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MADCAM1 Antikörper

MADCAM1 Reaktivität: Human IA, IHC (fro), FACS, InhA, IHC (p), WB Wirt: Maus Monoclonal 314G8 unconjugated
Pubmed (1 reference)
Produktnummer ABIN2192055
$605.98
Zzgl. Versandkosten $45.00
100 μg
Lieferung in 6 bis 8 Werktagen
  • Target Alle MADCAM1 Antikörper anzeigen
    MADCAM1
    Reaktivität
    • 47
    • 42
    • 3
    • 1
    Human
    Wirt
    • 45
    • 19
    • 5
    Maus
    Klonalität
    • 45
    • 24
    Monoklonal
    Konjugat
    • 27
    • 8
    • 7
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    Dieser MADCAM1 Antikörper ist unkonjugiert
    Applikation
    • 32
    • 29
    • 26
    • 26
    • 17
    • 11
    • 11
    • 8
    • 5
    • 5
    • 5
    • 4
    • 2
    • 1
    • 1
    • 1
    Immunoassay (IA), Immunohistochemistry (Frozen Sections) (IHC (fro)), Flow Cytometry (FACS), Inhibition Assay (InhA), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
    Sterilität
    0.2 μm filtered
    Klon
    314G8
  • Applikationshinweise
    For immunohistology, flow cytometry and Western blotting dilutions to be used depend on detection system applied. It is recommended that users test the reagent and determine their own optimal dilutions. The typical starting working dilution is 1:50. For inhibition of biological activity in vitro dilutions have to be made according to the amounts of MAdCAM-1 to be inactivated.
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Buffer
    PBS, containing 0.1 % bovine serum albumin.
    Lagerung
    4 °C
    Informationen zur Lagerung
    Product should be stored at 4 °C. Under recommended storage conditions, product is stable for one year.
    Haltbarkeit
    12 months
  • Leung, Lehnert, Kanwar, Yang, Mon, McNeil, Krissansen: "Bioassay detects soluble MAdCAM-1 in body fluids." in: Immunology and cell biology, Vol. 82, Issue 4, pp. 400-9, (2004) (PubMed).

  • Target
    MADCAM1
    Andere Bezeichnung
    Madcam-1 (MADCAM1 Produkte)
    Synonyme
    MACAM1, AV211525, mucosal vascular addressin cell adhesion molecule 1, MADCAM1, Madcam1
    Hintergrund
    The monocolonal antibody 314G8 reacts with human mucosal addressin cell adhesion molecules-1 (MAdCAM-1), a key player in mediating the infiltration of leukocytes into chronically inflamed tissue. MAdCAM-1 is a cell-surface Ig superfamily member composed of two extracellular Ig domains, followed by a mucin-like domain, a transmembrane domain and a short cytoplasmatic domain. It interacts via its N- terminal Ig domain with the lymphocyte homing receptor alpha4beta7, which plays a critical role in forming the gut-associated lymphoid system. MAdCAM-1 promotes the adhesion of T- and B cells, monocytes/macrophages, and potentially eosinophils, basophils, and differentiated mast cells to the vascular endothelium. Mucosal addressin cell adhesion molecule-1 RNA transcripts are predominantly expressed in the small intestine, mesenteric lymph nodes, colon and spleen, and are very weakly expresssed in human pancreas and brain. The monocolonal antibody 314G8 recognizes a site in the N- terminal Ig domain of MAdCAM-1. The monoclonal antibody 314G8 detects MAdCAM-1 on venules in the spleen and small intestine. MAdCAM-1 is strongly expressed in the synovium of osteoarthritis patients, predominantly on the endothelial lining of blood vessels, but also within the vessel lumen. The monoclonal antibody 314G8 may be useful in diagnosis of inflammation in humans by monitoring the presence and levels of MAdCAM-1.
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