anti-Mucosal Vascular Addressin Cell Adhesion Molecule 1 (MADCAM1) Antikörper

The protein encoded by MADCAM1 is an endothelial cell adhesion molecule that interacts preferentially with the leukocyte beta7 integrin LPAM-1 (alpha4beta7), L-selectin, and VLA-4 (alpha4beta1) on myeloid cells to direct leukocytes into mucosal and inflamed tissues. Zusätzlich bieten wir Ihnen Mucosal Vascular Addressin Cell Adhesion Molecule 1 Kits (42) und Mucosal Vascular Addressin Cell Adhesion Molecule 1 Proteine (9) und viele weitere Produktgruppen zu diesem Protein an.

Alle Antikörper anzeigen Gen GeneID UniProt
MADCAM1 8174 Q13477
MADCAM1 17123  
MADCAM1 54266 O70540
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Top anti-Mucosal Vascular Addressin Cell Adhesion Molecule 1 Antikörper auf antikoerper-online.de

Showing 10 out of 203 products:

Katalog Nr. Reaktivität Wirt Konjugat Applikation Bilder Menge Anbieter Lieferzeit Preis Details
Human Kaninchen Unkonjugiert IHC (fro), IHC (p), WB 100 μg Anmelden zum Anzeigen 4 bis 6 Tage
$280.00
Details
Maus Ratte Biotin FACS   0.5 mg Anmelden zum Anzeigen 6 bis 8 Tage
$918.21
Details
Human Kaninchen Unkonjugiert WB 100 μL Anmelden zum Anzeigen 2 bis 3 Tage
$289.00
Details
Maus Ratte Unkonjugiert IHC (f), IHC (fro), FACS   1 mL Anmelden zum Anzeigen 6 bis 8 Tage
$194.19
Details
Maus Ratte Unkonjugiert BR, IAC, IHC (fro), FACS, IP, WB   0.5 mg Anmelden zum Anzeigen 6 bis 8 Tage
$335.23
Details
Maus Ratte Unkonjugiert CyTOF, FACS 500 μg Anmelden zum Anzeigen 10 bis 12 Tage
$261.92
Details
Human Kaninchen Unkonjugiert WB 50 μg Anmelden zum Anzeigen 7 bis 9 Tage
$551.83
Details
Human Maus APC FACS Detection of MAdCAM-1 in HeLa Human Cell Line by Flow Cytometry. HeLa human cervical epithelial carcinoma cell line was stained with Mouse Anti-Human MAdCAM-1 APC-conjugated Monoclonal Antibody. 100 Tests Anmelden zum Anzeigen 8 bis 9 Tage
$393.30
Details
Maus Kaninchen Unkonjugiert ICC, IHC, WB Figure. Western Blot; Sample: Lane1: Mouse Spleen Tissue; Lane2: Mouse Intestine Tissue; Lane3: Mouse Brain Tissue; Lane4: Mouse Liver Tissue. 100 μg Anmelden zum Anzeigen 13 bis 16 Tage
$342.00
Details
Human Maus Unkonjugiert FACS, IHC (p), ELISA, WB Human Colon (formalin-fixed, paraffin-embedded) stained with MADCAM1 antibody ABIN462006 at 10 ug/ml followed by biotinylated anti-mouse IgG secondary antibody ABIN481714, alkaline phosphatase-streptavidin and chromogen. Human Spleen (formalin-fixed, paraffin-embedded) stained with MADCAM1 antibody ABIN462006 at 10 ug/ml followed by biotinylated anti-mouse IgG secondary antibody ABIN481714, alkaline phosphatase-streptavidin and chromogen. 100 μg Anmelden zum Anzeigen 7 bis 9 Tage
$484.00
Details

MADCAM1 Antikörper nach Reaktivität, Anwendung, Klonalität and Konjugat

Attribute Applikationen Wirt Klonalität Konjugat
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Am meisten referenzierte anti-Mucosal Vascular Addressin Cell Adhesion Molecule 1 Antikörper

  1. Mouse (Murine) Monoclonal MADCAM1 Primary Antibody für BR, IAC - ABIN967383 : Berg, McEvoy, Berlin, Bargatze, Butcher: L-selectin-mediated lymphocyte rolling on MAdCAM-1. in Nature 1994 (PubMed)
    Show all 11 Pubmed References

  2. Mouse (Murine) Monoclonal MADCAM1 Primary Antibody für BR, IAC - ABIN1176979 : Hänninen, Salmi, Simell, Andrew, Jalkanen: Recirculation and homing of lymphocyte subsets: dual homing specificity of beta 7-integrin(high)-lymphocytes in nonobese diabetic mice. in Blood 1996 (PubMed)
    Show all 9 Pubmed References

  3. Mouse (Murine) Monoclonal MADCAM1 Primary Antibody für FACS - ABIN2689831 : Berlin, Berg, Briskin, Andrew, Kilshaw, Holzmann, Weissman, Hamann, Butcher: Alpha 4 beta 7 integrin mediates lymphocyte binding to the mucosal vascular addressin MAdCAM-1. in Cell 1993 (PubMed)
    Show all 7 Pubmed References

  4. Mouse (Murine) Monoclonal MADCAM1 Primary Antibody für IHC (f), IHC (fro) - ABIN2689830 : Briskin, McEvoy, Butcher: MAdCAM-1 has homology to immunoglobulin and mucin-like adhesion receptors and to IgA1. in Nature 1993 (PubMed)
    Show all 4 Pubmed References

  5. Mouse (Murine) Monoclonal MADCAM1 Primary Antibody für IHC (f), IHC (fro) - ABIN2689829 : Streeter, Berg, Rouse, Bargatze, Butcher: A tissue-specific endothelial cell molecule involved in lymphocyte homing. in Nature 1988 (PubMed)
    Show all 3 Pubmed References

  6. Human Monoclonal MADCAM1 Primary Antibody für EIA, FACS - ABIN120238 : Leung, Lehnert, Kanwar, Yang, Mon, McNeil, Krissansen: Bioassay detects soluble MAdCAM-1 in body fluids. in Immunology and cell biology 2004 (PubMed)
    Show all 3 Pubmed References

  7. Human Monoclonal MADCAM1 Primary Antibody für EIA, FACS - ABIN320242 : Leung, Greene, Ni, Raymond, Lehnert, Langley, Krissansen: Cloning of the mucosal addressin MAdCAM-1 from human brain: identification of novel alternatively spliced transcripts. in Immunology and cell biology 1997 (PubMed)
    Show all 3 Pubmed References

  8. Human Monoclonal MADCAM1 Primary Antibody für ELISA, Func - ABIN2475465 : Herron: Selective nerve root block in patient selection for lumbar surgery: surgical results. in Journal of spinal disorders 1992 (PubMed)
    Show all 4 Pubmed References

  9. Human Monoclonal MADCAM1 Primary Antibody für ELISA, IHC (fro) - ABIN2475453 : Olloquequi, Montes, Prats, Rodríguez, Montero, García-Valero, Ferrer: Significant increase of CD57+ cells in pulmonary lymphoid follicles of COPD patients. in The European respiratory journal 2011 (PubMed)
    Show all 4 Pubmed References

Weitere Antikörper gegen Mucosal Vascular Addressin Cell Adhesion Molecule 1 Interaktionspartner

Human Mucosal Vascular Addressin Cell Adhesion Molecule 1 (MADCAM1) Interaktionspartner

  1. Both the ACT-1 (zeige TRAF3IP2 Antikörper) assay and the MAdCAM-1 assay demonstrated acceptable reproducibility and repeatability. The assays were sufficiently stable to allow for clinical use. During clinical testing the assays demonstrated that vedolizumab was able to saturate peripheral cells at all doses tested.

  2. Doxo-induced apoptosis has a role in inhibiting hepatocellular carcinoma by targeting Madcam1 and AKT (zeige AKT1 Antikörper) and blocking protein translation initiation

  3. MADCAM1 is up-regulated in liver cirrhosis with expression on peribiliary vascular plexus and lymphoid aggregates

  4. Domain 1 of mucosal addressin cell adhesion molecule (zeige MCAM Antikörper) has an I1-set fold and a flexible integrin-binding loop.

  5. Findings suggest that the inactive alpha4beta7 and alpha4beta7 activated by different stimuli have distinct conformations with different structural requirements for MAdCAM-1 binding.

  6. Ca2 (zeige CA2 Antikörper)+ is essential for cell tethering in flow and rolling interactions through alpha 4 integrins with MAdCAM-1 as substrate; Mg2 (zeige MUC7 Antikörper)+ promotes firm adhesion of cells on MAdCAM-1 but with much lower tethering efficiency in shear flow.

  7. A crystal structure for the two extracellular amino-terminal domains of human MAdCAM-1

  8. more extensive expression of MAdCAM-1 in Crohn's disease (CrD (zeige CRX Antikörper)), than in ulcerative colitis, which could contribute not only to mucosal inflammation, but also to transmural inflammation in CrD (zeige CRX Antikörper).

  9. MAdCAM-1/integrin alpha4beta7 homing system may participate in gastric inflammation in response to H pylori-infection and contributes to MALT formation, typically leading to the development of nodular gastritis.

  10. PI3-K (zeige PIK3CA Antikörper)/Akt (zeige AKT1 Antikörper) is involved in the gut (zeige GUSB Antikörper)-specific differentiation of human intestinal microvascular endothelial cells, which results in expression of the mucosal addressin MAdCAM-1

Mouse (Murine) Mucosal Vascular Addressin Cell Adhesion Molecule 1 (MADCAM1) Interaktionspartner

  1. Loss of MAdCAM-1 has beneficial effects regarding the development of NASH (zeige SAMSN1 Antikörper) - manifested by reduced hepatic oxidative stress and decreased inflammation. In contrast, beta7-Integrin-deficiency results in increased steatohepatitis.

  2. The results uncovered a previously unknown role of integrin a4b7-MAdCAM-1 interactions as drivers of colitis by directing inflammatory monocytes into the colon.

  3. beta7 integrin, when expressed by hematopoietic stem cells (HSC (zeige FUT1 Antikörper)), interacted with its endothelial ligand MAdCAM-1 in the Bone marrow microenvironment, thereby promoting HSC (zeige FUT1 Antikörper) homing and engraftment.

  4. Nkx2-3 deficiency reprograms the endothelial addressin preference for lymphocyte homing in Peyer's patches.

  5. findings indicate that alpha4beta7*IgG can be used as a probe for functional MAdCAM-1 expressed on HEVs in GALT (zeige GALT Antikörper) and could potentially serve as an anti-inflammatory drug inhibiting GALT (zeige GALT Antikörper)-specific lymphocyte migration

  6. ectopic expression of MAdCAM-1 at the BBB does not increase alpha4beta7-integrin-mediated immune cell trafficking into the CNS during MOG(aa35-55)-induced experimental autoimmune encephalomyelitis

  7. Observed a significant decrease in expression of ICAM-1 (zeige ICAM1 Antikörper) and MAdCAM-1 mRNA/protein in lactobacillus plantarum treated colitis.

  8. results suggest that AT1R (zeige AGTRAP Antikörper) regulates the expression of MAdCAM-1 under colonic inflammatory conditions through regulation of the translocation of NF-kappaB (zeige NFKB1 Antikörper) into the nucleus

  9. Lymphocyte binding to MAdCAM-1 via alpha4beta7 integrin activates a signal transduction pathway involving tyrosine phosphorylation of paxillin (zeige PXN Antikörper) and p105(Cas-L (zeige NEDD9 Antikörper))

  10. Mucosal addressin cell adhesion molecule 1 plays an unexpected role in the development of mouse guard hair.

Mucosal Vascular Addressin Cell Adhesion Molecule 1 (MADCAM1) Antigen-Profil

Protein Überblick

The protein encoded by this gene is an endothelial cell adhesion molecule that interacts preferentially with the leukocyte beta7 integrin LPAM-1 (alpha4beta7), L-selectin, and VLA-4 (alpha4beta1) on myeloid cells to direct leukocytes into mucosal and inflamed tissues. It is a member of the immunoglobulin family and is similar to ICAM1 and VCAM1. At least seven alternatively spliced transcripts encoding different protein isoforms have been found for this gene, but the full-length nature of some variants has not been determined.

Genbezeichner und Symbole assoziert mit MADCAM1

  • mucosal vascular addressin cell adhesion molecule 1 (MADCAM1) Antikörper
  • mucosal vascular addressin cell adhesion molecule 1 (Madcam1) Antikörper
  • AV211525 Antikörper
  • MACAM1 Antikörper

Bezeichner auf Proteinebene für MADCAM1

MAdCAM-1 , hMAdCAM-1 , mucosal addressin cell adhesion molecule 1 , mucosal addressin cell adhesion molecule-1 , mMAdCAM-1 , rMAdCAM-1 , mucosal addressin cellular adhesion molecule-1

GENE ID SPEZIES
8174 Homo sapiens
17123 Mus musculus
54266 Rattus norvegicus
485103 Canis lupus familiaris
492312 Sus scrofa
527275 Bos taurus
100858236 Gallus gallus
654333 Ovis aries
100722478 Cavia porcellus
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