonjugiert WB Western blot analysis of extracts of various cells, using NSD1 antibody. 100 μL Anmelden zum Anzeigen 16 Days
$334.77
Details
Human Maus Unkonjugiert WB   100 μL Anmelden zum Anzeigen 16 Days
$273.11
Details
Human Kaninchen Unkonjugiert IF (p), IHC (p) Formalin-fixed and paraffin embedded rat brain labeled with Anti-NSD1 Polyclonal Antibody, Unconjugated  at 1:200 followed by conjugation to the secondary antibody and DAB staining. Formalin-fixed and paraffin embedded rat brain labeled with Anti-NSD1 Polyclonal Antibody, Unconjugated  at 1:200 followed by conjugation to the secondary antibody and DAB staining. 100 μL Anmelden zum Anzeigen 3 bis 7 Tage
$306.90
Details
Human Maus Unkonjugiert DB 50 μg Anmelden zum Anzeigen 6 bis 8 Tage
$285.71
Details
Human Maus Unkonjugiert ELISA, WB Western Blot detection against Immunogen (37.62 KDa) . Detection limit for recombinant GST tagged NSD1 is 3 ng/ml as a capture antibody. 100 μg Anmelden zum Anzeigen 11 bis 12 Tage
$440.00
Details
Human Kaninchen Unkonjugiert IHC, IHC (p) Immunohistochemistry: KMT3B/NSD1 Antibody  - Immunohistochemical staining of human testis shows strong nuclear positivity in cells in seminiferous ducts and Leydig cells. 100 μL Anmelden zum Anzeigen 10 bis 13 Tage
$491.63
Details
Human Maus Unkonjugiert ELISA, WB   100 μg Anmelden zum Anzeigen 7 bis 9 Tage
$537.17
Details
Human Kaninchen Unkonjugiert ELISA, IHC 200 μL Anmelden zum Anzeigen 12 bis 14 Tage
$438.90
Details

Am meisten referenzierte anti-NSD1 Antikörper

  1. Mammalian Monoclonal NSD1 Primary Antibody für ISt, IHC - ABIN1304874 : Satterlee, Beckel-Mitchener, McAllister, Procaccini, Rutter, Tyson, Chadwick: Community resources and technologies developed through the NIH Roadmap Epigenomics Program. in Methods in molecular biology (Clifton, N.J.) 2014 (PubMed)

  2. Human Polyclonal NSD1 Primary Antibody für ICC, IF - ABIN151269 : Quintana, Dupuy, Bravo, Casanova, Alameda, Page, Sánchez-Viera, Ramírez, Navarro: A transposon-based analysis of gene mutations related to skin cancer development. in The Journal of investigative dermatology 2013 (PubMed)

  3. Human Monoclonal NSD1 Primary Antibody für ELISA, WB - ABIN528606 : Lu, Jackson, Wang, Yang, Chance, Miyagi, Gudkov, Stark: Regulation of NF-kappaB by NSD1/FBXL11-dependent reversible lysine methylation of p65. in Proceedings of the National Academy of Sciences of the United States of America 2010 (PubMed)

  4. Human Polyclonal NSD1 Primary Antibody für WB - ABIN3068973 : Streubel, Watson, Jammula, Scelfo, Fitzpatrick, Oliviero, McCole, Conway, Glancy, Negri, Dillon, Wynne, Pasini, Krogan, Bracken, Cagney: The H3K36me2 Methyltransferase Nsd1 Demarcates PRC2-Mediated H3K27me2 and H3K27me3 Domains in Embryonic Stem Cells. in Molecular cell 2018 (PubMed)

Weitere Antikörper gegen NSD1 Interaktionspartner

Human Nuclear Receptor Binding SET Domain Protein 1 (NSD1) Interaktionspartner

  1. Intratumoral heterogeneity (ITH) of NSD1 mutation in a colorectal cancers suggests that NSD1 mutation occurred during tumour progression rather than as an early event.

  2. variable expression of the Sotos syndrome caused by NSD1 mutation

  3. In this report, we described a new patient with Sotos syndrome caused by a 5q35 microdeletion spanning approximately 1.9 Mb in size and including the complete NSD1 gene

  4. NSD1 Inactivation is associated with Clear Cell Renal Cell Carcinomas.

  5. Nuclear receptor binding SET domain protein 1 (NSD1)duplication in 5q35 pathogenic variants could be detected in five out of 43 Silver-Russell syndrome (SRS (zeige SMS Antikörper)) patients.

  6. Study illustrates the dynamic behavior of the post-SET loop and the presence of a few distinct conformations for NSD1 protein. In every case, the post-SET loop remains in an autoinhibitory position blocking the peptide-binding cleft, suggesting that another interaction is required to optimally position NSD1 in an active conformation.

  7. NSD1 mutation is associated with severe connective tissue laxity including aortic dilatation in Sotos syndrome.

  8. NSD1 mutation is associated with Hyperinsulinemic hypoglycemia.

  9. Studies indicate that the NSD methyltransferases NSD1, NSD2/WHSC1/MMSET (zeige WHSC1 Antikörper) and NSD3/WHSC1L1 (zeige WHSC1L1 Antikörper) were overexpressed, amplified or somatically mutated in multiple types of cancer, suggesting their critical role in cancer.

  10. The genome-wide impact of a highly significant NSD1(+/-)-specific signature that differentiates pathogenic NSD1 mutations from controls, benign NSD1 variants and the clinically overlapping Weaver (zeige KCNJ6 Antikörper) syndrome is described.

Mouse (Murine) Nuclear Receptor Binding SET Domain Protein 1 (NSD1) Interaktionspartner

  1. Silencing of Nsd1 followed by LLO stimulation led to increased caspase-1 (zeige CASP1 Antikörper) activation, enhanced post-translational maturation of IL-1beta (zeige IL1B Antikörper) and IL-18 (zeige IL18 Antikörper) and elevated pyroptosis, a form of cell death associated with inflammation.

  2. Nsd1 contains consensus TFII-I (zeige GTF2I Antikörper) binding sites in the proximal promoters; the chromatin immunoprecipitation analysis showed that TFII-I (zeige GTF2I Antikörper) transcription factors are recruited to these sites in vivo in Williams-Beuren syndrome.

  3. all of the H3K36-specific methyltransferases, including ASH1L (zeige ASH1L Antikörper), HYPB (zeige SETD2 Antikörper), NSD1, and NSD2 (zeige WHSC1 Antikörper) were inhibited by ubH2A, whereas the other histone methyltransferases, including PRC2, G9a (zeige EHMT2 Antikörper), and Pr-Set7 (zeige SETD8 Antikörper) were not affected by ubH2A.

  4. NSD1 interaction with liganded NRs (zeige SPNS1 Antikörper) including ERa, AR, RARa (zeige RARA Antikörper), RXRa (zeige RXRA Antikörper), TRb (zeige AATF Antikörper), PPARg (zeige PPARG Antikörper) and VDR (zeige CYP27B1 Antikörper) is mediated by an LXXLL motif. Interaction with the NR2E/F subfamily including COUP-TFI (zeige NR2F1 Antikörper), COUP-TFII (zeige NR2F2 Antikörper), EAR2 (zeige NR2F6 Antikörper) and TLX (zeige NR2E1 Antikörper) requires an overlapping F/YSXXLXXL/Y motif.

  5. Data show that nuclear receptor-binding SET domain-containing protein (NSD1) is a developmental regulatory protein with histone methyltransferase activity that exerts function(s) essential for early post-implantation development.

  6. Nizp1 (zeige ZNF496 Antikörper) contains a novel type of zinc finger motif that functions as a docking site for NSD1

NSD1 Antigen-Profil

Protein Überblick

This gene encodes a protein containing a SET domain, 2 LXXLL motifs, 3 nuclear translocation signals (NLSs), 4 plant homeodomain (PHD) finger regions, and a proline-rich region. The encoded protein enhances androgen receptor (AR) transactivation, and this enhancement can be increased further in the presence of other androgen receptor associated coregulators. This protein may act as a nucleus-localized, basic transcriptional factor and also as a bifunctional transcriptional regulator. Mutations of this gene have been associated with Sotos syndrome and Weaver syndrome. One version of childhood acute myeloid leukemia is the result of a cryptic translocation with the breakpoints occurring within nuclear receptor-binding Su-var, enhancer of zeste, and trithorax domain protein 1 on chromosome 5 and nucleoporin, 98-kd on chromosome 11. Two transcript variants encoding distinct isoforms have been identified for this gene.

Genbezeichner und Symbole assoziert mit NSD1

  • nuclear receptor binding SET domain protein 1 (NSD1) Antikörper
  • nuclear receptor binding SET domain protein 1 (nsd1) Antikörper
  • nuclear receptor binding SET domain protein 1 (Nsd1) Antikörper
  • histone-lysine N-methyltransferase, H3 lysine-36 and H4 lysine-20 specific (LOC540197) Antikörper
  • nuclear receptor-binding SET-domain protein 1 (Nsd1) Antikörper
  • AI528500 Antikörper
  • ARA267 Antikörper
  • KMT3B Antikörper
  • NSD1 Antikörper
  • SOTOS Antikörper
  • SOTOS1 Antikörper
  • STO Antikörper

Bezeichner auf Proteinebene für NSD1

nuclear receptor binding SET domain protein 1 , histone-lysine N-methyltransferase, H3 lysine-36 and H4 lysine-20 specific-like , H3-K36-HMTase , H4-K20-HMTase , NR-binding SET domain-containing protein , androgen receptor coactivator 267 kDa protein , androgen receptor-associated coregulator 267 , androgen receptor-associated protein of 267 kDa , histone-lysine N-methyltransferase, H3 lysine-36 and H4 lysine-20 specific , lysine N-methyltransferase 3B , nuclear receptor-binding SET domain-containing protein 1

GENE ID SPEZIES
416214 Gallus gallus
471754 Pan troglodytes
706131 Macaca mulatta
100058570 Equus caballus
100145675 Xenopus (Silurana) tropicalis
100355926 Oryctolagus cuniculus
100461473 Pongo abelii
100477428 Ailuropoda melanoleuca
100538695 Meleagris gallopavo
64324 Homo sapiens
306764 Rattus norvegicus
489094 Canis lupus familiaris
100524976 Sus scrofa
540197 Bos taurus
18193 Mus musculus
Ausgewählte Anbieter für anti-NSD1 (NSD1) Antikörper
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