Protein Überblick

Histone methyltransferase that plays an essential role in early development and hematopoiesis. Catalytic subunit of the MLL1/MLL complex, a multiprotein complex that mediates both methylation of 'Lys-4' of histone H3 (H3K4me) complex and acetylation of 'Lys-16' of histone H4 (H4K16ac). In the MLL1/MLL complex, it specifically mediates H3K4me, a specific tag for epigenetic transcriptional activation. Has weak methyltransferase activity by itself, and requires other component of the MLL1/MLL complex to obtain full methyltransferase activity. Has no activity toward histone H3 phosphorylated on 'Thr-3', less activity toward H3 dimethylated on 'Arg-8' or 'Lys-9', while it has higher activity toward H3 acetylated on 'Lys-9'. Required for transcriptional activation of HOXA9. Promotes PPP1R15A-induced apoptosis (By similarity).

Genbezeichner und Symbole assoziert mit MLL1

• lysine methyltransferase 2A (Kmt2a) Antikörper
• lysine (K)-specific methyltransferase 2A (Kmt2a) Antikörper

• 6430520K01 Antikörper
• ALL-1 Antikörper
• All1 Antikörper
• Cxxc7 Antikörper
• HRX Antikörper
• Alle Synonyme
• HTRX1 Antikörper
• mKIAA4050 Antikörper
• Mll Antikörper
• Mll1 Antikörper

Bezeichner auf Proteinebene für MLL1

Mixed-lineage leukemia (also acute lymphocytic leukemia 1 or tritorax Drosophila gene) , histone-lysine N-methyltransferase MLL , myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila) , myeloid/lymphoid or mixed-lineage leukemia 1 , histone-lysine N-methyltransferase 2A , lysine N-methyltransferase 2A , myeloid/lymphoid or mixed-lineage leukemia protein 1 , trithorax Drosophila , zinc finger protein HRX