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MICU1 encodes an essential regulator of mitochondrial Ca2+ uptake under basal conditions. Zusätzlich bieten wir Ihnen MICU1 Antikörper (42) und MICU1 Proteine (11) und viele weitere Produktgruppen zu diesem Protein an.
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the absence of MICU1, both Mn(2+) and Ca(2 (zeige CA2 ELISA Kits)+) can pass through the uniporter, as evidenced by mitochondrial Mn(2+) uptake assays, mitochondrial membrane potential measurements, and mitoplast electrophysiology.
Mitochondrial Ca(2 (zeige CA2 ELISA Kits)+) uptake is controlled by protein arginine methyl transferase 1 that asymmetrically methylates MICU1, resulting in decreased Ca(2 (zeige CA2 ELISA Kits)+) sensitivity. UCP2 (zeige UCP2 ELISA Kits)/3 normalize Ca(2 (zeige CA2 ELISA Kits)+) sensitivity of methylated MICU1 and, thus, re-establish mitochondrial Ca(2 (zeige CA2 ELISA Kits)+) uptake activity.
MICU2 restricts spatial crosstalk between InsP3R (zeige ITPR1 ELISA Kits) and MCU (zeige MCU ELISA Kits) channels by regulating threshold and gain of MICU1-mediated inhibition and activation of MCU (zeige MCU ELISA Kits).
study concludes that cooperative, high-affinity interaction of the MICU1-MICU2 complex with Ca(2 (zeige CA2 ELISA Kits)+) serves as an on-off switch, leading to a tightly controlled channel, capable of responding directly to cytosolic Ca(2 (zeige CA2 ELISA Kits)+) signals
MICU1 serves as a signal-noise discriminator in mitochondrial calcium signalling, limiting the energetic costs of mitochondrial Ca2 (zeige CA2 ELISA Kits)+ signalling which may undermine oxidative phosphorylation, especially in tissues with highly dynamic energetic demands.
Results showed that the SNP on EF-hand Ca2 (zeige CA2 ELISA Kits)+ binding domains of MICU1 gene had no effect in phenotypic characters of bipolar disorder patients
Our experiments provide novel details about how MCU (zeige MCU ELISA Kits)/EMRE is regulated by MICU1 and an original approach to investigate MCU (zeige MCU ELISA Kits)/EMRE activation in intact cells.
Data show that ribosomal protein S3 (RPS3 (zeige RPS3 ELISA Kits)) knockdown decreased mitochondrial calcium uptake 1 protein (MICU1) expression.
Loss of heterozygosity of MICU1 gene on chromosome 10q is associated with pancreatic cancer.
Expression of MICU1 mutants lacking functional Ca2 (zeige CA2 ELISA Kits)+-binding sites leads to a striking loss of Ca2 (zeige CA2 ELISA Kits)+ uptake in HEK293 cells.
MICU1 exerted protection against myocardial ischemia/reperfusion injury via prevention of mitochondrial Ca2 (zeige CA2 ELISA Kits)+ overload, preservation of mitochondrial integrity and promotion of mitochondrial energy metabolism.
that MICU1 serves as a molecular gatekeeper preventing calcium overload and suggests that modulating the calcium uniporter could have widespread therapeutic benefits
a possible role for tissue-specific stoichiometry between the Ca(2 (zeige CA2 ELISA Kits)+)-sensing regulators (MICUs) and pore unit (MCU (zeige MCU ELISA Kits)) of the uniporter, was investigated.
A MICU1 splice variant confers high sensitivity to the mitochondrial Ca(2 (zeige CA2 ELISA Kits)+) uptake machinery of skeletal muscle.
MICU1 was downregulated in db/db (zeige LEPR ELISA Kits) mouse hearts, which contributes to myocardial apoptosis in diabetes. Importantly, the reconstitution of MICU1 in diabetic hearts significantly inhibited the development of diabetic cardiomyopathy, as evidenced by enhanced cardiac function and reduced cardiac hypertrophy and myocardial fibrosis in db/db (zeige LEPR ELISA Kits) mice.
MICU1 regulation of mitochondrial Ca(2 (zeige CA2 ELISA Kits)+) uptake dictates survival and liver regeneration.
This gene encodes an essential regulator of mitochondrial Ca2+ uptake under basal conditions. The encoded protein interacts with the mitochondrial calcium uniporter, a mitochondrial inner membrane Ca2+ channel, and is essential in preventing mitochondrial Ca2+ overload, which can cause excessive production of reactive oxygen species and cell stress. Alternatively spliced transcript variants encoding different isoforms have been described.
, atopy-related autoantigen CALC
, calcium uptake protein 1, mitochondrial
, calcium-binding atopy-related autoantigen 1
, calcium binding atopy-related autoantigen 1
, calcium-binding atopy-related autoantigen 1 homolog