anti-Nuclear Receptor Binding SET Domain Protein 1 (NSD1) Antikörper

NSD1 encodes a protein containing a SET domain, 2 LXXLL motifs, 3 nuclear translocation signals (NLSs), 4 plant homeodomain (PHD) finger regions, and a proline-rich region. Zusätzlich bieten wir Ihnen und viele weitere Produktgruppen zu diesem Protein an.

Alle Antikörper anzeigen Gen GeneID UniProt
NSD1 64324 Q96L73
NSD1 306764  
NSD1 18193  
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Top anti-NSD1 Antikörper auf antikoerper-online.de

Showing 10 out of 50 products:

Katalog Nr. Reaktivität Wirt Konjugat Applikation Bilder Menge Lieferzeit Preis Details
Human Kaninchen Unkonjugiert WB Western blot analysis of extracts of various cells, using NSD1 antibody. 100 μL 11 bis 13 Tage
$366.77
Details
Human Kaninchen Unkonjugiert IF (p), IHC (p) Formalin-fixed and paraffin embedded rat brain labeled with Anti-NSD1 Polyclonal Antibody, Unconjugated  at 1:200 followed by conjugation to the secondary antibody and DAB staining. Formalin-fixed and paraffin embedded rat brain labeled with Anti-NSD1 Polyclonal Antibody, Unconjugated  at 1:200 followed by conjugation to the secondary antibody and DAB staining. 100 μL 3 bis 7 Tage
$317.90
Details
Human Maus Unkonjugiert WB   100 μL Verfügbar
$546.20
Details
Human Maus Unkonjugiert ELISA, WB Western Blot detection against Immunogen (37.62 KDa) . Detection limit for recombinant GST tagged NSD1 is 3 ng/ml as a capture antibody. 100 μg 11 bis 12 Tage
$440.00
Details
Human Maus Unkonjugiert DB   50 μg 11 bis 14 Tage
$493.17
Details
Human Maus Unkonjugiert ELISA, WB   100 μg 11 bis 14 Tage
$551.83
Details
Human Kaninchen Unkonjugiert ELISA, IHC 200 μL 12 bis 14 Tage
$438.90
Details
Human Maus Unkonjugiert ELISA, WB Western Blot detection against Immunogen (37.99 KDa) . 50 μL 11 bis 12 Tage
$305.71
Details
Human Kaninchen Cy3 IF (p)   100 μL 14 bis 21 Tage
$416.90
Details
Human Kaninchen Alexa Fluor 647 IF (p)   100 μL 14 bis 21 Tage
$416.90
Details

Am meisten referenzierte anti-NSD1 Antikörper

  1. Human Monoclonal NSD1 Primary Antibody für ELISA, WB - ABIN528606 : Lu, Jackson, Wang, Yang, Chance, Miyagi, Gudkov, Stark: Regulation of NF-kappaB by NSD1/FBXL11-dependent reversible lysine methylation of p65. in Proceedings of the National Academy of Sciences of the United States of America 2010 (PubMed)

  2. Mammalian Monoclonal NSD1 Primary Antibody für ISt, IHC - ABIN1304874 : Satterlee, Beckel-Mitchener, McAllister, Procaccini, Rutter, Tyson, Chadwick: Community resources and technologies developed through the NIH Roadmap Epigenomics Program. in Methods in molecular biology (Clifton, N.J.) 2014 (PubMed)

  3. Human Polyclonal NSD1 Primary Antibody für ICC, IF - ABIN151269 : Quintana, Dupuy, Bravo, Casanova, Alameda, Page, Sánchez-Viera, Ramírez, Navarro: A transposon-based analysis of gene mutations related to skin cancer development. in The Journal of investigative dermatology 2013 (PubMed)

  4. Human Polyclonal NSD1 Primary Antibody für WB - ABIN3068973 : Streubel, Watson, Jammula, Scelfo, Fitzpatrick, Oliviero, McCole, Conway, Glancy, Negri, Dillon, Wynne, Pasini, Krogan, Bracken, Cagney: The H3K36me2 Methyltransferase Nsd1 Demarcates PRC2-Mediated H3K27me2 and H3K27me3 Domains in Embryonic Stem Cells. in Molecular cell 2018 (PubMed)

Weitere Antikörper gegen NSD1 Interaktionspartner

Human Nuclear Receptor Binding SET Domain Protein 1 (NSD1) Interaktionspartner

  1. This study identifies a favorable subtype of HPV-negative head and neck squamous cell carcinoma (HNSCC) linked to NSD1 mutation, hypomethylation, and cisplatin sensitivity

  2. exonic splicing events were present in all samples (N = 23) regardless of the NUP98-NSD1 suggesting that these novel splice events are unassociated with t(5;11)

  3. Mutations in NSD1 or NSD2 are independent favorable prognostic biomarkers for laryngeal cancer.

  4. Intratumoral heterogeneity (ITH) of NSD1 mutation in a colorectal cancers suggests that NSD1 mutation occurred during tumour progression rather than as an early event.

  5. variable expression of the Sotos syndrome caused by NSD1 mutation

  6. In this report, we described a new patient with Sotos syndrome caused by a 5q35 microdeletion spanning approximately 1.9 Mb in size and including the complete NSD1 gene

  7. NSD1 Inactivation is associated with Clear Cell Renal Cell Carcinomas.

  8. Nuclear receptor binding SET domain protein 1 (NSD1)duplication in 5q35 pathogenic variants could be detected in five out of 43 Silver-Russell syndrome (SRS) patients.

  9. Study illustrates the dynamic behavior of the post-SET loop and the presence of a few distinct conformations for NSD1 protein. In every case, the post-SET loop remains in an autoinhibitory position blocking the peptide-binding cleft, suggesting that another interaction is required to optimally position NSD1 in an active conformation.

  10. NSD1 mutation is associated with severe connective tissue laxity including aortic dilatation in Sotos syndrome.

  11. NSD1 mutation is associated with Hyperinsulinemic hypoglycemia.

  12. Studies indicate that the NSD methyltransferases NSD1, NSD2/WHSC1/MMSET and NSD3/WHSC1L1 were overexpressed, amplified or somatically mutated in multiple types of cancer, suggesting their critical role in cancer.

  13. The genome-wide impact of a highly significant NSD1(+/-)-specific signature that differentiates pathogenic NSD1 mutations from controls, benign NSD1 variants and the clinically overlapping Weaver syndrome is described.

  14. The results describe the binding of NSD1, 2 and 3 catalytic domains CD) on histone tails through recognition of histone-lysine and methylation properties.

  15. NSD1 interacted with RNAPII and bound to GSTM3 -63A/C TATA box.

  16. Acute myeloid leukemia can be reproduced in mice by transducing mouse mesenchymal stem cells with the human NUP98-NSD1 fusion and the FLT3-ITD mutated constracts.

  17. This report describes, for the first time, a Korean family with two generations of Stotos syndrome resulting from a novel intragenic NSD1 mutation.

  18. NSD1 prefers aromatic, hydrophobic, and basic residues at the -2, -1 and +2, and +1 sites of its substrate peptide in histone H3.

  19. support to the adoption of screening for NUP98-NSD1 in pediatric AML without otherwise favorable genetic markers

  20. all of the H3K36-specific methyltransferases, including ASH1L, HYPB, NSD1, and NSD2 were inhibited by ubH2A, whereas the other histone methyltransferases, including PRC2, G9a, and Pr-Set7 were not affected by ubH2A.

Mouse (Murine) Nuclear Receptor Binding SET Domain Protein 1 (NSD1) Interaktionspartner

  1. Nsd1 is a key modulator of PRC2 function required for regulating the demarcation of genome-wide H3K27me2 and H3K27me3 domains in embryonic stem cells.

  2. Silencing of Nsd1 followed by LLO stimulation led to increased caspase-1 activation, enhanced post-translational maturation of IL-1beta and IL-18 and elevated pyroptosis, a form of cell death associated with inflammation.

  3. Nsd1 contains consensus TFII-I binding sites in the proximal promoters; the chromatin immunoprecipitation analysis showed that TFII-I transcription factors are recruited to these sites in vivo in Williams-Beuren syndrome.

  4. all of the H3K36-specific methyltransferases, including ASH1L, HYPB, NSD1, and NSD2 were inhibited by ubH2A, whereas the other histone methyltransferases, including PRC2, G9a, and Pr-Set7 were not affected by ubH2A.

  5. NSD1 interaction with liganded NRs including ERa, AR, RARa, RXRa, TRb, PPARg and VDR is mediated by an LXXLL motif. Interaction with the NR2E/F subfamily including COUP-TFI, COUP-TFII, EAR2 and TLX requires an overlapping F/YSXXLXXL/Y motif.

  6. Data show that nuclear receptor-binding SET domain-containing protein (NSD1) is a developmental regulatory protein with histone methyltransferase activity that exerts function(s) essential for early post-implantation development.

  7. Nizp1 contains a novel type of zinc finger motif that functions as a docking site for NSD1

NSD1 Antigen-Profil

Protein Überblick

This gene encodes a protein containing a SET domain, 2 LXXLL motifs, 3 nuclear translocation signals (NLSs), 4 plant homeodomain (PHD) finger regions, and a proline-rich region. The encoded protein enhances androgen receptor (AR) transactivation, and this enhancement can be increased further in the presence of other androgen receptor associated coregulators. This protein may act as a nucleus-localized, basic transcriptional factor and also as a bifunctional transcriptional regulator. Mutations of this gene have been associated with Sotos syndrome and Weaver syndrome. One version of childhood acute myeloid leukemia is the result of a cryptic translocation with the breakpoints occurring within nuclear receptor-binding Su-var, enhancer of zeste, and trithorax domain protein 1 on chromosome 5 and nucleoporin, 98-kd on chromosome 11. Two transcript variants encoding distinct isoforms have been identified for this gene.

Genbezeichner und Symbole assoziert mit NSD1

  • nuclear receptor binding SET domain protein 1 (NSD1) Antikörper
  • nuclear receptor binding SET domain protein 1 (nsd1) Antikörper
  • nuclear receptor binding SET domain protein 1 (Nsd1) Antikörper
  • histone-lysine N-methyltransferase, H3 lysine-36 and H4 lysine-20 specific (LOC540197) Antikörper
  • nuclear receptor-binding SET-domain protein 1 (Nsd1) Antikörper
  • AI528500 Antikörper
  • ARA267 Antikörper
  • KMT3B Antikörper
  • NSD1 Antikörper
  • SOTOS Antikörper
  • SOTOS1 Antikörper
  • STO Antikörper

Bezeichner auf Proteinebene für NSD1

nuclear receptor binding SET domain protein 1 , histone-lysine N-methyltransferase, H3 lysine-36 and H4 lysine-20 specific-like , H3-K36-HMTase , H4-K20-HMTase , NR-binding SET domain-containing protein , androgen receptor coactivator 267 kDa protein , androgen receptor-associated coregulator 267 , androgen receptor-associated protein of 267 kDa , histone-lysine N-methyltransferase, H3 lysine-36 and H4 lysine-20 specific , lysine N-methyltransferase 3B , nuclear receptor-binding SET domain-containing protein 1

GENE ID SPEZIES
416214 Gallus gallus
471754 Pan troglodytes
706131 Macaca mulatta
100058570 Equus caballus
100145675 Xenopus (Silurana) tropicalis
100355926 Oryctolagus cuniculus
100461473 Pongo abelii
100477428 Ailuropoda melanoleuca
100538695 Meleagris gallopavo
64324 Homo sapiens
306764 Rattus norvegicus
489094 Canis lupus familiaris
100524976 Sus scrofa
540197 Bos taurus
18193 Mus musculus
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