Matrix Metallopeptidase 1 (Interstitial Collagenase) Proteine (MMP1)

Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Zusätzlich bieten wir Ihnen MMP1 Antikörper (319) und MMP1 Kits (135) und viele weitere Produktgruppen zu diesem Protein an.

alle Proteine anzeigen Gen GeneID UniProt
MMP1 4312 P03956
MMP1 17386 P33435
MMP1 300339  
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Katalog Nr. Origin Quelle Konjugat Bilder Menge Anbieter Lieferzeit Preis Details
Human Cells Human His tag 10 μg Anmelden zum Anzeigen 14 bis 16 Tage
HEK-293 Cells Human His tag 50 μg Anmelden zum Anzeigen 2 bis 3 Tage
Insektenzellen Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 50 Days
HEK-293 Cells Human His tag Validation with Western Blot 10 μg Anmelden zum Anzeigen 8 bis 11 Tage
Escherichia coli (E. coli) Human Unkonjugiert Validation with Western Blot 10 μg Anmelden zum Anzeigen 8 bis 11 Tage
Human Human Unkonjugiert 10 μg Anmelden zum Anzeigen 6 bis 7 Tage
HEK-293 Cells Human His tag Validation with Western Blot 10 μg Anmelden zum Anzeigen 8 bis 11 Tage
Human Cells Human His tag   50 μg Anmelden zum Anzeigen 4 Days
Escherichia coli (E. coli) Human His tag 100 μg Anmelden zum Anzeigen 13 bis 16 Tage
HEK-293 Cells Human Unkonjugiert   10 μg Anmelden zum Anzeigen 10 bis 12 Tage

MMP1 Proteine nach Spezies und Herkunft

Origin Exprimiert in Konjugat
Human , , , , , ,
, ,
Mouse (Murine)

Rat (Rattus)

Am meisten referenzierte MMP1 Proteine

  1. Human MMP1 Protein expressed in Human Cells - ABIN2003013 : Desrochers, Jeffrey, Weiss: Interstitial collagenase (matrix metalloproteinase-1) expresses serpinase activity. in The Journal of clinical investigation 1991 (PubMed)
    Show all 5 Pubmed References

Weitere Proteine zu Matrix Metallopeptidase 1 (Interstitial Collagenase) (MMP1) Interaktionspartnern

Human Matrix Metallopeptidase 1 (Interstitial Collagenase) (MMP1) Interaktionspartner

  1. study to explore the relationship between 2 polymorphisms (MMP-1-755 T/G [rs498186] and MMP-3 (zeige MMP3 Proteine) A/C [rs632478]) and disc degeneration; no significant association of the MMP-1 polymorphism with disc degeneration was found

  2. Expression of GSDMC is increased by UV irradiation in human skin keratinocytes. GSDMC induction contributes to the increase of MMP-1 expression specifically via activation of ERK (zeige EPHB2 Proteine) and JNK (zeige MAPK8 Proteine) pathways.

  3. our results suggest that the typical 1G/2G MMP-1 polymorphic site did not play a direct determinant role in breast cancer among Taiwanese women.

  4. The maternal and fetal 1G/1G MMP1 gene polymorphisms may be strong genetic markers of preeclampsia, occurring either individually or together.

  5. The current study indicated that MMP1 has a key role in the regulation of cervical tumor growth and lymph node metastasis via epithelial mesenchymal transition to a certain extent

  6. 2G allele of MMP-1, C allele of MMP-2 (zeige MMP2 Proteine) and 5A/6A genotype of MMP-3 (zeige MMP3 Proteine) are associated with susceptibility and disease progression of type 2 diabetic nephropathy

  7. this study provides insights into the development of a possible alternative therapy manipulating MMP-1 and the mTOR (zeige FRAP1 Proteine) signaling pathway in Epidermal growth factor receptor (zeige EGFR Proteine)-tyrosine kinase (zeige RET Proteine) inhibitor-resistant lung adenocarcinoma.

  8. Specific silencing that targeted AMPK (zeige PRKAA1 Proteine) resulted in the enhancement of mobility and contractility and in the production of MMP-1 and MMP-2 (zeige MMP2 Proteine).

  9. MMP-1 genotype may accelerate the development of HIV-associated neurocognitive disorder (HAND) whereas MMP3 (zeige MMP3 Proteine) -1612 5A5A genotype may reduce the risk of pathogenesis of HAND.

  10. Authors observed a significant increase in the immunoexpression of collagen I and III in patients with DCM and a significant reduction in the immunoexpression of MMP-1 compared with the control group. Also, the collagen I and TIMP-1 (zeige TIMP1 Proteine) expression indicated a positive linear correlation and respectively a negative linear relationship with collagen III and MMP-1.

Pig (Porcine) Matrix Metallopeptidase 1 (Interstitial Collagenase) (MMP1) Interaktionspartner

  1. the identification of MMP1 and MMP10 (zeige MMP10 Proteine) genes in swine is reported.

  2. increased interstitial MMP1 activity during ischemia and reperfusion is a result of the endothelin protein kinase c pathway and may be due to enhanced phosphorylation of mmp1

  3. Results indicate that leukemia inhibitory factor (LIF (zeige LIF Proteine)) and Oncostatin M (zeige OSM Proteine) increase the expression of MMP-1, MMP-3 (zeige MMP3 Proteine), and TIMP-1 (zeige TIMP1 Proteine) several fold, and that their expression is reduced to basal levels in the presence of the LIF (zeige LIF Proteine) antagonist MH35-BD.

Fruit Fly (Drosophila melanogaster) Matrix Metallopeptidase 1 (Interstitial Collagenase) (MMP1) Interaktionspartner

  1. results suggest that Ubx regulates organ shape by controlling Mmp1 expression, and the extent and timing of extracellular matrix degradation.

  2. This work identifies Draper-dependent activation of MMP-1 as a novel cascade required for proper glial clearance of severed axons.

  3. Mmp1 negatively regulates ectopic eye differentiation by restricting the rate of proliferation and the levels of expression of retinal-determining genes dachshund and eyes absent.

  4. Data indicate that matrix metalloproteinases mmp1 and mmp2 (zeige MMP2 Proteine) mutants have distinct heart phenotypes.

  5. These data demonstrate that Mmp1 modulates PDF processing, which leads to daily structural remodeling and circadian behavior.

  6. A primary function of Mmp1, under the control of the JNK (zeige MAPK8 Proteine) pathway, is to promote basement membrane repair, which in turn may permit cell migration and the restoration of a continuous tissue.

  7. Drosophila Mmp1 is involved in the regulation of ISC proliferation for maintenance of gut (zeige GUSB Proteine) homeostasis

  8. Study identified three genes, regeneration (rgn (zeige RGN Proteine)), augmenter of liver regeneration (alr (zeige GFER Proteine)) and Matrix metalloproteinase-1 (Mmp1) expressed specifically in blastema cells during disc regeneration.

Mouse (Murine) Matrix Metallopeptidase 1 (Interstitial Collagenase) (MMP1) Interaktionspartner

  1. Estrogen-related receptor gamma (ERRgamma (zeige ESRRG Proteine)) overexpression in chondrocytes directly upregulates matrix metalloproteinase (MMP)-3 (zeige MMP3 Proteine) and MMP13 (zeige MMP13 Proteine), which are known to play crucial roles in cartilage destruction in osteoarthritis (OA).

  2. Infection with Mycobacterium bovis results in increase in interleukin-1alpha, TGF-beta1 (zeige TGFB1 Proteine), and MMP1 in multinucleated macrophages.

  3. MMP-2 (zeige MMP2 Proteine) promoted and MMP-13 (zeige MMP13 Proteine) disrupted vasculogenic mimicry formation in large cell lung cancer by cleaving laminin-5 to influence EGFR (zeige EGFR Proteine) signal activation.

  4. The data demonstrate that MMP13 (zeige MMP13 Proteine) and CTGF (zeige CTGF Proteine) play a crucial role in modulation of fibrogenic mediators while promoting hepatic fibrogenesis.

  5. CXCL10 (zeige CXCL10 Proteine) has strong inhibitory effects on neovascularization, whereas MMP13 (zeige MMP13 Proteine) is required for neovascularization in C. albicans-infected corneas.

  6. that MMP-13 (zeige MMP13 Proteine) is a central protease in infarct development and cortical remodeling during post-stroke neurorepair

  7. the phenotype seen in the Hdac4 (zeige HDAC5 Proteine)(-/-) mice is partially derived from elevation in MMP-13 (zeige MMP13 Proteine) and may be due to a bone remodeling disorder caused by overexpression of this enzyme.

  8. MEF2C (zeige MEF2C Proteine) is necessary for Mmp13 (zeige MMP13 Proteine) gene expression at the transcriptional level and participates in PTH (zeige PTH Proteine)-stimulated Mmp13 (zeige MMP13 Proteine) gene expression by increased binding to c-FOS at the AP-1 (zeige JUN Proteine) site in the Mmp13 (zeige MMP13 Proteine) promoter.

  9. data reveal a novel involvement of MMP-13 (zeige MMP13 Proteine) in regulating dendritic cell (DC) immunobiology through moderating MHC-I surface presentation, endocytosis and cytokine/chemokine (zeige CCL1 Proteine) secretion; furthermore, the reduced MHC-I surface presentation by DCs resulted in a poor CD8 (zeige CD8A Proteine)(+) T-cell response in vitro; MMP-13 (zeige MMP13 Proteine) might be a promising target for therapeutic intervention in inflammatory diseases

  10. The progressive process of articular cartilage degeneration was significantly delayed in the knee joints of Ddr2 (zeige DDR2 Proteine)-deficient mice in comparison to their control littermates. Articular cartilage damage in the knee joints of the mice was associated with increased expression profiles of both Ddr2 (zeige DDR2 Proteine) and matrix metalloproteinase 13 (zeige MMP13 Proteine).

Cow (Bovine) Matrix Metallopeptidase 1 (Interstitial Collagenase) (MMP1) Interaktionspartner

  1. BoHV-4 infection affects various pathways related to cell proliferation and cell surface integrity, at least three of which were centered on upregulation of matrix metalloproteinase 1 (MMP1). MMP1 transcription was upregulated by the BoHV-4 transactivator IE2/RTA (zeige RBM9 Proteine), leading to abnormally high metalloproteinase tissue levels, potentially leading to defective endometrium healing and unresolved inflammation.

  2. The expression patterns of MMP1, MMP2 (zeige MMP2 Proteine), and MMP8 (zeige MMP8 Proteine) were explored during fetal and postnatal development of longissimus dorsi muscle in cattle, and the relationships of MMP1, MMP2 (zeige MMP2 Proteine), and MMP8 (zeige MMP8 Proteine) expression levels with meat quality traits were analyzed in cattle. The expression of MMP1, MMP2 (zeige MMP2 Proteine), and MMP8 (zeige MMP8 Proteine) were also tested in four kinds of fat tissues and three kinds of skeletal muscle tissues.

  3. Data suggest that luteolytic factors (such as interferon gamma (zeige IFNG Proteine), tumor necrosis factor alpha (zeige TNF Proteine), and PGF2a) control expression of MMP1, other matrix metalloproteinases, and tissue inhibitors of metalloproteinase in cultured luteal cells.

  4. The results showed that a decrease in MMP-1 and MMP-2 (zeige MMP2 Proteine) gene expression is accompanied with a decrease in NO concentrations in infertile cows affected with ovarian cysts.

  5. Cytoskeletal tension modulates MMP-1 gene expression from tenocytes on micropillar substrates.

  6. MMP-1 promotes VEGFR2 (zeige KDR Proteine) expression and proliferation of endothelial cells through stimulation of PAR-1 (zeige F2R Proteine) and activation of NF-kappaB (zeige NFKB1 Proteine)

  7. These data identify atypical PKC isozymes as STAT and ERK activators that mediate c-fos and collagenase expression.

  8. the differential expression and localization of membrane-type 1 matrix metalloproteinase (zeige MMP14 Proteine) in the corpus luteum suggest that it may have multiple functions throughout the course of the estrous cycle,including activation of pro-MMP-2 (zeige MMP2 Proteine)

  9. increased in bovine preovulatory follicles following the gonadotropin surge but no up-regulation of MMP-1 and MMP-13 (zeige MMP13 Proteine) (follicular apex (zeige APEX1 Proteine) vs. base) for the preovulatory collagenolysis required for follicle rupture

  10. identification of MT1-MMP (zeige MMP14 Proteine) in odontoclasts during deciduous tooth resorption might be relevant to the migration activity that these cells have to gain access to the root surface

Rabbit Matrix Metallopeptidase 1 (Interstitial Collagenase) (MMP1) Interaktionspartner

  1. These results suggest that PEP-1-SIRT2 (zeige SIRT2 Proteine) promotes matrix metalloproteinases-induced dedifferentiation via ERK (zeige MAPK1 Proteine) signaling in articular chondrocytes. .

  2. Circulating smoke components, including acrolein, contribute to vascular diseases through enhanced MMP-1 and decreased TIMP-3 (zeige TIMP3 Proteine) secretion.

Horse (Equine) Matrix Metallopeptidase 1 (Interstitial Collagenase) (MMP1) Interaktionspartner

  1. ANXA2 (zeige ANXA2 Proteine) and MMP1 might participate in remodeling during wound healing in the horse.

  2. The polymorphism in the promoter of the MMP-1 gene could be a risk factor for early implant failure of total hip arthroplasty.

  3. These results suggest that MMP-1 and IL-8 (zeige IL8 Proteine) are both involved in the exercise-induced stress response, and this represents a starting point from which to understand the adaptive responses to this phenomenon.

Xenopus laevis Matrix Metallopeptidase 1 (Interstitial Collagenase) (MMP1) Interaktionspartner

MMP1 Protein Überblick

Protein Überblick

Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. This gene encodes a secreted enzyme which breaks down the interstitial collagens, types I, II, and III. The gene is part of a cluster of MMP genes which localize to chromosome 11q22.3. Alternative splicing results in multiple transcript variants.

Genbezeichner und Symbole assoziert mit MMP1

  • matrix metallopeptidase 1 (MMP1)
  • Matrix metalloproteinase 1 (Mmp1)
  • matrix metalloproteinase 1 (RB11133)
  • matrix metalloproteinase 1 (Mmp1)
  • matrix metallopeptidase 13 (Mmp13)
  • matrix metallopeptidase 1 (interstitial collagenase) (MMP1)
  • matrix metallopeptidase 1 S homeolog (mmp1.S)
  • interstitial collagenase (LOC100727966)
  • matrix metallopeptidase 1 (Mmp1)
  • CG4859 Protein
  • Clg Protein
  • Clgn Protein
  • col4 Protein
  • dm1-MMP Protein
  • Dmel\\CG4859 Protein
  • dmmp1 Protein
  • l(2)k04809 Protein
  • MMP-1 Protein
  • MMP-13 Protein
  • Mmp1 Protein
  • Mmp 1 Protein
  • Mmp1a Protein
  • mmp18 Protein

Bezeichner auf Proteinebene für MMP1

fibroblast collagenase , interstitial collagenase , matrix metalloprotease 1 , matrix metalloproteinase 1 , MMP-1 , matrix metalloproteinase 1 (type I collagenase) , matrix metalloproteinase-1 , CG4859-PC , CG4859-PD , CG4859-PE , CG4859-PF , CG4859-PG , CG4859-PH , CG4859-PI , CG4859-PJ , CG4859-PK , CG4859-PL , Mmp1-PC , Mmp1-PD , Mmp1-PE , Mmp1-PF , Mmp1-PG , Mmp1-PH , Mmp1-PI , Mmp1-PJ , Mmp1-PK , Mmp1-PL , Collagenase-3 , collagenase 3 , collagenase-1 , matrix metalloproteinase 13 , matrix metalloproteinase-13 , MMP-18 , collagenase-4 , matrix metalloproteinase-18 , xCol4 , matrix metallopeptidase 1a , matrix metalloproteinase 1a (interstitial collagenase) , myocardial collagenase

4312 Homo sapiens
397320 Sus scrofa
37949 Drosophila melanogaster
1790862 Rhodopirellula baltica SH 1
100144547 Bombyx mori
17386 Mus musculus
281308 Bos taurus
100009110 Oryctolagus cuniculus
489428 Canis lupus familiaris
100033896 Equus caballus
495287 Xenopus laevis
101120355 Ovis aries
100727966 Cavia porcellus
300339 Rattus norvegicus
Ausgewählte Anbieter für MMP1 Proteine (MMP1)
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